Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind ... See more...

Aliases for STARD5 Gene

Aliases for STARD5 Gene

  • StAR Related Lipid Transfer Domain Containing 5 2 3 5
  • StAR-Related Lipid Transfer Protein 5 3 4
  • START Domain-Containing Protein 5 3 4
  • START Domain Containing 5 2 3
  • StAR-Related Lipid Transfer (START) Domain Containing 5 3
  • MGC10327 2
  • STARD5 5
  • StARD5 4

External Ids for STARD5 Gene

Previous GeneCards Identifiers for STARD5 Gene

  • GC15M077563
  • GC15M074762
  • GC15M079180
  • GC15M079320
  • GC15M079392
  • GC15M081601
  • GC15M058363

Summaries for STARD5 Gene

Entrez Gene Summary for STARD5 Gene

  • Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for STARD5 Gene

STARD5 (StAR Related Lipid Transfer Domain Containing 5) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Synthesis of bile acids and bile salts. Gene Ontology (GO) annotations related to this gene include lipid binding and bile acid binding. An important paralog of this gene is STARD6.

UniProtKB/Swiss-Prot Summary for STARD5 Gene

  • May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Gene Wiki entry for STARD5 Gene

Additional gene information for STARD5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STARD5 Gene

Genomics for STARD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STARD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J081321 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 607 +0.4 391 3.6 SP1 CREB1 ATF7 PRDM10 REST ZNF692 POLR2A TARDBP DDX20 ZNF143 STARD5 TMC3-AS1 ENSG00000286488 IL16
GH15J081291 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22 +25.8 25801 14.7 SP1 CREB1 REST ZNF692 POLR2A BACH1 FOXA1 LARP7 STAT3 JUND IL16 piR-53038 piR-59520 TLNRD1 STARD5 TMC3 ENSG00000271725 piR-46911
GH15J081284 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +37.3 37326 5.1 ARID3A RUNX3 NR2F2 HDGF POLR2A TBP ATF2 YY1 MTA3 REST lnc-STARD5-2 TLNRD1 STARD5 TMC3 ENSG00000271725 IL16 piR-46911
GH15J081409 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 -86.4 -86444 1.4 CEBPG CTCF REST RAD21 SCRT2 CEBPB ZNF335 SMC3 ZNF610 KLF17 TMC3-AS1 STARD5 TMC3 ENSG00000275995 piR-50748 MEX3B
GH15J081310 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +10.6 10607 6.1 CREB1 ZBTB33 ZNF629 RELA IKZF2 POLR2A ZNF600 PKNOX1 ATF7 EED TLNRD1 TMC3 ENSG00000271725 STARD5 IL16 ENSG00000286488 piR-32839
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STARD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STARD5

Top Transcription factor binding sites by QIAGEN in the STARD5 gene promoter:
  • c-Myb
  • c-Myc
  • FOXO4
  • GR
  • GR-alpha
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • N-Myc
  • STAT5B

Genomic Locations for STARD5 Gene

Genomic Locations for STARD5 Gene
chr15:81,309,053-81,324,183
(GRCh38/hg38)
Size:
15,131 bases
Orientation:
Minus strand
chr15:81,601,394-81,616,524
(GRCh37/hg19)
Size:
15,131 bases
Orientation:
Minus strand

Genomic View for STARD5 Gene

Genes around STARD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD5 Gene

Proteins for STARD5 Gene

  • Protein details for STARD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY2-STAR5_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 5
    Protein Accession:
    Q9NSY2
    Secondary Accessions:
    • P59094

    Protein attributes for STARD5 Gene

    Size:
    213 amino acids
    Molecular mass:
    23794 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STARD5 Gene

    Alternative splice isoforms for STARD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD5 Gene

Post-translational modifications for STARD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STARD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STARD5 Gene

Domains & Families for STARD5 Gene

Gene Families for STARD5 Gene

Protein Domains for STARD5 Gene

Suggested Antigen Peptide Sequences for STARD5 Gene

GenScript: Design optimal peptide antigens:
  • START domain-containing protein 5 (STAR5_HUMAN)
genes like me logo Genes that share domains with STARD5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STARD5 Gene

Function for STARD5 Gene

Molecular function for STARD5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Phenotypes From GWAS Catalog for STARD5 Gene

Gene Ontology (GO) - Molecular Function for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0015485 cholesterol binding IDA 18403318
GO:0032052 bile acid binding IEA --
GO:0120020 intermembrane cholesterol transfer activity IDA 18403318
genes like me logo Genes that share ontologies with STARD5: view
genes like me logo Genes that share phenotypes with STARD5: view

Animal Models for STARD5 Gene

MGI Knock Outs for STARD5:
  • Stard5 Stard5<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD5 Gene

Localization for STARD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD5 gene
Compartment Confidence
cytosol 4
extracellular 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with STARD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STARD5 Gene

Pathways & Interactions for STARD5 Gene

PathCards logo

SuperPathways for STARD5 Gene

genes like me logo Genes that share pathways with STARD5: view

Pathways by source for STARD5 Gene

1 GeneGo (Thomson Reuters) pathway for STARD5 Gene
  • Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

Interacting Proteins for STARD5 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000304032 Q9NSY2-STAR5_HUMAN for STARD5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for STARD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0015721 bile acid and bile salt transport TAS --
GO:0070508 cholesterol import IDA 18403318
GO:0120009 intermembrane lipid transfer IEA --
genes like me logo Genes that share ontologies with STARD5: view

No data available for SIGNOR curated interactions for STARD5 Gene

Drugs & Compounds for STARD5 Gene

No Compound Related Data Available

Transcripts for STARD5 Gene

mRNA/cDNA for STARD5 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD5

Alternative Splicing Database (ASD) splice patterns (SP) for STARD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6: - -

Relevant External Links for STARD5 Gene

GeneLoc Exon Structure for
STARD5

Expression for STARD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STARD5 Gene

mRNA differential expression in normal tissues according to GTEx for STARD5 Gene

This gene is overexpressed in Liver (x6.7), Skin - Sun Exposed (Lower leg) (x5.6), and Skin - Not Sun Exposed (Suprapubic) (x5.6).

Protein differential expression in normal tissues from HIPED for STARD5 Gene

This gene is overexpressed in Oral epithelium (21.0), Gallbladder (11.6), Esophagus (7.2), Liver (6.8), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STARD5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STARD5

SOURCE GeneReport for Unigene cluster for STARD5 Gene:

Hs.513075

Evidence on tissue expression from TISSUES for STARD5 Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Pancreas(4.1)
  • Stomach(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with STARD5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD5 Gene

Orthologs for STARD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STARD5 30 31
  • 99.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STARD5 30 31
  • 84.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STARD5 30 31
  • 84.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stard5 30
  • 84.12 (n)
Mouse
(Mus musculus)
Mammalia Stard5 30 17 31
  • 83.96 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia STARD5 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STARD5 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves STARD5 30 31
  • 66.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STARD5 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stard5 30
  • 64.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC796844 30
  • 59.75 (n)
STARD5 31
  • 50 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for STARD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for STARD5 Gene

ENSEMBL:
Gene Tree for STARD5 (if available)
TreeFam:
Gene Tree for STARD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STARD5: view image

Paralogs for STARD5 Gene

Paralogs for STARD5 Gene

(2) SIMAP similar genes for STARD5 Gene using alignment to 2 proteins:

  • STAR5_HUMAN
  • H0YLW4_HUMAN

Pseudogenes.org Pseudogenes for STARD5 Gene

genes like me logo Genes that share paralogs with STARD5: view

Variants for STARD5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STARD5 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs4384572 - p.Gly74Ser

Additional dbSNP identifiers (rs#s) for STARD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for STARD5 Gene

Variant ID Type Subtype PubMed ID
esv2749949 CNV deletion 23290073
nsv1048788 CNV loss 25217958

Variation tolerance for STARD5 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD5 Gene

Disorders for STARD5 Gene

Additional Disease Information for STARD5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for STARD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STARD5 Gene

Publications for STARD5 Gene

  1. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. (PMID: 12011452) Soccio RE … Breslow JL (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. (PMID: 15760897) Soccio RE … Breslow JL (The Journal of biological chemistry 2005) 3 23
  4. Human StarD5, a cytosolic StAR-related lipid binding protein. (PMID: 15897605) Rodriguez-Agudo D … Pandak WM (Journal of lipid research 2005) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for STARD5 Gene

Sources for STARD5 Gene