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Aliases for STARD13 Gene

Aliases for STARD13 Gene

  • StAR Related Lipid Transfer Domain Containing 13 2 3 5
  • Long Intergenic Non-Protein Coding RNA 464 2 3
  • Deleted In Liver Cancer 2 Protein 3 4
  • GT650 3 4
  • Dlc2 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 13 3
  • Rho GTPase Activating Protein On Chromosome 13q12 3
  • StAR-Related Lipid Transfer Protein 13 3
  • START Domain-Containing Protein 13 4
  • Rho GTPase-Activating Protein 4
  • START Domain Containing 13 2
  • LINC00464 3
  • ARHGAP37 3
  • 46H23.2 4
  • StARD13 4
  • DLC-2 4

External Ids for STARD13 Gene

Previous HGNC Symbols for STARD13 Gene

  • LINC00464

Previous GeneCards Identifiers for STARD13 Gene

  • GC13M031663
  • GC13M027663
  • GC13M032613
  • GC13M031475
  • GC13M032575
  • GC13M033677
  • GC13M014489

Summaries for STARD13 Gene

Entrez Gene Summary for STARD13 Gene

  • This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for STARD13 Gene

STARD13 (StAR Related Lipid Transfer Domain Containing 13) is a Protein Coding gene. Diseases associated with STARD13 include Hepatocellular Carcinoma and Arteriovenous Malformations Of The Brain. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and lipid binding. An important paralog of this gene is DLC1.

UniProtKB/Swiss-Prot for STARD13 Gene

  • GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.

Gene Wiki entry for STARD13 Gene

Additional gene information for STARD13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD13 Gene

Genomics for STARD13 Gene

GeneHancer (GH) Regulatory Elements for STARD13 Gene

Promoters and enhancers for STARD13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I033270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.4 +398.3 398255 16.6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 YY1 SLC30A9 STARD13 N4BP2L2 STARD13-AS RFC3 KL LINC02344
GH13I033202 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570 +471.0 470972 7.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 RAD21 RARA HSF1 SCRT2 ZNF143 STARD13 STARD13-AS KL LINC02344
GH13I033181 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.2 +485.5 485522 18.8 HDGF PKNOX1 FOXA2 SMAD1 FEZF1 YBX1 IRF4 ZNF207 ZNF143 ATF7 STARD13 KL STARD13-AS LINC02344
GH13I033674 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE 550.8 -0.9 -894 5.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 IRF4 YY1 ZNF766 ZNF207 ENSG00000230490 STARD13 RFC3
GH13I033255 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.6 +414.9 414908 12.6 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 FOS RXRA SP5 STARD13-AS STARD13 KL LINC02344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STARD13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STARD13 gene promoter:

Genomic Locations for STARD13 Gene

Genomic Locations for STARD13 Gene
573,701 bases
Minus strand

Genomic View for STARD13 Gene

Genes around STARD13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD13 Gene

Proteins for STARD13 Gene

  • Protein details for STARD13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    StAR-related lipid transfer protein 13
    Protein Accession:
    Secondary Accessions:
    • A2A309
    • A2A310
    • Q5HYH1
    • Q5TAE3
    • Q6UN61
    • Q86TP6
    • Q86WQ3
    • Q86XT1

    Protein attributes for STARD13 Gene

    1113 amino acids
    Molecular mass:
    124967 Da
    Quaternary structure:
    • Homodimer. Interacts with TAX1BP1.

    Three dimensional structures from OCA and Proteopedia for STARD13 Gene

    Alternative splice isoforms for STARD13 Gene


neXtProt entry for STARD13 Gene

Post-translational modifications for STARD13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD13 Gene

Domains & Families for STARD13 Gene

Gene Families for STARD13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD13: view

No data available for UniProtKB/Swiss-Prot for STARD13 Gene

Function for STARD13 Gene

Molecular function for STARD13 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.

Phenotypes From GWAS Catalog for STARD13 Gene

Gene Ontology (GO) - Molecular Function for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 14697242
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD13: view
genes like me logo Genes that share phenotypes with STARD13: view

Animal Models for STARD13 Gene

MGI Knock Outs for STARD13:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD13 Gene

Localization for STARD13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD13 Gene

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD13 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 3
cytoskeleton 2
plasma membrane 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005811 lipid droplet IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STARD13: view

Pathways & Interactions for STARD13 Gene

genes like me logo Genes that share pathways with STARD13: view

Pathways by source for STARD13 Gene

1 GeneTex pathway for STARD13 Gene
3 Reactome pathways for STARD13 Gene

Gene Ontology (GO) - Biological Process for STARD13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043542 endothelial cell migration IMP 20208559
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP 20208559
genes like me logo Genes that share ontologies with STARD13: view

No data available for SIGNOR curated interactions for STARD13 Gene

Drugs & Compounds for STARD13 Gene

No Compound Related Data Available

Transcripts for STARD13 Gene

Unigene Clusters for STARD13 Gene

StAR-related lipid transfer (START) domain containing 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP10: - -
SP12: -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP9: -

Relevant External Links for STARD13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STARD13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD13 Gene

Protein differential expression in normal tissues from HIPED for STARD13 Gene

This gene is overexpressed in Heart (17.0), Urinary Bladder (13.3), Fetal heart (9.2), Platelet (7.2), Kidney (6.9), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STARD13 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD13 Gene:


SOURCE GeneReport for Unigene cluster for STARD13 Gene:


mRNA Expression by UniProt/SwissProt for STARD13 Gene:

Tissue specificity: Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.

Evidence on tissue expression from TISSUES for STARD13 Gene

  • Skin(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with STARD13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD13 Gene

Orthologs for STARD13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for STARD13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STARD13 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia STARD13 33 34
  • 87.59 (n)
(Bos Taurus)
Mammalia STARD13 33 34
  • 86.29 (n)
(Monodelphis domestica)
Mammalia STARD13 34
  • 86 (a)
(Mus musculus)
Mammalia Stard13 33 16 34
  • 85.88 (n)
(Rattus norvegicus)
Mammalia Stard13 33
  • 85 (n)
(Ornithorhynchus anatinus)
Mammalia STARD13 34
  • 71 (a)
(Gallus gallus)
Aves STARD13 33 34
  • 75.41 (n)
(Anolis carolinensis)
Reptilia STARD13 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stard13 33
  • 69.32 (n)
Str.6797 33
(Danio rerio)
Actinopterygii stard13a 33 34
  • 66.35 (n)
stard13b 34
  • 49 (a)
si:dkeyp-23e4.3 34
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for STARD13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STARD13 Gene

Gene Tree for STARD13 (if available)
Gene Tree for STARD13 (if available)

Paralogs for STARD13 Gene

(3) SIMAP similar genes for STARD13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with STARD13: view

Variants for STARD13 Gene

Sequence variations from dbSNP and Humsavar for STARD13 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000002973 -- 33,528,868(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000009352 -- 33,626,344(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000019025 -- 33,323,596(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000023608 -- 33,358,209(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000040681 -- 33,488,386(-) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STARD13 Gene

Variant ID Type Subtype PubMed ID
dgv100e215 CNV deletion 23714750
dgv3108n54 CNV loss 21841781
dgv3109n54 CNV loss 21841781
dgv3110n54 CNV loss 21841781
dgv3111n54 CNV loss 21841781
dgv320n67 CNV loss 20364138
dgv345e199 CNV deletion 23128226
dgv346e199 CNV deletion 23128226
esv1005893 CNV deletion 20482838
esv1518161 CNV insertion 17803354
esv21834 CNV gain 19812545
esv2410834 CNV deletion 18987734
esv2421478 CNV deletion 20811451
esv2609362 CNV deletion 19546169
esv2661694 CNV deletion 23128226
esv2661972 CNV deletion 23128226
esv27387 CNV loss 19812545
esv2747244 CNV deletion 23290073
esv2747245 CNV deletion 23290073
esv2747246 CNV deletion 23290073
esv2747247 CNV deletion 23290073
esv275565 CNV loss 21479260
esv29481 CNV loss 19812545
esv32975 CNV loss 17666407
esv3302542 CNV tandem duplication 20981092
esv3444349 CNV duplication 20981092
esv3550291 CNV deletion 23714750
esv3550292 CNV deletion 23714750
esv3631736 CNV loss 21293372
esv3631737 CNV loss 21293372
esv3631738 CNV gain 21293372
esv3631739 CNV loss 21293372
esv3631740 CNV loss 21293372
esv3631741 CNV loss 21293372
esv3631743 CNV loss 21293372
esv3892325 CNV loss 25118596
nsv1069499 CNV deletion 25765185
nsv1069745 CNV deletion 25765185
nsv1112261 CNV deletion 24896259
nsv1132369 CNV duplication 24896259
nsv1141760 CNV insertion 24896259
nsv1146668 CNV insertion 26484159
nsv436167 CNV deletion 17901297
nsv437163 CNV loss 16327808
nsv438249 CNV loss 16468122
nsv472661 CNV novel sequence insertion 20440878
nsv476544 CNV novel sequence insertion 20440878
nsv477627 CNV novel sequence insertion 20440878
nsv510328 OTHER sequence alteration 20534489
nsv510578 CNV deletion 20534489
nsv514693 CNV loss 21397061
nsv519343 CNV loss 19592680
nsv526667 CNV loss 19592680
nsv561435 CNV gain 21841781
nsv561447 CNV loss 21841781
nsv561455 CNV loss 21841781
nsv63989 CNV deletion 16902084
nsv819300 CNV gain 19587683
nsv820553 CNV deletion 20802225
nsv832578 CNV gain 17160897
nsv9065 CNV gain 18304495
nsv958139 CNV deletion 24416366
nsv983738 CNV deletion 23825009
nsv991 CNV deletion 18451855
nsv992 CNV insertion 18451855
nsv993 CNV deletion 18451855
nsv994 CNV deletion 18451855

Variation tolerance for STARD13 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.21; 88.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD13 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD13 Gene

Disorders for STARD13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for STARD13 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
arteriovenous malformations of the brain
  • bavm
fibrosarcoma of bone
  • fibrosarcoma of the bone
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STARD13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STARD13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD13 Gene

Publications for STARD13 Gene

  1. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. (PMID: 16217026) Leung TH … Ng IO (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  2. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. (PMID: 12531887) Ching YP … Ng IO (The Journal of biological chemistry 2003) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Genome-wide association study of intracranial aneurysm identifies three new risk loci. (PMID: 20364137) Yasuno K … Günel M (Nature genetics 2010) 3 44 58

Products for STARD13 Gene

Sources for STARD13 Gene

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