The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the respon... See more...

Aliases for STAT5A Gene

Aliases for STAT5A Gene

  • Signal Transducer And Activator Of Transcription 5A 2 3 4 5
  • STAT5 3 4
  • MGF 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • STAT5A 5

External Ids for STAT5A Gene

Previous HGNC Symbols for STAT5A Gene

  • STAT5

Previous GeneCards Identifiers for STAT5A Gene

  • GC17M039918
  • GC17P042595
  • GC17P040348
  • GC17P040812
  • GC17P037694
  • GC17P036204
  • GC17P040439

Summaries for STAT5A Gene

Entrez Gene Summary for STAT5A Gene

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for STAT5A Gene

STAT5A (Signal Transducer And Activator Of Transcription 5A) is a Protein Coding gene. Diseases associated with STAT5A include Chronic Leukemia and Myeloproliferative Neoplasm. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and obsolete signal transducer activity. An important paralog of this gene is STAT5B.

UniProtKB/Swiss-Prot Summary for STAT5A Gene

  • Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Gene Wiki entry for STAT5A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAT5A Gene

Genomics for STAT5A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STAT5A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT5A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAT5A

Top Transcription factor binding sites by QIAGEN in the STAT5A gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • GR
  • NF-1
  • NF-1/L

Genomic Locations for STAT5A Gene

Genomic Locations for STAT5A Gene
chr17:42,287,547-42,311,943
(GRCh38/hg38)
Size:
24,397 bases
Orientation:
Plus strand
chr17:40,439,565-40,463,961
(GRCh37/hg19)
Size:
24,397 bases
Orientation:
Plus strand

Genomic View for STAT5A Gene

Genes around STAT5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT5A Gene

Proteins for STAT5A Gene

  • Protein details for STAT5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42229-STA5A_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 5A
    Protein Accession:
    P42229
    Secondary Accessions:
    • Q1KLZ6

    Protein attributes for STAT5A Gene

    Size:
    794 amino acids
    Molecular mass:
    90647 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.

    Alternative splice isoforms for STAT5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT5A Gene

Post-translational modifications for STAT5A Gene

  • Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425).
  • ISGylated.
  • Ubiquitination at Lys644, Lys675, and Lys689
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for STAT5A

No data available for DME Specific Peptides for STAT5A Gene

Domains & Families for STAT5A Gene

Gene Families for STAT5A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for STAT5A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54464, highly similar to Signal transducer and activator of transcription 5A (Q1KLZ6_HUMAN)
  • Signal transducer and activator of transcription 5A (Q8WWS9_HUMAN)
  • Signal transducer and activator of transcription 5A (STA5A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42229

UniProtKB/Swiss-Prot:

STA5A_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT5A: view

Function for STAT5A Gene

Molecular function for STAT5A Gene

UniProtKB/Swiss-Prot Function:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
GENATLAS Biochemistry:
signal transducer and activator of transcription 5A of the GH JAK/STAT pathway,constitutively expressed in peripheral blood lymphocytes,activated by a variety of hormones and cytokines including interleukin 2,interacting with T cell receptor and stimulating T cell proliferation

Phenotypes From GWAS Catalog for STAT5A Gene

Gene Ontology (GO) - Molecular Function for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,TAS 7719937
genes like me logo Genes that share ontologies with STAT5A: view
genes like me logo Genes that share phenotypes with STAT5A: view

Animal Models for STAT5A Gene

MGI Knock Outs for STAT5A:

Animal Model Products

CRISPR Products

Transcription Factor Targets for STAT5A Gene

Selected GeneGlobe predicted Target genes for STAT5A
Targeted motifs for STAT5A Gene
HOMER Transcription Factor Regulatory Elements motif STAT5A
  • Consensus sequence: ATTTCTNAGAAA Submotif: canonical Cell Type: mCD4+ GEO ID: GSE12346

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT5A

Clone Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for STAT5A Gene

Localization for STAT5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT5A Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT5A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with STAT5A: view

Pathways & Interactions for STAT5A Gene

PathCards logo

SuperPathways for STAT5A Gene

SuperPathway Contained pathways
1 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.42
.36
2 Immune response IL-23 signaling pathway
.44
.44
.38
.36
.36
3 RET signaling
4 IL-2 Pathway
.54
.51
.49
.49
.48
5 Th17 cell differentiation
.36
.01
genes like me logo Genes that share pathways with STAT5A: view

Pathways by source for STAT5A Gene

16 GeneGo (Thomson Reuters) pathways for STAT5A Gene
  • Development Angiopoietin - Tie2 signaling
  • Development Endothelin-1/EDNRA transactivation of EGFR
  • Development EPO-induced Jak-STAT pathway
  • Development Flt3 signaling
  • Development PDGF signaling via STATs and NF-kB
21 Qiagen pathways for STAT5A Gene
  • Angiopoietin-TIE2 Signaling
  • Chemokine Signaling
  • CNTF Signaling
  • ErbB2-ErbB3 Heterodimers
  • Erythropoietin Pathway
1 Cell Signaling Technology pathway for STAT5A Gene
1 GeneTex pathway for STAT5A Gene

SIGNOR curated interactions for STAT5A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 20489169
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8631883
GO:0006952 defense response IBA 21873635
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with STAT5A: view

Drugs & Compounds for STAT5A Gene

(43) Drugs for STAT5A Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niclosamide Approved, Investigational, Vet_approved Pharma STAT3 inhibitor; also inhibits mTORC1 signaling 16
SH-4-54 Pharma STAT inhibitor, potent 0

(29) Additional Compounds for STAT5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for STAT5A Gene

Compound Action Cas Number
Niclosamide 50-65-7
SH-4-54 STAT inhibitor, potent 1456632-40-8
genes like me logo Genes that share compounds with STAT5A: view

Drug Products

Transcripts for STAT5A Gene

mRNA/cDNA for STAT5A Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT5A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1:
SP2: -
SP3: - - - -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:
SP12: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for STAT5A Gene

GeneLoc Exon Structure for
STAT5A

Expression for STAT5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAT5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAT5A Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for STAT5A Gene

This gene is overexpressed in Lymph node (15.6), Peripheral blood mononuclear cells (15.3), and Tlymphocyte (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT5A Gene



Protein tissue co-expression partners for STAT5A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAT5A

SOURCE GeneReport for Unigene cluster for STAT5A Gene:

Hs.437058

Evidence on tissue expression from TISSUES for STAT5A Gene

  • Blood(3.8)
  • Bone marrow(3.6)
  • Lymph node(3.5)
  • Spleen(3.4)
  • Liver(3.3)
  • Intestine(3.2)
  • Skin(3)
  • Kidney(3)
  • Lung(3)
  • Heart(3)
  • Nervous system(2.8)
  • Muscle(2.8)
  • Pancreas(2.7)
  • Adrenal gland(2.5)
  • Thyroid gland(2.4)
  • Stomach(2.4)
  • Bone(2.1)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with STAT5A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT5A Gene

Orthologs for STAT5A Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT5A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STAT5A 30 31
  • 99.54 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STAT5A 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia STAT5A 30 31
  • 91.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STAT5A 30 31
  • 91.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Stat5a 30 17 31
  • 90.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stat5a 30
  • 90.37 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 78 (a)
OneToMany
Chicken
(Gallus gallus)
Aves STAT5 31
  • 88 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 86 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.17235 30
Zebrafish
(Danio rerio)
Actinopterygii stat5.1 31
  • 78 (a)
ManyToMany
stat5.2 31
  • 74 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11837 30
African malaria mosquito
(Anopheles gambiae)
Insecta STAT2 30
  • 53.55 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Stat92E 31 32
  • 32 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y51H4A.17 32
  • 28 (a)
sta-1 31
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3791 31
  • 50 (a)
OneToMany
Species where no ortholog for STAT5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STAT5A Gene

ENSEMBL:
Gene Tree for STAT5A (if available)
TreeFam:
Gene Tree for STAT5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT5A: view image

Paralogs for STAT5A Gene

Paralogs for STAT5A Gene

(6) SIMAP similar genes for STAT5A Gene using alignment to 6 proteins:

  • STA5A_HUMAN
  • C9JVV6_HUMAN
  • K7EIF9_HUMAN
  • K7EK35_HUMAN
  • K7EM17_HUMAN
  • Q8WWS9_HUMAN
genes like me logo Genes that share paralogs with STAT5A: view

Variants for STAT5A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAT5A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
691386 Uncertain Significance: Pyloric stenosis; Esophageal atresia 42,304,551(+) G/A MISSENSE_VARIANT
731253 Benign: not provided 42,295,708(+) G/A SYNONYMOUS_VARIANT
735034 Benign: not provided 42,307,611(+) G/C SYNONYMOUS_VARIANT
768884 Benign: not provided 42,309,043(+) A/G INTRON_VARIANT
785569 Benign: not provided 42,299,826(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for STAT5A Gene

Structural Variations from Database of Genomic Variants (DGV) for STAT5A Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833449 CNV loss 17160897

Variation tolerance for STAT5A Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 50.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAT5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT5A Gene

Disorders for STAT5A Gene

MalaCards: The human disease database

(47) MalaCards diseases for STAT5A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic leukemia
  • cll
myeloproliferative neoplasm
  • campomelic dysplasia
polycythemia vera
  • pv
erythrocytosis, familial, 1
  • ecyt1
systemic mastocytosis
  • corneal dystrophy, subepithelial mucinous
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STAT5A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with STAT5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAT5A Gene

Publications for STAT5A Gene

  1. A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α. (PMID: 20065083) Kreil S … German CML Study Group (Haematologica 2010) 3 23 41
  2. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. (PMID: 17639043) Vaclavicek A … Försti A (Endocrine-related cancer 2007) 3 23 41
  3. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PMID: 15677474) Martens N … Gertler A (The Journal of biological chemistry 2005) 3 4 23
  4. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. (PMID: 12954634) Litterst CM … Pfitzner E (The Journal of biological chemistry 2003) 3 4 23
  5. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. (PMID: 8631883) Lin JX … Leonard WJ (The Journal of biological chemistry 1996) 2 3 23

Products for STAT5A Gene