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Aliases for STAT6 Gene

Aliases for STAT6 Gene

  • Signal Transducer And Activator Of Transcription 6 2 3 3 5
  • Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced 2 3
  • Transcription Factor IL-4 STAT 3
  • STAT, Interleukin4-Induced 3
  • IL-4-STAT 3
  • IL-4 Stat 4
  • D12S1644 3
  • STAT6B 3
  • STAT6C 3

External Ids for STAT6 Gene

Previous GeneCards Identifiers for STAT6 Gene

  • GC12M057464
  • GC12M057713
  • GC12M057205
  • GC12M055775
  • GC12M054527
  • GC12M057489

Summaries for STAT6 Gene

Entrez Gene Summary for STAT6 Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for STAT6 Gene

STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hemangiopericytoma, Malignant and Nut Allergy. Among its related pathways are Development IGF-1 receptor signaling and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5A.

UniProtKB/Swiss-Prot for STAT6 Gene

  • Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Gene Wiki entry for STAT6 Gene

Additional gene information for STAT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT6 Gene

Genomics for STAT6 Gene

GeneHancer (GH) Regulatory Elements for STAT6 Gene

Promoters and enhancers for STAT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057126 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.5 -1.3 -1299 13.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS SP3 LRP1 STAT6 HSPD1P4 NABP2 NAB2 DDIT3 MBD6 LRP1-AS
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 659.7 +20.9 20885 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J057238 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -107.5 -107549 4.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF143 NDUFA4L2 DTX3 NXPH4 ANKRD52 ENSG00000257740 NAB2 INHBE TSPAN31 MYO1A PAN2
GH12J057077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 +53.1 53142 3.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 NEMP1 BAZ2A ZC3H10 MBD6 ENSG00000258317 RN7SL809P CDK4 MYO1A ZBTB39 ATP23
GH12J057228 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -98.4 -98428 3.4 HDGF CLOCK FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ENSG00000276727 SHMT2 MIR1228 STAT6 ENSG00000224713 NDUFA4L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STAT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAT6 gene promoter:
  • STAT3
  • AP-1
  • NF-kappaB1
  • NF-kappaB
  • AP-2alpha
  • AP-2alphaA
  • AP-2alpha isoform 4
  • AP-2alpha isoform 3
  • AP-2alpha isoform 2

Genomic Locations for STAT6 Gene

Genomic Locations for STAT6 Gene
chr12:57,095,404-57,132,139
(GRCh38/hg38)
Size:
36,736 bases
Orientation:
Minus strand
chr12:57,489,187-57,525,922
(GRCh37/hg19)
Size:
36,736 bases
Orientation:
Minus strand

Genomic View for STAT6 Gene

Genes around STAT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT6 Gene

Proteins for STAT6 Gene

  • Protein details for STAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42226-STAT6_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 6
    Protein Accession:
    P42226
    Secondary Accessions:
    • A8K316
    • B7ZA27
    • F5GXI9
    • Q5FBW5
    • Q71UP4

    Protein attributes for STAT6 Gene

    Size:
    847 amino acids
    Molecular mass:
    94135 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.

    Three dimensional structures from OCA and Proteopedia for STAT6 Gene

    Alternative splice isoforms for STAT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT6 Gene

Post-translational modifications for STAT6 Gene

  • Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
  • Mono-ADP-ribosylated by PARP14.
  • Ubiquitination at isoforms=2, 3647 and posLast=319319
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for STAT6 Gene

Domains & Families for STAT6 Gene

Gene Families for STAT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for STAT6 Gene

Graphical View of Domain Structure for InterPro Entry

P42226

UniProtKB/Swiss-Prot:

STAT6_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT6: view

Function for STAT6 Gene

Molecular function for STAT6 Gene

UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
GENATLAS Biochemistry:
signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells

Phenotypes From GWAS Catalog for STAT6 Gene

Gene Ontology (GO) - Molecular Function for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8810328
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 8810328
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with STAT6: view
genes like me logo Genes that share phenotypes with STAT6: view

Animal Models for STAT6 Gene

MGI Knock Outs for STAT6:

Animal Model Products

CRISPR Products

Transcription Factor Targets for STAT6 Gene

Selected GeneGlobe predicted Target genes for STAT6
Targeted motifs for STAT6 Gene
HOMER Transcription Factor Regulatory Elements motif STAT6
  • Consensus sequence: ANTTCTTAAGAA Submotif: canonical Cell Type: CD4 GEO ID: GSE22104

Clone Products

  • Addgene plasmids for STAT6

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for STAT6 Gene

Localization for STAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT6 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT6 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT6: view

Pathways & Interactions for STAT6 Gene

genes like me logo Genes that share pathways with STAT6: view

SIGNOR curated interactions for STAT6 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0002296 T-helper 1 cell lineage commitment IEA --
GO:0002829 negative regulation of type 2 immune response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with STAT6: view

Drugs & Compounds for STAT6 Gene

(15) Drugs for STAT6 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
signal transducer and activator of transcription 6 fragment Pharma STAT6 transcription factor 0

(14) Additional Compounds for STAT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for STAT6 Gene

Compound Action Cas Number
signal transducer and activator of transcription 6 fragment STAT6 transcription factor
genes like me logo Genes that share compounds with STAT6: view

Drug Products

Transcripts for STAT6 Gene

Unigene Clusters for STAT6 Gene

Signal transducer and activator of transcription 6, interleukin-4 induced:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for STAT6

Alternative Splicing Database (ASD) splice patterns (SP) for STAT6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - -
SP2:
SP3:
SP4: - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - -
SP8: - - -
SP9:
SP10:
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - - -
SP14:
SP15:

ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - -
SP14:
SP15:

Relevant External Links for STAT6 Gene

GeneLoc Exon Structure for
STAT6
ECgene alternative splicing isoforms for
STAT6

Expression for STAT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAT6 Gene

mRNA differential expression in normal tissues according to GTEx for STAT6 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for STAT6 Gene

This gene is overexpressed in Lymph node (17.0) and Stomach (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT6 Gene



Protein tissue co-expression partners for STAT6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STAT6 Gene:

STAT6

SOURCE GeneReport for Unigene cluster for STAT6 Gene:

Hs.524518

Evidence on tissue expression from TISSUES for STAT6 Gene

  • Lung(4.1)
  • Blood(3.7)
  • Intestine(3.7)
  • Nervous system(3.7)
  • Spleen(3.2)
  • Lymph node(3.1)
  • Skin(3)
  • Kidney(2.8)
  • Liver(2.6)
  • Bone marrow(2.5)
  • Muscle(2.4)
  • Heart(2.2)
  • Stomach(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT6 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Regions:
Head and neck:
  • ear
Thorax:
  • heart
General:
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with STAT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for STAT6 Gene

Orthologs for STAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAT6 34 33
  • 98.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STAT6 34 33
  • 91.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STAT6 34 33
  • 90.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stat6 16 34 33
  • 85.46 (n)
rat
(Rattus norvegicus)
Mammalia Stat6 33
  • 85.37 (n)
oppossum
(Monodelphis domestica)
Mammalia STAT6 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAT6 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAT6 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stat6 33
  • 58.02 (n)
zebrafish
(Danio rerio)
Actinopterygii stat6 34 33
  • 51.72 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 34 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 35
  • 29 (a)
sta-1 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
ManyToMany
Species where no ortholog for STAT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT6 Gene

ENSEMBL:
Gene Tree for STAT6 (if available)
TreeFam:
Gene Tree for STAT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT6: view image

Paralogs for STAT6 Gene

Paralogs for STAT6 Gene

(6) SIMAP similar genes for STAT6 Gene using alignment to 13 proteins:

  • STAT6_HUMAN
  • G3V2H4_HUMAN
  • G3V2L2_HUMAN
  • G3V2M3_HUMAN
  • G3V2X7_HUMAN
  • G3V370_HUMAN
  • G3V3E9_HUMAN
  • G3V568_HUMAN
  • G3V5I8_HUMAN
  • G3V5K5_HUMAN
  • H0YIY2_HUMAN
  • H0YJH6_HUMAN
  • Q5FBW6_HUMAN
genes like me logo Genes that share paralogs with STAT6: view

Variants for STAT6 Gene

Sequence variations from dbSNP and Humsavar for STAT6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs483352723 uncertain-significance, not provided 57,107,292(-) A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000113180 -- 57,099,468(-) C/T intron_variant
rs1000138612 -- 57,112,853(-) C/T upstream_transcript_variant
rs1000446839 -- 57,101,086(-) T/C intron_variant
rs1000488507 -- 57,105,682(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STAT6 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for STAT6 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAT6 Gene

Human Gene Mutation Database (HGMD)
STAT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT6 Gene

Disorders for STAT6 Gene

MalaCards: The human disease database

(27) MalaCards diseases for STAT6 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemangiopericytoma, malignant
  • hemangiopericytoma
nut allergy
  • allergy to nuts
meninges hemangiopericytoma
  • hemangiopericytoma of meninges
primary mediastinal b-cell lymphoma
  • large cell lymphoma of the mediastinum
allergic asthma
  • atopic asthma
- elite association - COSMIC cancer census association via MalaCards
Search STAT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STAT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STAT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAT6 Gene

Publications for STAT6 Gene

  1. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. (PMID: 17210636) Lu X … Lossos IS (Molecular and cellular biology 2007) 3 4 22 58
  2. Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. (PMID: 17362266) Yabiku K … Takasu N (Clinical and experimental immunology 2007) 3 22 44 58
  3. The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. (PMID: 15888279) Klein W … Griga T (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2005) 3 22 44 58
  4. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PMID: 14757047) Razeto A … Becker S (Journal of molecular biology 2004) 3 4 22 58
  5. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. (PMID: 12759487) Tamura K … Morikawa A (International archives of allergy and immunology 2003) 3 22 44 58

Products for STAT6 Gene

  • Addgene plasmids for STAT6