Aliases for STAT3 Gene
Aliases for STAT3 Gene
External Ids for STAT3 Gene
- HGNC: 11364
- Entrez Gene: 6774
- Ensembl: ENSG00000168610
- OMIM: 102582
- UniProtKB: P40763
Previous GeneCards Identifiers for STAT3 Gene
- GC17M040032
- GC17M042622
- GC17M040375
- GC17M040840
- GC17M037718
- GC17M040465
- GC17M036231
Summaries for STAT3 Gene
-
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
GeneCards Summary for STAT3 Gene
STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Autoimmune Disease, Multisystem, Infantile-Onset, 1 and Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant. Among its related pathways are Development EGFR signaling via small GTPases and Estrogen Receptor Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.
UniProtKB/Swiss-Prot for STAT3 Gene
-
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
-
STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade, the basis of the signal transduction mechanism for many cytokine receptors. STATs are activated by phosphorylation by JAKs.
Additional gene information for STAT3 Gene
- Monarch Initiative
- Search for STAT3 at DataMed
- Search for STAT3 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT3 Gene
Genomics for STAT3 Gene
GeneHancer (GH) Regulatory Elements for STAT3 Gene
Promoters and enhancers for STAT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around STAT3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STAT3 gene promoter:
Regulatory Element Products
Genomic Locations for STAT3 Gene
Genomic Locations for STAT3 Gene
- chr17:42,313,324-42,388,568
- (GRCh38/hg38)
- Size:
- 75,245 bases
- Orientation:
- Minus strand
- chr17:40,465,342-40,540,586
- (GRCh37/hg19)
Genomic View for STAT3 Gene
Genes around STAT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Ensembl
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
STAT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAT3 Gene
Proteins for STAT3 Gene
-
Protein details for STAT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40763-STAT3_HUMAN
- Recommended name:
- Signal transducer and activator of transcription 3
- Protein Accession:
- P40763
- A8K7B8
- K7ENL3
- O14916
- Q9BW54
Protein attributes for STAT3 Gene
- Size:
- 770 amino acids
- Molecular mass:
- 88068 Da
- Quaternary structure:
-
- Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the Lys-129 acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with STAT3; the interaction is independent of STAT3 TYR-705 phosphorylation status (PubMed:25476455). Interacts with FGFR4 (PubMed:26675719). Interacts with OCAD1 (By similarity).
- (Microbial infection) Interacts with HCV core protein.
- Miscellaneous:
-
- Involved in the gp130-mediated signaling pathway.
Protein Expression for STAT3 Gene
Post-translational modifications for STAT3 Gene
- Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).
- Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).
- Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.
- Ubiquitination at posLast=8787, isoforms=3, 297, isoforms=3, 2177, posLast=180180, isoforms=3, 2244, isoforms=3, 2294, and posLast=709709
Other Protein References for STAT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STAT3 (STAT3)
- Cell Signaling Technology (CST) Antibodies for STAT3 (STAT3)
-
Custom Antibody ServicesOriGene Antibodies for STAT3
- CF500177
- TA500177
- TA347058
- TA336974
- TA328065
- TA327600
- TA326213
- TA326060
- TA325896
- TA325895
- TA325894
- TA325893
- TA325892
- TA325891
- TA324777
- TA324629
- TA322897
- TA319710
- TA309956
- TA303135
- TA302716
- TA302174
- TA300380
- AP26348PU-N
- AP23374PU-N
- AP20998PU-N
- AP20907PU-N
- AP12718PU-N
- AP06328PU-N
- AP06327PU-N
- AP02587PU-S
- AP02587PU-N
- AP02345PU-S
- AP02345PU-N
- AP02344PU-S
- AP02344PU-N
- AP01692PU-N
- AP01691PU-N
- AP01233PU-N
- AM06536SU-N
- AM06296SU-N
- AM00149PU-N
- AM00148PU-N
- AM00148FC-N
- AM00148BT-N
- Novus Biologicals Antibodies for STAT3
-
Abcam antibodies for STAT3
-
Cloud-Clone Corp. Antibodies for STAT3
- Invitrogen Antibodies for STAT3
- antibodies-online: Search results for 655 available STAT3 Antibodies ranked by validation data
- Compare Top STAT3 Antibodies
-
Recommended
- 1 PLA Antibody (anti-rat)
- 2 ICFC Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 4 ICS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 17 FACS Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 212 WB Antibodies (anti-rat)
- 1 PLA Antibody (anti-human)
- 1 IVI Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 10 ICS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 28 FACS Antibodies (anti-human)
- 510 WB Antibodies (anti-human)
- 1 PLA Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 10 ICS Antibodies (anti-mouse)
- 22 FACS Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 272 WB Antibodies (anti-mouse)
- GeneTex STAT3 antibody for STAT3
-
Custom Antibody ServicesProSci Antibodies for STAT3
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAT3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT3
- Origene Custom Protein Services for STAT3
-
Cloud-Clone Corp. Proteins for STAT3
- Search GeneTex for Proteins for STAT3
-
ProSci Proteins for STAT3
-
Abcam proteins for STAT3
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for STAT3 (STAT3)
- Novus Biologicals ELISA Kits for STAT3
- Cell Signaling Technology (CST) Sandwich ELISA Kits for STAT3 (STAT3)
-
Cloud-Clone Corp. Assay Kits for STAT3
-
Abcam assays for STAT3
No data available for DME Specific Peptides for STAT3 Gene
Domains & Families for STAT3 Gene
Gene Families for STAT3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for STAT3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for STAT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P40763- Family:
-
- Belongs to the transcription factor STAT family.
Function for STAT3 Gene
Molecular function for STAT3 Gene
- GENATLAS Biochemistry:
- signal transducer and activator of transcription 3,homologous to p91,component of the interferon stimulated gene factor 3 complexes,involved in IL6 and related cytokines induced signal transduction by JAK kinases,also involved in the G1 to S cell cycle transition,induced by IL6ST (GP130),playing a critical role in the maintenance of an undifferentiated ES phenotype,widely expressed,located in the cytoplasm and translocated to the nucleus after tyrosine phosphorylation,inhibited by protein phosphatase 2D,persistently activated in many cancers and transformed cell lines and required in cell culture for transformation and blocking of apoptosis
- UniProtKB/Swiss-Prot Function:
- Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
Phenotypes From GWAS Catalog for STAT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 16835372 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 16946298 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | 22783022 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 16835372 |
Phenotypes for STAT3 Gene
- MGI mutant phenotypes for STAT3:
-
inferred from 13 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for STAT3:
-
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Upregulation of NF-kappaB pathway after LMP1 stimulation
Animal Models for STAT3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for STAT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STAT3 gene
- Search ViGene Biosciences for STAT3
CRISPR Products
-
OriGene CRISPR knockouts for STAT3
- genomics-online: gRNA clones - Search results for 153 available STAT3 gene related products
- Overview of 153 available STAT3 gene related products
- Applied Biological Materials CRISPR for STAT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT3
- GenScript: Design CRISPR guide RNA sequences for STAT3
miRNA for STAT3 Gene
- miRTarBase miRNAs that target STAT3
-
- hsa-mir-20b-5p (MIRT000497)
- hsa-mir-125b-5p (MIRT005006)
- hsa-mir-337-3p (MIRT006959)
- hsa-mir-155-5p (MIRT021003)
- hsa-mir-93-5p (MIRT028178)
- hsa-mir-21-5p (MIRT031079)
- hsa-mir-92a-3p (MIRT049359)
- hsa-mir-20a-5p (MIRT050559)
- hsa-let-7e-5p (MIRT051593)
- hsa-mir-124-3p (MIRT052931)
- hsa-mir-130b-3p (MIRT053071)
- hsa-mir-106a-5p (MIRT053229)
- bta-mir-10a (MIRT053798)
- bta-mir-17-5p (MIRT053854)
- bta-mir-21-5p (MIRT053881)
- hsa-mir-106b-5p (MIRT054144)
- hsa-mir-874-3p (MIRT054273)
- hsa-mir-4516 (MIRT054631)
- hsa-mir-17-5p (MIRT054903)
- hsa-mir-200a-3p (MIRT145857)
- hsa-mir-544a (MIRT386936)
- hsa-mir-181a-5p (MIRT438217)
- hsa-mir-1234-3p (MIRT438669)
- hsa-mir-1181 (MIRT438928)
- hsa-mir-6878-5p (MIRT466950)
- hsa-mir-5681a (MIRT466951)
- hsa-mir-6837-5p (MIRT466952)
- hsa-mir-4685-5p (MIRT466953)
- hsa-mir-7113-5p (MIRT466954)
- hsa-mir-6754-5p (MIRT466955)
- hsa-mir-4270 (MIRT466956)
- hsa-mir-4441 (MIRT466957)
- hsa-mir-922 (MIRT466958)
- hsa-mir-6760-5p (MIRT466959)
- hsa-mir-1288-5p (MIRT466960)
- hsa-mir-6871-3p (MIRT466961)
- hsa-mir-6809-3p (MIRT492162)
- hsa-mir-6833-3p (MIRT492163)
- hsa-mir-4768-5p (MIRT492164)
- hsa-mir-1178-3p (MIRT492165)
- hsa-mir-7158-5p (MIRT492166)
- hsa-mir-4684-5p (MIRT492167)
- hsa-mir-138-2-3p (MIRT492168)
- hsa-mir-371b-3p (MIRT492169)
- hsa-mir-548n (MIRT492170)
- hsa-mir-6875-3p (MIRT642424)
- hsa-mir-5581-3p (MIRT642425)
- hsa-mir-4778-3p (MIRT642426)
- hsa-mir-7110-3p (MIRT642427)
- hsa-mir-6845-3p (MIRT642428)
- hsa-mir-877-3p (MIRT642429)
- hsa-mir-618 (MIRT642430)
- hsa-mir-6807-5p (MIRT666063)
- hsa-mir-4720-3p (MIRT666064)
- hsa-mir-6762-3p (MIRT666065)
- hsa-mir-4804-3p (MIRT666066)
- hsa-mir-6872-3p (MIRT666067)
- hsa-mir-7151-3p (MIRT679673)
- hsa-mir-5095 (MIRT679674)
- hsa-mir-365b-5p (MIRT679675)
- hsa-mir-365a-5p (MIRT679676)
- hsa-mir-8052 (MIRT679677)
- hsa-mir-3199 (MIRT679678)
- hsa-mir-6789-3p (MIRT679679)
- hsa-mir-500b-3p (MIRT679680)
- hsa-mir-4438 (MIRT679681)
- hsa-mir-519d-3p (MIRT726433)
- hsa-mir-520c-3p (MIRT731450)
- hsa-mir-125a-5p (MIRT731625)
- hsa-mir-21-3p (MIRT731935)
- hsa-mir-519a-3p (MIRT732189)
- hsa-mir-148a-3p (MIRT732362)
- hsa-mir-223-3p (MIRT732553)
- hsa-let-7c-5p (MIRT732605)
- hsa-mir-29b-1-5p (MIRT732849)
- hsa-mir-23a-3p (MIRT732901)
- hsa-mir-323a-3p (MIRT733906)
- hsa-mir-375 (MIRT734093)
- hsa-mir-124-5p (MIRT734340)
- hsa-mir-29b-3p (MIRT734349)
- hsa-let-7a-5p (MIRT734721)
- hsa-mir-340-5p (MIRT735102)
- hsa-mir-410-5p (MIRT735428)
Transcription Factor Targets for STAT3 Gene
Targeted motifs for STAT3 Gene
HOMER Transcription Factor Regulatory Elements motif STAT3
- Consensus sequence: CTTCCGGGAA Submotif: canonical Cell Type: mES GEO ID: GSE11431
miRNA Products
- Search ViGene Biosciences for STAT3
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for STAT3
- Browse OriGene Inhibitory RNA Products For STAT3
- genomics-online: shRNA clones - Search results for 153 available STAT3 gene related products
- Overview of 153 available STAT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STAT3 gene
Clone Products
-
OriGene ORF clones in human for STAT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STAT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT3
- Applied Biological Materials Clones for STAT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT3
Cell Line Products
-
Horizon Cell Lines for STAT3
-
ViGene Biosciences adenoviral particle packaged cDNA for STAT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for STAT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for STAT3 gene
No data available for Enzyme Numbers (IUBMB) for STAT3 Gene
Localization for STAT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAT3 Gene
- Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| extracellular | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
| endosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 16835372 |
| GO:0005634 | nucleus | ISS,IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | TAS,ISS | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for STAT3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
.36
|
|
| 2 | Immune response IL-23 signaling pathway | ||
| 3 | RET signaling | ||
| 4 | Th17 cell differentiation |
.01
|
|
| 5 | Prolactin Signaling Pathway | ||
Pathways by source for STAT3 Gene
3 Sino Biological pathways for STAT3 Gene
1 GeneTex pathway for STAT3 Gene
1 Cell Signaling Technology pathway for STAT3 Gene
55 BioSystems pathways for STAT3 Gene
36 Reactome pathways for STAT3 Gene
2 PharmGKB pathways for STAT3 Gene
26 KEGG pathways for STAT3 Gene
24 GeneGo (Thomson Reuters) pathways for STAT3 Gene
15 R&D Systems pathways for STAT3 Gene
1 Tocris pathway for STAT3 Gene
34 Qiagen pathways for STAT3 Gene
Interacting Proteins for STAT3 Gene
Selected Interacting proteins:
P40763-STAT3_HUMAN
ENSP00000264657
for STAT3 Gene via
MINT
STRING
UniProtKB
IID
| Symbol | External ID(s) | Details |
|---|---|---|
| CSF3R | ||
| ECHS1 | ||
| ERBB2 | ||
| GADD45GIP1 | ||
| EGFR |
SIGNOR curated interactions for STAT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 8675499 |
| GO:0001659 | temperature homeostasis | ISS | -- |
| GO:0001754 | eye photoreceptor cell differentiation | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,IDA | 15664994 |
Drugs & Compounds for STAT3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) Tocris Compounds for STAT3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cryptotanshinone | STAT3 inhibitor. Also displays multiple other activities | 35825-57-1 |
| Napabucasin | STAT3 inhibitor; also blocks cancer stem cell self-renewal | 83280-65-3 |
| Niclosamide | STAT3 inhibitor; also inhibits mTORC1 signaling | 50-65-7 |
| SD 1008 | JAK2/STAT3 signaling pathway inhibitor | 960201-81-4 |
(12) ApexBio Compounds for STAT3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Corylifol A | 775351-88-7 | |
| Cryptotanshinone | STAT3/AChE inhibitor | 35825-57-1 |
| Cucurbitacin I | STAT3/JAK2 signaling inhibitor | 2222-07-3 |
| FLLL32 | STAT3 inhibitor | 1226895-15-3 |
| HO-3867 | STAT3 inhibitor, selective | 1172133-28-6 |
| Niclosamide | 50-65-7 | |
| Nifuroxazide | Antidiarrheal agent | 965-52-6 |
| NSC 74859 | Stat3 inhibitor | 501919-59-1 |
| SD 1008 | Inhibitor of JAK2/STAT3 signaling pathway,apoptosis inducer | 960201-81-4 |
| SH-4-54 | STAT inhibitor, potent | 1456632-40-8 |
| Stattic | STAT3 inhibitor,small-molecule and potent | 19983-44-9 |
| WP1066 | JAK2/STAT3 inhibitor,cell-permeable | 857064-38-1 |
Transcripts for STAT3 Gene
mRNA/cDNA for STAT3 Gene
- (12) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (522) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STAT3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for STAT3
- genomics-online: gRNA clones - Search results for 153 available STAT3 gene related products
- Overview of 153 available STAT3 gene related products
- Applied Biological Materials CRISPR for STAT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT3
- GenScript: Design CRISPR guide RNA sequences for STAT3
miRNA Products
- Search ViGene Biosciences for STAT3
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for STAT3
- Browse OriGene Inhibitory RNA Products For STAT3
- genomics-online: shRNA clones - Search results for 153 available STAT3 gene related products
- Overview of 153 available STAT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for STAT3 gene
Clone Products
-
OriGene ORF clones in human for STAT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STAT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT3
- Applied Biological Materials Clones for STAT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT3
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | · | 24d | · | 24e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | - |
Expression for STAT3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STAT3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STAT3 Gene:
STAT3SOURCE GeneReport for Unigene cluster for STAT3 Gene:
Hs.463059mRNA Expression by UniProt/SwissProt for STAT3 Gene:
P40763-STAT3_HUMAN
Tissue specificity:
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for STAT3 Gene
- Liver(4.8)
- Kidney(4.7)
- Pancreas(4.6)
- Nervous system(4.6)
- Lung(4.1)
- Blood(3.8)
- Skin(3.7)
- Muscle(3.6)
- Heart(3.5)
- Intestine(3.5)
- Spleen(3.4)
- Bone marrow(3.3)
- Lymph node(3.3)
- Eye(2.8)
- Stomach(2.6)
- Thyroid gland(2.5)
- Adrenal gland(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- middle ear
- mouth
- neck
- nose
- sinus
- skull
- tooth
Thorax:
- chest wall
- clavicle
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- intestine
- large intestine
- small intestine
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for STAT3
-
OriGene qPCR primer pairs and template standards for STAT3
- genomics-online: primer clones - Search results for 153 available STAT3 gene related products
- Overview of 153 available STAT3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for STAT3 Gene
Orthologs for STAT3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | STAT3 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | STAT3 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | STAT3 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STAT3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | STAT3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Stat3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Stat3 33 |
|
||
| chicken (Gallus gallus) |
Aves | STAT3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | STAT3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498278 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | stat3-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stat3 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11857 33 |
|
- Species where no ortholog for STAT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)