Aliases for STAT4 Gene
External Ids for STAT4 Gene
Previous GeneCards Identifiers for STAT4 Gene
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
GeneCards Summary for STAT4 Gene
STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include Systemic Lupus Erythematosus 11 and Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis. Among its related pathways are Th2 Differentiation Pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.
UniProtKB/Swiss-Prot for STAT4 Gene
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.