Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog ... See more...

Aliases for STAU2 Gene

Aliases for STAU2 Gene

  • Staufen Double-Stranded RNA Binding Protein 2 2 3 5
  • Double-Stranded RNA-Binding Protein Staufen Homolog 2 3 4
  • Staufen, RNA Binding Protein, Homolog 2 (Drosophila) 2
  • Staufen (Drosophila, RNA-Binding Protein) Homolog 2 2
  • Staufen, RNA Binding Protein, Homolog 2 3
  • Staufen Homolog 2 3
  • 39K2 3
  • 39K3 3

External Ids for STAU2 Gene

Previous GeneCards Identifiers for STAU2 Gene

  • GC08M074273
  • GC08M074055
  • GC08M074382
  • GC08M074383
  • GC08M074495
  • GC08M074332
  • GC08M069823

Summaries for STAU2 Gene

Entrez Gene Summary for STAU2 Gene

  • Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for STAU2 Gene

STAU2 (Staufen Double-Stranded RNA Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU1.

UniProtKB/Swiss-Prot Summary for STAU2 Gene

  • RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).

Gene Wiki entry for STAU2 Gene

Additional gene information for STAU2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAU2 Gene

Genomics for STAU2 Gene

GeneHancer (GH) Regulatory Elements for STAU2 Gene

Promoters and enhancers for STAU2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J073745 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.1 1107 4 HNRNPK ZNF217 EP300 CTCF SIN3A MYC POLR2G GTF2E2 PHF8 ZNF639 STAU2 lnc-UBE2W-1 RDH10 RF00017-7129 ENSG00000258677
GH08J073792 Promoter/Enhancer 1.4 UCNEbase EPDnew Ensembl ENCODE 11.8 -46.1 -46093 2 NR2F2 CEBPG FOS CEBPB STAT3 MAX NR2F1 NR2C2 NR2F6 JUN UBE2W STAU2 lnc-STAU2-3 piR-33905-087 ENSG00000258677
GH08J073892 Enhancer 1 FANTOM5 Ensembl ENCODE 10.4 -145.7 -145692 1.2 USF1 TOE1 CTBP1 NFYB MYNN ZNF318 BHLHE40 VEZF1 MITF ATF4 ELOC TMEM70 STAU2 GDAP1 ENSG00000253596 UBE2W ENSG00000286113 LINC01617 piR-57757-006
GH08J073858 Enhancer 0.5 Ensembl 16.4 -112.6 -112593 3.8 PRDM6 PRDM10 ATF7 SPI1 ZBTB33 ZNF770 ZSCAN4 BCLAF1 RUNX3 STAU2 ELOC TMEM70 UBE2W piR-54764-614 ENSG00000258677
GH08J073834 Enhancer 0.7 ENCODE 10.7 -88.0 -87981 1.2 EP300 RCOR1 TRIM22 POLR2A USF2 NBN FOSL1 E2F6 BATF ELF1 RF00017-7131 RN7SL760P UBE2W STAU2 piR-50308-621 ENSG00000258677
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAU2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAU2

Top Transcription factor binding sites by QIAGEN in the STAU2 gene promoter:
  • c-Myb
  • E2F
  • E2F-1
  • En-1
  • GR
  • GR-alpha
  • Hlf
  • HOXA5
  • RSRFC4
  • SREBP-1c

Genomic Locations for STAU2 Gene

Genomic Locations for STAU2 Gene
chr8:73,420,369-73,747,708
(GRCh38/hg38)
Size:
327,340 bases
Orientation:
Minus strand
chr8:74,332,604-74,659,943
(GRCh37/hg19)
Size:
327,340 bases
Orientation:
Minus strand

Genomic View for STAU2 Gene

Genes around STAU2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAU2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAU2 Gene

Proteins for STAU2 Gene

  • Protein details for STAU2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUL3-STAU2_HUMAN
    Recommended name:
    Double-stranded RNA-binding protein Staufen homolog 2
    Protein Accession:
    Q9NUL3
    Secondary Accessions:
    • A0A0A0MTC5
    • B7Z1I6
    • B7Z292
    • B7Z8B4
    • E7ER74
    • E9PEI3
    • E9PF26
    • E9PF50
    • Q6AHY7
    • Q96HM0
    • Q96HM1
    • Q9NVI5
    • Q9UGG6

    Protein attributes for STAU2 Gene

    Size:
    570 amino acids
    Molecular mass:
    62608 Da
    Quaternary structure:
    • Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).
    SequenceCaution:
    • Sequence=BAA91766.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14522.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH10527.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for STAU2 Gene

neXtProt entry for STAU2 Gene

Post-translational modifications for STAU2 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for STAU2
  • Santa Cruz Biotechnology (SCBT) Antibodies for STAU2

No data available for DME Specific Peptides for STAU2 Gene

Domains & Families for STAU2 Gene

Gene Families for STAU2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STAU2 Gene

Blocks:
  • Double-stranded RNA binding (DsRBD) domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STAU2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95458, Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila)(STAU2), mRNA (Q2TBD5_HUMAN)
  • Double-stranded RNA-binding protein Staufen homolog 2 (STAU2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUL3

UniProtKB/Swiss-Prot:

STAU2_HUMAN :
  • The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
Domain:
  • The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
genes like me logo Genes that share domains with STAU2: view

Function for STAU2 Gene

Molecular function for STAU2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).
GENATLAS Biochemistry:
Drosophila Staufen homolog 2,ubiquitously expressed,putatively involved in gene regulation

Phenotypes From GWAS Catalog for STAU2 Gene

Gene Ontology (GO) - Molecular Function for STAU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003725 double-stranded RNA binding IDA,TAS 21266579
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with STAU2: view
genes like me logo Genes that share phenotypes with STAU2: view

Animal Models for STAU2 Gene

MGI Knock Outs for STAU2:
  • Stau2 Stau2<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for STAU2 Gene

miRTarBase miRNAs that target STAU2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAU2 Gene

Localization for STAU2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAU2 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAU2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytoskeleton 4
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with STAU2: view

Pathways & Interactions for STAU2 Gene

PathCards logo

SuperPathways for STAU2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAU2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for STAU2 Gene

Drugs & Compounds for STAU2 Gene

(1) Drugs for STAU2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with STAU2: view

Transcripts for STAU2 Gene

mRNA/cDNA for STAU2 Gene

7 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAU2 Gene

No ASD Table

Relevant External Links for STAU2 Gene

GeneLoc Exon Structure for
STAU2

Expression for STAU2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAU2 Gene

Protein differential expression in normal tissues from HIPED for STAU2 Gene

This gene is overexpressed in Lung (52.6) and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAU2 Gene



Protein tissue co-expression partners for STAU2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAU2

SOURCE GeneReport for Unigene cluster for STAU2 Gene:

Hs.561815

Evidence on tissue expression from TISSUES for STAU2 Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with STAU2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAU2 Gene

Orthologs for STAU2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAU2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAU2 30
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia STAU2 31 30
  • 95.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STAU2 31 30
  • 93.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stau2 17 31 30
  • 90.99 (n)
rat
(Rattus norvegicus)
Mammalia Stau2 30
  • 89.82 (n)
oppossum
(Monodelphis domestica)
Mammalia STAU2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 73 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
-- 31
  • 25 (a)
OneToMany
chicken
(Gallus gallus)
Aves STAU2 31 30
  • 82.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAU2 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stau2 30
  • 72.65 (n)
Str.11080 30
African clawed frog
(Xenopus laevis)
Amphibia stau2-prov 30
zebrafish
(Danio rerio)
Actinopterygii stau2 31 30
  • 70.42 (n)
OneToOne
zgc55287 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007478 30
  • 52.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta stau 31
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea stau-1 31
  • 24 (a)
OneToMany
Species where no ortholog for STAU2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAU2 Gene

ENSEMBL:
Gene Tree for STAU2 (if available)
TreeFam:
Gene Tree for STAU2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAU2: view image

Paralogs for STAU2 Gene

(4) SIMAP similar genes for STAU2 Gene using alignment to 14 proteins:

  • STAU2_HUMAN
  • E5RFK1_HUMAN
  • E5RGQ5_HUMAN
  • E5RGT3_HUMAN
  • E5RJ67_HUMAN
  • E5RJN7_HUMAN
  • E7EPX0_HUMAN
  • E7EVI1_HUMAN
  • E7EVJ4_HUMAN
  • E9PH62_HUMAN
  • F8VPI7_HUMAN
  • G5EA18_HUMAN
  • H0YBY0_HUMAN
  • Q2TBD5_HUMAN

Pseudogenes.org Pseudogenes for STAU2 Gene

genes like me logo Genes that share paralogs with STAU2: view

Variants for STAU2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAU2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
740784 Benign: not provided 73,595,287(-) C/A MISSENSE_VARIANT
770946 Benign: not provided 73,613,846(-) G/A SYNONYMOUS_VARIANT
rs949493 - p.Val198Met

Additional dbSNP identifiers (rs#s) for STAU2 Gene

Structural Variations from Database of Genomic Variants (DGV) for STAU2 Gene

Variant ID Type Subtype PubMed ID
dgv3842n106 CNV deletion 24896259
esv2103697 CNV deletion 18987734
esv23121 CNV gain 19812545
esv2327053 CNV deletion 18987734
esv2343023 CNV deletion 18987734
esv2512239 CNV deletion 19546169
esv2535782 CNV deletion 19546169
esv2664752 CNV deletion 23128226
esv2670478 CNV deletion 23128226
esv2671792 CNV deletion 23128226
esv2737154 CNV deletion 23290073
esv2737164 CNV deletion 23290073
esv2737165 CNV deletion 23290073
esv2737166 CNV deletion 23290073
esv2737167 CNV deletion 23290073
esv2737168 CNV deletion 23290073
esv28754 CNV loss 19812545
esv3306689 CNV mobile element insertion 20981092
esv3426977 CNV insertion 20981092
esv3543654 CNV deletion 23714750
esv3543657 CNV deletion 23714750
esv3543659 CNV deletion 23714750
esv3572833 CNV loss 25503493
esv3572834 CNV loss 25503493
esv3617634 CNV loss 21293372
esv3617635 CNV gain 21293372
esv3617636 CNV gain 21293372
esv3617638 CNV loss 21293372
esv3617639 CNV loss 21293372
nsv1015482 CNV loss 25217958
nsv1020902 CNV loss 25217958
nsv1032026 CNV loss 25217958
nsv1109971 CNV deletion 24896259
nsv1124352 CNV deletion 24896259
nsv395886 CNV deletion 16902084
nsv473349 CNV novel sequence insertion 20440878
nsv507473 OTHER sequence alteration 20534489
nsv522502 CNV loss 19592680
nsv524697 CNV loss 19592680
nsv6258 CNV deletion 18451855
nsv951445 CNV duplication 24416366
nsv951446 CNV deletion 24416366

Variation tolerance for STAU2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAU2 Gene

Human Gene Mutation Database (HGMD)
STAU2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAU2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAU2 Gene

Disorders for STAU2 Gene

Additional Disease Information for STAU2

No disorders were found for STAU2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAU2 Gene

Publications for STAU2 Gene

  1. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles. (PMID: 12140260) Duchaîne TF … DesGroseillers L (Journal of cell science 2002) 3 4 23 54
  2. Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. (PMID: 10585778) Buchner G … Franco B (Genomics 1999) 2 3 4 54
  3. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. (PMID: 23125361) Loedige I … Filipowicz W (Nucleic acids research 2013) 3 4 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for STAU2 Gene

Sources for STAU2 Gene