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Aliases for STEAP2 Gene

Aliases for STEAP2 Gene

  • STEAP2 Metalloreductase 2 3 5
  • Six Transmembrane Epithelial Antigen Of The Prostate 2 2 3
  • Protein Up-Regulated In Metastatic Prostate Cancer 3 4
  • Six-Transmembrane Epithelial Antigen Of Prostate 2 3 4
  • STEAP Family Member 2, Metalloreductase 2 3
  • SixTransMembrane Protein Of Prostate 1 3 4
  • Prostate Cancer-Associated Protein 1 3 4
  • PCANAP1 3 4
  • PUMPCn 3 4
  • STAMP1 3 4
  • Protein Upregulated In Metastatic Prostate Cancer 3
  • Prostate Cancer Associated Protein 1 2
  • Metalloreductase STEAP2 3
  • EC 1.16.1.- 4
  • EC 1.16.1 56
  • IPCA1 3
  • STMP 3

External Ids for STEAP2 Gene

Previous HGNC Symbols for STEAP2 Gene


Previous GeneCards Identifiers for STEAP2 Gene

  • GC07U990362
  • GC07P088377
  • GC07P089439
  • GC07P089453
  • GC07P089485
  • GC07P089678
  • GC07P089796
  • GC07P084453

Summaries for STEAP2 Gene

Entrez Gene Summary for STEAP2 Gene

  • This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for STEAP2 Gene

STEAP2 (STEAP2 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP2 include Prostate Cancer. Among its related pathways are Insulin receptor recycling and Mineral absorption. Gene Ontology (GO) annotations related to this gene include transporter activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP3.

UniProtKB/Swiss-Prot for STEAP2 Gene

  • Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Gene Wiki entry for STEAP2 Gene

Additional gene information for STEAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STEAP2 Gene

Genomics for STEAP2 Gene

GeneHancer (GH) Regulatory Elements for STEAP2 Gene

Promoters and enhancers for STEAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I090210 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 574 +44.1 44057 2.3 HDGF FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5 ZHX2 STEAP2 STEAP2-AS1 STEAP1 GC07P090219
GH07I090214 Promoter/Enhancer 0.7 EPDnew dbSUPER 560.8 +46.2 46210 0.1 STEAP2 CFAP69 ENSG00000207488 STEAP2-AS1 GC07P090219
GH07I090153 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.1 -12.7 -12747 2 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 STEAP1 STEAP2 STEAP2-AS1
GH07I090244 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.8 +78.0 77977 2 FOXA2 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 IRF4 YY1 ZNF207 ZNF143 CFAP69 STEAP2 GTPBP10 STEAP1 GC07P090252
GH07I090345 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.3 +179.1 179134 2.7 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 GTPBP10 ENSG00000280440 PIR48694 STEAP1 STEAP2 ENSG00000234459 CLDN12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STEAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STEAP2 gene promoter:

Genomic Locations for STEAP2 Gene

Genomic Locations for STEAP2 Gene
70,548 bases
Plus strand

Genomic View for STEAP2 Gene

Genes around STEAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP2 Gene

Proteins for STEAP2 Gene

  • Protein details for STEAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloreductase STEAP2
    Protein Accession:
    Secondary Accessions:
    • A4D1F1
    • G5E9C6
    • Q6UXN6
    • Q6YPB1
    • Q8IUE7

    Protein attributes for STEAP2 Gene

    490 amino acids
    Molecular mass:
    56056 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP2 Gene


neXtProt entry for STEAP2 Gene

Selected DME Specific Peptides for STEAP2 Gene


Post-translational modifications for STEAP2 Gene

Domains & Families for STEAP2 Gene

Gene Families for STEAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for STEAP2 Gene

Suggested Antigen Peptide Sequences for STEAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STEAP family.
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP2: view

Function for STEAP2 Gene

Molecular function for STEAP2 Gene

UniProtKB/Swiss-Prot Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).

Enzyme Numbers (IUBMB) for STEAP2 Gene

Phenotypes From GWAS Catalog for STEAP2 Gene

Gene Ontology (GO) - Molecular Function for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IDA 12095985
GO:0008823 cupric reductase activity IBA,IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052851 ferric-chelate reductase (NADPH) activity IBA,IEA --
genes like me logo Genes that share ontologies with STEAP2: view

Phenotypes for STEAP2 Gene

genes like me logo Genes that share phenotypes with STEAP2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STEAP2 Gene

Localization for STEAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP2 Gene

Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
endosome 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 12095985
GO:0005829 cytosol IDA 12095985
GO:0005886 plasma membrane IEA,IDA 12095985
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with STEAP2: view

Pathways & Interactions for STEAP2 Gene

genes like me logo Genes that share pathways with STEAP2: view

Pathways by source for STEAP2 Gene

1 KEGG pathway for STEAP2 Gene

Interacting Proteins for STEAP2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8NFT2-STEA2_HUMAN ENSP00000287908 for STEAP2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for STEAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006893 Golgi to plasma membrane transport IDA 12095985
GO:0006897 endocytosis IDA 12095985
GO:0009725 response to hormone IDA 12095985
GO:0015677 copper ion import IBA,IEA --
genes like me logo Genes that share ontologies with STEAP2: view

No data available for SIGNOR curated interactions for STEAP2 Gene

Drugs & Compounds for STEAP2 Gene

(3) Drugs for STEAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
heme Pharma Agonist 0
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with STEAP2: view

Transcripts for STEAP2 Gene

Unigene Clusters for STEAP2 Gene

STEAP family member 2, metalloreductase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -

Relevant External Links for STEAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STEAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STEAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STEAP2 Gene

This gene is overexpressed in Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for STEAP2 Gene

This gene is overexpressed in Prostate (36.4), Breast (15.8), and Fetal Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STEAP2 Gene

Protein tissue co-expression partners for STEAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STEAP2 Gene:


SOURCE GeneReport for Unigene cluster for STEAP2 Gene:


mRNA Expression by UniProt/SwissProt for STEAP2 Gene:

Tissue specificity: Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

Evidence on tissue expression from TISSUES for STEAP2 Gene

  • Intestine(4.3)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with STEAP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP2 Gene

Orthologs for STEAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STEAP2 33 34
  • 99.47 (n)
(Monodelphis domestica)
Mammalia STEAP2 34
  • 97 (a)
(Bos Taurus)
Mammalia STEAP2 33 34
  • 93.33 (n)
(Canis familiaris)
Mammalia STEAP2 33 34
  • 93.2 (n)
(Ornithorhynchus anatinus)
Mammalia STEAP2 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Steap2 33
  • 86.5 (n)
(Mus musculus)
Mammalia Steap2 33 16 34
  • 86.3 (n)
(Gallus gallus)
Aves STEAP2 33 34
  • 80.3 (n)
(Anolis carolinensis)
Reptilia STEAP2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia steap2 33
  • 75.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8813 33
(Danio rerio)
Actinopterygii steap2 33 34
  • 65.78 (n)
Species where no ortholog for STEAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STEAP2 Gene

Gene Tree for STEAP2 (if available)
Gene Tree for STEAP2 (if available)

Paralogs for STEAP2 Gene

Paralogs for STEAP2 Gene

(6) SIMAP similar genes for STEAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STEAP2: view

Variants for STEAP2 Gene

Sequence variations from dbSNP and Humsavar for STEAP2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000005900 -- 90,238,012(+) C/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000014686 -- 90,235,069(+) A/T 3_prime_UTR_variant, intron_variant
rs1000048082 -- 90,242,589(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000076813 -- 90,218,601(+) A/G intron_variant
rs1000181549 -- 90,210,678(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP2 Gene

Variant ID Type Subtype PubMed ID
nsv515997 CNV gain+loss 19592680
nsv508465 CNV deletion 20534489
nsv464626 CNV gain 19166990
esv3576402 CNV gain 25503493
esv2759545 CNV gain 17122850
esv2752188 CNV gain 17911159
esv24241 CNV loss 19812545
dgv6529n100 CNV gain 25217958
dgv6525n100 CNV gain 25217958
dgv11493n54 CNV gain 21841781

Variation tolerance for STEAP2 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.44; 97.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP2 Gene

Disorders for STEAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STEAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STEAP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STEAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STEAP2 Gene

Publications for STEAP2 Gene

  1. Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. (PMID: 12095985) Korkmaz KS … Saatcioglu F (The Journal of biological chemistry 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The Steap proteins are metalloreductases. (PMID: 16609065) Ohgami RS … Fleming MD (Blood 2006) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. (PMID: 12429817) Porkka KP … Visakorpi T (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4 58

Products for STEAP2 Gene

Sources for STEAP2 Gene

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