Aliases for STARD7 Gene

Aliases for STARD7 Gene

  • StAR Related Lipid Transfer Domain Containing 7 2 3 5
  • GTT1 2 3 4
  • StAR-Related Lipid Transfer Protein 7, Mitochondrial 3 4
  • Gestational Trophoblastic Tumor Protein 1 3 4
  • START Domain-Containing Protein 7 3 4
  • START Domain Containing 7 2 3
  • StAR-Related Lipid Transfer (START) Domain Containing 7 3
  • STARD7 5
  • StARD7 4
  • FAME2 3

External Ids for STARD7 Gene

Previous GeneCards Identifiers for STARD7 Gene

  • GC02M094722
  • GC02M095304
  • GC02M096318
  • GC02M096335
  • GC02M096272
  • GC02M096214
  • GC02M096850
  • GC02M090811

Summaries for STARD7 Gene

GeneCards Summary for STARD7 Gene

STARD7 (StAR Related Lipid Transfer Domain Containing 7) is a Protein Coding gene. Diseases associated with STARD7 include Epilepsy, Familial Adult Myoclonic, 2 and Familial Adult Myoclonic Epilepsy. Among its related pathways are Synthesis of PC and Metabolism. Gene Ontology (GO) annotations related to this gene include lipid binding. An important paralog of this gene is PCTP.

UniProtKB/Swiss-Prot Summary for STARD7 Gene

  • May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Gene Wiki entry for STARD7 Gene

Additional gene information for STARD7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STARD7 Gene

Genomics for STARD7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STARD7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STARD7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STARD7

Top Transcription factor binding sites by QIAGEN in the STARD7 gene promoter:
  • AhR
  • Arnt
  • CBF(2)
  • HSF2
  • Meis-1a
  • Meis-1b
  • NF-Y
  • Pax-2
  • Pax-2a
  • Pax-3

Genomic Locations for STARD7 Gene

Genomic Locations for STARD7 Gene
chr2:96,184,859-96,208,846
(GRCh38/hg38)
Size:
23,988 bases
Orientation:
Minus strand
chr2:96,850,597-96,874,573
(GRCh37/hg19)
Size:
23,977 bases
Orientation:
Minus strand

Genomic View for STARD7 Gene

Genes around STARD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD7 Gene

Proteins for STARD7 Gene

  • Protein details for STARD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ5-STAR7_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 7, mitochondrial
    Protein Accession:
    Q9NQZ5
    Secondary Accessions:
    • D3DXG9
    • Q53T44
    • Q6GU43
    • Q969M6

    Protein attributes for STARD7 Gene

    Size:
    370 amino acids
    Molecular mass:
    43113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF81750.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH07894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH08894.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH09998.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12774.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12793.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13279.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14076.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14274.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD7 Gene

Post-translational modifications for STARD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD7 Gene

Domains & Families for STARD7 Gene

Gene Families for STARD7 Gene

Protein Domains for STARD7 Gene

Suggested Antigen Peptide Sequences for STARD7 Gene

GenScript: Design optimal peptide antigens:
  • START domain-containing protein 7 (STAR7_HUMAN)
genes like me logo Genes that share domains with STARD7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STARD7 Gene

Function for STARD7 Gene

Molecular function for STARD7 Gene

UniProtKB/Swiss-Prot Function:
May play a protective role in mucosal tissues by preventing exaggerated allergic responses.

Phenotypes From GWAS Catalog for STARD7 Gene

Gene Ontology (GO) - Molecular Function for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27499296
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD7: view
genes like me logo Genes that share phenotypes with STARD7: view

Human Phenotype Ontology for STARD7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for STARD7 Gene

MGI Knock Outs for STARD7:
  • Stard7 Stard7<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for STARD7 Gene

miRTarBase miRNAs that target STARD7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for STARD7 Gene

Localization for STARD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD7 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD7 gene
Compartment Confidence
mitochondrion 5
extracellular 3
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with STARD7: view

Pathways & Interactions for STARD7 Gene

genes like me logo Genes that share pathways with STARD7: view

Gene Ontology (GO) - Biological Process for STARD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001773 myeloid dendritic cell activation IEA --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006954 inflammatory response IEA --
GO:0035745 T-helper 2 cell cytokine production IEA --
GO:0042092 type 2 immune response IEA --
genes like me logo Genes that share ontologies with STARD7: view

No data available for SIGNOR curated interactions for STARD7 Gene

Drugs & Compounds for STARD7 Gene

No Compound Related Data Available

Transcripts for STARD7 Gene

mRNA/cDNA for STARD7 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD7

Alternative Splicing Database (ASD) splice patterns (SP) for STARD7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for STARD7 Gene

GeneLoc Exon Structure for
STARD7

Expression for STARD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STARD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD7 Gene

This gene is overexpressed in Neutrophil (29.3), Breast (10.8), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STARD7 Gene



Protein tissue co-expression partners for STARD7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STARD7

SOURCE GeneReport for Unigene cluster for STARD7 Gene:

Hs.469331

mRNA Expression by UniProt/SwissProt for STARD7 Gene:

Q9NQZ5-STAR7_HUMAN
Tissue specificity: Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.

Evidence on tissue expression from TISSUES for STARD7 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Lung(3.6)
  • Heart(2.7)
  • Muscle(2.7)
  • Liver(2.7)
  • Kidney(2.4)
  • Intestine(2.2)
  • Eye(2)
  • Spleen(2)
  • Blood(2)
genes like me logo Genes that share expression patterns with STARD7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD7 Gene

Orthologs for STARD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STARD7 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STARD7 30 31
  • 92.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stard7 30
  • 89.72 (n)
Mouse
(Mus musculus)
Mammalia Stard7 30 17 31
  • 89.1 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STARD7 30 31
  • 88.85 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STARD7 31
  • 84 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STARD7 31
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STARD7 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stard7 30
  • 67.01 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-200l5.5 30
  • 64.58 (n)
STARD7 31
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004792 30
  • 45.97 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6565 30 32
  • 45.59 (n)
Worm
(Caenorhabditis elegans)
Secernentea C06H2.2 31
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7984 31
  • 30 (a)
OneToOne
Species where no ortholog for STARD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STARD7 Gene

ENSEMBL:
Gene Tree for STARD7 (if available)
TreeFam:
Gene Tree for STARD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STARD7: view image

Paralogs for STARD7 Gene

Paralogs for STARD7 Gene

genes like me logo Genes that share paralogs with STARD7: view

Variants for STARD7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STARD7 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs2276650 - p.Arg140Pro

Additional dbSNP identifiers (rs#s) for STARD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for STARD7 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv3591652 OTHER inversion 21293372
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv525780 CNV loss 19592680
nsv834305 CNV gain 17160897

Variation tolerance for STARD7 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD7 Gene

Disorders for STARD7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for STARD7 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with STARD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD7 Gene

Publications for STARD7 Gene

  1. GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization. (PMID: 15013637) Durand S … Genti-Raimondi S (Placenta 2004) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. (PMID: 30945288) Liu H … Yang C (The Journal of pathology 2019) 3
  4. Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2. (PMID: 31664034) Corbett MA … Gecz J (Nature communications 2019) 3
  5. PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. (PMID: 29301859) Saita S … Langer T (The EMBO journal 2018) 3

Products for STARD7 Gene

  • Signalway Proteins for STARD7

Sources for STARD7 Gene