Aliases for STAT4 Gene
Aliases for STAT4 Gene
External Ids for STAT4 Gene
- HGNC: 11365
- Entrez Gene: 6775
- Ensembl: ENSG00000138378
- OMIM: 600558
- UniProtKB: Q14765
Previous GeneCards Identifiers for STAT4 Gene
- GC02M190088
- GC02M190596
- GC02M191858
- GC02M192096
- GC02M191719
- GC02M191602
- GC02M183754
- GC02M191894
Summaries for STAT4 Gene
-
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
GeneCards Summary for STAT4 Gene
STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include Systemic Lupus Erythematosus 11 and Lupus Erythematosus. Among its related pathways are Immune response_IL-12 signaling pathway and Jak-Stat Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.
UniProtKB/Swiss-Prot for STAT4 Gene
-
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Additional gene information for STAT4 Gene
- Monarch Initiative
- Search for STAT4 at DataMed
- Search for STAT4 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT4 Gene
Genomics for STAT4 Gene
GeneHancer (GH) Regulatory Elements for STAT4 Gene
Promoters and enhancers for STAT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around STAT4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STAT4 gene promoter:
-
- IRF-1
- GR-alpha
- GR
- GATA-3
- Bach1
- c-Jun
- c-Fos
- AP-1
- POU2F1
- POU2F1a
Regulatory Element Products
Genomic Locations for STAT4 Gene
Genomic Locations for STAT4 Gene
- chr2:191,029,576-191,246,172
- (GRCh38/hg38)
- Size:
- 216,597 bases
- Orientation:
- Minus strand
- chr2:191,894,302-192,016,322
- (GRCh37/hg19)
- Size:
- 122,021 bases
- Orientation:
- Minus strand
Genomic View for STAT4 Gene
Genes around STAT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q32.2-q32.3 by Entrez Gene
- 2q32.2-q32.3 by HGNC
- 2q32.3 by Ensembl
STAT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAT4 Gene
Proteins for STAT4 Gene
-
Protein details for STAT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14765-STAT4_HUMAN
- Recommended name:
- Signal transducer and activator of transcription 4
- Protein Accession:
- Q14765
- Q96NZ6
Protein attributes for STAT4 Gene
- Size:
- 748 amino acids
- Molecular mass:
- 85941 Da
- Quaternary structure:
-
- Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.
Protein Expression for STAT4 Gene
Post-translational modifications for STAT4 Gene
- Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for STAT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STAT4 (STAT4)
-
Custom Antibody ServicesOriGene Antibodies for STAT4
- AM31022PU-N
- AP01694PU-N
- AP02346PU-N
- AP02346PU-S
- AP02588PU-N
- AP02588PU-S
- AP06329PU-N
- AP06415PU-N
- AP08356PU-N
- AP21276PU-N
- AP21277PU-N
- AP26361PU-N
- TA309957
- TA324196
- TA324197
- TA324198
- TA325897
- TA325898
- TA500005
- CF500005
- TA502878
- CF502878
- TA502880
- CF502880
- TA502939
- CF502939
- TA502940
- CF502940
- TA502969
- CF502969
- TA502982
- CF502982
- TA503022
- CF503022
- TA503023
- CF503023
- TA503024
- CF503024
- TA503041
- CF503041
- TA600183
- TA700183
- TA700192
- TA700193
- TA700194
- TA700195
- Novus Biologicals Antibodies for STAT4
-
Abcam antibodies for STAT4
- Invitrogen Antibodies for STAT4
- antibodies-online: Search results for 294 available STAT4 Antibodies ranked by validation data
- Compare Top STAT4 Antibodies
-
Recommended
- 208 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 5 ICS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 84 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- GeneTex Stat4 Antibody for STAT4
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAT4
- Sino Biological Antibodies for STAT4
Protein Products
-
OriGene Purified Proteins for STAT4
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT4
- Origene Custom Protein Services for STAT4
- Sino Biological Recombinant Proteins for STAT4
- Sino Biological Cell Lysates for STAT4
- Search GeneTex for Proteins for STAT4
-
Abcam proteins for STAT4
Assay Products
-
Abcam assays for STAT4
No data available for DME Specific Peptides for STAT4 Gene
Domains & Families for STAT4 Gene
Gene Families for STAT4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for STAT4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STAT4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14765- Family:
-
- Belongs to the transcription factor STAT family.
Function for STAT4 Gene
Molecular function for STAT4 Gene
- UniProtKB/Swiss-Prot Function:
- Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
- GENATLAS Biochemistry:
- signal transducer and activator of transcription 4,involved in IL12 signal transduction,expressed in spleen,heart,brain
Phenotypes From GWAS Catalog for STAT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS,IEA | 9284918 |
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22740693 |
Phenotypes for STAT4 Gene
- MGI mutant phenotypes for STAT4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for STAT4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT4
-
CRISPR Products
-
OriGene CRISPR knockouts for STAT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT4
- genomics-online: gRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- Applied Biological Materials CRISPR for STAT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT4
- GenScript: Design CRISPR guide RNA sequences for STAT4
miRNA for STAT4 Gene
- miRTarBase miRNAs that target STAT4
Transcription Factor Targets for STAT4 Gene
Targeted motifs for STAT4 Gene
HOMER Transcription Factor Regulatory Elements motif STAT4
- Consensus sequence: NTTTCCAGGAAA Submotif: canonical Cell Type: CD4 GEO ID: GSE22104
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT4
- Browse OriGene Inhibitory RNA Products For STAT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT4
- genomics-online: shRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for STAT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT4
- Applied Biological Materials Clones for STAT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT4
Cell Line Products
-
Horizon Cell Lines for STAT4
No data available for Enzyme Numbers (IUBMB) for STAT4 Gene
Localization for STAT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAT4 Gene
- Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for STAT4 Gene
Pathways & Interactions for STAT4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Th1 Differentiation Pathway | ||
| 3 | CNTF Signaling |
.50
.50
|
.46
|
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | GPCR Pathway |
.62
|
|
Pathways by source for STAT4 Gene
1 Sino Biological pathway for STAT4 Gene
7 BioSystems pathways for STAT4 Gene
1 PharmGKB pathway for STAT4 Gene
6 KEGG pathways for STAT4 Gene
4 GeneGo (Thomson Reuters) pathways for STAT4 Gene
7 R&D Systems pathways for STAT4 Gene
12 Qiagen pathways for STAT4 Gene
1 Cell Signaling Technology pathway for STAT4 Gene
Interacting Proteins for STAT4 Gene
Selected Interacting proteins:
ENSP00000351255
Q14765-STAT4_HUMAN
for STAT4 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for STAT4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007259 | JAK-STAT cascade | TAS | 9284918 |
| GO:0019221 | cytokine-mediated signaling pathway | TAS,IEA | -- |
Transcripts for STAT4 Gene
mRNA/cDNA for STAT4 Gene
- (5) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000358470 2769 bps (uc002usn.3)
- ENST00000392320 2822 bps (uc002usm.3)
- ENST00000463951 619 bps (uc061qtj.1)
- ENST00000495849 2208 bps (uc061qtk.1)
- ENST00000470708 515 bps (uc061qtl.1)
Unigene Clusters for STAT4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for STAT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT4
- genomics-online: gRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- Applied Biological Materials CRISPR for STAT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT4
- GenScript: Design CRISPR guide RNA sequences for STAT4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT4
- Browse OriGene Inhibitory RNA Products For STAT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT4
- genomics-online: shRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for STAT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT4
- Applied Biological Materials Clones for STAT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT4
Expression for STAT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Adipose (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for STAT4 Gene
This gene is overexpressed in Whole Blood (x5.6) and Brain - Cortex (x4.3).
This gene is overexpressed in Peripheral blood mononuclear cells (18.0), CD8 Tcells (15.2), Lymph node (9.4), and NK cells (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STAT4 Gene
NURSA nuclear receptor signaling pathways regulating expression of STAT4 Gene:
STAT4SOURCE GeneReport for Unigene cluster for STAT4 Gene:
Hs.80642Evidence on tissue expression from TISSUES for STAT4 Gene
- Blood(3.4)
- Nervous system(3.1)
- Lymph node(2.3)
- Spleen(2.3)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- face
- head
- jaw
- mandible
- maxilla
- meninges
- mouth
- neck
- skull
- tooth
Thorax:
- esophagus
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- penis
- testicle
- vagina
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for STAT4
-
OriGene qPCR primer pairs for STAT4
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for STAT4 Gene
Orthologs for STAT4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STAT4 33 |
|
||
| cow (Bos Taurus) |
Mammalia | STAT4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | STAT4 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | STAT4 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stat4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stat4 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STAT4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STAT4 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stat4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stat4 34 33 |
|
OneToOne |
- Species where no ortholog for STAT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for STAT4 Gene
- ENSEMBL:
- Gene Tree for STAT4 (if available)
- TreeFam:
- Gene Tree for STAT4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAT4: view image
Paralogs for STAT4 Gene
(8) SIMAP similar genes for STAT4 Gene using alignment to 9 proteins:
- STAT4_HUMAN
- B7SIX5_HUMAN
- C9JFG0_HUMAN
- C9JM11_HUMAN
- D3DPI9_HUMAN
- E9PBE2_HUMAN
- E9PG69_HUMAN
- Q53RU2_HUMAN
- Q53S87_HUMAN
Variants for STAT4 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs7574865 | risk-factor, Systemic lupus erythematosus 11 | 191,099,907(-) | T/G | intron_variant | |
| VAR_036002 | A breast cancer sample | p.Glu112Gln | |||
| rs3024866 | benign, not specified | 191,058,115(-) | G/A | intron_variant | |
| rs1000005308 | -- | 191,075,354(-) | A/G | intron_variant | |
| rs1000042334 | -- | 191,136,489(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv25901 | CNV | loss | 19812545 |
| esv2657029 | CNV | deletion | 23128226 |
| esv2676475 | CNV | deletion | 23128226 |
| esv2721278 | CNV | deletion | 23290073 |
| esv2721279 | CNV | deletion | 23290073 |
| esv2721280 | CNV | deletion | 23290073 |
| esv3560730 | CNV | deletion | 23714750 |
| esv3593761 | CNV | loss | 21293372 |
| esv3593762 | CNV | gain | 21293372 |
| nsv1133282 | CNV | tandem duplication | 24896259 |
| nsv834493 | CNV | gain | 17160897 |
| nsv999391 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.09;
22.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAT4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT4 Gene
Disorders for STAT4 Gene
(15) MalaCards diseases for STAT4 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| systemic lupus erythematosus 11 |
|
|
| lupus erythematosus |
|
|
| systemic lupus erythematosus |
|
|
| rheumatoid factor-negative juvenile idiopathic arthritis |
|
|
| pediatric systemic lupus erythematosus |
|
|
Search STAT4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
STAT4_HUMAN- Systemic lupus erythematosus 11 (SLEB11) [MIM:612253]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:17804842, ECO:0000269 PubMed:19109131}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17804842}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for STAT4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for STAT4 Gene
Publications for STAT4 Gene
- Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy. (PMID: 20045654) Hahn WH … Kim SD (Cytokine 2010) 3 22 44 58
- Influence of STAT4 polymorphism in primary Sjögren's syndrome. (PMID: 20360187) Palomino-Morales RJ … Martín J (The Journal of rheumatology 2010) 3 22 44 58
- Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis. (PMID: 19588142) Lee YH … Song GG (Rheumatology international 2010) 3 22 44 58
- Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort. (PMID: 19717398) Hellquist A … Kere J (Annals of the rheumatic diseases 2010) 3 22 44 58
- A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus. (PMID: 19762360) Svenungsson E … Rönnblom L (Annals of the rheumatic diseases 2010) 3 22 44 58
Products for STAT4 Gene
- R&D Systems Antibodies for STAT4 (STAT4)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for STAT4
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for STAT4
- AM31022PU-N
- AP01694PU-N
- AP02346PU-N
- AP02346PU-S
- AP02588PU-N
- AP02588PU-S
- AP06329PU-N
- AP06415PU-N
- AP08356PU-N
- AP21276PU-N
- AP21277PU-N
- AP26361PU-N
- TA309957
- TA324196
- TA324197
- TA324198
- TA325897
- TA325898
- TA500005
- CF500005
- TA502878
- CF502878
- TA502880
- CF502880
- TA502939
- CF502939
- TA502940
- CF502940
- TA502969
- CF502969
- TA502982
- CF502982
- TA503022
- CF503022
- TA503023
- CF503023
- TA503024
- CF503024
- TA503041
- CF503041
- TA600183
- TA700183
- TA700192
- TA700193
- TA700194
- TA700195
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for STAT4
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT4
- Origene Custom Protein Services for STAT4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT4
- Browse OriGene Inhibitory RNA Products For STAT4
- OriGene qPCR primer pairs and template standards for STAT4
- OriGene qPCR primer pairs for STAT4
- OriGene CRISPR knockouts for STAT4
- OriGene ORF clones in human for STAT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STAT4
- GenScript: Next-day shipping of latest version cDNA ORF clones for STAT4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for STAT4
- GenScript Custom Assay Services for STAT4
- GenScript Custom overexpressing Cell Line Services for STAT4
- GenScript: Design CRISPR guide RNA sequences for STAT4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for STAT4
- Browse Sino Biological cDNA Clones
- Sino Biological Recombinant Proteins for STAT4
- Sino Biological Cell Lysates for STAT4
- Sino Biological Antibodies for STAT4
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STAT4
- Novus Biologicals lysates and proteins for STAT4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for STAT4
- Abcam proteins for STAT4
- Abcam assays for STAT4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT4
- VectorBuilder custom plasmid, inducible vectors for STAT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT4
- antibodies-online: Search results for 294 available STAT4 Antibodies ranked by validation data
- Compare Top STAT4 Antibodies
- Recommended
- 208 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 5 ICS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 84 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 71 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Search results for 39 available STAT4 Elisa Kits ranked by validation data
- Compare Top STAT4 Elisa Kits
- antibodies-online: Search results for 8 available STAT4 Proteins ranked by validation data
- Compare Top STAT4 Proteins
- GeneTex Stat4 Antibody for STAT4
- Search GeneTex for Proteins for STAT4
- Santa Cruz Biotechnology (SCBT) Antibodies for STAT4
- Search Santa Cruz Biotechnology (SCBT) for STAT4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STAT4
- Horizon Cell Lines for STAT4
- genomics-online: cdna clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- orf clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- genomics-online: gRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- genomics-online: primer clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- genomics-online: shRNA clones - Search results for 90 available STAT4 gene related products
- Overview of 90 available STAT4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT4
- GeneCopoeia miRNA 3'UTR Target clone products for STAT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT4
Sources for STAT4 Gene
- (1) GeneCards
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- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt