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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant and Autoimmune Disease, Multisystem, Infantile-Onset, 1. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Interleukin-11 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.
STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade, the basis of the signal transduction mechanism for many cytokine receptors. STATs are activated by phosphorylation by JAKs.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 17324931 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 19390056 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | 22783022 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA,IMP | 16946298 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA,ISA | -- |
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IDA | 24429361 |
GO:0005737 | cytoplasm | TAS,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Immune response IL-9 signaling pathway
.42
IL-9 Pathway
.36
|
|
2 | Immune response IL-23 signaling pathway |
Development PDGF signaling via STATs and NF-kB
.44
Immune response IL-23 signaling pathway
.44
Development Angiopoietin - Tie2 signaling
.38
Angiopoietin-TIE2 Signaling
.36
|
Immune response IL-10 signaling pathway
.36
|
3 | RET signaling | ||
4 | Th17 cell differentiation |
Immune response IL-22 signaling pathway
.36
IL-22 Pathway
.01
|
|
5 | Prolactin Signaling Pathway |
Development Prolactin receptor signaling
.38
|
Symbol | External ID(s) | Details |
---|---|---|
CSF3R | ||
ECHS1 | ||
EGFR | ||
ERBB2 | ||
GADD45GIP1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 8675499 |
GO:0001659 | temperature homeostasis | ISS | -- |
GO:0001754 | eye photoreceptor cell differentiation | ISS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA,IDA | 15664994 |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Niclosamide | Approved, Investigational, Vet_approved | Pharma | STAT3 inhibitor; also inhibits mTORC1 signaling | 16 | ||
rituximab | Approved | Pharma | Therapeutic Antibodies | 2024 | ||
Amphotericin B | Approved, Investigational | Pharma | 150 | |||
Clotrimazole | Approved, Vet_approved | Pharma | Pore Blocker, Inhibition, Agonist, Antagonist, Channel blocker, Gating inhibitor | 3024 | ||
Durvalumab | Approved, Investigational | Pharma | 469 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Cryptotanshinone | STAT3 inhibitor. Also displays multiple other activities | 35825-57-1 |
Napabucasin | STAT3 inhibitor; also blocks cancer stem cell self-renewal | 83280-65-3 |
Niclosamide | STAT3 inhibitor; also inhibits mTORC1 signaling | 50-65-7 |
SD 1008 | JAK2/STAT3 signaling pathway inhibitor | 960201-81-4 |
Compound | Action | Cas Number |
---|---|---|
Corylifol A | 775351-88-7 | |
Cryptotanshinone | STAT3/AChE inhibitor | 35825-57-1 |
Cucurbitacin I | STAT3/JAK2 signaling inhibitor | 2222-07-3 |
FLLL32 | STAT3 inhibitor | 1226895-15-3 |
HO-3867 | STAT3 inhibitor, selective | 1172133-28-6 |
Niclosamide | 50-65-7 | |
Nifuroxazide | Antidiarrheal agent | 965-52-6 |
NSC 74859 | Stat3 inhibitor | 501919-59-1 |
SD 1008 | Inhibitor of JAK2/STAT3 signaling pathway,apoptosis inducer | 960201-81-4 |
SH-4-54 | STAT inhibitor, potent | 1456632-40-8 |
Stattic | STAT3 inhibitor,small-molecule and potent | 19983-44-9 |
WP1066 | JAK2/STAT3 inhibitor,cell-permeable | 857064-38-1 |