This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provide... See more...

Aliases for STARD3 Gene

Aliases for STARD3 Gene

  • StAR Related Lipid Transfer Domain Containing 3 2 3 5
  • Metastatic Lymph Node Gene 64 Protein 3 4
  • StAR-Related Lipid Transfer Protein 3 3 4
  • START Domain-Containing Protein 3 3 4
  • MLN 64 3 4
  • MLN64 3 4
  • CAB1 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 3 3
  • Steroidogenic Acute Regulatory Protein Related 3
  • Metastatic Lymph Node Protein 64 3
  • START Domain Containing 3 2
  • Protein CAB1 4
  • StARD3 4
  • Es64 3

External Ids for STARD3 Gene

Previous GeneCards Identifiers for STARD3 Gene

  • GC17P037292
  • GC17P039791
  • GC17P037703
  • GC17P038168
  • GC17P035046
  • GC17P037793
  • GC17P033587

Summaries for STARD3 Gene

Entrez Gene Summary for STARD3 Gene

  • This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for STARD3 Gene

STARD3 (StAR Related Lipid Transfer Domain Containing 3) is a Protein Coding gene. Diseases associated with STARD3 include Breast Cancer. Among its related pathways are Metabolism and Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF). Gene Ontology (GO) annotations related to this gene include lipid binding and cholesterol transporter activity. An important paralog of this gene is STARD3NL.

UniProtKB/Swiss-Prot Summary for STARD3 Gene

  • Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).

Additional gene information for STARD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STARD3 Gene

Genomics for STARD3 Gene

GeneHancer (GH) Regulatory Elements for STARD3 Gene

Promoters and enhancers for STARD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J039631 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 518.7 -2.4 -2378 8.2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C NRF1 POLR2G NCOR1 GTF2E2 PHF8 STARD3 MED24 PGAP3 MED1 CDK12 MSL1 LOC105371762 TCAP PNMT NEUROD2
GH17J039642 Promoter 0.6 EPDnew 500.4 +5.6 5639 0.1 ZNF623 HDAC2 RBM25 KDM1A ZMYM3 SMARCA5 STARD3 TCAP
GH17J040138 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 20.4 +503.3 503259 3.2 HNRNPK EP300 ZSCAN5C SIN3A NRF1 TCF12 ZNF300 POLR2G BCLAF1 RBAK CASC3 lnc-NR1D1-2 MED1 SMARCE1 CDK12 SNORD124 MED24 MSL1 RPL19 IGFBP4
GH17J040470 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 +849.4 849370 32.1 ZNF217 CTCF TCF12 ZNF300 POLR2G JUND FOS TEAD4 ZNF639 EP300 TNS4 SNORD124 SMARCE1 IGFBP4 MED24 THRA KRT10 STARD3 RPL23AP75 KRT222
GH17J040306 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +680.6 680586 23.1 RXRA ZBTB40 ZNF217 CTCF SIN3A TCF12 NRF1 ZNF300 POLR2G USF1 RARA ENSG00000287644 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 TMEM99 CDC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STARD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STARD3

Top Transcription factor binding sites by QIAGEN in the STARD3 gene promoter:
  • Oct-B1
  • oct-B3
  • Sp1

Genomic Locations for STARD3 Gene

Genomic Locations for STARD3 Gene
chr17:39,637,080-39,664,201
(GRCh38/hg38)
Size:
27,122 bases
Orientation:
Plus strand
chr17:37,793,318-37,820,454
(GRCh37/hg19)
Size:
27,137 bases
Orientation:
Plus strand

Genomic View for STARD3 Gene

Genes around STARD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD3 Gene

Proteins for STARD3 Gene

  • Protein details for STARD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14849-STAR3_HUMAN
    Recommended name:
    StAR-related lipid transfer protein 3
    Protein Accession:
    Q14849
    Secondary Accessions:
    • A8MXA4
    • B4DUY1
    • F5H0G2
    • Q53Y53
    • Q96HM9

    Protein attributes for STARD3 Gene

    Size:
    445 amino acids
    Molecular mass:
    50502 Da
    Quaternary structure:
    • Homodimer (PubMed:15718238, PubMed:16709157). Interacts (via the MENTAL domain) with STARD3NL (PubMed:15718238, PubMed:16709157). Interacts (via FFAT motif) with VAPA (PubMed:24105263, PubMed:28377464). Interacts (via FFAT motif) with VAPB (PubMed:24105263, PubMed:28377464).

    Three dimensional structures from OCA and Proteopedia for STARD3 Gene

    Alternative splice isoforms for STARD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STARD3 Gene

Post-translational modifications for STARD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD3 Gene

Domains & Families for STARD3 Gene

Gene Families for STARD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins
  • Transporters

Protein Domains for STARD3 Gene

Blocks:
  • Lipid-binding START
  • Steroidogenic acute regulatory protein signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STARD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59424, highly similar to MLN 64 protein (A8MXA4_HUMAN)
  • START domain-containing protein 3 (STAR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14849

UniProtKB/Swiss-Prot:

STAR3_HUMAN :
  • The FFAT motif mediates interaction with VAPA and VAPB.
  • Belongs to the STARD3 family.
Domain:
  • The FFAT motif mediates interaction with VAPA and VAPB.
  • The START domain mediates lipid-transfer between membranes. It contains a hydrophobic cavity able to accommodate one lipid molecule, thereby serving as a 'hydrophobic bridge' across the aqueous gap between donor and acceptor organelle membranes.
  • The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (PubMed:11053434). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).
Family:
  • Belongs to the STARD3 family.
genes like me logo Genes that share domains with STARD3: view

Function for STARD3 Gene

Molecular function for STARD3 Gene

UniProtKB/Swiss-Prot Function:
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).
UniProtKB/Swiss-Prot Induction:
Not regulated by increases in total cholesterol content, or by marked alterations in cholesterol flux.

Phenotypes From GWAS Catalog for STARD3 Gene

Gene Ontology (GO) - Molecular Function for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15718238
GO:0008289 lipid binding IEA --
GO:0015485 cholesterol binding IDA 12011453
GO:0042803 protein homodimerization activity IDA 15718238
GO:0120020 intermembrane cholesterol transfer activity IEA --
genes like me logo Genes that share ontologies with STARD3: view
genes like me logo Genes that share phenotypes with STARD3: view

Animal Models for STARD3 Gene

MGI Knock Outs for STARD3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD3 Gene

Localization for STARD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD3 Gene

Late endosome membrane; Multi-pass membrane protein. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269 PubMed:24105263}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD3 gene
Compartment Confidence
endosome 5
nucleus 4
cytosol 4
plasma membrane 3
mitochondrion 3
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9139840
GO:0005739 mitochondrion IEA --
GO:0005765 lysosomal membrane HDA 17897319
genes like me logo Genes that share ontologies with STARD3: view

Pathways & Interactions for STARD3 Gene

PathCards logo

SuperPathways for STARD3 Gene

genes like me logo Genes that share pathways with STARD3: view

Pathways by source for STARD3 Gene

1 GeneGo (Thomson Reuters) pathway for STARD3 Gene
  • Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

Gene Ontology (GO) - Biological Process for STARD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 7490069
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0006701 progesterone biosynthetic process IEA --
GO:0006839 mitochondrial transport TAS 9270027
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with STARD3: view

No data available for SIGNOR curated interactions for STARD3 Gene

Drugs & Compounds for STARD3 Gene

(2) Drugs for STARD3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for STARD3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STARD3: view

Transcripts for STARD3 Gene

mRNA/cDNA for STARD3 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - -
SP18:
SP19: - - - - - - -
SP20:
SP21:
SP22:
SP23: - - - - - -
SP24:

ExUns: 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:

ExUns: 17b ^ 18
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for STARD3 Gene

GeneLoc Exon Structure for
STARD3

Expression for STARD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STARD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STARD3 Gene

This gene is overexpressed in Plasma (20.4), Lung (19.0), and Cervix (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STARD3 Gene



Protein tissue co-expression partners for STARD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STARD3

SOURCE GeneReport for Unigene cluster for STARD3 Gene:

Hs.728838

mRNA Expression by UniProt/SwissProt for STARD3 Gene:

Q14849-STAR3_HUMAN
Tissue specificity: Expressed in retina.

Evidence on tissue expression from TISSUES for STARD3 Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Intestine(4.3)
  • Skin(4.3)
  • Spleen(4.3)
  • Lymph node(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with STARD3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD3 Gene

Orthologs for STARD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD3 31 30
  • 98.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STARD3 31 30
  • 91.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STARD3 31 30
  • 90.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stard3 17 31 30
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Stard3 30
  • 88.31 (n)
oppossum
(Monodelphis domestica)
Mammalia STARD3 31
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STARD3 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD3 31 30
  • 76.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STARD3 31
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard3 30
  • 70.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68989 30
zebrafish
(Danio rerio)
Actinopterygii stard3 31 30
  • 67.82 (n)
OneToOne
mln64-pen 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007057 30
  • 49.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta Start1 31 30
  • 48.85 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-340 31 30
  • 41.76 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for STARD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD3 Gene

ENSEMBL:
Gene Tree for STARD3 (if available)
TreeFam:
Gene Tree for STARD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STARD3: view image

Paralogs for STARD3 Gene

Paralogs for STARD3 Gene

(2) SIMAP similar genes for STARD3 Gene using alignment to 11 proteins:

  • STAR3_HUMAN
  • C9J555_HUMAN
  • J3KSH0_HUMAN
  • J3KSL3_HUMAN
  • J3KT87_HUMAN
  • J3QLA7_HUMAN
  • J3QLM1_HUMAN
  • J3QLS1_HUMAN
  • J3QRG8_HUMAN
  • J3QRM3_HUMAN
  • J3QS10_HUMAN

Pseudogenes.org Pseudogenes for STARD3 Gene

genes like me logo Genes that share paralogs with STARD3: view

Variants for STARD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STARD3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs11556624 - p.Gly216Ala
rs1877031 - p.Arg117Gln

Additional dbSNP identifiers (rs#s) for STARD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for STARD3 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
nsv2047 CNV insertion 18451855
nsv457738 CNV loss 19166990
nsv473159 CNV novel sequence insertion 20440878
nsv516757 CNV loss 19592680
nsv521294 CNV loss 19592680
nsv528093 CNV loss 19592680
nsv574991 CNV loss 21841781
nsv574992 CNV loss 21841781

Variation tolerance for STARD3 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.10; 96.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD3 Gene

Human Gene Mutation Database (HGMD)
STARD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD3 Gene

Disorders for STARD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STARD3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STARD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STARD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD3 Gene

Publications for STARD3 Gene

  1. MLN64 and MENTHO, two mediators of endosomal cholesterol transport. (PMID: 16709157) Alpy F … Tomasetto C (Biochemical Society transactions 2006) 3 4 23 54
  2. Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol. (PMID: 16990645) Murcia M … Roux B (Journal of lipid research 2006) 3 4 23 54
  3. Functional characterization of the MENTAL domain. (PMID: 15718238) Alpy F … Tomasetto C (The Journal of biological chemistry 2005) 3 4 23 54
  4. MLN64 is involved in actin-mediated dynamics of late endocytic organelles. (PMID: 15930133) Hölttä-Vuori M … Ikonen E (Molecular biology of the cell 2005) 3 4 23 54
  5. MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria. (PMID: 12070139) Zhang M … Strauss JF (The Journal of biological chemistry 2002) 3 4 23 54

Products for STARD3 Gene