Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of sta... See more...

Aliases for STAU1 Gene

Aliases for STAU1 Gene

  • Staufen Double-Stranded RNA Binding Protein 1 2 3 5
  • Double-Stranded RNA-Binding Protein Staufen Homolog 1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 150 2 3
  • PPP1R150 2 3
  • STAU 3 4
  • Staufen, RNA Binding Protein, Homolog 1 (Drosophila) 2
  • Staufen (Drosophila, RNA-Binding Protein) 2
  • Staufen, RNA Binding Protein (Drosophila) 2
  • Staufen, RNA Binding Protein, Homolog 1 3
  • STAU1 5

External Ids for STAU1 Gene

Previous HGNC Symbols for STAU1 Gene

  • STAU

Previous GeneCards Identifiers for STAU1 Gene

  • GC20M047164
  • GC20M047729
  • GC20M044479

Summaries for STAU1 Gene

Entrez Gene Summary for STAU1 Gene

  • Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

GeneCards Summary for STAU1 Gene

STAU1 (Staufen Double-Stranded RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with STAU1 include Influenza and Leukodystrophy, Hypomyelinating, 12. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STAU2.

UniProtKB/Swiss-Prot Summary for STAU1 Gene

  • Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
  • (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.

Gene Wiki entry for STAU1 Gene

Additional gene information for STAU1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAU1 Gene

Genomics for STAU1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STAU1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J049184 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 603.2 +32.5 32471 5.2 SP1 CREB1 GATAD2A PRDM10 ZNF629 TFE3 ZNF512 RFX1 SIX5 IKZF1 STAU1 lnc-ZNFX1-2 DDX27 CSE1L SNORD12B ARFGEF2 ZFAS1 PREX1 lnc-DDX27-3
GH20J049216 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.5 462 4.3 CEBPG SP1 CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 REST ZNF629 DDX27 STAU1 ZFAS1 CSE1L lnc-ZNFX1-2
GH20J048816 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.6 +396.3 396349 13.7 CEBPG CREB1 ZBTB33 ARID3A YBX1 PRDM10 IKZF1 KDM1A BACH1 TARDBP PREX1 DDX27 ZNFX1 STAU1 lnc-STAU1-5 ENSG00000278231
GH20J049268 Promoter/Enhancer 1 Ensembl ENCODE 11 -49.4 -49406 1 RCOR2 ZNF143 TRIM22 RELB RUNX3 ZNF580 KAT7 KDM1A AFF1 NBN RF00017-3619 CSE1L DDX27 STAU1 RNF114 ZNFX1 piR-53157
GH20J049051 Enhancer 1 Ensembl ENCODE 10.6 +164.9 164894 6.8 GATAD2A REST SP1 POLR2A PKNOX1 CEBPA SCRT2 SOX13 ZNF316 YY1 ARFGEF2 STAU1 CSE1L CSE1L-AS1 RF00017-3617 DDX27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAU1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAU1

Top Transcription factor binding sites by QIAGEN in the STAU1 gene promoter:
  • aMEF-2
  • AML1a
  • Ik-2
  • LUN-1
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • POU6F1 (c2)
  • RelA

Genomic Locations for STAU1 Gene

Genomic Locations for STAU1 Gene
chr20:49,113,339-49,219,295
(GRCh38/hg38)
Size:
105,957 bases
Orientation:
Minus strand
chr20:47,729,876-47,804,904
(GRCh37/hg19)
Size:
75,029 bases
Orientation:
Minus strand

Genomic View for STAU1 Gene

Genes around STAU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAU1 Gene

Proteins for STAU1 Gene

  • Protein details for STAU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95793-STAU1_HUMAN
    Recommended name:
    Double-stranded RNA-binding protein Staufen homolog 1
    Protein Accession:
    O95793
    Secondary Accessions:
    • A8K9Z4
    • E1P5Y1
    • E1P608
    • Q5JW29
    • Q6GTM4
    • Q9H5B4
    • Q9H5B5
    • Q9Y3Q2

    Protein attributes for STAU1 Gene

    Size:
    577 amino acids
    Molecular mass:
    63182 Da
    Quaternary structure:
    • Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
    • (Microbial infection) Interacts with HERV-K rec and gag proteins.
    • (Microbial infection) Interacts with HIV-1 GAG polyprotein.
    • (Microbial infection) Interacts with influenza virus NS1 protein.
    • (Microbial infection) Interacts with Ebola virus NP, VP30 and VP35.

    Three dimensional structures from OCA and Proteopedia for STAU1 Gene

    Alternative splice isoforms for STAU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAU1 Gene

Post-translational modifications for STAU1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STAU1 Gene

Domains & Families for STAU1 Gene

Gene Families for STAU1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for STAU1 Gene

InterPro:
Blocks:
  • Double-stranded RNA binding (DsRBD) domain
ProtoNet:

Suggested Antigen Peptide Sequences for STAU1 Gene

GenScript: Design optimal peptide antigens:
  • STAU1 protein (Q6PJX3_HUMAN)
  • Double-stranded RNA-binding protein Staufen homolog 1 (STAU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95793

UniProtKB/Swiss-Prot:

STAU1_HUMAN :
  • One of the DRDB could be involved in RER binding.
Domain:
  • One of the DRDB could be involved in RER binding.
  • The C-terminal contains the tubulin binding domain (TBD).
genes like me logo Genes that share domains with STAU1: view

Function for STAU1 Gene

Molecular function for STAU1 Gene

UniProtKB/Swiss-Prot Function:
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
GENATLAS Biochemistry:
Drosophila Staufen homolog 1,involved,in mRNA transport and localization

Phenotypes From GWAS Catalog for STAU1 Gene

Gene Ontology (GO) - Molecular Function for STAU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0003725 double-stranded RNA binding TAS,IEA --
GO:0005515 protein binding IPI 15121898
GO:0008157 protein phosphatase 1 binding IEA --
genes like me logo Genes that share ontologies with STAU1: view
genes like me logo Genes that share phenotypes with STAU1: view

Animal Models for STAU1 Gene

MGI Knock Outs for STAU1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAU1 Gene

Localization for STAU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAU1 Gene

Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAU1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 4
endoplasmic reticulum 4
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STAU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19029303
GO:0005783 endoplasmic reticulum IDA 23907398
GO:0005791 rough endoplasmic reticulum TAS,IEA --
GO:0005829 cytosol IDA --
GO:0005875 microtubule associated complex TAS 10022909
genes like me logo Genes that share ontologies with STAU1: view

Pathways & Interactions for STAU1 Gene

PathCards logo

SuperPathways for STAU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0034599 cellular response to oxidative stress IEA --
GO:0045070 positive regulation of viral genome replication IMP 23907398
GO:0046726 positive regulation by virus of viral protein levels in host cell IMP 23907398
GO:0050804 modulation of chemical synaptic transmission IEA --
genes like me logo Genes that share ontologies with STAU1: view

No data available for Pathways by source and SIGNOR curated interactions for STAU1 Gene

Drugs & Compounds for STAU1 Gene

No Compound Related Data Available

Transcripts for STAU1 Gene

mRNA/cDNA for STAU1 Gene

14 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAU1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAU1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10: - - - -
SP11:

Relevant External Links for STAU1 Gene

GeneLoc Exon Structure for
STAU1

Expression for STAU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STAU1 Gene

This gene is overexpressed in Lung (9.8), Fetal Brain (6.3), and Islet of Langerhans (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAU1 Gene



Protein tissue co-expression partners for STAU1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAU1

SOURCE GeneReport for Unigene cluster for STAU1 Gene:

Hs.596704

mRNA Expression by UniProt/SwissProt for STAU1 Gene:

O95793-STAU1_HUMAN
Tissue specificity: Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.

Evidence on tissue expression from TISSUES for STAU1 Gene

  • Nervous system(5)
  • Kidney(4.7)
  • Skin(4.7)
  • Lung(3.7)
  • Intestine(3.6)
  • Liver(3.4)
  • Muscle(3.2)
  • Eye(3.2)
  • Heart(3.2)
  • Stomach(3.1)
  • Blood(2.9)
  • Spleen(2.7)
  • Thyroid gland(2.5)
  • Lymph node(2.4)
  • Bone marrow(2.3)
  • Pancreas(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with STAU1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAU1 Gene

Orthologs for STAU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAU1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STAU1 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STAU1 31
  • 94 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stau1 30
  • 87.18 (n)
Mouse
(Mus musculus)
Mammalia Stau1 30 17 31
  • 87.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STAU1 31
  • 80 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia STAU1 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STAU1 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STAU1 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STAU1 31
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398937 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.8280 30
Zebrafish
(Danio rerio)
Actinopterygii stau1 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta stau 31
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea stau-1 31
  • 21 (a)
OneToMany
Species where no ortholog for STAU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STAU1 Gene

ENSEMBL:
Gene Tree for STAU1 (if available)
TreeFam:
Gene Tree for STAU1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAU1: view image

Paralogs for STAU1 Gene

(3) SIMAP similar genes for STAU1 Gene using alignment to 5 proteins:

  • STAU1_HUMAN
  • F6UDC6_HUMAN
  • Q5JW28_HUMAN
  • Q5JW30_HUMAN
  • Q6PJX3_HUMAN

Pseudogenes.org Pseudogenes for STAU1 Gene

genes like me logo Genes that share paralogs with STAU1: view

Variants for STAU1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAU1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
769472 Benign: not provided 49,153,924(-) A/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for STAU1 Gene

Structural Variations from Database of Genomic Variants (DGV) for STAU1 Gene

Variant ID Type Subtype PubMed ID
esv2670489 CNV deletion 23128226
esv2762079 CNV gain 21179565
esv3646010 CNV gain 21293372
esv3646011 CNV loss 21293372
esv3646012 CNV loss 21293372
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958
nsv1072544 CNV deletion 25765185
nsv435739 CNV deletion 17901297
nsv965881 CNV duplication 23825009

Variation tolerance for STAU1 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAU1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAU1 Gene

Disorders for STAU1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for STAU1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
leukodystrophy, hypomyelinating, 12
  • hld12
retinitis pigmentosa 18
  • rp18
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search STAU1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with STAU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAU1 Gene

Publications for STAU1 Gene

  1. The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. (PMID: 18498651) Chatel-Chaix L … Desgroseillers L (Retrovirology 2008) 3 4 23
  2. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. (PMID: 15680326) Kim YK … Maquat LE (Cell 2005) 2 3 23
  3. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. (PMID: 8884277) DesGroseillers L … Lemieux N (Genomics 1996) 2 3 23
  4. Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis. (PMID: 30301857) Fang J … Bradrick SS (mBio 2018) 3 4
  5. Staufen-1 interacts with the human endogenous retrovirus family HERV-K(HML-2) rec and gag proteins and increases virion production. (PMID: 23926355) Hanke K … Bannert N (Journal of virology 2013) 3 4

Products for STAU1 Gene

Sources for STAU1 Gene