Aliases for STARD13 Gene
External Ids for STARD13 Gene
Previous HGNC Symbols for STARD13 Gene
Previous GeneCards Identifiers for STARD13 Gene
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for STARD13 Gene
STARD13 (StAR Related Lipid Transfer Domain Containing 13) is a Protein Coding gene. Diseases associated with STARD13 include Hepatocellular Carcinoma and Intracranial Aneurysm. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and lipid binding. An important paralog of this gene is DLC1.
UniProtKB/Swiss-Prot Summary for STARD13 Gene
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.