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Aliases for STARD8 Gene

Aliases for STARD8 Gene

  • StAR Related Lipid Transfer Domain Containing 8 2 3 5
  • Deleted In Liver Cancer 3 Protein 3 4
  • START Domain Containing 8 2 3
  • DLC3 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 8 3
  • StAR-Related Lipid Transfer Protein 8 3
  • START Domain-Containing Protein 8 4
  • START-GAP3 4
  • STARTGAP3 3
  • ARHGAP38 3
  • KIAA0189 4
  • StARD8 4
  • DLC-3 4

External Ids for STARD8 Gene

Previous GeneCards Identifiers for STARD8 Gene

  • GC0XP064091
  • GC0XP065390
  • GC0XP066100
  • GC0XP066734
  • GC0XP067650
  • GC0XP067784
  • GC0XP067867
  • GC0XP061695

Summaries for STARD8 Gene

Entrez Gene Summary for STARD8 Gene

  • This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]

GeneCards Summary for STARD8 Gene

STARD8 (StAR Related Lipid Transfer Domain Containing 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and lipid binding. An important paralog of this gene is STARD13.

UniProtKB/Swiss-Prot for STARD8 Gene

  • Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.

Gene Wiki entry for STARD8 Gene

Additional gene information for STARD8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD8 Gene

Genomics for STARD8 Gene

GeneHancer (GH) Regulatory Elements for STARD8 Gene

Promoters and enhancers for STARD8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI068692 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 588.4 +49.8 49816 9.4 HDAC1 RAD21 YY1 ZNF335 TCF12 POLR2B GLIS2 GATA2 EGR2 SP3 STARD8 COX6CP12 ACTR3P2
GH0XI068646 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.1 55 1.6 CTCF ZNF449 SIN3A ZIC2 ZNF335 GLIS2 POLR2A ZBTB48 NFYB ZBTB20 STARD8 YIPF6 ACTR3P2
GH0XI068648 Enhancer 0.6 Ensembl ENCODE 550.8 +1.4 1435 0.8 SP1 GFI1B PRDM10 STARD8 YIPF6 ACTR3P2
GH0XI068672 Enhancer 0.6 Ensembl ENCODE 13.6 +25.3 25278 1.4 RXRA NR2F2 COX6CP12 STARD8 ENSG00000260118 ACTR3P2
GH0XI068683 Enhancer 1.3 FANTOM5 Ensembl ENCODE 6.1 +37.8 37823 3.4 HDAC1 PKNOX1 RB1 NFRKB ZNF76 GLIS2 ARID2 ZNF366 EGR1 EGR2 STARD8 ACTR3P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STARD8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STARD8 gene promoter:

Genomic Locations for STARD8 Gene

Genomic Locations for STARD8 Gene
chrX:68,647,666-68,725,842
(GRCh38/hg38)
Size:
78,177 bases
Orientation:
Plus strand
chrX:67,867,508-67,945,684
(GRCh37/hg19)

Genomic View for STARD8 Gene

Genes around STARD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD8 Gene

Proteins for STARD8 Gene

  • Protein details for STARD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92502-STAR8_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 8
    Protein Accession:
    Q92502
    Secondary Accessions:
    • A8K6T2
    • D3DVT9
    • Q5JST0
    • Q68DG7

    Protein attributes for STARD8 Gene

    Size:
    1023 amino acids
    Molecular mass:
    112601 Da
    Quaternary structure:
    • Binds both the SH2 and PTB domains of TNS1.
    SequenceCaution:
    • Sequence=BAA11506.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for STARD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD8 Gene

Post-translational modifications for STARD8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for STARD8 Gene

Domains & Families for STARD8 Gene

Suggested Antigen Peptide Sequences for STARD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD8: view

No data available for UniProtKB/Swiss-Prot for STARD8 Gene

Function for STARD8 Gene

Molecular function for STARD8 Gene

UniProtKB/Swiss-Prot Function:
Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.

Gene Ontology (GO) - Molecular Function for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD8: view
genes like me logo Genes that share phenotypes with STARD8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STARD8 Gene

Localization for STARD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD8 Gene

Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD8 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with STARD8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STARD8 Gene

Pathways & Interactions for STARD8 Gene

genes like me logo Genes that share pathways with STARD8: view

Pathways by source for STARD8 Gene

3 Reactome pathways for STARD8 Gene

Gene Ontology (GO) - Biological Process for STARD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with STARD8: view

No data available for SIGNOR curated interactions for STARD8 Gene

Drugs & Compounds for STARD8 Gene

No Compound Related Data Available

Transcripts for STARD8 Gene

Unigene Clusters for STARD8 Gene

StAR-related lipid transfer (START) domain containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5: -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for STARD8 Gene

GeneLoc Exon Structure for
STARD8
ECgene alternative splicing isoforms for
STARD8

Expression for STARD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD8 Gene

This gene is overexpressed in Monocytes (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STARD8 Gene



Protein tissue co-expression partners for STARD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD8 Gene:

STARD8

SOURCE GeneReport for Unigene cluster for STARD8 Gene:

Hs.95140

mRNA Expression by UniProt/SwissProt for STARD8 Gene:

Q92502-STAR8_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, lung and placenta.

Evidence on tissue expression from TISSUES for STARD8 Gene

  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with STARD8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD8 Gene

Orthologs for STARD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD8 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STARD8 33 34
  • 86.86 (n)
dog
(Canis familiaris)
Mammalia STARD8 33 34
  • 86.5 (n)
mouse
(Mus musculus)
Mammalia Stard8 33 16 34
  • 83.58 (n)
rat
(Rattus norvegicus)
Mammalia Stard8 33
  • 83.48 (n)
oppossum
(Monodelphis domestica)
Mammalia STARD8 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD8 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD8 33 34
  • 68.71 (n)
lizard
(Anolis carolinensis)
Reptilia STARD8 34
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stard8 33 34
  • 58.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
Species where no ortholog for STARD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD8 Gene

ENSEMBL:
Gene Tree for STARD8 (if available)
TreeFam:
Gene Tree for STARD8 (if available)

Paralogs for STARD8 Gene

(2) SIMAP similar genes for STARD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with STARD8: view

Variants for STARD8 Gene

Sequence variations from dbSNP and Humsavar for STARD8 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs139380533 A breast cancer sample 68,717,716(+) G/A coding_sequence_variant, missense_variant
VAR_036589 A breast cancer sample p.Glu242Lys
rs1000135820 -- 68,652,078(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000141396 -- 68,725,343(+) T/C 3_prime_UTR_variant
rs1000242080 -- 68,660,867(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STARD8 Gene

Variant ID Type Subtype PubMed ID
nsv6944 CNV deletion 18451855
nsv6943 CNV insertion 18451855
nsv516469 CNV gain 19592680
esv3432313 CNV insertion 20981092
esv3379724 CNV insertion 20981092
esv3310548 CNV novel sequence insertion 20981092
esv2669195 CNV deletion 23128226
esv1584074 OTHER inversion 17803354

Variation tolerance for STARD8 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD8 Gene

Disorders for STARD8 Gene

Additional Disease Information for STARD8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STARD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD8 Gene

Publications for STARD8 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology. (PMID: 17976533) Kawai K … Yagisawa H (Biochemical and biophysical research communications 2007) 3 4 58
  4. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. (PMID: 17517630) Qian X … Lowy DR (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 58
  5. Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. (PMID: 17297465) Durkin ME … Popescu NC (Oncogene 2007) 3 4 58

Products for STARD8 Gene

Sources for STARD8 Gene

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