This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional e... See more...

Aliases for STEAP2 Gene

Aliases for STEAP2 Gene

  • STEAP2 Metalloreductase 2 3 5
  • STAMP1 2 3 4
  • Six Transmembrane Epithelial Antigen Of The Prostate 2 2 3
  • Protein Up-Regulated In Metastatic Prostate Cancer 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 2 3 4
  • STEAP Family Member 2, Metalloreductase 2 3
  • SixTransMembrane Protein Of Prostate 1 3 4
  • Prostate Cancer-Associated Protein 1 3 4
  • Metalloreductase STEAP2 3 4
  • PCANAP1 3 4
  • PUMPCn 3 4
  • STMP 2 3
  • Protein Upregulated In Metastatic Prostate Cancer 3
  • Prostate Cancer Associated Protein 1 2
  • EC 1.16.1.- 4
  • EC 1.16.1 50
  • STEAP2 5
  • IPCA-1 2
  • IPCA1 3

External Ids for STEAP2 Gene

Previous HGNC Symbols for STEAP2 Gene

  • PCANAP1

Previous GeneCards Identifiers for STEAP2 Gene

  • GC07U990362
  • GC07P088377
  • GC07P089439
  • GC07P089453
  • GC07P089485
  • GC07P089678
  • GC07P089796
  • GC07P084453

Summaries for STEAP2 Gene

Entrez Gene Summary for STEAP2 Gene

  • This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP2 Gene

STEAP2 (STEAP2 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP2 include Prostate Cancer and Deficiency Anemia. Among its related pathways are Insulin receptor recycling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP3.

UniProtKB/Swiss-Prot Summary for STEAP2 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STEAP2 Gene

Genomics for STEAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STEAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STEAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STEAP2

Top Transcription factor binding sites by QIAGEN in the STEAP2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • GATA-1
  • HNF-4alpha1
  • RSRFC4

Genomic Locations for STEAP2 Gene

Latest Assembly
chr7:90,167,590-90,243,408
(GRCh38/hg38)
Size:
75,819 bases
Orientation:
Plus strand

Previous Assembly
chr7:89,841,054-89,866,997
(GRCh37/hg19 by Entrez Gene)
Size:
25,944 bases
Orientation:
Plus strand

chr7:89,796,904-89,867,451
(GRCh37/hg19 by Ensembl)
Size:
70,548 bases
Orientation:
Plus strand

Genomic View for STEAP2 Gene

Genes around STEAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP2 Gene

Proteins for STEAP2 Gene

  • Protein details for STEAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFT2-STEA2_HUMAN
    Recommended name:
    Metalloreductase STEAP2
    Protein Accession:
    Q8NFT2
    Secondary Accessions:
    • A4D1F1
    • G5E9C6
    • Q6UXN6
    • Q6YPB1
    • Q8IUE7

    Protein attributes for STEAP2 Gene

    Size:
    490 amino acids
    Molecular mass:
    56056 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP2 Gene

Selected DME Specific Peptides for STEAP2 Gene

Q8NFT2:
  • GTKYRRFP
  • NQYPESNAEYLA

Post-translational modifications for STEAP2 Gene

  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

Domains & Families for STEAP2 Gene

Gene Families for STEAP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for STEAP2 Gene

Suggested Antigen Peptide Sequences for STEAP2 Gene

GenScript: Design optimal peptide antigens:
  • Six transmembrane prostate protein v1 (Q6YPB2_HUMAN)
  • SixTransMembrane protein of prostate 1 (STEA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NFT2

UniProtKB/Swiss-Prot:

STEA2_HUMAN :
  • Belongs to the STEAP family.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP2: view

Function for STEAP2 Gene

Molecular function for STEAP2 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP2 Gene

Phenotypes From GWAS Catalog for STEAP2 Gene

Gene Ontology (GO) - Molecular Function for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008823 cupric reductase activity IEA,IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with STEAP2: view
genes like me logo Genes that share phenotypes with STEAP2: view

Animal Models for STEAP2 Gene

MGI Knock Outs for STEAP2:
  • Steap2 Steap2<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for STEAP2

miRNA for STEAP2 Gene

miRTarBase miRNAs that target STEAP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STEAP2

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STEAP2 Gene

Localization for STEAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP2 Gene

Endosome membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP2 gene
Compartment Confidence
plasma membrane 5
endosome 5
cytosol 5
golgi apparatus 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005769 early endosome IDA 12095985
GO:0005829 cytosol IDA 12095985
GO:0005886 plasma membrane IBA,IDA 12095985
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with STEAP2: view

Pathways & Interactions for STEAP2 Gene

genes like me logo Genes that share pathways with STEAP2: view

Pathways by source for STEAP2 Gene

1 KEGG pathway for STEAP2 Gene

Interacting Proteins for STEAP2 Gene

Gene Ontology (GO) - Biological Process for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006893 Golgi to plasma membrane transport IDA 12095985
GO:0006897 endocytosis IDA 12095985
GO:0009725 response to hormone IDA 12095985
GO:0015677 copper ion import IEA,IBA 21873635
genes like me logo Genes that share ontologies with STEAP2: view

No data available for SIGNOR curated interactions for STEAP2 Gene

Drugs & Compounds for STEAP2 Gene

(3) Drugs for STEAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
NAD Experimental Pharma 0
heme Pharma 0
genes like me logo Genes that share compounds with STEAP2: view

Transcripts for STEAP2 Gene

mRNA/cDNA for STEAP2 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STEAP2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for STEAP2 Gene

GeneLoc Exon Structure for
STEAP2

Expression for STEAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STEAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP2 Gene

This gene is overexpressed in Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for STEAP2 Gene

This gene is overexpressed in Prostate (36.4), Breast (15.8), and Fetal Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STEAP2 Gene



Protein tissue co-expression partners for STEAP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STEAP2

SOURCE GeneReport for Unigene cluster for STEAP2 Gene:

Hs.489051

mRNA Expression by UniProt/SwissProt for STEAP2 Gene:

Q8NFT2-STEA2_HUMAN
Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

Evidence on tissue expression from TISSUES for STEAP2 Gene

  • Intestine(4.4)
  • Lung(2.6)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with STEAP2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP2 Gene

Orthologs for STEAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STEAP2 29 30
  • 99.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STEAP2 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia STEAP2 29 30
  • 93.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STEAP2 29 30
  • 93.2 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STEAP2 30
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Steap2 29
  • 86.5 (n)
Mouse
(Mus musculus)
Mammalia Steap2 29 16 30
  • 86.3 (n)
OneToOne
Chicken
(Gallus gallus)
Aves STEAP2 29 30
  • 80.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STEAP2 30
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia steap2 29
  • 75.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8813 29
Zebrafish
(Danio rerio)
Actinopterygii steap2 29 30
  • 65.78 (n)
OneToOne
Species where no ortholog for STEAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STEAP2 Gene

ENSEMBL:
Gene Tree for STEAP2 (if available)
TreeFam:
Gene Tree for STEAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STEAP2: view image
Alliance of Genome Resources:
Additional Orthologs for STEAP2

Paralogs for STEAP2 Gene

Paralogs for STEAP2 Gene

(6) SIMAP similar genes for STEAP2 Gene using alignment to 5 proteins:

  • STEA2_HUMAN
  • B5MC02_HUMAN
  • C9JHX5_HUMAN
  • C9JLP2_HUMAN
  • Q6YPB2_HUMAN
genes like me logo Genes that share paralogs with STEAP2: view

Variants for STEAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STEAP2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs13228098 -- p.Gly214Glu
rs17863046 -- p.Asp40Tyr
rs194520 -- p.Phe17Cys
rs194524 -- p.Arg456Gln
rs194525 -- p.Met475Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STEAP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STEAP2 Gene

Variant ID Type Subtype PubMed ID
dgv11493n54 CNV gain 21841781
dgv6525n100 CNV gain 25217958
dgv6529n100 CNV gain 25217958
esv24241 CNV loss 19812545
esv2752188 CNV gain 17911159
esv2759545 CNV gain 17122850
esv3576402 CNV gain 25503493
nsv464626 CNV gain 19166990
nsv508465 CNV deletion 20534489
nsv515997 CNV gain+loss 19592680

Variation tolerance for STEAP2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.44; 97.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STEAP2
Leiden Open Variation Database (LOVD)
STEAP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP2 Gene

Disorders for STEAP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STEAP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
deficiency anemia
  • anemia
aceruloplasminemia
  • hemosiderosis, systemic, due to aceruloplasminemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STEAP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with STEAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP2 Gene

Publications for STEAP2 Gene

  1. Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. (PMID: 12095985) Korkmaz KS … Saatcioglu F (The Journal of biological chemistry 2002) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. The Steap proteins are metalloreductases. (PMID: 16609065) Ohgami RS … Fleming MD (Blood 2006) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. (PMID: 12429817) Porkka KP … Visakorpi T (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4

Products for STEAP2 Gene

Sources for STEAP2 Gene