Aliases for STC2 Gene
External Ids for STC2 Gene
Previous GeneCards Identifiers for STC2 Gene
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
GeneCards Summary for STC2 Gene
STC2 (Stanniocalcin 2) is a Protein Coding gene. Diseases associated with STC2 include Breast Cancer and Renal Cell Carcinoma, Nonpapillary. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is STC1.
UniProtKB/Swiss-Prot Summary for STC2 Gene
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.