STAT1 Gene (Protein Coding)

Signal Transducer And Activator Of Transcription 1

GCID:: GC02M190964

GIFtS:: 55

Genes Participants

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-... See more...

Aliases for STAT1 Gene

Signal Transducer And Activator Of Transcription 1 ² ³ ⁵
Transcription Factor ISGF-3 Components P91/P84 ² ³ ⁴
Signal Transducer And Activator Of Transcription 1-Alpha/Beta ³ ⁴
Signal Transducer And Activator Of Transcription 1, 91kDa ² ³
Signal Transducer And Activator Of Transcription 1, 91kD ² ³

CANDF7 ³
IMD31A ³
IMD31B ³
IMD31C ³
ISGF-3 ³
STAT91 ³

External Ids for STAT1 Gene

HGNC: 11362
Entrez Gene: 6772
Ensembl: ENSG00000115415
OMIM: 600555
UniProtKB: P42224

Previous GeneCards Identifiers for STAT1 Gene

GC02M190028
GC02M190536
GC02M191797
GC02M192036
GC02M191659
GC02M191542
GC02M191829
GC02M183693

Search aliases for STAT1 gene in PubMed and other databases

Summaries for STAT1 Gene

Entrez Gene Summary for STAT1 Gene

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

CIViC Summary for STAT1 Gene

GeneCards Summary for STAT1 Gene

STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31A. Among its related pathways are FGFR1 mutant receptor activation and Th1 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein homodimerization activity. An important paralog of this gene is STAT4.

UniProtKB/Swiss-Prot Summary for STAT1 Gene

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
- STAT1_HUMAN,P42224

Gene Wiki entry for STAT1 Gene

Additional gene information for STAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAT1 Gene

Genomics for STAT1 Gene

GeneHancer (GH) Regulatory Elements for STAT1 Gene

Promoters and enhancers for STAT1 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH02J191011	Promoter/Enhancer	2.5	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	508.6	+7.3	7261	4.6	EP300 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC POLR2G SP1	STAT1 MF281465 lnc-GLS-3 ENSG00000231858 MSTN NAB1 GLS HIBCH STAT4 RAB1AP1
GH02J191018	Promoter/Enhancer	2.3	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	500.7	-0.1	-109	6.1	RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 MYC	ENSG00000231858 STAT1 lnc-GLS-2 MSTN GLS ENSG00000230686 lnc-STAT4-3
GH02J191048	Enhancer	1.2	Ensembl ENCODE dbSUPER	16.9	-29.1	-29067	4.1	ZSCAN5C TCF12 FOS EP300 ZIC2 TCF7 CUX1 SKI TRIM22 TEAD1	STAT1 ENSG00000231858 ENSG00000230686 GLS ENSG00000288064 piR-61240-151 STAT4
GH02J190979	Enhancer	1.3	Ensembl ENCODE CraniofacialAtlas dbSUPER	12.3	+40.4	40435	3	ZNF217 FOS ZIC2 REST TRIM28 GATAD2B CTBP1 OSR2 NR2F2 SIN3A	GLS ENSG00000230686 STAT1 ENSG00000231858 HSALNG0021139 RAB1AP1
GH02J191052	Enhancer	0.8	ENCODE dbSUPER	12.2	-31.3	-31340	0.2	CTCF REST TGIF2 RAD21 SKI TRIM22 SMC3 SIX5 MBD1 ATF3	ENSG00000230686 ENSG00000231858 STAT1 ENSG00000288064 piR-61240-151 STAT4

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAT1

Top Transcription factor binding sites by QIAGEN in the STAT1 gene promoter:

AP-1
c-Myc
COMP1
FOXO1
FOXO1a
IRF-1
Max1
RSRFC4
S8
STAT5B

Genomic Locations for STAT1 Gene

chr2:190,964,358-191,020,960: (GRCh38/hg38)

Size:: 56,603 bases
Orientation:: Minus strand

chr2:191,829,084-191,885,686: (GRCh37/hg19)

Size:: 56,603 bases
Orientation:: Minus strand

Genomic View for STAT1 Gene

Genes around STAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

2q32.2 by HGNC
2q32.2 by Entrez Gene
2q32.2 by Ensembl

STAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for STAT1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for STAT1 Gene

NC_000002.12

Proteins for STAT1 Gene

Protein details for STAT1 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P42224-STAT1_HUMAN

Recommended name:

Signal transducer and activator of transcription 1-alpha/beta

Protein Accession:

P42224

Secondary Accessions:
- A8K989
- B2RCA0
- D2KFR8
- D3DPI7
- Q53S88
- Q53XW4
- Q68D00
- Q9UDL5
Protein attributes for STAT1 Gene
Size:

750 amino acids

Molecular mass:

87335 Da
Quaternary structure:
Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation (PubMed:8605877, PubMed:28753426). Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation (PubMed:8605877). The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9 (By similarity). Interacts (phosphorylated at Ser-727) with PIAS1; the interaction results in release of STAT1 from its target gene (PubMed:9724754, PubMed:17897103). Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466' (PubMed:9121453). Interacts with IFNAR2 (PubMed:9121453). Found in a complex with NMI and CREBBP/CBP (PubMed:9989503). Interacts with NMI which is required for CREBBP/CBP recruitment to the complex (PubMed:9989503). Interacts with PTK2/FAK1 (PubMed:11278462). Interacts with SRC (By similarity). Interacts with ERBB4 (phosphorylated) (PubMed:18721752). Interacts with PARP9 and DTX3L independently of IFN-beta or IFN-gamma-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788). Interacts with histone acetyltransferase EP300/p300 in response to INF-gamma stimulation (PubMed:26479788). Interacts with OTOP1 (By similarity).

(Microbial infection) Interacts with Sendai virus C', C, Y1 and Y2 proteins, preventing activation of ISRE and GAS promoter.

(Microbial infection) Interacts with Nipah virus P, V and W proteins preventing activation of ISRE and GAS promoter.

(Microbial infection) Interacts with Rabies virus phosphoprotein preventing activation of ISRE and GAS promoter.

(Microbial infection) Interacts with HCV core protein; the interaction results in STAT1 degradation.

(Microbial infection) Interacts with ebolavirus protein VP24.
Three dimensional structures from OCA and Proteopedia for STAT1 Gene
- 1BF5 (3D)
- 1YVL (3D)
- 2KA6 (3D)
- 3WWT (3D)
Alternative splice isoforms for STAT1 Gene
UniProtKB/Swiss-Prot:
P42224-1

P42224-2

neXtProt entry for STAT1 Gene

Protein Expression for STAT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for STAT1 Gene

Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701.
- P42224-STAT1_HUMAN
Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity.
- P42224-STAT1_HUMAN
ISGylated.
- P42224-STAT1_HUMAN
Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-ribosylation prevents phosphorylation at Tyr-701 (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question and the lack of phosphorylation may be due to sumoylation of Lys-703 (PubMed:29858569).
- P42224-STAT1_HUMAN
Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense.
- P42224-STAT1_HUMAN
Ubiquitination at Lys592 and Lys652
- NX_P42224 (NX_P42224-1)
Modification sites at PhosphoSitePlus
- P42224

Other Protein References for STAT1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Miltenyi Biotec B.V. & Co. KG

G Biosciences

RayBiotech Rabbit anti-P-STAT1 antibody, Rabbit anti-Human P-STAT1 antibody, and Rabbit anti-P-STAT1(694~705aa)

NSJ Bioreagents STAT1 Antibody

Creative Diagnostics Anti-STAT1 monoclonal antibody, clone 0C23

Creative Biolabs

BioLegend

OriGene Antibodies for STAT1
- AP12715PU-N
- AP20384PU-N
- AP20906PU-N
- AP20997PU-N
- AP23359PU-N
- AP26340PU-N
- AP31321PU-N
- AP31341PU-N
- CF500521
- CF500542
- CF500565
- CF500566
- TA305937
- TA309955
- TA309995
- TA312584
- TA312585
- TA312586
- TA312587
- TA312588
- TA319404
- TA319709
- TA320467
- TA322425
- TA322427
- TA322428
- TA324682
- TA324835
- TA325885
- TA325886
- TA325887
- TA325888
- TA347057
- TA354432
- TA354830
- TA354831
- TA500521
- TA500521S
- TA500542
- TA500542S
- TA500565
- TA500565S
- TA500566
- TA500566S
Custom Antibody Services

Novus Biologicals Antibodies for STAT1

Abcam antibodies for STAT1
- STAT1
- STAT1 alpha

Invitrogen Antibodies for STAT1 (AFLGC-STAT1)

Biorbyt antibodies for STAT1
- orb11426
- orb12612
- orb14572
- orb178908
- orb18072
- orb214616
- orb214617
- orb214618
- orb223104
- orb223105
- orb223196
- orb223197
- orb224009
- orb338823
- orb379231
- orb379233
- orb44237
- orb49089
- orb536774
- orb542497

Boster Bio Antibodies for STAT1
- PA1075
- A00036-2
- P00036
- PB9510
- M00036
- M00036-1
- M00036-2
- PA1508

ProSci Antibodies for STAT1
- signal transducer and activator of transcription 1, 91kDa [7195]
- signal transducer and activator of transcription 1, 91kDa [1021]
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for STAT1

Sino Biological Antibodies for STAT1

Protein Products

G Biosciences Human STAT1, Lyophilized

OriGene Purified Proteins for STAT1
- NM_139266
- NM_007315
- NM_139266
- NM_007315
- NM_007315
- NM_139266
- NM_007315
- NM_007315
- NM_007315
- NM_007315
- NM_139266
- NM_007315
- NM_009283
- NM_139266
Search Origene for MassSpec and Protein Over-expression Lysates for STAT1
Origene Custom Protein Services for STAT1

Novus Biologicals proteins and lysates for STAT1

Sino Biological Recombinant Proteins for STAT1
Sino Biological Cell Lysates for STAT1

ProSpec Recombinant Proteins for STAT1

antibodies-online: "Show 21 available STAT 1, beta Proteins ranked by validation data"
"Compare Top STAT 1, beta Proteins"

Signalway Proteins for STAT1
- AP75774
- AP88266
- GP10069

ProSci Proteins for STAT1
- signal transducer and activator of transcription 1

Abcam proteins for STAT1
- STAT1
- STAT1 alpha

Assay Products

G Biosciences Immunotag™ Human STAT1 (Signal Transducer and Activator of Transcription 1) ELISA and Immunotag™ Signal transducer and activator of transcription 1-alpha/beta ELISA Kit

RayBiotech

Creative Diagnostics Human STAT1 ELISA Matched Antibody Pair and STAT1 (pS727) (Human/Mouse) ELISA Kit

Aviva Systems Biology Phospho-STAT1 (Ser727) Colorimetric Cell-Based ELISA Kit (OKAG02056), STAT1 ELISA Kit (Human) (OKCD02896), and STAT1 ELISA Kit (Human) (OKCD07630)

Boster Bio ELISA Kits for STAT1
- EKC2513
- EKC2514
- EKC1541

Signalway ELISA kits for STAT1
- EK6671

Browse Sino Biological Assays

No data available for DME Specific Peptides for STAT1 Gene

Domains & Families for STAT1 Gene

Gene Families for STAT1 Gene

HGNC:

SH2 domain containing

Human Protein Atlas (HPA):

Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Protein Domains for STAT1 Gene

Blocks:

STAT protein

InterPro:

ProtoNet:

P42224

Suggested Antigen Peptide Sequences for STAT1 Gene

GenScript: Design optimal peptide antigens:

Signal transducer and activator of transcription 1 variant a (Q67C41_HUMAN)
Signal transducer and activator of transcription 1 (Q9UK44_HUMAN)
Transcription factor ISGF-3 components p91/p84 (STAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42224

UniProtKB/Swiss-Prot:

STAT1_HUMAN :

Belongs to the transcription factor STAT family.

Family:

Belongs to the transcription factor STAT family.

Function for STAT1 Gene

Molecular function for STAT1 Gene

UniProtKB/Swiss-Prot Function:

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

STAT1_HUMAN,P42224

GENATLAS Biochemistry:

signal transducer and activator of transcription 1,91kDa,activated during monocyte to macrophage differentiation as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes such as ICAM1 and FCGR1

STAT1

Phenotypes From GWAS Catalog for STAT1 Gene

Gene Ontology (GO) - Molecular Function for STAT1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA	18035482
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IDA	23386060
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS,IDA	19274049
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	21873635
GO:0003677	DNA binding	IEA	--

Phenotypes for STAT1 Gene

MGI mutant phenotypes for STAT1:

inferred from 15 alleles

GenomeRNAi human phenotypes for STAT1:

Human Phenotype Ontology for STAT1 Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for STAT1 Gene

MGI Knock Outs for STAT1:

Stat1 ^{Stat1<tm1Rds>}
Stat1 ^{Stat1<tm1Dlv>}
Stat1 ^{Stat1<tm2b(EUCOMM)Wtsi>}
Stat1 ^{Stat1<tm1.2Mmul>}

Animal Model Products

Taconic Biosciences Mouse Models for STAT1
- Stat1

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for STAT1 - Select products 50% OFF >
* STAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for STAT1
- GA104659
- GA204122
- KN201075
- KN201075BN
- KN201075LP
- KN201075RB
- KN401075
- KN516843

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAT1

genomics-online: gRNA clones - "Search for available STAT 1, beta gRNA products"
"Overview of 175 available STAT 1, beta gene related products"
Recommended
- pCMV-SPORT6
- pOTB7
- pCMV-SPORT6ccdB
- pExpress-1
- pCS107
- pTCN
- pBluescript SK-
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPM-N-D-C-HA
- pPB-N-His

Santa Cruz Biotechnology (SCBT) CRISPR for STAT1

miRNA for STAT1 Gene

miRTarBase miRNAs that target STAT1

Transcription Factor Targets for STAT1 Gene

Selected GeneGlobe predicted Target genes for STAT1

Targeted motifs for STAT1 Gene

HOMER Transcription Factor Regulatory Elements motif STAT1

Consensus sequence: NATTTCCNGGAAAT Submotif: canonical Cell Type: HelaS3 GEO ID: GSE12782

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for STAT1

Browse OriGene miRNA Products For STAT1

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for STAT1
Browse OriGene Inhibitory RNA Products For STAT1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAT1

genomics-online: shRNA clones - "Search for available STAT 1, beta shRNA products"
"Overview of 175 available STAT 1, beta gene related products"
Recommended
- pCMV-SPORT6
- pOTB7
- pCMV-SPORT6ccdB
- pExpress-1
- pCS107
- pTCN
- pBluescript SK-
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPM-N-D-C-HA
- pPB-N-His

Search Santa Cruz Biotechnology (SCBT) for STAT1 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for STAT1 - Select products 50% OFF >
* STAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for STAT1
- SC203451
- SC215993
- MC200236
- MC228848
- MC228867
- RN200448
- RN200449
- SC115595
- SC128145
OriGene ORF clones in human,mouse,rat for STAT1
- MG227437
- MR227437
- MR227437L3
- MR227437L4
- MR231059
- MR231078
- RC201075
- RC201075L1
- RC201075L2
- RC201075L3
- RC201075L4
- RC213858
- RC213858L1
- RC213858L2
- RC213858L3
- RC213858L4
- RG201075
- RG213858
- RR200448
- RR200448L3
- RR200448L4
- RR200449
- RR200449L3
- RR200449L4
- MR227437L3V
- MR227437L4V
- RC201075L1V
- RC201075L2V
- RC201075L3V
- RC201075L4V
- RC213858L1V
- RC213858L2V
- RC213858L3V
- RC213858L4V
- RR200448L3V
- RR200448L4V
- RR200449L3V
- RR200449L4V
- RC403201
- RC403202
- RC403203
- RC403204
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for STAT1

Addgene plasmids for STAT1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAT1

genomics-online: cdna clones - "Search for available STAT 1, beta CDNA products"
"Overview of 175 available STAT 1, beta gene related products"
Recommended
- pCMV-SPORT6
- pOTB7
- pCMV-SPORT6ccdB
- pExpress-1
- pCS107
- pTCN
- pBluescript SK-
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPM-N-D-C-HA
- pPB-N-His
orf clones - "Search for available STAT 1, beta ORF products"
"Overview of 175 available STAT 1, beta gene related products"
Recommended
- pCMV-SPORT6
- pOTB7
- pCMV-SPORT6ccdB
- pExpress-1
- pCS107
- pTCN
- pBluescript SK-
- pUC19
- pORF
- pDONR223
- pPM-C-HA
- pPM-C-His
- pPM-N-D-C-HA
- pPB-N-His

Human STAT1 (NP_009330) VersaClone cDNA (RDC1455)

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for STAT1

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for STAT1

Horizon Cell Lines for STAT1

No data available for Enzyme Numbers (IUBMB) for STAT1 Gene

Localization for STAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT1 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269 PubMed:15322115, ECO:0000269 PubMed:26479788, ECO:0000269 PubMed:28753426}.

P42224-STAT1_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	3
extracellular	3
cytoskeleton	3
mitochondrion	3
peroxisome	2
endoplasmic reticulum	2
endosome	2
lysosome	2
golgi apparatus	2

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (4)
Nucleoplasm (4)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAT1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA,ISA	--
GO:0005634	colocalizes_with nucleus	IEA,IDA	26479788
GO:0005654	nucleoplasm	IDA,TAS	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IEA,IDA	10692450

Pathways & Interactions for STAT1 Gene

SuperPathways for STAT1 Gene

	SuperPathway	Contained pathways
1	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	IL-21 Signaling Pathways .90 IL-7 Signaling Pathways .90 IL-9 Signaling Pathways .90 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways .90	IL-2 Signaling Pathways .88 Immune response IL-9 signaling pathway .42 IL-9 Pathway .36
2	Toll-like Receptor Signaling Pathway	Toll-like receptor signaling pathway .92 Toll-like Receptor Signaling Pathway .92 Regulation of toll-like receptor signaling pathway .71	Hepatitis B .37 Hepatitis C .34
3	Th17 cell differentiation	Th1 and Th2 cell differentiation .55 Th17 cell differentiation .55 Inflammatory bowel disease (IBD) .37	Immune response IL-22 signaling pathway .36 IL-22 Pathway .01
4	Immune response IL-23 signaling pathway	Development PDGF signaling via STATs and NF-kB .44 Immune response IL-23 signaling pathway .44 Development Angiopoietin - Tie2 signaling .38	Immune response IL-10 signaling pathway .36 IL23-mediated signaling events .35
5	Prolactin Signaling Pathway	Development Prolactin receptor signaling .38 Prolactin Signaling Pathway .38	Prolactin signaling pathway .34 Leptin signaling pathway .33

Pathways by source for STAT1 Gene

4 Sino Biological pathways for STAT1 Gene

48 BioSystems pathways for STAT1 Gene

24 Reactome pathways for STAT1 Gene

2 PharmGKB pathways for STAT1 Gene

28 KEGG pathways for STAT1 Gene

19 GeneGo (Thomson Reuters) pathways for STAT1 Gene

Bacterial infections in CF airways
Cell adhesion PLAU signaling
Development Angiopoietin - Tie2 signaling
Development CNTF receptor signaling
Development EGFR signaling pathway

12 R&D Systems pathways for STAT1 Gene

1 Tocris pathway for STAT1 Gene

MAPK Pathway

28 Qiagen pathways for STAT1 Gene

BRCA1 Pathway
CNTF Signaling
Colorectal Cancer Metastasis
EGF Pathway
ErbB2-ErbB3 Heterodimers

1 Cell Signaling Technology pathway for STAT1 Gene

NF-kappaB Signaling

1 GeneTex pathway for STAT1 Gene

JAK-STAT pathway

Interacting Proteins for STAT1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P42224-STAT1_HUMAN ENSP00000354394 for STAT1 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
- (XENO)	P27958 ⁴ P06498 ⁴ P03255-1 ⁴ P03255-2 ⁴ P26664 ⁴	EBI-1057697, EBI-8753518 EBI-15711971, EBI-16085959 EBI-1057697, EBI-6692439 EBI-1057697, EBI-6859460 EBI-1057697, EBI-6941357
EGFR	P00533 ⁴ ²⁰ ¹²⁷ ENSP00000275493 ²¹	EBI-1057697, EBI-297353 MINT-8026130 STRING: ENSP00000275493 IID: # exp=16 # pred=2
ERBB2	P04626 ⁴ ²⁰ ¹²⁷ ENSP00000269571 ²¹	EBI-1057697, EBI-641062 MINT-74754 STRING: ENSP00000269571 IID: # exp=2 # pred=1
IFNAR1	P17181 ⁴ ²⁰ ¹²⁷ ENSP00000270139 ²¹	EBI-1057697, EBI-1547250 MINT-8029458 STRING: ENSP00000270139 IID: # exp=1 # pred=2
IFNGR1	P15260 ⁴ ²⁰ ¹²⁷ ENSP00000356713 ²¹	EBI-1057697, EBI-1030755 MINT-8025899 STRING: ENSP00000356713 IID: # exp=9 # pred=3

GPS-Prot Interaction Network for STAT1

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SIGNOR curated interactions for STAT1 Gene

Activates:

Inactivates:

RELA
MMP13

Is activated by:

Is inactivated by:

Gene Ontology (GO) - Biological Process for STAT1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	--
GO:0001937	negative regulation of endothelial cell proliferation	IMP	16585190
GO:0002053	positive regulation of mesenchymal cell proliferation	ISS	--
GO:0002230	positive regulation of defense response to virus by host	IMP	26479788
GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS	--

Drugs & Compounds for STAT1 Gene

(58) Drugs for STAT1 Gene - From: ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name	Status	Disease Links	Group	Mechanism of Action	Clinical Trials
Fludarabine	Approved	MalaCards Medline Plus	Pharma	DNA synthsis inhibitor	1470,1470
Methimazole	Approved	MalaCards Medline Plus	Pharma	ICAM-1 inhibitor	19
Niclosamide	Approved, Investigational, Vet_approved	MalaCards Medline Plus	Pharma	STAT3 inhibitor; also inhibits mTORC1 signaling	10
Nifuroxazide	Experimental	MalaCards Medline Plus	Pharma	Antidiarrheal agent	0
Sulforaphane	Investigational	MalaCards Medline Plus	Pharma		58

(53) Additional Compounds for STAT1 Gene - From: Novoseek

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs

(6) ApexBio Compounds for STAT1 Gene

Compound	Action	Cas Number
Fludarabine	DNA synthsis inhibitor	21679-14-1
Fludarabine Phosphate (Fludara)	Inhibits STAT1 activation and DNA synthesis	75607-67-9
Methimazole	ICAM-1 inhibitor	60-56-0
Niclosamide		50-65-7
Nifuroxazide	Antidiarrheal agent	965-52-6
SH-4-54	STAT inhibitor, potent	1456632-40-8

Drug Products

G Biosciences Human STAT1, Lyophilized

Browse Tocris compounds for STAT1

ApexBio compounds for STAT1

Transcripts for STAT1 Gene