This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residue... See more...

Aliases for STC2 Gene

Aliases for STC2 Gene

  • Stanniocalcin 2 2 3 5
  • Stanniocalcin-Related Protein 3 4
  • STC-Related Protein 3 4
  • Stanniocalcin-2 3 4
  • STC-2 3 4
  • STCRP 3 4

External Ids for STC2 Gene

Previous GeneCards Identifiers for STC2 Gene

  • GC05M173001
  • GC05M173443
  • GC05M172677
  • GC05M172722
  • GC05M172674
  • GC05M172741
  • GC05M167836

Summaries for STC2 Gene

Entrez Gene Summary for STC2 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC2 Gene

STC2 (Stanniocalcin 2) is a Protein Coding gene. Diseases associated with STC2 include Breast Cancer and Renal Cell Carcinoma, Nonpapillary. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is STC1.

UniProtKB/Swiss-Prot Summary for STC2 Gene

  • Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Gene Wiki entry for STC2 Gene

Additional gene information for STC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STC2 Gene

Genomics for STC2 Gene

GeneHancer (GH) Regulatory Elements for STC2 Gene

Promoters and enhancers for STC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J173322 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +2.0 1976 9.4 FOXK2 ZNF217 CTCF MYC NRF1 POLR2G USF1 SP1 NCOR1 RBAK lnc-BNIP1-5 STC2 lnc-NKX2-5-7 SH3PXD2B CREBRF BOD1 ENSG00000204758 DUSP1 RNU6-500P ENSG00000253955
GH05J173494 Enhancer 1.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.1 -168.7 -168698 7.2 USF1 NCOR1 SKI TEAD1 CTCF ESRRA TCF12 EZH2 GATA3 FOSL2 STC2 lnc-BNIP1-6 lnc-BNIP1-4 LOC105377732
GH05J173515 Enhancer 0.7 Ensembl ENCODE 5.3 -186.2 -186248 1.1 CTBP1 FOS CEBPB JUN ELF1 JUND FOXA1 EP300 DPF2 ZNF217 ENSG00000253244 STC2 ENSG00000253768 lnc-BNIP1-6 LOC105377733 lnc-BNIP1-4 LOC105377732
GH05J173333 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 3 -4.5 -4544 2.5 EP300 ATF2 ZNF316 TRIM24 FOS CEBPG FOSL2 CEBPB POLR2H JUN RNU6-500P STC2 lnc-BNIP1-5 MIR8056
GH05J173354 Enhancer 0.2 Ensembl 12.6 -25.6 -25597 0.6 STC2 RF00994-881 RF00026-911 RNU6-500P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STC2

Top Transcription factor binding sites by QIAGEN in the STC2 gene promoter:
  • ATF6
  • c-Myc
  • E2F
  • HNF-4alpha1
  • Max
  • MAZR
  • POU2F1
  • POU2F1a
  • S8
  • STAT5A

Genomic Locations for STC2 Gene

Genomic Locations for STC2 Gene
chr5:173,314,713-173,329,503
(GRCh38/hg38)
Size:
14,791 bases
Orientation:
Minus strand
chr5:172,741,716-172,756,506
(GRCh37/hg19)
Size:
14,791 bases
Orientation:
Minus strand

Genomic View for STC2 Gene

Genes around STC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC2 Gene

Proteins for STC2 Gene

  • Protein details for STC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76061-STC2_HUMAN
    Recommended name:
    Stanniocalcin-2
    Protein Accession:
    O76061

    Protein attributes for STC2 Gene

    Size:
    302 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for STC2 Gene

Post-translational modifications for STC2 Gene

  • Glycosylation at Asn73 and Thr232
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for STC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for STC2
  • Santa Cruz Biotechnology (SCBT) Antibodies for STC2

No data available for DME Specific Peptides for STC2 Gene

Domains & Families for STC2 Gene

Gene Families for STC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for STC2 Gene

Blocks:
  • Stanniocalcin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STC2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA PSEC0097 fis, clone NT2RP2002139, highly similar to Stanniocalcin-2 (Q6FHC9_HUMAN)
  • Stanniocalcin-related protein (STC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76061

UniProtKB/Swiss-Prot:

STC2_HUMAN :
  • Belongs to the stanniocalcin family.
Family:
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC2: view

Function for STC2 Gene

Molecular function for STC2 Gene

UniProtKB/Swiss-Prot Function:
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Phenotypes From GWAS Catalog for STC2 Gene

Gene Ontology (GO) - Molecular Function for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0019899 enzyme binding IDA 22503972
GO:0020037 heme binding IDA 22503972
GO:0042803 protein homodimerization activity IDA 15486227
genes like me logo Genes that share ontologies with STC2: view
genes like me logo Genes that share phenotypes with STC2: view

Animal Models for STC2 Gene

MGI Knock Outs for STC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for STC2

CRISPR Products

miRNA for STC2 Gene

miRTarBase miRNAs that target STC2

Clone Products

  • Addgene plasmids for STC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STC2 Gene

Localization for STC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STC2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IDA,IEA 22503972
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with STC2: view

Pathways & Interactions for STC2 Gene

PathCards logo

SuperPathways for STC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007165 signal transduction IEA --
GO:0007566 embryo implantation IEA --
GO:0010629 negative regulation of gene expression IDA 9753616
genes like me logo Genes that share ontologies with STC2: view

No data available for Pathways by source and SIGNOR curated interactions for STC2 Gene

Drugs & Compounds for STC2 Gene

(4) Drugs for STC2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with STC2: view

Transcripts for STC2 Gene

mRNA/cDNA for STC2 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for STC2

Alternative Splicing Database (ASD) splice patterns (SP) for STC2 Gene

No ASD Table

Relevant External Links for STC2 Gene

GeneLoc Exon Structure for
STC2

Expression for STC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC2 Gene

This gene is overexpressed in Breast - Mammary Tissue (x7.3).

Protein differential expression in normal tissues from HIPED for STC2 Gene

This gene is overexpressed in Amniocyte (42.3), Plasma (14.6), and Serum (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STC2 Gene



Protein tissue co-expression partners for STC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STC2

SOURCE GeneReport for Unigene cluster for STC2 Gene:

Hs.233160

mRNA Expression by UniProt/SwissProt for STC2 Gene:

O76061-STC2_HUMAN
Tissue specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for STC2 Gene

  • Muscle(4.5)
  • Kidney(4.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with STC2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for STC2 Gene

Orthologs for STC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STC2 31 30
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STC2 31 30
  • 91.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STC2 31 30
  • 90.4 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STC2 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stc2 17 31 30
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Stc2 30
  • 84.57 (n)
oppossum
(Monodelphis domestica)
Mammalia STC2 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves STC2 31 30
  • 71.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STC2 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stc2 30
  • 65.09 (n)
zebrafish
(Danio rerio)
Actinopterygii stc2a 31 30
  • 61.58 (n)
OneToMany
stc2b 31
  • 46 (a)
OneToMany
Species where no ortholog for STC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC2 Gene

ENSEMBL:
Gene Tree for STC2 (if available)
TreeFam:
Gene Tree for STC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STC2: view image

Paralogs for STC2 Gene

Paralogs for STC2 Gene

(1) SIMAP similar genes for STC2 Gene using alignment to 4 proteins:

  • STC2_HUMAN
  • E5RG57_HUMAN
  • H0YB13_HUMAN
  • Q6FHC9_HUMAN
genes like me logo Genes that share paralogs with STC2: view

Variants for STC2 Gene

Additional dbSNP identifiers (rs#s) for STC2 Gene

Variation tolerance for STC2 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STC2 Gene

Human Gene Mutation Database (HGMD)
STC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for STC2 Gene

Disorders for STC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for STC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards
Search STC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STC2 Gene

Publications for STC2 Gene

  1. Molecular cloning of a second human stanniocalcin homologue (STC2). (PMID: 9753616) Ishibashi K … Imai M (Biochemical and biophysical research communications 1998) 2 3 4 23 54
  2. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. (PMID: 9723890) Chang AC … Reddel RR (Molecular and cellular endocrinology 1998) 2 3 4 23 54
  3. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. (PMID: 10450831) Moore EE … De Jongh KS (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1999) 3 4 23 54
  4. Molecular cloning and characterization of stanniocalcin-related protein. (PMID: 10022771) DiMattia GE … Wagner GF (Molecular and cellular endocrinology 1998) 3 4 23 54
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 41 54

Products for STC2 Gene

Sources for STC2 Gene