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Aliases for STAT3 Gene

Aliases for STAT3 Gene

  • Signal Transducer And Activator Of Transcription 3 2 3 5
  • Acute-Phase Response Factor 3 4
  • APRF 3 4
  • Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor) 2
  • DNA-Binding Protein APRF 3
  • ADMIO1 3
  • ADMIO 3
  • HIES 3

External Ids for STAT3 Gene

Previous GeneCards Identifiers for STAT3 Gene

  • GC17M040032
  • GC17M042622
  • GC17M040375
  • GC17M040840
  • GC17M037718
  • GC17M040465
  • GC17M036231

Summaries for STAT3 Gene

Entrez Gene Summary for STAT3 Gene

  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

CIViC summary for STAT3 Gene

GeneCards Summary for STAT3 Gene

STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Autoimmune Disease, Multisystem, Infantile-Onset, 1 and Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant. Among its related pathways are Development EGFR signaling via small GTPases and Estrogen Receptor Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT3 Gene

  • Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

Tocris Summary for STAT3 Gene

  • STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade, the basis of the signal transduction mechanism for many cytokine receptors. STATs are activated by phosphorylation by JAKs.

Gene Wiki entry for STAT3 Gene

Additional gene information for STAT3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT3 Gene

Genomics for STAT3 Gene

GeneHancer (GH) Regulatory Elements for STAT3 Gene

Promoters and enhancers for STAT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.2 +0.1 120 4.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 STAT3 GC17M042386 ENSG00000267765 ENSG00000267002 ENSG00000259623 NBR1 CCR10 KAT2A CNTNAP1 KLHL10
GH17I042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -290.1 -290130 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 HSD17B1P1 ENSG00000267002 HMGN1P29 HMGN2P15 ENSG00000259623
GH17I042832 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -445.1 -445073 3.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 BECN1 PSME3 NKIRAS2 MEOX1 ENSG00000212149 PTGES3L-AARSD1 RPL27 COA3 CNTD1 STAT3
GH17I042772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -385.8 -385846 4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 VPS25 HMGN1P29 DHX8 ENSG00000267758 LINC00910 HMGN2P15 NBR2 NKIRAS2 CNTNAP1 MEOX1
GH17I042796 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -409.4 -409372 2.8 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 CNTD1 COA3 ENSG00000267340 PLEKHH3 NKIRAS2 MEOX1 HMGN2P15 RAMP2-AS1 ENSG00000267765 PTP4A2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STAT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAT3 gene promoter:

Genomic Locations for STAT3 Gene

Genomic Locations for STAT3 Gene
chr17:42,313,324-42,388,568
(GRCh38/hg38)
Size:
75,245 bases
Orientation:
Minus strand
chr17:40,465,342-40,540,586
(GRCh37/hg19)

Genomic View for STAT3 Gene

Genes around STAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT3 Gene

Proteins for STAT3 Gene

  • Protein details for STAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40763-STAT3_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 3
    Protein Accession:
    P40763
    Secondary Accessions:
    • A8K7B8
    • K7ENL3
    • O14916
    • Q9BW54

    Protein attributes for STAT3 Gene

    Size:
    770 amino acids
    Molecular mass:
    88068 Da
    Quaternary structure:
    • Forms a homodimer or a heterodimer with a related family member (at least STAT1) (PubMed:28065600). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation (By similarity). Interacts with ARL2BP; interaction is enhanced with ARL2. Interacts with NEK6 (By similarity). Binds to CDK9 when activated and nuclear. Interacts with BMX. Interacts with ZIPK/DAPK3. Interacts with PIAS3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. In prostate cancer cells, interacts with STAT3 and promotes DNA binding activity of STAT3. Interacts with STMN3, antagonizing its microtubule-destabilizing activity. Interacts with the Lys-129 acetylated form of BIRC5/survivin. Interacts with FER. Interacts (via SH2 domain) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with STAT3; the interaction is independent of STAT3 TYR-705 phosphorylation status (PubMed:25476455). Interacts with FGFR4 (PubMed:26675719). Interacts with OCAD1 (By similarity).
    • (Microbial infection) Interacts with HCV core protein.
    Miscellaneous:
    • Involved in the gp130-mediated signaling pathway.

    Three dimensional structures from OCA and Proteopedia for STAT3 Gene

    Alternative splice isoforms for STAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT3 Gene

Post-translational modifications for STAT3 Gene

  • Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).
  • Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600).
  • Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.
  • Ubiquitination at posLast=8787, isoforms=3, 297, isoforms=3, 2177, posLast=180180, isoforms=3, 2244, isoforms=3, 2294, and posLast=709709

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for STAT3 (STAT3)
  • Abcam antibodies for STAT3

No data available for DME Specific Peptides for STAT3 Gene

Domains & Families for STAT3 Gene

Gene Families for STAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for STAT3 Gene

Graphical View of Domain Structure for InterPro Entry

P40763

UniProtKB/Swiss-Prot:

STAT3_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT3: view

Function for STAT3 Gene

Molecular function for STAT3 Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription 3,homologous to p91,component of the interferon stimulated gene factor 3 complexes,involved in IL6 and related cytokines induced signal transduction by JAK kinases,also involved in the G1 to S cell cycle transition,induced by IL6ST (GP130),playing a critical role in the maintenance of an undifferentiated ES phenotype,widely expressed,located in the cytoplasm and translocated to the nucleus after tyrosine phosphorylation,inhibited by protein phosphatase 2D,persistently activated in many cancers and transformed cell lines and required in cell culture for transformation and blocking of apoptosis
UniProtKB/Swiss-Prot Function:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

Phenotypes From GWAS Catalog for STAT3 Gene

Gene Ontology (GO) - Molecular Function for STAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 16835372
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP 16946298
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22783022
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 16835372
genes like me logo Genes that share ontologies with STAT3: view
genes like me logo Genes that share phenotypes with STAT3: view

Human Phenotype Ontology for STAT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STAT3 Gene

MGI Knock Outs for STAT3:

Animal Model Products

miRNA for STAT3 Gene

miRTarBase miRNAs that target STAT3

Transcription Factor Targets for STAT3 Gene

Selected GeneGlobe predicted Target genes for STAT3
Targeted motifs for STAT3 Gene
HOMER Transcription Factor Regulatory Elements motif STAT3
  • Consensus sequence: CTTCCGGGAA Submotif: canonical Cell Type: mES GEO ID: GSE11431

Clone Products

  • Addgene plasmids for STAT3

No data available for Enzyme Numbers (IUBMB) for STAT3 Gene

Localization for STAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT3 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 4
extracellular 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16835372
GO:0005634 nucleus ISS,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS,ISS --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with STAT3: view

Pathways & Interactions for STAT3 Gene

genes like me logo Genes that share pathways with STAT3: view

Pathways by source for STAT3 Gene

SIGNOR curated interactions for STAT3 Gene

Gene Ontology (GO) - Biological Process for STAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 8675499
GO:0001659 temperature homeostasis ISS --
GO:0001754 eye photoreceptor cell differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 15664994
genes like me logo Genes that share ontologies with STAT3: view

Drugs & Compounds for STAT3 Gene

(106) Drugs for STAT3 Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethambutol Approved Pharma 87
Isoniazid Approved, Investigational Pharma 164
Pyrazinamide Approved, Investigational Pharma 94
Rifampin Approved Pharma Agonist 376
Streptomycin Approved, Vet_approved Pharma 20

(52) Additional Compounds for STAT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for STAT3 Gene

Compound Action Cas Number
Cryptotanshinone STAT3 inhibitor. Also displays multiple other activities 35825-57-1
Napabucasin STAT3 inhibitor; also blocks cancer stem cell self-renewal 83280-65-3
Niclosamide STAT3 inhibitor; also inhibits mTORC1 signaling 50-65-7
SD 1008 JAK2/STAT3 signaling pathway inhibitor 960201-81-4

(12) ApexBio Compounds for STAT3 Gene

Compound Action Cas Number
Corylifol A 775351-88-7
Cryptotanshinone STAT3/AChE inhibitor 35825-57-1
Cucurbitacin I STAT3/JAK2 signaling inhibitor 2222-07-3
FLLL32 STAT3 inhibitor 1226895-15-3
HO-3867 STAT3 inhibitor, selective 1172133-28-6
Niclosamide 50-65-7
Nifuroxazide Antidiarrheal agent 965-52-6
NSC 74859 Stat3 inhibitor 501919-59-1
SD 1008 Inhibitor of JAK2/STAT3 signaling pathway,apoptosis inducer 960201-81-4
SH-4-54 STAT inhibitor, potent 1456632-40-8
Stattic STAT3 inhibitor,small-molecule and potent 19983-44-9
WP1066 JAK2/STAT3 inhibitor,cell-permeable 857064-38-1
genes like me logo Genes that share compounds with STAT3: view

Drug Products

Transcripts for STAT3 Gene

Unigene Clusters for STAT3 Gene

Signal transducer and activator of transcription 3 (acute-phase response factor):
Representative Sequences:

Clone Products

  • Addgene plasmids for STAT3

Alternative Splicing Database (ASD) splice patterns (SP) for STAT3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c · 24d · 24e
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for STAT3 Gene

GeneLoc Exon Structure for
STAT3
ECgene alternative splicing isoforms for
STAT3

Expression for STAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAT3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STAT3 Gene



Protein tissue co-expression partners for STAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STAT3 Gene:

STAT3

SOURCE GeneReport for Unigene cluster for STAT3 Gene:

Hs.463059

mRNA Expression by UniProt/SwissProt for STAT3 Gene:

P40763-STAT3_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for STAT3 Gene

  • Liver(4.8)
  • Kidney(4.7)
  • Pancreas(4.6)
  • Nervous system(4.6)
  • Lung(4.1)
  • Blood(3.8)
  • Skin(3.7)
  • Muscle(3.6)
  • Heart(3.5)
  • Intestine(3.5)
  • Spleen(3.4)
  • Bone marrow(3.3)
  • Lymph node(3.3)
  • Eye(2.8)
  • Stomach(2.6)
  • Thyroid gland(2.5)
  • Adrenal gland(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • ear
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • sinus
  • skull
  • tooth
Thorax:
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with STAT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for STAT3 Gene

Orthologs for STAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAT3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia STAT3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STAT3 34 33
  • 99.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAT3 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAT3 33 34
  • 93.77 (n)
dog
(Canis familiaris)
Mammalia STAT3 33 34
  • 93.12 (n)
mouse
(Mus musculus)
Mammalia Stat3 16 34 33
  • 91.39 (n)
rat
(Rattus norvegicus)
Mammalia Stat3 33
  • 91.34 (n)
chicken
(Gallus gallus)
Aves STAT3 33 34
  • 83.55 (n)
lizard
(Anolis carolinensis)
Reptilia STAT3 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498278 33
  • 79.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia stat3-A 33
zebrafish
(Danio rerio)
Actinopterygii stat3 34 33
  • 78.45 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11857 33
Species where no ortholog for STAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAT3 Gene

ENSEMBL:
Gene Tree for STAT3 (if available)
TreeFam:
Gene Tree for STAT3 (if available)

Paralogs for STAT3 Gene

Paralogs for STAT3 Gene