The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 med... See more...

Aliases for STAT6 Gene

Aliases for STAT6 Gene

  • Signal Transducer And Activator Of Transcription 6 2 3 4 5
  • Signal Transducer And Activator Of Transcription 6, Interleukin-4 Induced 2 3
  • IL-4-STAT 2 3
  • D12S1644 2 3
  • Transcription Factor IL-4 STAT 3
  • STAT, Interleukin4-Induced 3
  • EC 2.4.1.227 51
  • EC 2.7.7.6 51
  • IL-4 Stat 4
  • STAT6B 3
  • STAT6C 3
  • STAT6 5

External Ids for STAT6 Gene

Previous GeneCards Identifiers for STAT6 Gene

  • GC12M057464
  • GC12M057713
  • GC12M057205
  • GC12M055775
  • GC12M054527
  • GC12M057489

Summaries for STAT6 Gene

Entrez Gene Summary for STAT6 Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

CIViC Summary for STAT6 Gene

GeneCards Summary for STAT6 Gene

STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hemangiopericytoma, Malignant and Nut Allergy. Among its related pathways are Signaling by GPCR and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot Summary for STAT6 Gene

  • Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Gene Wiki entry for STAT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAT6 Gene

Genomics for STAT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STAT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAT6

Top Transcription factor binding sites by QIAGEN in the STAT6 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • NF-kappaB
  • NF-kappaB1
  • STAT3

Genomic Locations for STAT6 Gene

Genomic Locations for STAT6 Gene
chr12:57,095,408-57,132,139
(GRCh38/hg38)
Size:
36,732 bases
Orientation:
Minus strand
chr12:57,489,187-57,525,922
(GRCh37/hg19)
Size:
36,736 bases
Orientation:
Minus strand

Genomic View for STAT6 Gene

Genes around STAT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT6 Gene

Proteins for STAT6 Gene

  • Protein details for STAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42226-STAT6_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 6
    Protein Accession:
    P42226
    Secondary Accessions:
    • A8K316
    • B7ZA27
    • F5GXI9
    • Q5FBW5
    • Q71UP4

    Protein attributes for STAT6 Gene

    Size:
    847 amino acids
    Molecular mass:
    94135 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.

    Three dimensional structures from OCA and Proteopedia for STAT6 Gene

    Alternative splice isoforms for STAT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT6 Gene

Selected DME Specific Peptides for STAT6 Gene

P42226:
  • GGSLGAQ
  • GRGYVPA

Post-translational modifications for STAT6 Gene

  • Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
  • Mono-ADP-ribosylated by PARP14.
  • Ubiquitination at Lys319 and Lys647
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for STAT6

Protein Products

  • Abcam proteins for STAT6

Domains & Families for STAT6 Gene

Gene Families for STAT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for STAT6 Gene

GenScript: Design optimal peptide antigens:
  • STAT6B (Q56TK0_HUMAN)
  • Signal transducer and activator of transcription 6 nirs variant 1 (Q5FBW6_HUMAN)
  • STAT6 (Q6LCD8_HUMAN)
  • IL-4 Stat (STAT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42226

UniProtKB/Swiss-Prot:

STAT6_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT6: view

Function for STAT6 Gene

Molecular function for STAT6 Gene

UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
GENATLAS Biochemistry:
signal transducer and activator of transcription 6,specifically activated by IL4 and IL13,overlapping D12S1644,with several alternatively spliced variants,expressed at higher levels in pancreatic beta cells

Enzyme Numbers (IUBMB) for STAT6 Gene

Phenotypes From GWAS Catalog for STAT6 Gene

Gene Ontology (GO) - Molecular Function for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8810328
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 8810328
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with STAT6: view
genes like me logo Genes that share phenotypes with STAT6: view

Human Phenotype Ontology for STAT6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STAT6 Gene

MGI Knock Outs for STAT6:

Animal Model Products

CRISPR Products

Transcription Factor Targets for STAT6 Gene

Selected GeneGlobe predicted Target genes for STAT6
Targeted motifs for STAT6 Gene
HOMER Transcription Factor Regulatory Elements motif STAT6
  • Consensus sequence: ANTTCTTAAGAA Submotif: canonical Cell Type: CD4 GEO ID: GSE22104

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT6

Clone Products

  • Addgene plasmids for STAT6

Localization for STAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT6 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT6 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT6: view

Pathways & Interactions for STAT6 Gene

genes like me logo Genes that share pathways with STAT6: view

Pathways by source for STAT6 Gene

2 GeneGo (Thomson Reuters) pathways for STAT6 Gene
  • Development PDGF signaling via STATs and NF-kB
  • Immune response IL-4 signaling pathway
12 Qiagen pathways for STAT6 Gene
  • CNTF Signaling
  • ErbB2-ErbB3 Heterodimers
  • FLT3 Signaling
  • GPCR Pathway
  • IL-3 Pathway
1 Cell Signaling Technology pathway for STAT6 Gene
1 GeneTex pathway for STAT6 Gene

SIGNOR curated interactions for STAT6 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0002296 T-helper 1 cell lineage commitment IEA --
GO:0002829 negative regulation of type 2 immune response IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8810328
genes like me logo Genes that share ontologies with STAT6: view

Drugs & Compounds for STAT6 Gene

(15) Drugs for STAT6 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
signal transducer and activator of transcription 6 fragment Pharma STAT6 transcription factor 0

(14) Additional Compounds for STAT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for STAT6 Gene

Compound Action Cas Number
signal transducer and activator of transcription 6 fragment STAT6 transcription factor
genes like me logo Genes that share compounds with STAT6: view

Drug Products

Transcripts for STAT6 Gene

mRNA/cDNA for STAT6 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
25 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT6

Clone Products

  • Addgene plasmids for STAT6

Alternative Splicing Database (ASD) splice patterns (SP) for STAT6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - -
SP2:
SP3:
SP4: - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - -
SP8: - - -
SP9:
SP10:
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - - -
SP14:
SP15:

ExUns: 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - -
SP14:
SP15:

Relevant External Links for STAT6 Gene

GeneLoc Exon Structure for
STAT6

Expression for STAT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAT6 Gene

mRNA differential expression in normal tissues according to GTEx for STAT6 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for STAT6 Gene

This gene is overexpressed in Lymph node (17.0) and Stomach (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT6 Gene



Protein tissue co-expression partners for STAT6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAT6

SOURCE GeneReport for Unigene cluster for STAT6 Gene:

Hs.524518

Evidence on tissue expression from TISSUES for STAT6 Gene

  • Lung(4.2)
  • Nervous system(4)
  • Intestine(4)
  • Blood(3.9)
  • Spleen(3.7)
  • Lymph node(3.7)
  • Skin(3.4)
  • Kidney(3.4)
  • Liver(3.3)
  • Bone marrow(3.3)
  • Muscle(3.1)
  • Heart(3)
  • Stomach(2.8)
  • Thyroid gland(2.7)
  • Pancreas(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.3)
  • Bone(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT6 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Regions:
Head and neck:
  • ear
Thorax:
  • heart
General:
  • blood
  • blood vessel
genes like me logo Genes that share expression patterns with STAT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for STAT6 Gene

Orthologs for STAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STAT6 30 31
  • 98.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STAT6 30 31
  • 91.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STAT6 30 31
  • 90.4 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Stat6 30 17 31
  • 85.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stat6 30
  • 85.37 (n)
Oppossum
(Monodelphis domestica)
Mammalia STAT6 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STAT6 31
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STAT6 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stat6 30
  • 58.02 (n)
Zebrafish
(Danio rerio)
Actinopterygii stat6 30 31
  • 51.72 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Stat92E 31 32
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 32
  • 29 (a)
sta-1 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
ManyToMany
Species where no ortholog for STAT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STAT6 Gene

ENSEMBL:
Gene Tree for STAT6 (if available)
TreeFam:
Gene Tree for STAT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT6: view image

Paralogs for STAT6 Gene

Paralogs for STAT6 Gene

(6) SIMAP similar genes for STAT6 Gene using alignment to 13 proteins:

  • STAT6_HUMAN
  • G3V2H4_HUMAN
  • G3V2L2_HUMAN
  • G3V2M3_HUMAN
  • G3V2X7_HUMAN
  • G3V370_HUMAN
  • G3V3E9_HUMAN
  • G3V568_HUMAN
  • G3V5I8_HUMAN
  • G3V5K5_HUMAN
  • H0YIY2_HUMAN
  • H0YJH6_HUMAN
  • Q5FBW6_HUMAN
genes like me logo Genes that share paralogs with STAT6: view

Variants for STAT6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAT6 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
719355 Benign: not provided 57,099,819(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
724684 Likely Benign: not provided 57,102,868(-) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
727949 Likely Benign: not provided 57,107,725(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
733916 Likely Benign: not provided 57,096,708(-) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
733917 Benign: not provided 57,098,524(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for STAT6 Gene

Structural Variations from Database of Genomic Variants (DGV) for STAT6 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for STAT6 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAT6 Gene

Human Gene Mutation Database (HGMD)
STAT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT6 Gene

Disorders for STAT6 Gene

MalaCards: The human disease database

(44) MalaCards diseases for STAT6 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemangiopericytoma, malignant
  • hemangiopericytoma
nut allergy
  • allergy to nuts
primary mediastinal b-cell lymphoma
  • large cell lymphoma of the mediastinum
allergic asthma
  • atopic asthma
beta-lactam allergy
- elite association - COSMIC cancer census association via MalaCards
Search STAT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STAT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STAT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAT6 Gene

Publications for STAT6 Gene

  1. Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. (PMID: 19282076) Sperati CJ … Kao WH (American journal of kidney diseases : the official journal of the National Kidney Foundation 2009) 3 23 41
  2. Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome. (PMID: 19011907) Ikeuchi Y … Morikawa A (Pediatric nephrology (Berlin, Germany) 2009) 3 23 41
  3. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. (PMID: 17210636) Lu X … Lossos IS (Molecular and cellular biology 2007) 3 4 23
  4. Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. (PMID: 17362266) Yabiku K … Takasu N (Clinical and experimental immunology 2007) 3 23 41
  5. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. (PMID: 17532201) Li Y … Zhang L (Respiratory medicine 2007) 3 23 41

Products for STAT6 Gene