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Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of sta... See more...
Aliases for STAU1 Gene
Aliases for STAU1 Gene
External Ids for STAU1 Gene
- HGNC: 11370
- Entrez Gene: 6780
- Ensembl: ENSG00000124214
- OMIM: 601716
- UniProtKB: O95793
Previous HGNC Symbols for STAU1 Gene
- STAU
Previous GeneCards Identifiers for STAU1 Gene
- GC20M047164
- GC20M047729
- GC20M044479
Summaries for STAU1 Gene
-
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]
GeneCards Summary for STAU1 Gene
STAU1 (Staufen Double-Stranded RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with STAU1 include Influenza and Leukodystrophy, Hypomyelinating, 12. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU2.
UniProtKB/Swiss-Prot Summary for STAU1 Gene
-
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
-
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
Additional gene information for STAU1 Gene
- HGNC(11370)
- Entrez Gene(6780)
- Ensembl(ENSG00000124214)
- OMIM(601716)
- UniProtKB(O95793)
- Open Targets Platform(ENSG00000124214)
- Search for STAU1 at DataMed
- Search for STAU1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAU1 Gene
Genomics for STAU1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STAU1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STAU1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAU1
- Top Transcription factor binding sites by QIAGEN in the STAU1 gene promoter:
-
- aMEF-2
- AML1a
- Ik-2
- LUN-1
- MEF-2A
- NF-kappaB
- NF-kappaB1
- Olf-1
- POU6F1 (c2)
- RelA
Genomic Locations for STAU1 Gene
Genomic Locations for STAU1 Gene
- chr20:49,113,339-49,219,295
- (GRCh38/hg38)
- Size:
- 105,957 bases
- Orientation:
- Minus strand
- chr20:47,729,876-47,804,904
- (GRCh37/hg19)
- Size:
- 75,029 bases
- Orientation:
- Minus strand
Genomic View for STAU1 Gene
Genes around STAU1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.13 by HGNC
- 20q13.13 by Entrez Gene
- 20q13.13 by Ensembl
STAU1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAU1 Gene
Proteins for STAU1 Gene
-
Protein details for STAU1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95793-STAU1_HUMAN
- Recommended name:
- Double-stranded RNA-binding protein Staufen homolog 1
- Protein Accession:
- O95793
- A8K9Z4
- E1P5Y1
- E1P608
- Q5JW29
- Q6GTM4
- Q9H5B4
- Q9H5B5
- Q9Y3Q2
Protein attributes for STAU1 Gene
- Size:
- 577 amino acids
- Molecular mass:
- 63182 Da
- Quaternary structure:
-
- Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
- (Microbial infection) Interacts with HERV-K rec and gag proteins.
- (Microbial infection) Interacts with HIV-1 GAG polyprotein.
- (Microbial infection) Interacts with influenza virus NS1 protein.
- (Microbial infection) Interacts with Ebola virus NP, VP30 and VP35.
Three dimensional structures from OCA and Proteopedia for STAU1 Gene
Protein Expression for STAU1 Gene
Post-translational modifications for STAU1 Gene
Other Protein References for STAU1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences STAU1 / Staufen Antibody (LS-B5343) and STAU1 / Staufen Antibody (LS-B5715)
- G Biosciences Immunotag™ STAU1 Antibody
- Novus Biologicals Antibodies for STAU1
-
Abcam antibodies for STAU1
- Invitrogen Antibodies for STAU1 (AFLGC-Stau1)
-
Custom Antibody ServicesProSci Antibodies for STAU1
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAU1
- Sino Biological Antibodies for STAU1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STAU1
- Origene Custom Protein Services for STAU1
-
Abcam proteins for STAU1
No data available for DME Specific Peptides for STAU1 Gene
Domains & Families for STAU1 Gene
Gene Families for STAU1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for STAU1 Gene
Suggested Antigen Peptide Sequences for STAU1 Gene
- GenScript: Design optimal peptide antigens:
-
- STAU1 protein (Q6PJX3_HUMAN)
- Double-stranded RNA-binding protein Staufen homolog 1 (STAU1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95793- Domain:
-
- One of the DRDB could be involved in RER binding.
- The C-terminal contains the tubulin binding domain (TBD).
Function for STAU1 Gene
Molecular function for STAU1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
- GENATLAS Biochemistry:
- Drosophila Staufen homolog 1,involved,in mRNA transport and localization
Phenotypes From GWAS Catalog for STAU1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22681889 |
| GO:0003725 | double-stranded RNA binding | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 15121898 |
| GO:0008157 | protein phosphatase 1 binding | IEA | -- |
Phenotypes for STAU1 Gene
- MGI mutant phenotypes for STAU1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for STAU1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased ionizing radiation sensitivity
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased virus production
- Decreased Aire reporter expression
Animal Models for STAU1 Gene
- MGI Knock Outs for STAU1:
-
- Stau1 Stau1<tm1Apa>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STAU1 - Select products 50% OFF >
- * STAU1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STAU1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAU1
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAU1
miRNA for STAU1 Gene
- miRTarBase miRNAs that target STAU1
-
- hsa-miR-132-3p (MIRT021842)
- hsa-miR-27a-3p (MIRT028692)
- hsa-miR-16-5p (MIRT031669)
- hsa-miR-877-5p (MIRT037250)
- hsa-miR-30e-5p (MIRT044157)
- hsa-miR-5011-5p (MIRT118652)
- hsa-miR-218-5p (MIRT439527)
- hsa-miR-30e-3p (MIRT466932)
- hsa-miR-30d-3p (MIRT466933)
- hsa-miR-30a-3p (MIRT466934)
- hsa-miR-6513-5p (MIRT466935)
- hsa-miR-5089-5p (MIRT466936)
- hsa-miR-6728-5p (MIRT466937)
- hsa-miR-769-3p (MIRT466938)
- hsa-miR-450b-3p (MIRT466939)
- hsa-miR-222-5p (MIRT466940)
- hsa-miR-190a-3p (MIRT466941)
- hsa-miR-374b-5p (MIRT466942)
- hsa-miR-374a-5p (MIRT466943)
- hsa-miR-3147 (MIRT466944)
- hsa-miR-4425 (MIRT466945)
- hsa-miR-1290 (MIRT466946)
- hsa-miR-16-1-3p (MIRT466947)
- hsa-miR-4781-3p (MIRT466948)
- hsa-miR-218-2-3p (MIRT466949)
- hsa-miR-30d-5p (MIRT726429)
- hsa-miR-30c-5p (MIRT726430)
- hsa-miR-30b-5p (MIRT726431)
- hsa-miR-30a-5p (MIRT726432)
- hsa-miR-9-5p (MIRT734623)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAU1
- Browse OriGene Inhibitory RNA Products For STAU1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU1
Clone Products
- Applied Biological Materials (abm): Clones for STAU1 - Select products 50% OFF >
- * STAU1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207800
- MG226029
- MG226033
- MR207800
- MR207800L3
- MR207800L4
- MR226029
- MR226029L3
- MR226029L4
- MR226033
- MR226033L3
- MR226033L4
- MR230153
- RC208387
- RC208387L3
- RC208387L4
- RC210564
- RC210564L3
- RC210564L4
- RC215637
- RC215637L3
- RC215637L4
- RC218095
- RC218095L1
- RC218095L2
- RC218095L3
- RC218095L4
- RC218152
- RC218152L1
- RC218152L2
- RC218152L3
- RC218152L4
- RG208387
- RG210564
- RG215637
- RG218095
- RG218152
- RR200249
- RR200249L3
- RR200249L4
- RR200250
- RR200250L3
- RR200250L4
- MR207800L3V
- MR207800L4V
- MR226029L3V
- MR226029L4V
- MR226033L3V
- MR226033L4V
- RC208387L3V
- RC208387L4V
- RC210564L3V
- RC210564L4V
- RC215637L3V
- RC215637L4V
- RC218095L1V
- RC218095L2V
- RC218095L3V
- RC218095L4V
- RC218152L1V
- RC218152L2V
- RC218152L3V
- RC218152L4V
- RR200249L3V
- RR200249L4V
- RR200250L3V
- RR200250L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAU1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAU1
Cell Line Products
-
Horizon Cell Lines for STAU1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAU1 Gene
Localization for STAU1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAU1 Gene
- Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 4 |
| endoplasmic reticulum | 4 |
| cytosol | 4 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 19029303 |
| GO:0005783 | endoplasmic reticulum | IDA | 23907398 |
| GO:0005791 | rough endoplasmic reticulum | TAS,IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005875 | microtubule associated complex | TAS | 10022909 |
Pathways & Interactions for STAU1 Gene
Interacting Proteins for STAU1 Gene
Selected Interacting proteins:
O95793-STAU1_HUMAN
ENSP00000360922
for STAU1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STAU1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016032 | viral process | IEA | -- |
| GO:0034599 | cellular response to oxidative stress | IEA | -- |
| GO:0045070 | positive regulation of viral genome replication | IMP | 23907398 |
| GO:0046726 | positive regulation by virus of viral protein levels in host cell | IMP | 23907398 |
| GO:0050804 | modulation of chemical synaptic transmission | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for STAU1 Gene
Transcripts for STAU1 Gene
mRNA/cDNA for STAU1 Gene
- 14 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000340954 3334 nts (view in UCSC)
- ENST00000347458 3136 nts (view in UCSC)
- ENST00000360426 3211 nts (view in UCSC)
- ENST00000371792 3130 nts (view in UCSC)
- ENST00000371802 3154 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for STAU1 - Select products 50% OFF >
- * STAU1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for STAU1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAU1
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAU1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAU1
- Browse OriGene Inhibitory RNA Products For STAU1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU1
Clone Products
- Applied Biological Materials (abm): Clones for STAU1 - Select products 50% OFF >
- * STAU1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207800
- MG226029
- MG226033
- MR207800
- MR207800L3
- MR207800L4
- MR226029
- MR226029L3
- MR226029L4
- MR226033
- MR226033L3
- MR226033L4
- MR230153
- RC208387
- RC208387L3
- RC208387L4
- RC210564
- RC210564L3
- RC210564L4
- RC215637
- RC215637L3
- RC215637L4
- RC218095
- RC218095L1
- RC218095L2
- RC218095L3
- RC218095L4
- RC218152
- RC218152L1
- RC218152L2
- RC218152L3
- RC218152L4
- RG208387
- RG210564
- RG215637
- RG218095
- RG218152
- RR200249
- RR200249L3
- RR200249L4
- RR200250
- RR200250L3
- RR200250L4
- MR207800L3V
- MR207800L4V
- MR226029L3V
- MR226029L4V
- MR226033L3V
- MR226033L4V
- RC208387L3V
- RC208387L4V
- RC210564L3V
- RC210564L4V
- RC215637L3V
- RC215637L4V
- RC218095L1V
- RC218095L2V
- RC218095L3V
- RC218095L4V
- RC218152L1V
- RC218152L2V
- RC218152L3V
- RC218152L4V
- RR200249L3V
- RR200249L4V
- RR200250L3V
- RR200250L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAU1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAU1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
Relevant External Links for STAU1 Gene
- GeneLoc Exon Structure for
- STAU1
Expression for STAU1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Liver (Hepatobiliary System)
This gene is overexpressed in Lung (9.8), Fetal Brain (6.3), and Islet of Langerhans (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAU1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAU1
SOURCE GeneReport for Unigene cluster for STAU1 Gene:
Hs.596704mRNA Expression by UniProt/SwissProt for STAU1 Gene:
O95793-STAU1_HUMAN
Tissue specificity:
Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
Evidence on tissue expression from TISSUES for STAU1 Gene
- Nervous system(5)
- Kidney(4.7)
- Skin(4.7)
- Lung(3.7)
- Intestine(3.6)
- Liver(3.4)
- Muscle(3.2)
- Eye(3.2)
- Heart(3.2)
- Stomach(3.1)
- Blood(2.9)
- Spleen(2.7)
- Thyroid gland(2.5)
- Lymph node(2.4)
- Bone marrow(2.3)
- Pancreas(2.3)
- Adrenal gland(2.2)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for STAU1
-
OriGene qPCR primer pairs and template standards for STAU1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAU1 Gene
Orthologs for STAU1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STAU1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STAU1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stau1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Stau1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | STAU1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STAU1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STAU1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STAU1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STAU1 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398937 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.8280 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | stau1 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | stau 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | stau-1 31 |
|
OneToMany |
- Species where no ortholog for STAU1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STAU1 Gene
- ENSEMBL:
- Gene Tree for STAU1 (if available)
- TreeFam:
- Gene Tree for STAU1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAU1: view image
Paralogs for STAU1 Gene
Paralogs for STAU1 Gene
(3) SIMAP similar genes for STAU1 Gene using alignment to 5 proteins:
- STAU1_HUMAN
- F6UDC6_HUMAN
- Q5JW28_HUMAN
- Q5JW30_HUMAN
- Q6PJX3_HUMAN
Pseudogenes.org Pseudogenes for STAU1 Gene
Variants for STAU1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAU1 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769472 | Benign: not provided | 49,153,924(-) | A/C | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670489 | CNV | deletion | 23128226 |
| esv2762079 | CNV | gain | 21179565 |
| esv3646010 | CNV | gain | 21293372 |
| esv3646011 | CNV | loss | 21293372 |
| esv3646012 | CNV | loss | 21293372 |
| nsv1064443 | CNV | gain | 25217958 |
| nsv1067146 | CNV | loss | 25217958 |
| nsv1072544 | CNV | deletion | 25765185 |
| nsv435739 | CNV | deletion | 17901297 |
| nsv965881 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.80;
47.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAU1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- STAU1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAU1 Gene
Disorders for STAU1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| influenza |
|
|
| leukodystrophy, hypomyelinating, 12 |
|
|
| retinitis pigmentosa 18 |
|
|
| retinitis pigmentosa |
|
|
Search STAU1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STAU1
No data available for UniProtKB/Swiss-Prot and Genatlas for STAU1 Gene
Publications for STAU1 Gene
- The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. (PMID: 18498651) Chatel-Chaix L … Desgroseillers L (Retrovirology 2008) 3 4 23
- Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. (PMID: 15680326) Kim YK … Maquat LE (Cell 2005) 2 3 23
- Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. (PMID: 8884277) DesGroseillers L … Lemieux N (Genomics 1996) 2 3 23
- Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis. (PMID: 30301857) Fang J … Bradrick SS (mBio 2018) 3 4
- Staufen-1 interacts with the human endogenous retrovirus family HERV-K(HML-2) rec and gag proteins and increases virion production. (PMID: 23926355) Hanke K … Bannert N (Journal of virology 2013) 3 4
ExternalLinks
Products for STAU1 Gene
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- Invitrogen Antibodies for STAU1 (AFLGC-Stau1)
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- antibodies-online: Show 23 available STAU1 Antibodies ranked by validation data
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Sources for STAU1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB