External Ids for STC1 Gene
Previous HGNC Symbols for STC1 Gene
Previous GeneCards Identifiers for STC1 Gene
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
GeneCards Summary for STC1 Gene
STC1 (Stanniocalcin 1) is a Protein Coding gene. Diseases associated with STC1 include Myasthenic Syndrome, Congenital, 6, Presynaptic and Fibrosarcoma. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is STC2.
UniProtKB/Swiss-Prot Summary for STC1 Gene
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.