Aliases for STAU1 Gene
- Staufen Double-Stranded RNA Binding Protein 1 2 3 5
- Double-Stranded RNA-Binding Protein Staufen Homolog 1 3 4
- Protein Phosphatase 1, Regulatory Subunit 150 2 3
- STAU 3 4
- Staufen, RNA Binding Protein, Homolog 1 (Drosophila) 2
- Staufen (Drosophila, RNA-Binding Protein) 2
- Staufen, RNA Binding Protein (Drosophila) 2
- Staufen, RNA Binding Protein, Homolog 1 3
- PPP1R150 3
External Ids for STAU1 Gene
Previous HGNC Symbols for STAU1 Gene
Previous GeneCards Identifiers for STAU1 Gene
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for STAU1 Gene
STAU1 (Staufen Double-Stranded RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with STAU1 include Influenza and Leukodystrophy, Hypomyelinating, 12. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU2.
UniProtKB/Swiss-Prot Summary for STAU1 Gene
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.