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Aliases for STAT5A Gene

Aliases for STAT5A Gene

  • Signal Transducer And Activator Of Transcription 5A 2 3 3 5
  • STAT5 3 4
  • MGF 3

External Ids for STAT5A Gene

Previous HGNC Symbols for STAT5A Gene

  • STAT5

Previous GeneCards Identifiers for STAT5A Gene

  • GC17M039918
  • GC17P042595
  • GC17P040348
  • GC17P040812
  • GC17P037694
  • GC17P036204
  • GC17P040439

Summaries for STAT5A Gene

Entrez Gene Summary for STAT5A Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for STAT5A Gene

STAT5A (Signal Transducer And Activator Of Transcription 5A) is a Protein Coding gene. Diseases associated with STAT5A include Polycythemia Vera and Polycythemia. Among its related pathways are EGF/EGFR Signaling Pathway and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and obsolete signal transducer activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot for STAT5A Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Gene Wiki entry for STAT5A Gene

Additional gene information for STAT5A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT5A Gene

Genomics for STAT5A Gene

GeneHancer (GH) Regulatory Elements for STAT5A Gene

Promoters and enhancers for STAT5A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042285 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.9 +0.8 825 6 HDGF PKNOX1 ATF1 SMAD1 MLX SIN3A ZNF207 ZNF143 ATF7 RUNX3 STAT5A STAT5B NBR2 ENSG00000267002 ENSG00000267340 HMGN1P29 HSD17B1 KAT2A CNTD1 EZH1
GH17J042305 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.4 +18.6 18642 1.1 SMAD5 POLR2A RBM22 SUPT5H ZBTB17 STAT5A STAT5B ENSG00000236194 ATP6V0A1 MIR5010 PIR49037 GC17M042314
GH17J041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 27.3 -597.1 -597148 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 EIF1 GC17P041692 GC17P041691 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A
GH17J042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.2 +391.2 391151 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 DHX8 TUBG2 HMGN1P29 ENSG00000267758 ENSG00000267002 ENSG00000266962
GH17J042308 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26.2 +28.5 28509 15.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF263 MEF2D GC17M042314 HMGN1P29 ENSG00000267758 ACLY NBR2 STAT5A ENSG00000266962 ENSG00000267340 GHDC NBR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT5A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAT5A gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • c-Fos
  • NF-1/L
  • NF-1
  • GR

Genomic Locations for STAT5A Gene

Genomic Locations for STAT5A Gene
chr17:42,287,547-42,311,943
(GRCh38/hg38)
Size:
24,397 bases
Orientation:
Plus strand
chr17:40,439,565-40,463,961
(GRCh37/hg19)
Size:
24,397 bases
Orientation:
Plus strand

Genomic View for STAT5A Gene

Genes around STAT5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5A Gene

Proteins for STAT5A Gene

  • Protein details for STAT5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42229-STA5A_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5A
    Protein Accession:
    P42229
    Secondary Accessions:
    • Q1KLZ6

    Protein attributes for STAT5A Gene

    Size:
    794 amino acids
    Molecular mass:
    90647 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.

    Alternative splice isoforms for STAT5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT5A Gene

Post-translational modifications for STAT5A Gene

  • Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).
  • ISGylated.
  • Ubiquitination at isoforms=2689, isoforms=2675, and isoforms=2644
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for STAT5A

No data available for DME Specific Peptides for STAT5A Gene

Domains & Families for STAT5A Gene

Gene Families for STAT5A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P42229

UniProtKB/Swiss-Prot:

STA5A_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5A: view

Function for STAT5A Gene

Molecular function for STAT5A Gene

UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
GENATLAS Biochemistry:
signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively expressed in peripheral blood lymphocytes,activated by a variety of hormones and cytokines including interleukin 2,interacting with T cell receptor and stimulating T cell proliferation

Phenotypes From GWAS Catalog for STAT5A Gene

Gene Ontology (GO) - Molecular Function for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,TAS 7719937
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004871 obsolete signal transducer activity IEA --
genes like me logo Genes that share ontologies with STAT5A: view
genes like me logo Genes that share phenotypes with STAT5A: view

Animal Models for STAT5A Gene

MGI Knock Outs for STAT5A:

Animal Model Products

Transcription Factor Targets for STAT5A Gene

Selected GeneGlobe predicted Target genes for STAT5A
Targeted motifs for STAT5A Gene
HOMER Transcription Factor Regulatory Elements motif STAT5A
  • Consensus sequence: ATTTCTNAGAAA Submotif: canonical Cell Type: mCD4+ GEO ID: GSE12346

Clone Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for STAT5A Gene

Localization for STAT5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5A Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT5A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with STAT5A: view

Pathways & Interactions for STAT5A Gene

genes like me logo Genes that share pathways with STAT5A: view

SIGNOR curated interactions for STAT5A Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000255 allantoin metabolic process ISS --
GO:0001938 positive regulation of endothelial cell proliferation IMP 20489169
GO:0006101 citrate metabolic process ISS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006105 succinate metabolic process ISS --
genes like me logo Genes that share ontologies with STAT5A: view

Drugs & Compounds for STAT5A Gene

(44) Drugs for STAT5A Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niclosamide Approved, Investigational, Vet_approved Pharma STAT3 inhibitor; also inhibits mTORC1 signaling 9
SH-4-54 Pharma STAT inhibitor, potent 0

(28) Additional Compounds for STAT5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAT5A: view

Transcripts for STAT5A Gene

Unigene Clusters for STAT5A Gene

Signal transducer and activator of transcription 5A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1:
SP2: -
SP3: - - - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:
SP12: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STAT5A Gene

GeneLoc Exon Structure for
STAT5A
ECgene alternative splicing isoforms for
STAT5A

Expression for STAT5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAT5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5A Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for STAT5A Gene

This gene is overexpressed in Lymph node (15.6), Peripheral blood mononuclear cells (15.3), and Tlymphocyte (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT5A Gene



Protein tissue co-expression partners for STAT5A Gene

NURSA nuclear receptor signaling pathways regulating expression of STAT5A Gene:

STAT5A

SOURCE GeneReport for Unigene cluster for STAT5A Gene:

Hs.437058

Evidence on tissue expression from TISSUES for STAT5A Gene

  • Blood(3.5)
  • Bone marrow(3.2)
  • Liver(2.8)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Lung(2.4)
  • Intestine(2.3)
  • Kidney(2.3)
  • Skin(2.2)
  • Heart(2.1)
  • Muscle(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with STAT5A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT5A Gene

Orthologs for STAT5A Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAT5A 34 33
  • 99.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAT5A 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STAT5A 34 33
  • 91.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STAT5A 34 33
  • 91.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stat5a 16 34 33
  • 90.54 (n)
rat
(Rattus norvegicus)
Mammalia Stat5a 33
  • 90.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves STAT5 34
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17235 33
zebrafish
(Danio rerio)
Actinopterygii stat5.1 34
  • 78 (a)
ManyToMany
stat5.2 34
  • 74 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11837 33
African malaria mosquito
(Anopheles gambiae)
Insecta STAT2 33
  • 53.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 34 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 35
  • 28 (a)
sta-1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3791 34
  • 50 (a)
OneToMany
Species where no ortholog for STAT5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT5A Gene

ENSEMBL:
Gene Tree for STAT5A (if available)
TreeFam:
Gene Tree for STAT5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT5A: view image

Paralogs for STAT5A Gene

Paralogs for STAT5A Gene

(6) SIMAP similar genes for STAT5A Gene using alignment to 6 proteins:

  • STA5A_HUMAN
  • C9JVV6_HUMAN
  • K7EIF9_HUMAN
  • K7EK35_HUMAN
  • K7EM17_HUMAN
  • Q8WWS9_HUMAN
genes like me logo Genes that share paralogs with STAT5A: view

Variants for STAT5A Gene

Sequence variations from dbSNP and Humsavar for STAT5A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000424638 -- 42,289,094(+) T/C intron_variant
rs1000432381 -- 42,294,425(+) G/T intron_variant
rs1000662517 -- 42,298,751(+) T/G intron_variant
rs1000727263 -- 42,299,557(+) G/T intron_variant
rs1000753273 -- 42,288,754(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STAT5A Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833449 CNV loss 17160897

Variation tolerance for STAT5A Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 50.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAT5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5A Gene

Disorders for STAT5A Gene

MalaCards: The human disease database

(20) MalaCards diseases for STAT5A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polycythemia vera
  • pv
polycythemia
  • polycythemia vera
essential thrombocythemia
  • essential thrombocythaemia
myelofibrosis
  • myelofibrosis with myeloid metaplasia, somatic
bone marrow cancer
  • bone marrow neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STAT5A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STAT5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAT5A Gene

Publications for STAT5A Gene

  1. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PMID: 12954634) Litterst CM … Pfitzner E (The Journal of biological chemistry 2003) 3 4 22 58
  2. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin JX … Leonard WJ (The Journal of biological chemistry 1996) 2 3 22 58
  3. Identification and purification of human Stat proteins activated in response to interleukin-2. (PMID: 7719937) Hou J … McKnight SL (Immunity 1995) 2 3 4 58
  4. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α. (PMID: 20065083) Kreil S … German CML Study Group (Haematologica 2010) 3 44 58
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58

Products for STAT5A Gene