Aliases for STAT1 Gene
Aliases for STAT1 Gene
- Signal Transducer And Activator Of Transcription 1 2 3 5
- Transcription Factor ISGF-3 Components P91/P84 2 3 4
- Signal Transducer And Activator Of Transcription 1, 91kDa 2 3
- Signal Transducer And Activator Of Transcription 1, 91kD 2 3
- Signal Transducer And Activator Of Transcription 1-Alpha/Beta 3
- CANDF7 3
External Ids for STAT1 Gene
- HGNC: 11362
- Entrez Gene: 6772
- Ensembl: ENSG00000115415
- OMIM: 600555
- UniProtKB: P42224
Previous GeneCards Identifiers for STAT1 Gene
- GC02M190028
- GC02M190536
- GC02M191797
- GC02M192036
- GC02M191659
- GC02M191542
- GC02M191829
- GC02M183693
Summaries for STAT1 Gene
-
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for STAT1 Gene
STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31A. Among its related pathways are p38 MAPK Signaling Pathway (WikiPathways) and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is STAT4.
UniProtKB/Swiss-Prot for STAT1 Gene
-
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Additional gene information for STAT1 Gene
- Monarch Initiative
- Search for STAT1 at DataMed
- Search for STAT1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT1 Gene
Genomics for STAT1 Gene
GeneHancer (GH) Regulatory Elements for STAT1 Gene
Promoters and enhancers for STAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around STAT1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the STAT1 gene promoter:
-
- FOXO1a
- RSRFC4
- COMP1
- S8
- c-Myc
- Max1
- AP-1
- FOXO1
- STAT5B
- IRF-1
Regulatory Element Products
Genomic Locations for STAT1 Gene
Genomic Locations for STAT1 Gene
- chr2:190,964,358-191,020,960
- (GRCh38/hg38)
- Size:
- 56,603 bases
- Orientation:
- Minus strand
- chr2:191,829,084-191,885,686
- (GRCh37/hg19)
- Size:
- 56,603 bases
- Orientation:
- Minus strand
Genomic View for STAT1 Gene
Genes around STAT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q32.2 by Entrez Gene
- 2q32.2 by HGNC
- 2q32.2 by Ensembl
STAT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAT1 Gene
Proteins for STAT1 Gene
-
Protein details for STAT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42224-STAT1_HUMAN
- Recommended name:
- Signal transducer and activator of transcription 1-alpha/beta
- Protein Accession:
- P42224
- A8K989
- B2RCA0
- D2KFR8
- D3DPI7
- Q53S88
- Q53XW4
- Q68D00
- Q9UDL5
Protein attributes for STAT1 Gene
- Size:
- 750 amino acids
- Molecular mass:
- 87335 Da
- Quaternary structure:
-
- Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation (PubMed:8605877, PubMed:28753426). Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation (PubMed:8605877). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9 (By similarity). Interacts (phosphorylated at Ser-727) with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its target gene (PubMed:9724754, PubMed:17897103, PubMed:19136629). Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at Tyr-466 (PubMed:9121453). Interacts with IFNAR2 (PubMed:9121453). Found in a complex with NMI and CREBBP/CBP (PubMed:9989503). Interacts with NMI which is required for CREBBP/CBP recruitment to the complex (PubMed:9989503). Interacts with PTK2/FAK1 (PubMed:11278462). Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated) (PubMed:18721752). Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 Tyr-701 phosphorylation (PubMed:26479788). Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation (PubMed:26479788). Interacts with OTOP1 (By similarity).
- (Microbial infection) Interacts with Sendai virus C, C, Y1 and Y2 proteins, preventing activation of ISRE and GAS promoter.
- (Microbial infection) Interacts with Nipah virus P, V and W proteins preventing activation of ISRE and GAS promoter.
- (Microbial infection) Interacts with Rabies virus phosphoprotein preventing activation of ISRE and GAS promoter.
- (Microbial infection) Interacts with HCV core protein; the interaction results in STAT1 degradation.
Three dimensional structures from OCA and Proteopedia for STAT1 Gene
Protein Expression for STAT1 Gene
Post-translational modifications for STAT1 Gene
- Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.
- Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.
- ISGylated.
- Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-ribosylation prevents phosphorylation at Tyr-701.
- Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense.
- Ubiquitination at posLast=652652 and isoforms=2592
- Modification sites at PhosphoSitePlus
Other Protein References for STAT1 Gene
Antibody Products
- R&D Systems Antibodies for STAT1 (STAT1)
-
Custom Antibody ServicesOriGene Antibodies for STAT1
- AP12715PU-N
- AP20384PU-N
- AP20906PU-N
- AP20997PU-N
- AP23359PU-N
- AP26340PU-N
- AP31321PU-N
- AP31341PU-N
- TA305937
- TA309955
- TA309995
- TA312584
- TA312585
- TA312586
- TA312587
- TA312588
- TA319404
- TA319709
- TA320467
- TA322425
- TA322427
- TA322428
- TA324682
- TA324835
- TA325885
- TA325886
- TA325887
- TA325888
- TA328053
- TA347057
- TA500521
- CF500521
- TA500542
- CF500542
- TA500565
- CF500565
- TA500566
- CF500566
- Novus Biologicals Antibodies for STAT1
-
Abcam antibodies for STAT1
- Invitrogen Antibodies for STAT1
- antibodies-online: Search results for 648 available STAT1 Antibodies ranked by validation data
- Compare Top STAT1 Antibodies
-
Recommended
- 233 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 12 ICS Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 175 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 7 IHC Antibodies (anti-rat)
- 4 ICS Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 510 WB Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 18 FACS Antibodies (anti-human)
- 12 ICS Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 233 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 12 ICS Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 175 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 7 IHC Antibodies (anti-rat)
- 4 ICS Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 510 WB Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 18 FACS Antibodies (anti-human)
- 12 ICS Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 ICC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- GeneTex STAT1 Antibody for STAT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAT1
- Stat1 p91 (C-111)
- Stat1 p91 (C-111) X
- Stat1 p84/p91 (C-136)
- Stat1 p84/p91 (C-136) X
- p-Stat1 (A-2)
- p-Stat1 (A-2) X
- p-Stat1 p84/p91 (PSM1)
- Stat1 p84/p91 (SM2)
- Stat1 p84/p91 (ATO-4E9)
- p-Stat1 p84/p91 (6D777)
- Stat1 p84/p91 (6D776)
- p-Stat1 (12C5)
- p-Stat1 (pY701.4A)
- Stat1 p84/p91 (B-9)
- Stat1 p91 (H-1)
- Stat1 p91 (H-1) X
- Sino Biological Antibodies for STAT1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for STAT1
- Origene Custom Protein Services for STAT1
- Sino Biological Recombinant Proteins for STAT1
- Sino Biological Cell Lysates for STAT1
- ProSpec Recombinant Proteins for STAT1
- Search GeneTex for Proteins for STAT1
-
ProSci Proteins for STAT1
-
Abcam proteins for STAT1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for STAT1 (STAT1)
- Novus Biologicals ELISA Kits for STAT1
- antibodies-online: Search results for 46 available STAT1 Elisa Kits ranked by validation data
- Compare Top STAT1 Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
- 32 Human ELISA Kits
- 1 Monkey ELISA Kit
- 29 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 13 Rat (Rattus) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
- 32 Human ELISA Kits
- 1 Monkey ELISA Kit
- 29 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 13 Rat (Rattus) ELISA Kits
No data available for DME Specific Peptides for STAT1 Gene
Domains & Families for STAT1 Gene
Gene Families for STAT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for STAT1 Gene
Suggested Antigen Peptide Sequences for STAT1 Gene
Graphical View of Domain Structure for InterPro Entry
P42224- Family:
-
- Belongs to the transcription factor STAT family.
Function for STAT1 Gene
Molecular function for STAT1 Gene
- UniProtKB/Swiss-Prot Function:
- Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
- GENATLAS Biochemistry:
- signal transducer and activator of transcription 1,91kDa,activated during monocyte to macrophage differentiation as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes such as ICAM1 and FCGR1
Phenotypes From GWAS Catalog for STAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 18035482 |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IDA | 28753426 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 21268089 |
| GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | IDA | 28753426 |
Phenotypes for STAT1 Gene
- MGI mutant phenotypes for STAT1:
-
inferred from 13 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- liver/biliary system phenotype
- skeleton phenotype
- normal phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for STAT1:
-
- Increased transcriptional activity
- Increased cell death HMECs cells
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- shRNA abundance <= 50%
- Increased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for STAT1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for STAT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for STAT1
-
CRISPR Products
-
OriGene CRISPR knockouts for STAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT1
- genomics-online: gRNA clones - Search results for 157 available STAT1 gene related products
- Overview of 157 available STAT1 gene related products
- Applied Biological Materials CRISPR for STAT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT1
- GenScript: Design CRISPR guide RNA sequences for STAT1
miRNA for STAT1 Gene
- miRTarBase miRNAs that target STAT1
-
- hsa-mir-145-5p (MIRT000626)
- hsa-mir-146a-5p (MIRT021229)
- hsa-mir-34a-5p (MIRT025278)
- hsa-mir-615-3p (MIRT040456)
- hsa-mir-653-5p (MIRT640316)
- hsa-mir-203b-3p (MIRT640317)
- hsa-mir-7158-3p (MIRT640318)
- hsa-mir-4693-5p (MIRT640319)
- hsa-mir-5009-3p (MIRT640320)
- hsa-mir-501-5p (MIRT640321)
- hsa-mir-1183 (MIRT640322)
- hsa-mir-500a-5p (MIRT640323)
- hsa-mir-605-5p (MIRT640324)
- hsa-mir-140-5p (MIRT731704)
- hsa-mir-150-5p (MIRT733223)
- hsa-mir-223-3p (MIRT733224)
- hsa-mir-203a-3p (MIRT733720)
- rno-mir-146a-5p (MIRT734037)
- hsa-mir-450a-5p (MIRT734262)
- hsa-mir-155-5p (MIRT734272)
Transcription Factor Targets for STAT1 Gene
Targeted motifs for STAT1 Gene
HOMER Transcription Factor Regulatory Elements motif STAT1
- Consensus sequence: NATTTCCNGGAAAT Submotif: canonical Cell Type: HelaS3 GEO ID: GSE12782
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT1
- Browse OriGene Inhibitory RNA Products For STAT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT1
- genomics-online: shRNA clones - Search results for 157 available STAT1 gene related products
- Overview of 157 available STAT1 gene related products
Clone Products
-
OriGene ORF clones in human for STAT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT1
- VectorBuilder custom plasmid, inducible vectors for STAT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT1
- Applied Biological Materials Clones for STAT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT1
Cell Line Products
-
Horizon Cell Lines for STAT1
No data available for Enzyme Numbers (IUBMB) for STAT1 Gene
Localization for STAT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAT1 Gene
- Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269 PubMed:15322115, ECO:0000269 PubMed:26479788, ECO:0000269 PubMed:28753426}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 18035482 |
| GO:0005634 | colocalizes_with nucleus | IEA,IDA | 26479788 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 10692450 |
Pathways & Interactions for STAT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
.36
|
|
| 2 | Th17 cell differentiation |
.01
|
|
| 3 | Immune response IL-23 signaling pathway | ||
| 4 | Toll-like Receptor Signaling Pathway | ||
| 5 | Prolactin Signaling Pathway | ||
Pathways by source for STAT1 Gene
4 Sino Biological pathways for STAT1 Gene
1 GeneTex pathway for STAT1 Gene
48 BioSystems pathways for STAT1 Gene
24 Reactome pathways for STAT1 Gene
2 PharmGKB pathways for STAT1 Gene
25 KEGG pathways for STAT1 Gene
19 GeneGo (Thomson Reuters) pathways for STAT1 Gene
12 R&D Systems pathways for STAT1 Gene
1 Tocris pathway for STAT1 Gene
28 Qiagen pathways for STAT1 Gene
1 Cell Signaling Technology pathway for STAT1 Gene
Interacting Proteins for STAT1 Gene
Selected Interacting proteins:
P42224-STAT1_HUMAN
ENSP00000354394
for STAT1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for STAT1
SIGNOR curated interactions for STAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0001937 | negative regulation of endothelial cell proliferation | IMP | 16585190 |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | ISS | -- |
| GO:0002230 | positive regulation of defense response to virus by host | IMP | 26479788 |
| GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | ISS | -- |
Drugs & Compounds for STAT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1231,1231 | ||
| Methimazole | Approved | Pharma | ICAM-1 inhibitor | 0 | ||
| Niclosamide | Approved, Investigational, Vet_approved | Pharma | STAT3 inhibitor; also inhibits mTORC1 signaling | 9 | ||
| Sulforaphane | Investigational | Nutra | 50 | |||
| Protective Agents | Pharma | 7926 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(6) ApexBio Compounds for STAT1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fludarabine | DNA synthsis inhibitor | 21679-14-1 |
| Fludarabine Phosphate (Fludara) | Inhibits STAT1 activation and DNA synthesis | 75607-67-9 |
| Methimazole | ICAM-1 inhibitor | 60-56-0 |
| Niclosamide | 50-65-7 | |
| Nifuroxazide | Antidiarrheal agent | 965-52-6 |
| SH-4-54 | STAT inhibitor, potent | 1456632-40-8 |
Transcripts for STAT1 Gene
mRNA/cDNA for STAT1 Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (557) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000415035 663 bps (uc061qsz.1)
- ENST00000361099 4310 bps (uc002usj.3)
- ENST00000409465 3097 bps (uc010fse.3)
- ENST00000423282 477 bps (uc061qta.1)
- ENST00000392322 2716 bps (uc002usk.3)
Unigene Clusters for STAT1 Gene
- Signal transducer and activator of transcription 1, 91kDa:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for STAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT1
- genomics-online: gRNA clones - Search results for 157 available STAT1 gene related products
- Overview of 157 available STAT1 gene related products
- Applied Biological Materials CRISPR for STAT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAT1
- GenScript: Design CRISPR guide RNA sequences for STAT1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for STAT1
- Browse OriGene Inhibitory RNA Products For STAT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT1
- genomics-online: shRNA clones - Search results for 157 available STAT1 gene related products
- Overview of 157 available STAT1 gene related products
Clone Products
-
OriGene ORF clones in human for STAT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STAT1
- VectorBuilder custom plasmid, inducible vectors for STAT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STAT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for STAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT1
- Applied Biological Materials Clones for STAT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STAT1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | - |
Expression for STAT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Bone (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (13.9), Tlymphocyte (8.4), and Spleen (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of STAT1 Gene:
STAT1SOURCE GeneReport for Unigene cluster for STAT1 Gene:
Hs.743244Evidence on tissue expression from TISSUES for STAT1 Gene
- Nervous system(4.9)
- Liver(4.7)
- Skin(3.9)
- Blood(3.4)
- Lymph node(3.3)
- Spleen(3.3)
- Lung(3.2)
- Intestine(3.1)
- Kidney(3.1)
- Muscle(3)
- Heart(2.9)
- Bone marrow(2.7)
- Pancreas(2.7)
- Stomach(2.1)
- Eye(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- eye
- eyelid
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- pharynx
- skull
- tongue
- tooth
Thorax:
- esophagus
- lung
- thymus
Abdomen:
- liver
- spleen
Pelvis:
- vagina
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for STAT1
-
OriGene qPCR primer pairs for STAT1
- genomics-online: primer clones - Search results for 157 available STAT1 gene related products
- Overview of 157 available STAT1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STAT1 Gene
Orthologs for STAT1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | STAT1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | STAT1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC488449 33 |
|
||
| STAT1 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Stat1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | STAT1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Stat1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | STAT1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | STAT1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | STAT1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | stat1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398324 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | stat1a 34 33 |
|
OneToMany | |
| stat1b 34 |
|
OneToMany | |||
| stat1 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11900 33 |
|
- Species where no ortholog for STAT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for STAT1 Gene
- ENSEMBL:
- Gene Tree for STAT1 (if available)
- TreeFam:
- Gene Tree for STAT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAT1: view image
Paralogs for STAT1 Gene
(7) SIMAP similar genes for STAT1 Gene using alignment to 10 proteins:
- STAT1_HUMAN
- D2KFR9_HUMAN
- E7ENM1_HUMAN
- E7EPD2_HUMAN
- E9PH66_HUMAN
- H7BZ88_HUMAN
- H7BZB5_HUMAN
- J3KPM9_HUMAN
- Q67C41_HUMAN
- Q9UK44_HUMAN
Variants for STAT1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1036031197 | uncertain-significance, Familial Atypical Mycobacteriosis, Autosomal Dominant | 191,014,182(-) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs112108750 | likely-benign, Familial Atypical Mycobacteriosis, Autosomal Dominant | 190,978,863(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs11305 | benign, Familial Atypical Mycobacteriosis, Autosomal Dominant | 190,969,304(-) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs118149197 | likely-benign, Familial Atypical Mycobacteriosis, Autosomal Dominant | 191,013,663(-) | C/G | 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant | |
| rs137852677 | pathogenic, Immunodeficiency 31a, Immunodeficiency 31A (IMD31A) [MIM:614892] | 190,975,830(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Residual Variation Intolerance Score:
14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.74;
15.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT1 Gene
Disorders for STAT1 Gene
(53) MalaCards diseases for STAT1 Gene - From: HGMD, LncRNADisease, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 31c |
|
|
| immunodeficiency 31a |
|
|
| immunodeficiency 31b |
|
|
| melanoma |
|
|
| mumps |
|
Search STAT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
STAT1_HUMAN- Immunodeficiency 31B (IMD31B) [MIM:613796]: A disorder characterized by susceptibility to severe mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral illness. {ECO:0000269 PubMed:12590259, ECO:0000269 PubMed:20841510, ECO:0000269 PubMed:23709754}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Immunodeficiency 31A (IMD31A) [MIM:614892]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD31A has low penetrance, and affected individuals have relatively mild disease and good prognosis. IMD31A confers a predisposition to mycobacterial infections only, with no increased susceptibility to viral infections. {ECO:0000269 PubMed:11452125, ECO:0000269 PubMed:16934001, ECO:0000269 PubMed:22573496}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Immunodeficiency 31C (IMD31C) [MIM:614162]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21714643, ECO:0000269 PubMed:21727188, ECO:0000269 PubMed:23709754, ECO:0000269 PubMed:25288569, ECO:0000269 PubMed:26514428}. Note=The disease is caused by mutations affecting the gene represented in this entry. STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643). {ECO:0000269 PubMed:21714643}.
Additional Disease Information for STAT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology