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This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumo... See more...
Aliases for STARD13 Gene
Aliases for STARD13 Gene
External Ids for STARD13 Gene
- HGNC: 19164
- NCBI Entrez Gene: 90627
- Ensembl: ENSG00000133121
- OMIM®: 609866
- UniProtKB/Swiss-Prot: Q9Y3M8
Previous HGNC Symbols for STARD13 Gene
- LINC00464
Previous GeneCards Identifiers for STARD13 Gene
- GC13M031663
- GC13M027663
- GC13M032613
- GC13M031475
- GC13M032575
- GC13M033677
- GC13M014489
Summaries for STARD13 Gene
-
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for STARD13 Gene
STARD13 (StAR Related Lipid Transfer Domain Containing 13) is a Protein Coding gene. Diseases associated with STARD13 include Hepatocellular Carcinoma and Intracranial Aneurysm. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and lipid binding. An important paralog of this gene is DLC1.
UniProtKB/Swiss-Prot Summary for STARD13 Gene
-
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
Additional gene information for STARD13 Gene
- HGNC (19164)
- NCBI Entrez Gene (90627)
- Ensembl (ENSG00000133121)
- OMIM® (609866)
- UniProtKB/Swiss-Prot (Q9Y3M8)
- Open Targets Platform(ENSG00000133121)
- Monarch Initiative
- Search for STARD13 at DataMed
- Search for STARD13 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STARD13 Gene
Genomics for STARD13 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STARD13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STARD13 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STARD13
- Top Transcription factor binding sites by QIAGEN in the STARD13 gene promoter:
-
- CUTL1
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
Genomic Locations for STARD13 Gene
Latest Assembly
- chr13:33,103,137-33,676,829
- (GRCh38/hg38)
- Size:
- 573,693 bases
- Orientation:
- Minus strand
Previous Assembly
- chr13:33,677,274-34,250,931
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 573,658 bases
- Orientation:
- Minus strand
- chr13:33,677,272-33,924,767
- (GRCh37/hg19 by Ensembl)
- Size:
- 247,496 bases
- Orientation:
- Minus strand
Genomic View for STARD13 Gene
Genes around STARD13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q13.1 by HGNC
- 13q13.1-q13.2 by Entrez Gene
- 13q13.1 by Ensembl
STARD13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STARD13 Gene
Proteins for STARD13 Gene
-
Protein details for STARD13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3M8-STA13_HUMAN
- Recommended name:
- StAR-related lipid transfer protein 13
- Protein Accession:
- Q9Y3M8
- A2A309
- A2A310
- Q5HYH1
- Q5TAE3
- Q6UN61
- Q86TP6
- Q86WQ3
- Q86XT1
Protein attributes for STARD13 Gene
- Size:
- 1113 amino acids
- Molecular mass:
- 124967 Da
- Quaternary structure:
-
- Homodimer. Interacts with TAX1BP1.
Three dimensional structures from OCA and Proteopedia for STARD13 Gene
Protein Expression for STARD13 Gene
Post-translational modifications for STARD13 Gene
Other Protein References for STARD13 Gene
Antibodies for research
- G Biosciences Immunotag™ STA13 Antibody
- Novus Biologicals Antibodies for STARD13
-
Abcam antibodies for STARD13
- Invitrogen Antibodies for STARD13 (AFLGC-STARD13)
-
Biorbyt antibodies for STARD13
-
Custom Antibody ServicesProSci Antibodies for STARD13
-
Santa Cruz Biotechnology (SCBT) Antibodies for STARD13
Protein products for research
-
OriGene Purified Proteins for STARD13
- Search Origene for MassSpec and Protein Over-expression Lysates for STARD13
- Origene Custom Protein Services for STARD13
- antibodies-online: Show 3 available STARD13 Proteins ranked by validation data
- Compare Top STARD13 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Show 4 available STARD13 Elisa Kits ranked by validation data
- Compare Top STARD13 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for STARD13 Gene
Domains & Families for STARD13 Gene
Gene Families for STARD13 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for STARD13 Gene
- InterPro:
- Blocks:
-
- RhoGAP domain
- Lipid-binding START
- Sterile alpha motif homology 2
- ProtoNet:
Suggested Antigen Peptide Sequences for STARD13 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93332, Homo sapiens START domain containing 13 (STARD13), transcriptvariant gamma, mRNA (B2R789_HUMAN)
- START domain-containing protein 13 (STA13_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for STARD13 Gene
Function for STARD13 Gene
Molecular function for STARD13 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
Phenotypes From GWAS Catalog for STARD13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA,IPI | 14697242 |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for STARD13 Gene
- MGI mutant phenotypes for STARD13:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for STARD13:
Animal Models for STARD13 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STARD13 - Starting at $85 >
- * STARD13 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STARD13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STARD13
-
Santa Cruz Biotechnology (SCBT) CRISPR for STARD13
miRNA for STARD13 Gene
- miRTarBase miRNAs that target STARD13
-
- hsa-miR-125b-5p (MIRT006849)
- mmu-miR-301b-3p (MIRT008041)
- mmu-miR-223-3p (MIRT009711)
- mmu-miR-19b-3p (MIRT012546)
- mmu-miR-190a-5p (MIRT013678)
- hsa-miR-122-5p (MIRT023222)
- hsa-miR-4452 (MIRT276324)
- hsa-miR-3658 (MIRT500906)
- hsa-miR-1231 (MIRT500907)
- hsa-miR-183-3p (MIRT500908)
- hsa-miR-516b-5p (MIRT500909)
- hsa-miR-4276 (MIRT500910)
- hsa-miR-4653-3p (MIRT500911)
- hsa-miR-219a-1-3p (MIRT500912)
- hsa-miR-570-3p (MIRT500913)
- hsa-miR-3591-3p (MIRT500914)
- hsa-miR-21-3p (MIRT500915)
- hsa-miR-148b-3p (MIRT500916)
- hsa-miR-152-3p (MIRT500917)
- hsa-miR-148a-3p (MIRT500918)
- hsa-miR-301b-3p (MIRT500919)
- hsa-miR-301a-3p (MIRT500920)
- hsa-miR-454-3p (MIRT500921)
- hsa-miR-3666 (MIRT500922)
- hsa-miR-130b-3p (MIRT500923)
- hsa-miR-130a-3p (MIRT500924)
- hsa-miR-4295 (MIRT500925)
- hsa-miR-9-5p (MIRT733880)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STARD13
- Browse OriGene Inhibitory RNA Products For STARD13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD13
Clone products for research
- Applied Biological Materials (abm): Clones for STARD13 - Starting at $45 >
- * STARD13 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211650
- MG219198
- MR211650
- MR211650L3
- MR211650L4
- MR219198
- MR219198L3
- MR219198L4
- RC214456
- RC214456L3
- RC214456L4
- RC217815
- RC217815L3
- RC217815L4
- RC220640
- RC220640L3
- RC220640L4
- RC234649
- RC234716
- RC235159
- RG214456
- RG217815
- RG220640
- RG234649
- RG234716
- RG235159
- RR210290
- RR210290L3
- RR210290L4
- MR211650L3V
- MR211650L4V
- MR219198L3V
- MR219198L4V
- RC214456L3V
- RC214456L4V
- RC217815L3V
- RC217815L4V
- RC220640L3V
- RC220640L4V
- RR210290L3V
- RR210290L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STARD13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STARD13
Cell Lines for research
-
Horizon Cell Lines for STARD13
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD13 Gene
Localization for STARD13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STARD13 Gene
- Cytoplasm. Membrane. Peripheral membrane protein. Cytoplasmic side. Mitochondrion membrane. Peripheral membrane protein. Cytoplasmic side. Lipid droplet.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endosome | 2 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005811 | lipid droplet | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for STARD13 Gene
Pathways & Interactions for STARD13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Rho GTPases | ||
Pathways by source for STARD13 Gene
3 Reactome pathways for STARD13 Gene
1 GeneTex pathway for STARD13 Gene
Interacting Proteins for STARD13 Gene
Selected Interacting proteins:
Q9Y3M8-STA13_HUMAN
ENSP00000338785
for STARD13 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STARD13
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0030036 | actin cytoskeleton organization | IBA | 21873635 |
| GO:0035023 | regulation of Rho protein signal transduction | IBA | 21873635 |
| GO:0043542 | endothelial cell migration | IMP | 20208559 |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
Transcripts for STARD13 Gene
mRNA/cDNA for STARD13 Gene
- 7 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000255486 5798 nts (view in UCSC)
- ENST00000336934 5915 nts (view in UCSC)
- ENST00000344312 524 nts (view in UCSC)
- ENST00000399365 5784 nts (view in UCSC)
- ENST00000439831 945 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STARD13 - Starting at $85 >
- * STARD13 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STARD13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STARD13
-
Santa Cruz Biotechnology (SCBT) CRISPR for STARD13
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STARD13
- Browse OriGene Inhibitory RNA Products For STARD13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STARD13
Clone products for research
- Applied Biological Materials (abm): Clones for STARD13 - Starting at $45 >
- * STARD13 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211650
- MG219198
- MR211650
- MR211650L3
- MR211650L4
- MR219198
- MR219198L3
- MR219198L4
- RC214456
- RC214456L3
- RC214456L4
- RC217815
- RC217815L3
- RC217815L4
- RC220640
- RC220640L3
- RC220640L4
- RC234649
- RC234716
- RC235159
- RG214456
- RG217815
- RG220640
- RG234649
- RG234716
- RG235159
- RR210290
- RR210290L3
- RR210290L4
- MR211650L3V
- MR211650L4V
- MR219198L3V
- MR219198L4V
- RC214456L3V
- RC214456L4V
- RC217815L3V
- RC217815L4V
- RC220640L3V
- RC220640L4V
- RR210290L3V
- RR210290L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for STARD13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STARD13
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | - | ||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: |
Relevant External Links for STARD13 Gene
- GeneLoc Exon Structure for
- STARD13
Expression for STARD13 Gene
This gene is overexpressed in Heart (17.0), Urinary Bladder (13.3), Fetal heart (9.2), Platelet (7.2), Kidney (6.9), and Frontal cortex (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STARD13 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STARD13
SOURCE GeneReport for Unigene cluster for STARD13 Gene:
Hs.507704mRNA Expression by UniProt/SwissProt for STARD13 Gene:
Q9Y3M8-STA13_HUMAN
Tissue specificity:
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
Evidence on tissue expression from TISSUES for STARD13 Gene
- Skin(4.4)
- Nervous system(2.5)
- Heart(2.3)
- Kidney(2.2)
- Intestine(2.2)
- Lung(2.1)
- Liver(2.1)
Primer products for research
-
OriGene qPCR primer pairs for STARD13
-
OriGene qPCR primer pairs and template standards for STARD13
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD13 Gene
Orthologs for STARD13 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STARD13 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STARD13 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STARD13 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | STARD13 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Stard13 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stard13 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STARD13 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STARD13 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STARD13 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stard13 30 |
|
||
| Str.6797 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | stard13a 30 31 |
|
ManyToMany | |
| stard13b 31 |
|
ManyToMany | |||
| si:dkeyp-23e4.3 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for STARD13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for STARD13 Gene
- ENSEMBL:
- Gene Tree for STARD13 (if available)
- TreeFam:
- Gene Tree for STARD13 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STARD13: view image
Paralogs for STARD13 Gene
Variants for STARD13 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STARD13 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111691119 | Benign: not provided | 33,130,182(-) |
T/A NM_178006.4(STARD13):c.495A>T (p.Arg165=) |
SYNONYMOUS | |
| rs114088950 | Benign: not provided | 33,130,209(-) |
C/T NM_178006.4(STARD13):c.468G>A (p.Val156=) |
SYNONYMOUS | |
| rs114645645 | Likely Benign: not provided | 33,109,898(-) |
G/A NM_178006.4(STARD13):c.3022C>T (p.Pro1008Ser) |
MISSENSE | |
| rs117237914 | Benign: not provided | 33,106,808(-) |
C/T NM_178006.4(STARD13):c.3174G>A (p.Pro1058=) |
SYNONYMOUS | |
| rs142245407 | Likely Benign: not provided | 33,130,211(-) |
C/T NM_178006.4(STARD13):c.466G>A (p.Val156Met) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.21;
88.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STARD13 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD13 Gene
Disorders for STARD13 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
| intracranial aneurysm |
|
|
| arteriovenous malformations of the brain |
|
|
| non-syndromic x-linked intellectual disability |
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| adams-oliver syndrome |
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Search STARD13 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STARD13
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STARD13 Gene
Publications for STARD13 Gene
- Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. (PMID: 16217026) Leung TH … Ng IO (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
- Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. (PMID: 12531887) Ching YP … Ng IO (The Journal of biological chemistry 2003) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Genome-wide association study of intracranial aneurysm identifies three new risk loci. (PMID: 20364137) Yasuno K … Günel M (Nature genetics 2010) 3 41
ExternalLinks
Products for STARD13 Gene
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- antibodies-online: Show 3 available STARD13 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for STARD13
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- Santa Cruz Biotechnology (SCBT) CRISPR for STARD13
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- Horizon Cell Lines for STARD13
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STARD13
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Sources for STARD13 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
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