This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in ... See more...

Aliases for STC1 Gene

Aliases for STC1 Gene

  • Stanniocalcin 1 2 3 5
  • Stanniocalcin-1 3 4
  • STC 3 4
  • STC-1 4

External Ids for STC1 Gene

Previous HGNC Symbols for STC1 Gene

  • STC

Previous GeneCards Identifiers for STC1 Gene

  • GC08M023432
  • GC08M024052
  • GC08M023721
  • GC08M023755
  • GC08M022244
  • GC08M023700

Summaries for STC1 Gene

Entrez Gene Summary for STC1 Gene

  • This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for STC1 Gene

STC1 (Stanniocalcin 1) is a Protein Coding gene. Diseases associated with STC1 include Splenic Flexure Cancer and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is STC2.

UniProtKB/Swiss-Prot Summary for STC1 Gene

  • Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Gene Wiki entry for STC1 Gene

Additional gene information for STC1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STC1 Gene

Genomics for STC1 Gene

GeneHancer (GH) Regulatory Elements for STC1 Gene

Promoters and enhancers for STC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J023853 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 504.5 +0.9 862 2.9 ZSCAN5C POLR2A TRIM28 SAP30 RFX1 HDAC2 OSR2 MYNN SMC3 ZBTB17 STC1 ADAM28 piR-39858-603 RF00017-6889
GH08J023760 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +91.9 91906 4.2 NRF1 JUND FOS EP300 CTCF TCF12 CREB1 ZBTB17 GABPA SMARCC1 NKX3-1 STC1 SLC25A37 ENTPD4 ENSG00000254002 lnc-STC1-5 ENSG00000253471 RF00017-6889
GH08J023796 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.4 +56.6 56606 3.6 TCF12 JUND FOS ZIC2 REST POLR2A TRIM28 EP300 NR2F2 DEK STC1 ENSG00000271118 lnc-STC1-4 lnc-STC1-5 RF00017-6889
GH08J024152 Enhancer 1.1 FANTOM5 Ensembl ENCODE 12.5 -300.3 -300294 5 ZBTB40 TCF12 FOS POLR2A CTCF EP300 SMC3 REST BRCA1 FOSL2 STC1 piR-57135-089 ENSG00000253891
GH08J024216 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -363.5 -363535 3.1 TCF12 FOS TRIM28 EP300 ZEB1 OSR2 DEK KDM1A ZBTB17 REST STC1 HSALNG0064038 piR-56133-213
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STC1

Top Transcription factor binding sites by QIAGEN in the STC1 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • Lmo2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • Nkx2-5

Genomic Locations for STC1 Gene

Genomic Locations for STC1 Gene
chr8:23,841,921-23,854,807
(GRCh38/hg38)
Size:
12,887 bases
Orientation:
Minus strand
chr8:23,699,428-23,712,320
(GRCh37/hg19)
Size:
12,893 bases
Orientation:
Minus strand

Genomic View for STC1 Gene

Genes around STC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STC1 Gene

Proteins for STC1 Gene

  • Protein details for STC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52823-STC1_HUMAN
    Recommended name:
    Stanniocalcin-1
    Protein Accession:
    P52823
    Secondary Accessions:
    • B4DN22
    • Q71UE5

    Protein attributes for STC1 Gene

    Size:
    247 amino acids
    Molecular mass:
    27621 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for STC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STC1 Gene

Post-translational modifications for STC1 Gene

  • Glycosylation at Asn62, Thr205, and Ser237
  • Modification sites at PhosphoSitePlus

Other Protein References for STC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STC1 Gene

Domains & Families for STC1 Gene

Gene Families for STC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for STC1 Gene

Blocks:
  • Stanniocalcin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STC1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51498, highly similar to Stanniocalcin-1 (B4DN22_HUMAN)
  • Stanniocalcin (Q71UE5_HUMAN)
  • Stanniocalcin-1 (STC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52823

UniProtKB/Swiss-Prot:

STC1_HUMAN :
  • Belongs to the stanniocalcin family.
Family:
  • Belongs to the stanniocalcin family.
genes like me logo Genes that share domains with STC1: view

Function for STC1 Gene

Molecular function for STC1 Gene

UniProtKB/Swiss-Prot Function:
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
GENATLAS Biochemistry:
stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral homeostasis,likely by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and membrane bone

Phenotypes From GWAS Catalog for STC1 Gene

Gene Ontology (GO) - Molecular Function for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with STC1: view
genes like me logo Genes that share phenotypes with STC1: view

Animal Models for STC1 Gene

MGI Knock Outs for STC1:
  • Stc1 Stc1<tm1Rred>

Animal Model Products

  • Taconic Biosciences Mouse Models for STC1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STC1 Gene

Localization for STC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STC1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 12663264
GO:0005737 cytoplasm IDA 12663264
genes like me logo Genes that share ontologies with STC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STC1 Gene

Pathways & Interactions for STC1 Gene

PathCards logo

SuperPathways for STC1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with STC1: view

Pathways by source for STC1 Gene

1 BioSystems pathway for STC1 Gene

Interacting Proteins for STC1 Gene

;

Gene Ontology (GO) - Biological Process for STC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001886 endothelial cell morphogenesis IDA 14500721
GO:0003421 growth plate cartilage axis specification IDA 16377640
GO:0006874 cellular calcium ion homeostasis IDA 8700837
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with STC1: view

No data available for SIGNOR curated interactions for STC1 Gene

Drugs & Compounds for STC1 Gene

(8) Drugs for STC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for STC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STC1: view

Transcripts for STC1 Gene

mRNA/cDNA for STC1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STC1 Gene

No ASD Table

Relevant External Links for STC1 Gene

GeneLoc Exon Structure for
STC1

Expression for STC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STC1 Gene

This gene is overexpressed in Thyroid (x6.4) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for STC1 Gene

This gene is overexpressed in Cervix (51.6) and Milk (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STC1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STC1

SOURCE GeneReport for Unigene cluster for STC1 Gene:

Hs.25590

mRNA Expression by UniProt/SwissProt for STC1 Gene:

P52823-STC1_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.

Evidence on tissue expression from TISSUES for STC1 Gene

  • Kidney(4.7)
  • Intestine(4.5)
  • Lung(4.5)
  • Stomach(4.3)
  • Nervous system(2.9)
  • Blood(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with STC1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STC1 Gene

Orthologs for STC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STC1 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STC1 31 30
  • 94.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STC1 31 30
  • 92.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stc1 17 31 30
  • 91.63 (n)
rat
(Rattus norvegicus)
Mammalia Stc1 30
  • 91.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STC1 31
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STC1 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves STC1 31 30
  • 80.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STC1 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stc1 30
  • 69.76 (n)
zebrafish
(Danio rerio)
Actinopterygii stc1 31
  • 57 (a)
OneToMany
stc1l 31
  • 51 (a)
OneToMany
zgc66061 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11504 30
Species where no ortholog for STC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STC1 Gene

ENSEMBL:
Gene Tree for STC1 (if available)
TreeFam:
Gene Tree for STC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STC1: view image

Paralogs for STC1 Gene

Paralogs for STC1 Gene

(1) SIMAP similar genes for STC1 Gene using alignment to 2 proteins:

  • STC1_HUMAN
  • B4DN22_HUMAN
genes like me logo Genes that share paralogs with STC1: view

Variants for STC1 Gene

Additional dbSNP identifiers (rs#s) for STC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for STC1 Gene

Variant ID Type Subtype PubMed ID
esv3891377 CNV loss 25118596
nsv1028341 CNV gain 25217958
nsv831269 CNV gain 17160897

Variation tolerance for STC1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STC1 Gene

Disorders for STC1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for STC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
splenic flexure cancer
  • ca splenic flexure - colon
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
adult teratoma
von hippel-lindau syndrome
  • vhl
diverticulitis of colon
  • colonic diverticular disease
- elite association - COSMIC cancer census association via MalaCards
Search STC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STC1 Gene

Publications for STC1 Gene

  1. Comparative analysis of mammalian stanniocalcin genes. (PMID: 9794484) Varghese R … DiMattia GE (Endocrinology 1998) 3 4 23 54
  2. Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PMID: 9480753) Chang AC … Reddel RR (Genomics 1998) 2 3 23 54
  3. Human stanniocalcin: a possible hormonal regulator of mineral metabolism. (PMID: 8700837) Olsen HS … Wagner GF (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 41 54

Products for STC1 Gene

  • Boster Bio Antibodies for STC1
  • Boster Bio ELISA Kits for STC1

Sources for STC1 Gene