Aliases for STAT6 Gene
Aliases for STAT6 Gene
External Ids for STAT6 Gene
- HGNC: 11368
- Entrez Gene: 6778
- Ensembl: ENSG00000166888
- OMIM: 601512
- UniProtKB: P42226
Previous GeneCards Identifiers for STAT6 Gene
- GC12M057464
- GC12M057713
- GC12M057205
- GC12M055775
- GC12M054527
- GC12M057489
Summaries for STAT6 Gene
-
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for STAT6 Gene
STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hemangiopericytoma, Malignant and Nut Allergy. Among its related pathways are Development IGF-1 receptor signaling and Adipogenesis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5A.
UniProtKB/Swiss-Prot for STAT6 Gene
-
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Additional gene information for STAT6 Gene
- Monarch Initiative
- Search for STAT6 at DataMed
- Search for STAT6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT6 Gene
Genomics for STAT6 Gene
GeneHancer (GH) Regulatory Elements for STAT6 Gene
Promoters and enhancers for STAT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STAT6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STAT6 gene promoter:
-
- STAT3
- AP-1
- NF-kappaB1
- NF-kappaB
- AP-2alpha
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
Regulatory Element Products
Genomic Locations for STAT6 Gene
Genomic Locations for STAT6 Gene
- chr12:57,095,404-57,132,139
- (GRCh38/hg38)
- Size:
- 36,736 bases
- Orientation:
- Minus strand
- chr12:57,489,187-57,525,922
- (GRCh37/hg19)
- Size:
- 36,736 bases
- Orientation:
- Minus strand
Genomic View for STAT6 Gene
Genes around STAT6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by Entrez Gene
- 12q13 by HGNC
- 12q13.3 by Ensembl
STAT6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAT6 Gene
Proteins for STAT6 Gene
-
Protein details for STAT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42226-STAT6_HUMAN
- Recommended name:
- Signal transducer and activator of transcription 6
- Protein Accession:
- P42226
- A8K316
- B7ZA27
- F5GXI9
- Q5FBW5
- Q71UP4
Protein attributes for STAT6 Gene
- Size:
- 847 amino acids
- Molecular mass:
- 94135 Da
- Quaternary structure:
-
- Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
Three dimensional structures from OCA and Proteopedia for STAT6 Gene
Protein Expression for STAT6 Gene
Post-translational modifications for STAT6 Gene
- Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
- Mono-ADP-ribosylated by PARP14.
- Ubiquitination at isoforms=2, 3647 and posLast=319319
- Modification sites at PhosphoSitePlus
Other Protein References for STAT6 Gene
- ENSEMBL proteins:
-
- ENSP00000451742
- ENSP00000451546
- ENSP00000491116
- ENSP00000438451
- ENSP00000450747
- ENSP00000452203
- ENSP00000450732
- ENSP00000401486
- ENSP00000452394
- ENSP00000445409
- ENSP00000450428
- ENSP00000450921
- ENSP00000300134
- ENSP00000452373
- ENSP00000450510
- ENSP00000450665
- ENSP00000451209
- ENSP00000451909
- ENSP00000451074
- ENSP00000444530
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STAT6 (STAT6)
-
Custom Antibody ServicesOriGene Antibodies for STAT6
- AM00151PU-N
- AM00152PU-N
- AM06474SU-N
- AP01697PU-N
- AP01698PU-N
- AP02349PU-N
- AP02349PU-S
- AP02350PU-N
- AP02350PU-S
- AP02591PU-N
- AP02591PU-S
- AP02592PU-N
- AP02592PU-S
- AP06332PU-N
- AP06333PU-N
- SP2071P
- TA309960
- TA309961
- TA312080
- TA319167
- TA325906
- TA325907
- TA325908
- TA325909
- TA329203
- TA333294
- TA333295
- TA343363
- TA349221
- TA354095
- Novus Biologicals Antibodies for STAT6
- Invitrogen Antibodies for STAT6
- antibodies-online: Search results for 462 available STAT6 Antibodies ranked by validation data
- Compare Top STAT6 Antibodies
-
Recommended
- 141 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 5 ICS Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 319 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 18 IHC Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 7 ICS Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 89 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 2 ICS Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex STAT6 Antibody for STAT6
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAT6
- Sino Biological Antibodies for STAT6
Protein Products
-
OriGene Purified Proteins for STAT6
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT6
- Origene Custom Protein Services for STAT6
- Sino Biological Recombinant Proteins for STAT6
- Sino Biological Cell Lysates for STAT6
- Search GeneTex for Proteins for STAT6
-
ProSci Proteins for STAT6
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for STAT6 (STAT6)
No data available for DME Specific Peptides for STAT6 Gene
Domains & Families for STAT6 Gene
Gene Families for STAT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for STAT6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STAT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P42226- Family:
-
- Belongs to the transcription factor STAT family.
Function for STAT6 Gene
Molecular function for STAT6 Gene
- UniProtKB/Swiss-Prot Function:
- Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
- GENATLAS Biochemistry:
- signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells
Phenotypes From GWAS Catalog for STAT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 8810328 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 8810328 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for STAT6 Gene
- MGI mutant phenotypes for STAT6:
-
inferred from 3 alleles
- respiratory system phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for STAT6:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Increased cell number in S
- shRNA abundance <= 50%
- Mitotic spindle defects
- Decreased IL-8 secretion
- Increased viability
Animal Models for STAT6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT6
-
CRISPR Products
-
OriGene CRISPR knockouts for STAT6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT6
- genomics-online: gRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- Applied Biological Materials CRISPR for STAT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT6
- GenScript: Design CRISPR guide RNA sequences for STAT6
miRNA for STAT6 Gene
- miRTarBase miRNAs that target STAT6
Transcription Factor Targets for STAT6 Gene
Targeted motifs for STAT6 Gene
HOMER Transcription Factor Regulatory Elements motif STAT6
- Consensus sequence: ANTTCTTAAGAA Submotif: canonical Cell Type: CD4 GEO ID: GSE22104
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT6
- Browse OriGene Inhibitory RNA Products For STAT6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT6
- genomics-online: shRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for STAT6
- RC230536L1V
- RC230536L2V
- RC230537L1V
- RC230537L2V
- RC230469L1V
- RC230469L2V
- RC230470L1V
- RC230470L2V
- RC210065L1V
- RC210065L2V
- RC230536
- RC230536L1
- RC230536L2
- RG230536
- RC230537
- RC230537L1
- RC230537L2
- RG230537
- RC230469
- RC230469L1
- RC230469L2
- RG230469
- RC230470
- RC230470L1
- RC230470L2
- RG230470
- RC210065
- RC210065L1
- RC210065L2
- RG210065
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT6
- VectorBuilder custom plasmid, inducible vectors for STAT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT6
- genomics-online: cdna clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- orf clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- Applied Biological Materials Clones for STAT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT6
Cell Line Products
-
Horizon Cell Lines for STAT6
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for STAT6 Gene
Localization for STAT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAT6 Gene
- Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for STAT6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | CNTF Signaling |
.50
.50
|
.46
|
| 3 | Cytosolic sensors of pathogen-associated DNA | ||
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
Pathways by source for STAT6 Gene
1 Sino Biological pathway for STAT6 Gene
1 GeneTex pathway for STAT6 Gene
6 BioSystems pathways for STAT6 Gene
11 Reactome pathways for STAT6 Gene
7 KEGG pathways for STAT6 Gene
2 GeneGo (Thomson Reuters) pathways for STAT6 Gene
6 R&D Systems pathways for STAT6 Gene
12 Qiagen pathways for STAT6 Gene
1 Cell Signaling Technology pathway for STAT6 Gene
Interacting Proteins for STAT6 Gene
Selected Interacting proteins:
P42226-STAT6_HUMAN
ENSP00000300134
for STAT6 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for STAT6
SIGNOR curated interactions for STAT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002296 | T-helper 1 cell lineage commitment | IEA | -- |
| GO:0002829 | negative regulation of type 2 immune response | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Drugs & Compounds for STAT6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| signal transducer and activator of transcription 6 fragment | Pharma | STAT6 transcription factor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for STAT6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| signal transducer and activator of transcription 6 fragment | STAT6 transcription factor |
Transcripts for STAT6 Gene
mRNA/cDNA for STAT6 Gene
- (10) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (444) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000300134 4034 bps (uc001sna.5)
- ENST00000454075 3037 bps (uc009zpf.5)
- ENST00000537215 2886 bps (uc010srb.4)
- ENST00000538913 2879 bps (uc010srd.4)
- ENST00000543873 3119 bps (uc009zpe.5)
Unigene Clusters for STAT6 Gene
- Signal transducer and activator of transcription 6, interleukin-4 induced:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for STAT6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT6
- genomics-online: gRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- Applied Biological Materials CRISPR for STAT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT6
- GenScript: Design CRISPR guide RNA sequences for STAT6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT6
- Browse OriGene Inhibitory RNA Products For STAT6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT6
- genomics-online: shRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for STAT6
- RC230536L1V
- RC230536L2V
- RC230537L1V
- RC230537L2V
- RC230469L1V
- RC230469L2V
- RC230470L1V
- RC230470L2V
- RC210065L1V
- RC210065L2V
- RC230536
- RC230536L1
- RC230536L2
- RG230536
- RC230537
- RC230537L1
- RC230537L2
- RG230537
- RC230469
- RC230469L1
- RC230469L2
- RG230469
- RC230470
- RC230470L1
- RC230470L2
- RG230470
- RC210065
- RC210065L1
- RC210065L2
- RG210065
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT6
- VectorBuilder custom plasmid, inducible vectors for STAT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT6
- genomics-online: cdna clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- orf clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
- Applied Biological Materials Clones for STAT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT6
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||
| SP15: |
Expression for STAT6 Gene
mRNA differential expression in normal tissues according to GTEx for STAT6 Gene
This gene is overexpressed in Whole Blood (x4.8).
This gene is overexpressed in Lymph node (17.0) and Stomach (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STAT6 Gene:
STAT6SOURCE GeneReport for Unigene cluster for STAT6 Gene:
Hs.524518Evidence on tissue expression from TISSUES for STAT6 Gene
- Lung(4.1)
- Blood(3.7)
- Intestine(3.7)
- Nervous system(3.7)
- Spleen(3.2)
- Lymph node(3.1)
- Skin(3)
- Kidney(2.8)
- Liver(2.6)
- Bone marrow(2.5)
- Muscle(2.4)
- Heart(2.2)
- Stomach(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT6 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Regions:
Head and neck:
- ear
Thorax:
- heart
General:
- blood
- blood vessel
Primer Products
-
OriGene qPCR primer pairs and template standards for STAT6
-
OriGene qPCR primer pairs for STAT6
- genomics-online: primer clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for STAT6 Gene
Orthologs for STAT6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STAT6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STAT6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | STAT6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stat6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stat6 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | STAT6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STAT6 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | STAT6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stat6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stat6 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Stat92E 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y51H4A.17 35 |
|
|
|
| sta-1 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for STAT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for STAT6 Gene
- ENSEMBL:
- Gene Tree for STAT6 (if available)
- TreeFam:
- Gene Tree for STAT6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAT6: view image
Paralogs for STAT6 Gene
(6) SIMAP similar genes for STAT6 Gene using alignment to 13 proteins:
- STAT6_HUMAN
- G3V2H4_HUMAN
- G3V2L2_HUMAN
- G3V2M3_HUMAN
- G3V2X7_HUMAN
- G3V370_HUMAN
- G3V3E9_HUMAN
- G3V568_HUMAN
- G3V5I8_HUMAN
- G3V5K5_HUMAN
- H0YIY2_HUMAN
- H0YJH6_HUMAN
- Q5FBW6_HUMAN
Variants for STAT6 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs483352723 | uncertain-significance, not provided | 57,107,292(-) | A/C | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000113180 | -- | 57,099,468(-) | C/T | intron_variant | |
| rs1000138612 | -- | 57,112,853(-) | C/T | upstream_transcript_variant | |
| rs1000446839 | -- | 57,101,086(-) | T/C | intron_variant | |
| rs1000488507 | -- | 57,105,682(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.11;
38.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAT6 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT6 Gene
Disorders for STAT6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemangiopericytoma, malignant |
|
|
| nut allergy |
|
|
| meninges hemangiopericytoma |
|
|
| primary mediastinal b-cell lymphoma |
|
|
| allergic asthma |
|
Search STAT6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STAT6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for STAT6 Gene
Publications for STAT6 Gene
- T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. (PMID: 17210636) Lu X … Lossos IS (Molecular and cellular biology 2007) 3 4 22 58
- Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. (PMID: 17362266) Yabiku K … Takasu N (Clinical and experimental immunology 2007) 3 22 44 58
- The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. (PMID: 15888279) Klein W … Griga T (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2005) 3 22 44 58
- Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. (PMID: 14757047) Razeto A … Becker S (Journal of molecular biology 2004) 3 4 22 58
- Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. (PMID: 12759487) Tamura K … Morikawa A (International archives of allergy and immunology 2003) 3 22 44 58
Products for STAT6 Gene
- R&D Systems Antibodies for STAT6 (STAT6)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for STAT6 (STAT6)
- R&D Systems cDNA Clones for STAT6
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for STAT6
- AM00151PU-N
- AM00152PU-N
- AM06474SU-N
- AP01697PU-N
- AP01698PU-N
- AP02349PU-N
- AP02349PU-S
- AP02350PU-N
- AP02350PU-S
- AP02591PU-N
- AP02591PU-S
- AP02592PU-N
- AP02592PU-S
- AP06332PU-N
- AP06333PU-N
- SP2071P
- TA309960
- TA309961
- TA312080
- TA319167
- TA325906
- TA325907
- TA325908
- TA325909
- TA329203
- TA333294
- TA333295
- TA343363
- TA349221
- TA354095
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for STAT6
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT6
- Origene Custom Protein Services for STAT6
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT6
- Browse OriGene Inhibitory RNA Products For STAT6
- OriGene qPCR primer pairs and template standards for STAT6
- OriGene qPCR primer pairs for STAT6
- OriGene CRISPR knockouts for STAT6
- OriGene ORF clones in human for STAT6
- RC230536L1V
- RC230536L2V
- RC230537L1V
- RC230537L2V
- RC230469L1V
- RC230469L2V
- RC230470L1V
- RC230470L2V
- RC210065L1V
- RC210065L2V
- RC230536
- RC230536L1
- RC230536L2
- RG230536
- RC230537
- RC230537L1
- RC230537L2
- RG230537
- RC230469
- RC230469L1
- RC230469L2
- RG230469
- RC230470
- RC230470L1
- RC230470L2
- RG230470
- RC210065
- RC210065L1
- RC210065L2
- RG210065
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STAT6
- GenScript: Next-day shipping of latest version cDNA ORF clones for STAT6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STAT6
- GenScript Custom Assay Services for STAT6
- GenScript Custom overexpressing Cell Line Services for STAT6
- GenScript: Design CRISPR guide RNA sequences for STAT6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STAT6
- Sino Biological Human cDNA Clone for STAT6
- Sino Biological Recombinant Proteins for STAT6
- Sino Biological Cell Lysates for STAT6
- Sino Biological Antibodies for STAT6
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STAT6
- Novus Biologicals proteins and lysates for STAT6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for STAT6
- ApexBio compounds for STAT6
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT6
- VectorBuilder custom plasmid, inducible vectors for STAT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT6
- antibodies-online: Search results for 462 available STAT6 Antibodies ranked by validation data
- Compare Top STAT6 Antibodies
- Recommended
- 141 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 5 ICS Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 319 WB Antibodies (anti-human)
- 27 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 18 IHC Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 7 ICS Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 89 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 2 ICS Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 44 available STAT6 Elisa Kits ranked by validation data
- Compare Top STAT6 Elisa Kits
- antibodies-online: Search results for 15 available STAT6 Proteins ranked by validation data
- Compare Top STAT6 Proteins
- GeneTex STAT6 Antibody for STAT6
- Search GeneTex for Proteins for STAT6
- Santa Cruz Biotechnology (SCBT) Antibodies for STAT6
- Search Santa Cruz Biotechnology (SCBT) for STAT6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STAT6
- Horizon Cell Lines for STAT6
- genomics-online: cdna clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
- Recommended
- orf clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
- Recommended
- genomics-online: primer clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 151 available STAT6 gene related products
- Overview of 151 available STAT6 gene related products
- Recommended