Aliases for STEAP1B Gene

Aliases for STEAP1B Gene

  • STEAP Family Member 1B 2 3 4 5
  • STEAP Family Protein MGC87042 3

External Ids for STEAP1B Gene

Previous GeneCards Identifiers for STEAP1B Gene

  • GC07M022459

Summaries for STEAP1B Gene

GeneCards Summary for STEAP1B Gene

STEAP1B (STEAP Family Member 1B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cupric reductase activity and ferric-chelate reductase (NADPH) activity. An important paralog of this gene is STEAP1.

Additional gene information for STEAP1B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STEAP1B Gene

Genomics for STEAP1B Gene

GeneHancer (GH) Regulatory Elements for STEAP1B Gene

Promoters and enhancers for STEAP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J022498 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 768.8 +227.9 227879 2.1 CTCF ZBTB6 L3MBTL2 DACH1 GTF2F1 ZFX SP5 TRIM24 EGR1 ZNF560 STEAP1B lnc-RAPGEF5-1 RAPGEF5 GPNMB FAM126A piR-32214-615
GH07J022724 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 759.2 +0.5 454 5.3 CTCF ZBTB6 SMARCE1 POLR2A ZNF362 MYC L3MBTL2 RAD21 MAX DACH1 IL6-AS1 STEAP1B IL6 TRA2A FAM126A LOC100506178
GH07J022659 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 762.9 +55.5 55513 25 ZBTB40 SMARCE1 TCF7L2 NR2F6 ZNF217 NFYC ELF1 RELA HLF L3MBTL2 STEAP1B GPNMB IL6-AS1 IL6 TRA2A FAM126A ENSG00000226329 CLK2P1 LOC401312 lnc-STEAP1B-3
GH07J022705 Promoter 0.5 EPDnew 750.3 +21.8 21849 0.1 PKNOX1 ZNF354B piR-38265-007 piR-30107-013 STEAP1B IL6-AS1 TRA2A lnc-IL6-5
GH07J022569 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +152.2 152212 13.2 POLR2A CTBP1 ZNF217 RAD21 DACH1 MNT SP1 NCOA3 MAFK CEBPG IL6 IL6-AS1 STEAP1B LOC100506178 SNHG26 ENSG00000232949 lnc-RAPGEF5-3 lnc-STEAP1B-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STEAP1B on UCSC Golden Path with GeneCards custom track

Genomic Locations for STEAP1B Gene

Genomic Locations for STEAP1B Gene
chr7:22,419,444-22,727,613
(GRCh38/hg38)
Size:
308,170 bases
Orientation:
Minus strand
chr7:22,459,063-22,672,544
(GRCh37/hg19)
Size:
213,482 bases
Orientation:
Minus strand

Genomic View for STEAP1B Gene

Genes around STEAP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STEAP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STEAP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STEAP1B Gene

Proteins for STEAP1B Gene

  • Protein details for STEAP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NZ63-STEAL_HUMAN
    Recommended name:
    STEAP family member 1B
    Protein Accession:
    Q6NZ63
    Secondary Accessions:
    • B5MCI2

    Protein attributes for STEAP1B Gene

    Size:
    245 amino acids
    Molecular mass:
    28815 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for STEAP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STEAP1B Gene

Post-translational modifications for STEAP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STEAP1B Gene

No data available for DME Specific Peptides for STEAP1B Gene

Domains & Families for STEAP1B Gene

Gene Families for STEAP1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for STEAP1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STEAP1B Gene

GenScript: Design optimal peptide antigens:
  • STEAP family member 1B (STEAL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NZ63

UniProtKB/Swiss-Prot:

STEAL_HUMAN :
  • Belongs to the STEAP family.
Family:
  • Belongs to the STEAP family.
genes like me logo Genes that share domains with STEAP1B: view

Function for STEAP1B Gene

Phenotypes From GWAS Catalog for STEAP1B Gene

genes like me logo Genes that share phenotypes with STEAP1B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for STEAP1B Gene

Localization for STEAP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STEAP1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STEAP1B gene
Compartment Confidence
plasma membrane 4
endosome 3
peroxisome 1
nucleus 0
cytosol 0

Gene Ontology (GO) - Cellular Components for STEAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with STEAP1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STEAP1B Gene

Pathways & Interactions for STEAP1B Gene

PathCards logo

SuperPathways for STEAP1B Gene

No Data Available

Interacting Proteins for STEAP1B Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000384370 Q6NZ63-STEAL_HUMAN for STEAP1B Gene via STRING IID

Gene Ontology (GO) - Biological Process for STEAP1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STEAP1B Gene

Drugs & Compounds for STEAP1B Gene

No Compound Related Data Available

Transcripts for STEAP1B Gene

mRNA/cDNA for STEAP1B Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STEAP1B Gene

No ASD Table

Relevant External Links for STEAP1B Gene

GeneLoc Exon Structure for
STEAP1B
ECgene alternative splicing isoforms for
STEAP1B

Expression for STEAP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STEAP1B Gene

NURSA nuclear receptor signaling pathways regulating expression of STEAP1B Gene:

STEAP1B

SOURCE GeneReport for Unigene cluster for STEAP1B Gene:

Hs.729825

Evidence on tissue expression from TISSUES for STEAP1B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with STEAP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STEAP1B Gene

Orthologs for STEAP1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for STEAP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STEAP1B 32
  • 98.02 (n)
STEAP1 33
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 70 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 33
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Steap1 33
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 53 (a)
OneToMany
Species where no ortholog for STEAP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STEAP1B Gene

ENSEMBL:
Gene Tree for STEAP1B (if available)
TreeFam:
Gene Tree for STEAP1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STEAP1B: view image

Paralogs for STEAP1B Gene

Paralogs for STEAP1B Gene

(6) SIMAP similar genes for STEAP1B Gene using alignment to 4 proteins:

  • STEAL_HUMAN
  • B5MCI2_HUMAN
  • C9JE84_HUMAN
  • C9JL51_HUMAN
genes like me logo Genes that share paralogs with STEAP1B: view

Variants for STEAP1B Gene

Sequence variations from dbSNP and Humsavar for STEAP1B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000045886 -- 22,439,207(-) G/A/T intron_variant
rs1000108286 -- 22,433,005(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000127201 -- 22,439,865(-) C/T intron_variant
rs1000134058 -- 22,451,390(-) A/G intron_variant
rs1000141129 -- 22,458,715(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STEAP1B Gene

Variant ID Type Subtype PubMed ID
esv1507352 CNV deletion 17803354
esv1928956 CNV deletion 18987734
esv2590646 CNV deletion 19546169
esv2665146 CNV deletion 23128226
esv2667204 CNV deletion 23128226
esv2734122 CNV deletion 23290073
esv3541325 CNV deletion 23714750
esv3612512 CNV loss 21293372
esv3612518 CNV loss 21293372
esv3612520 CNV loss 21293372
esv991050 CNV deletion 20482838
nsv1076875 CNV deletion 25765185
nsv5658 CNV deletion 18451855
nsv7393 OTHER inversion 18451855
nsv830923 CNV gain 17160897
nsv958412 CNV deletion 24416366
nsv970801 CNV duplication 23825009

Variation tolerance for STEAP1B Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.66; 97.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STEAP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STEAP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STEAP1B Gene

Disorders for STEAP1B Gene

Additional Disease Information for STEAP1B

No disorders were found for STEAP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STEAP1B Gene

Publications for STEAP1B Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  3. Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms. (PMID: 25053991) Gomes IM … Maia CJ (Genes & cancer 2014) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M … Freedman BI (American journal of nephrology 2011) 3 56

Products for STEAP1B Gene

Sources for STEAP1B Gene