The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction trigger... See more...

Aliases for STAT5B Gene

Aliases for STAT5B Gene

  • Signal Transducer And Activator Of Transcription 5B 2 3 4 5
  • Transcription Factor STAT5B 3
  • STAT5B 5
  • STAT5 3

External Ids for STAT5B Gene

Previous GeneCards Identifiers for STAT5B Gene

  • GC17U990099
  • GC17M042509
  • GC17M040259
  • GC17M040726
  • GC17M040724
  • GC17M037604
  • GC17M040351
  • GC17M036116

Summaries for STAT5B Gene

Entrez Gene Summary for STAT5B Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]

CIViC Summary for STAT5B Gene

GeneCards Summary for STAT5B Gene

STAT5B (Signal Transducer And Activator Of Transcription 5B) is a Protein Coding gene. Diseases associated with STAT5B include Growth Hormone Insensitivity With Immunodeficiency and Acute Promyelocytic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT5A.

UniProtKB/Swiss-Prot Summary for STAT5B Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.

Gene Wiki entry for STAT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAT5B Gene

Genomics for STAT5B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STAT5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT5B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAT5B

Top Transcription factor binding sites by QIAGEN in the STAT5B gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • GR
  • NF-1
  • NF-1/L

Genomic Locations for STAT5B Gene

Genomic Locations for STAT5B Gene
chr17:42,199,177-42,288,437
(GRCh38/hg38)
Size:
89,261 bases
Orientation:
Minus strand
chr17:40,351,186-40,428,725
(GRCh37/hg19)
Size:
77,540 bases
Orientation:
Minus strand

Genomic View for STAT5B Gene

Genes around STAT5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5B Gene

Proteins for STAT5B Gene

  • Protein details for STAT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51692-STA5B_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5B
    Protein Accession:
    P51692
    Secondary Accessions:
    • Q8WWS8

    Protein attributes for STAT5B Gene

    Size:
    787 amino acids
    Molecular mass:
    89866 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 (PubMed:12954634). Interacts with NMI (PubMed:9989503). Interacts with SOCS7 (PubMed:15677474). Interacts (via SH2 domain) with INSR (PubMed:9428692). Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532).

    Three dimensional structures from OCA and Proteopedia for STAT5B Gene

neXtProt entry for STAT5B Gene

Post-translational modifications for STAT5B Gene

  • Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAT5B Gene

Antibody Products

No data available for DME Specific Peptides for STAT5B Gene

Domains & Families for STAT5B Gene

Gene Families for STAT5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for STAT5B Gene

GenScript: Design optimal peptide antigens:
  • Signal transducer and activator of transcription 5B (STA5B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51692

UniProtKB/Swiss-Prot:

STA5B_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5B: view

Function for STAT5B Gene

Molecular function for STAT5B Gene

UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
GENATLAS Biochemistry:
signal transducer and activator of transcription 5B,constitutively expressed in peripheral blood lymphocyte,activated by interleukin 2,also expressed in liver fibroblast,activated by GH,maybe involved in GH binding protein positive Laron syndrome children,interacting with T cell receptor and stimulating T cell proliferation

Phenotypes From GWAS Catalog for STAT5B Gene

Gene Ontology (GO) - Molecular Function for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA,IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with STAT5B: view
genes like me logo Genes that share phenotypes with STAT5B: view

Human Phenotype Ontology for STAT5B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STAT5B Gene

MGI Knock Outs for STAT5B:

Animal Model Products

CRISPR Products

Transcription Factor Targets for STAT5B Gene

Selected GeneGlobe predicted Target genes for STAT5B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT5B

Clone Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for STAT5B Gene

Localization for STAT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5B Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT5B gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STAT5B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STAT5B Gene

Pathways & Interactions for STAT5B Gene

PathCards logo

SuperPathways for STAT5B Gene

SuperPathway Contained pathways
1 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.42
.36
2 Immune response IL-23 signaling pathway
.44
.44
.38
.36
.36
3 RET signaling
4 IL-2 Pathway
.54
.51
.49
.49
.48
5 Prolactin Signaling Pathway
.38
genes like me logo Genes that share pathways with STAT5B: view

Pathways by source for STAT5B Gene

15 GeneGo (Thomson Reuters) pathways for STAT5B Gene
  • Development Angiopoietin - Tie2 signaling
  • Development Endothelin-1/EDNRA transactivation of EGFR
  • Development EPO-induced Jak-STAT pathway
  • Development PDGF signaling via STATs and NF-kB
  • Development Prolactin receptor signaling
21 Qiagen pathways for STAT5B Gene
  • Angiopoietin-TIE2 Signaling
  • Chemokine Signaling
  • CNTF Signaling
  • ErbB2-ErbB3 Heterodimers
  • Erythropoietin Pathway
1 Cell Signaling Technology pathway for STAT5B Gene
1 GeneTex pathway for STAT5B Gene

SIGNOR curated interactions for STAT5B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001553 luteinization IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS 8631883
GO:0006952 defense response IBA 21873635
genes like me logo Genes that share ontologies with STAT5B: view

Drugs & Compounds for STAT5B Gene

(13) Drugs for STAT5B Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target, inhibitor, Inhibition Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 324

(12) Additional Compounds for STAT5B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAT5B: view

Transcripts for STAT5B Gene

mRNA/cDNA for STAT5B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT5B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5B Gene

No ASD Table

Relevant External Links for STAT5B Gene

GeneLoc Exon Structure for
STAT5B

Expression for STAT5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAT5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5B Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for STAT5B Gene

This gene is overexpressed in Lymph node (9.4), Peripheral blood mononuclear cells (7.8), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT5B Gene



Protein tissue co-expression partners for STAT5B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAT5B

SOURCE GeneReport for Unigene cluster for STAT5B Gene:

Hs.595276

Evidence on tissue expression from TISSUES for STAT5B Gene

  • Nervous system(4)
  • Blood(3.9)
  • Bone marrow(3.5)
  • Spleen(3.5)
  • Lymph node(3.5)
  • Intestine(3.4)
  • Liver(3.4)
  • Muscle(3.3)
  • Kidney(3.3)
  • Skin(3.1)
  • Lung(3)
  • Heart(3)
  • Adrenal gland(2.8)
  • Pancreas(2.7)
  • Thyroid gland(2.6)
  • Stomach(2.5)
  • Bone(2.2)
  • Eye(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT5B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • endocrine
  • immune
  • lymphatic
  • respiratory
Regions:
Head and neck:
  • head
  • pituitary gland
Thorax:
  • lung
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with STAT5B: view

No data available for mRNA Expression by UniProt/SwissProt for STAT5B Gene

Orthologs for STAT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STAT5B 30 31
  • 96.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STAT5B 30 31
  • 92.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STAT5B 30 31
  • 92.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stat5b 30
  • 90.67 (n)
Mouse
(Mus musculus)
Mammalia Stat5b 30 17 31
  • 90.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToMany
Chicken
(Gallus gallus)
Aves STAT5 31
  • 91 (a)
OneToMany
STAT5B 30
  • 82.38 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 88 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stat5b 30
  • 77.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12087 30
Zebrafish
(Danio rerio)
Actinopterygii stat5.2 31
  • 74 (a)
ManyToMany
stat5.1 30 31
  • 73.03 (n)
ManyToMany
stat5b 30
Fruit Fly
(Drosophila melanogaster)
Insecta Stat92E 31 32
  • 32 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea sta-1 30 31
  • 42.12 (n)
OneToMany
Y51H4A.17 32
  • 29 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3791 31
  • 49 (a)
OneToMany
Species where no ortholog for STAT5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STAT5B Gene

ENSEMBL:
Gene Tree for STAT5B (if available)
TreeFam:
Gene Tree for STAT5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT5B: view image

Paralogs for STAT5B Gene

Paralogs for STAT5B Gene

(5) SIMAP similar genes for STAT5B Gene using alignment to 2 proteins:

  • STA5B_HUMAN
  • C9J4I3_HUMAN
genes like me logo Genes that share paralogs with STAT5B: view

Variants for STAT5B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAT5B Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
636867 Uncertain Significance: not provided 42,219,346(-) G/A MISSENSE_VARIANT
640215 Uncertain Significance: Laron syndrome with immunodeficiency 42,219,358(-) C/T MISSENSE_VARIANT
645112 Uncertain Significance: Laron syndrome with immunodeficiency 42,219,756(-) C/A MISSENSE_VARIANT
645841 Uncertain Significance: Laron syndrome with immunodeficiency 42,207,630(-) C/T MISSENSE_VARIANT
645970 Uncertain Significance: Laron syndrome with immunodeficiency 42,217,203(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for STAT5B Gene

Structural Variations from Database of Genomic Variants (DGV) for STAT5B Gene

Variant ID Type Subtype PubMed ID
dgv5599n54 CNV gain 21841781
esv2450397 CNV deletion 19546169
esv24591 CNV loss 19812545
nsv1056904 CNV gain 25217958
nsv1071385 CNV deletion 25765185
nsv1138540 CNV deletion 24896259
nsv1138541 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv575042 CNV loss 21841781
nsv575043 CNV gain 21841781
nsv575044 CNV loss 21841781
nsv575046 CNV gain+loss 21841781
nsv833449 CNV loss 17160897

Variation tolerance for STAT5B Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAT5B Gene

Human Gene Mutation Database (HGMD)
STAT5B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5B Gene

Disorders for STAT5B Gene

MalaCards: The human disease database

(45) MalaCards diseases for STAT5B Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
growth hormone insensitivity with immunodeficiency
  • laron syndrome due to postreceptor defect
acute promyelocytic leukemia
  • apl
laron syndrome
  • growth hormone insensitivity syndrome
t-cell large granular lymphocyte leukemia
  • large granular lymphocytic leukaemia
chronic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

STA5B_HUMAN
  • Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to exogeneous growth hormone therapy, and recurrent infections. {ECO:0000269 PubMed:13679528, ECO:0000269 PubMed:15827093, ECO:0000269 PubMed:22419735}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for STAT5B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STAT5B: view

No data available for Genatlas for STAT5B Gene

Publications for STAT5B Gene

  1. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin JX … Leonard WJ (The Journal of biological chemistry 1996) 2 3 4 23
  2. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α. (PMID: 20065083) Kreil S … German CML Study Group (Haematologica 2010) 3 23 41
  3. Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. (PMID: 17997837) Weaver AM … Silva CM (Breast cancer research : BCR 2007) 3 4 23
  4. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. (PMID: 17639043) Vaclavicek A … Försti A (Endocrine-related cancer 2007) 3 23 41
  5. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PMID: 12954634) Litterst CM … Pfitzner E (The Journal of biological chemistry 2003) 3 4 23

Products for STAT5B Gene

  • Signalway ELISA kits for STAT5B
  • Signalway Proteins for STAT5B