STAT1 Gene (Protein Coding)

Signal Transducer And Activator Of Transcription 1

GC02M190964
GIFtS:
54
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-... See more...

Aliases for STAT1 Gene

Aliases for STAT1 Gene

  • Signal Transducer And Activator Of Transcription 1 2 3 5
  • Transcription Factor ISGF-3 Components P91/P84 2 3 4
  • Signal Transducer And Activator Of Transcription 1-Alpha/Beta 3 4
  • Signal Transducer And Activator Of Transcription 1, 91kDa 2 3
  • Signal Transducer And Activator Of Transcription 1, 91kD 2 3
  • CANDF7 3
  • IMD31A 3
  • IMD31B 3
  • IMD31C 3
  • ISGF-3 3
  • STAT91 3

External Ids for STAT1 Gene

Previous GeneCards Identifiers for STAT1 Gene

  • GC02M190028
  • GC02M190536
  • GC02M191797
  • GC02M192036
  • GC02M191659
  • GC02M191542
  • GC02M191829
  • GC02M183693

Summaries for STAT1 Gene

Entrez Gene Summary for STAT1 Gene

  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAT1 Gene

STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31A. Among its related pathways are Interferon gamma signaling and Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is STAT4.

UniProtKB/Swiss-Prot Summary for STAT1 Gene

  • Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Gene Wiki entry for STAT1 Gene

Additional gene information for STAT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAT1 Gene

Genomics for STAT1 Gene

GeneHancer (GH) Regulatory Elements for STAT1 Gene

Promoters and enhancers for STAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAT1 gene promoter:
  • AP-1
  • c-Myc
  • COMP1
  • FOXO1
  • FOXO1a
  • IRF-1
  • Max1
  • RSRFC4
  • S8
  • STAT5B

Genomic Locations for STAT1 Gene

Genomic Locations for STAT1 Gene
chr2:190,964,358-191,020,960
(GRCh38/hg38)
Size:
56,603 bases
Orientation:
Minus strand
chr2:191,829,084-191,885,686
(GRCh37/hg19)
Size:
56,603 bases
Orientation:
Minus strand

Genomic View for STAT1 Gene

Genes around STAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STAT1 Gene

Proteins for STAT1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for STAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42224-STAT1_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 1-alpha/beta
    Protein Accession:
    P42224
    Secondary Accessions:
    • A8K989
    • B2RCA0
    • D2KFR8
    • D3DPI7
    • Q53S88
    • Q53XW4
    • Q68D00
    • Q9UDL5

    Protein attributes for STAT1 Gene

    Size:
    750 amino acids
    Molecular mass:
    87335 Da
    Quaternary structure:
    • Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation (PubMed:8605877, PubMed:28753426). Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation (PubMed:8605877). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9 (By similarity). Interacts (phosphorylated at Ser-727) with PIAS1; the interaction results in release of STAT1 from its target gene (PubMed:9724754, PubMed:17897103). Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453). Interacts with IFNAR2 (PubMed:9121453). Found in a complex with NMI and CREBBP/CBP (PubMed:9989503). Interacts with NMI which is required for CREBBP/CBP recruitment to the complex (PubMed:9989503). Interacts with PTK2/FAK1 (PubMed:11278462). Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated) (PubMed:18721752). Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788). Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation (PubMed:26479788). Interacts with OTOP1 (By similarity).
    • (Microbial infection) Interacts with Sendai virus C', C, Y1 and Y2 proteins, preventing activation of ISRE and GAS promoter.
    • (Microbial infection) Interacts with Nipah virus P, V and W proteins preventing activation of ISRE and GAS promoter.
    • (Microbial infection) Interacts with Rabies virus phosphoprotein preventing activation of ISRE and GAS promoter.
    • (Microbial infection) Interacts with HCV core protein; the interaction results in STAT1 degradation.
    • (Microbial infection) Interacts with ebolavirus protein VP24.

    Three dimensional structures from OCA and Proteopedia for STAT1 Gene

    Alternative splice isoforms for STAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT1 Gene

Protein Expression for STAT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for STAT1 Gene

  • Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.
  • Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.
  • ISGylated.
  • Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-ribosylation prevents phosphorylation at Tyr-701 (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question and the lack of phosphorylation may be due to sumoylation of Lys-703 (PubMed:29858569).
  • Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense.
  • Ubiquitination at Lys592 and Lys652
  • Modification sites at PhosphoSitePlus

Other Protein References for STAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for STAT1 Gene

Domains & Families for STAT1 Gene

Gene Families for STAT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for STAT1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STAT1 Gene

GenScript: Design optimal peptide antigens:
  • Signal transducer and activator of transcription 1 variant a (Q67C41_HUMAN)
  • Signal transducer and activator of transcription 1 (Q9UK44_HUMAN)
  • Transcription factor ISGF-3 components p91/p84 (STAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42224

UniProtKB/Swiss-Prot:

STAT1_HUMAN :
  • Belongs to the transcription factor STAT family.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT1: view

Function for STAT1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for STAT1 Gene

UniProtKB/Swiss-Prot Function:
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
GENATLAS Biochemistry:
signal transducer and activator of transcription 1,91kDa,activated during monocyte to macrophage differentiation as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes such as ICAM1 and FCGR1

Phenotypes From GWAS Catalog for STAT1 Gene

Gene Ontology (GO) - Molecular Function for STAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 18035482
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 23386060
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS,IDA 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with STAT1: view
genes like me logo Genes that share phenotypes with STAT1: view

Human Phenotype Ontology for STAT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STAT1 Gene

MGI Knock Outs for STAT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for STAT1

CRISPR Products

Transcription Factor Targets for STAT1 Gene

Selected GeneGlobe predicted Target genes for STAT1
Targeted motifs for STAT1 Gene
HOMER Transcription Factor Regulatory Elements motif STAT1
  • Consensus sequence: NATTTCCNGGAAAT Submotif: canonical Cell Type: HelaS3 GEO ID: GSE12782

Clone Products

  • Addgene plasmids for STAT1

No data available for Enzyme Numbers (IUBMB) for STAT1 Gene

Localization for STAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT1 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269 PubMed:15322115, ECO:0000269 PubMed:26479788, ECO:0000269 PubMed:28753426}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAT1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 18035482
GO:0005634 colocalizes_with nucleus IDA,IEA 26479788
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 10692450
genes like me logo Genes that share ontologies with STAT1: view

Pathways & Interactions for STAT1 Gene

genes like me logo Genes that share pathways with STAT1: view

Pathways by source for STAT1 Gene

1 Tocris pathway for STAT1 Gene
28 Qiagen pathways for STAT1 Gene
  • BRCA1 Pathway
  • CNTF Signaling
  • Colorectal Cancer Metastasis
  • EGF Pathway
  • ErbB2-ErbB3 Heterodimers
1 Cell Signaling Technology pathway for STAT1 Gene
1 GeneTex pathway for STAT1 Gene

SIGNOR curated interactions for STAT1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001937 negative regulation of endothelial cell proliferation IMP 16585190
GO:0002053 positive regulation of mesenchymal cell proliferation ISS --
GO:0002230 positive regulation of defense response to virus by host IMP 26479788
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS --
genes like me logo Genes that share ontologies with STAT1: view

Drugs & Compounds for STAT1 Gene

Products:

  1. Drug

(58) Drugs for STAT1 Gene - From: ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1425,1425
Methimazole Approved Pharma ICAM-1 inhibitor 18
Niclosamide Approved, Investigational, Vet_approved Pharma STAT3 inhibitor; also inhibits mTORC1 signaling 10
Nifuroxazide Experimental Pharma Antidiarrheal agent 0
Sulforaphane Investigational Pharma 58

(53) Additional Compounds for STAT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for STAT1 Gene

Compound Action Cas Number
Fludarabine DNA synthsis inhibitor 21679-14-1
Fludarabine Phosphate (Fludara) Inhibits STAT1 activation and DNA synthesis 75607-67-9
Methimazole ICAM-1 inhibitor 60-56-0
Niclosamide 50-65-7
Nifuroxazide Antidiarrheal agent 965-52-6
SH-4-54 STAT inhibitor, potent 1456632-40-8
genes like me logo Genes that share compounds with STAT1: view

Transcripts for STAT1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for STAT1 Gene

(2) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(557) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for STAT1

Alternative Splicing Database (ASD) splice patterns (SP) for STAT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:
SP2: -
SP3: -
SP4: - - -
SP5:
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: -
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: -

Relevant External Links for STAT1 Gene

GeneLoc Exon Structure for
STAT1
ECgene alternative splicing isoforms for
STAT1

Expression for STAT1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAT1 Gene

mRNA expression in normal human tissues for STAT1 Gene
mRNA expression by BioGPS for STAT1 GenemRNA expression by GTEx for STAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STAT1 Gene

This gene is overexpressed in Lymph node (13.9), Tlymphocyte (8.4), and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAT1 Gene



Protein tissue co-expression partners for STAT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STAT1 Gene:

STAT1

SOURCE GeneReport for Unigene cluster for STAT1 Gene:

Hs.743244

Evidence on tissue expression from TISSUES for STAT1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Skin(3.9)
  • Blood(3.4)
  • Lymph node(3.3)
  • Spleen(3.3)
  • Lung(3.2)
  • Intestine(3.1)
  • Kidney(3.1)
  • Muscle(3)
  • Heart(2.9)
  • Bone marrow(2.7)
  • Pancreas(2.7)
  • Stomach(2.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for STAT1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • lung
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with STAT1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STAT1 Gene

Orthologs for STAT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia STAT1 33 32
  • 99.49 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia STAT1 33 32
  • 90.96 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC488449 32
  • 90.44 (n)
STAT1 33
  • 56 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Stat1 32
  • 87.27 (n)
oppossum
(Monodelphis domestica)
 Mammalia STAT1 33
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Stat1 17 33 32
  • 86.74 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia STAT1 33
  • 51 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves STAT1 33 32
  • 76.24 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia STAT1 33
  • 42 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia stat1 32
  • 73.44 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398324 32
zebrafish
(Danio rerio)
 Actinopterygii stat1a 33 32
  • 63.6 (n)
 OneToMany
stat1b 33
  • 59 (a)
 OneToMany
stat1 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11900 32
Species where no ortholog for STAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAT1 Gene

ENSEMBL:
Gene Tree for STAT1 (if available)
TreeFam:
Gene Tree for STAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAT1: view image

Paralogs for STAT1 Gene

Paralogs for STAT1 Gene

(7) SIMAP similar genes for STAT1 Gene using alignment to 10 proteins:

  • STAT1_HUMAN
  • D2KFR9_HUMAN
  • E7ENM1_HUMAN
  • E7EPD2_HUMAN
  • E9PH66_HUMAN
  • H7BZ88_HUMAN
  • H7BZB5_HUMAN
  • J3KPM9_HUMAN
  • Q67C41_HUMAN
  • Q9UK44_HUMAN
genes like me logo Genes that share paralogs with STAT1: view

Variants for STAT1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for STAT1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs112108750 likely-benign, Familial Atypical Mycobacteriosis, Autosomal Dominant, Immunodeficiency 31C, Immunodeficiency 31a, Mycobacterial and viral infections, susceptibility to, autosomal recessive 190,978,863(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs11305 benign, Familial Atypical Mycobacteriosis, Autosomal Dominant 190,969,304(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1181214715 uncertain-significance, Immunodeficiency 31C, Immunodeficiency 31a, Mycobacterial and viral infections, susceptibility to, autosomal recessive 190,984,360(-) G/C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs118149197 likely-benign, Familial Atypical Mycobacteriosis, Autosomal Dominant 191,013,663(-) C/G 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs137852677 pathogenic, Immunodeficiency 31a, Immunodeficiency 31A (IMD31A) [MIM:614892] 190,975,830(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for STAT1 Gene