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Aliases for STARD10 Gene

Aliases for STARD10 Gene

  • StAR Related Lipid Transfer Domain Containing 10 2 3 5
  • Serologically Defined Colon Cancer Antigen 28 2 3 4
  • StAR-Related Lipid Transfer Protein 10 3 4
  • START Domain Containing 10 2 3
  • PCTP-Like Protein 3 4
  • Antigen NY-CO-28 3 4
  • SDCCAG28 3 4
  • PCTP-L 3 4
  • StAR-Related Lipid Transfer (START) Domain Containing 10 3
  • START Domain-Containing Protein 10 3
  • NY-CO-28 3
  • StARD10 4
  • CGI-52 3
  • PCTP2 3

External Ids for STARD10 Gene

Previous HGNC Symbols for STARD10 Gene

  • SDCCAG28

Previous GeneCards Identifiers for STARD10 Gene

  • GC11M074005
  • GC11M072192
  • GC11M072143
  • GC11M072465
  • GC11M068761

Summaries for STARD10 Gene

GeneCards Summary for STARD10 Gene

STARD10 (StAR Related Lipid Transfer Domain Containing 10) is a Protein Coding gene. Diseases associated with STARD10 include Hereditary Myopathy With Early Respiratory Failure. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for STARD10 Gene

  • May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Gene Wiki entry for STARD10 Gene

Additional gene information for STARD10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STARD10 Gene

Genomics for STARD10 Gene

GeneHancer (GH) Regulatory Elements for STARD10 Gene

Promoters and enhancers for STARD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I072775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 579.7 +11.1 11095 15.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A STARD10 MIR4692 FAM86C1 ARAP1 ENSG00000202522
GH11I072792 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 574.6 +0.1 106 3.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 STARD10 ARAP1 LOC105369380
GH11I072811 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.2 -20.0 -20042 5.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A ATG16L2 STARD10 ENSG00000248671 NUMA1 LOC100128494 ARAP1 ZNF705E RNU6-672P IL18BP ARAP1-AS1
GH11I072718 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +72.8 72814 5.3 HDGF PKNOX1 ATF1 ZNF2 BRCA1 YY1 POLR2B GLIS2 ZNF207 ZNF143 ARAP1 STARD10 LOC100128494 NUMA1 IL18BP ZNF705E OR7E126P ATG16L2 P2RY2 FCHSD2
GH11I072735 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 +54.0 53961 10 HDGF FOXA2 PKNOX1 YY1 ZNF143 FOS ZNF263 SP5 REST ZNF592 ARAP1 STARD10 ATG16L2 PDE2A P2RY2 FCHSD2 PIR40050 RPS12P20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STARD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STARD10 gene promoter:

Genomic Locations for STARD10 Gene

Genomic Locations for STARD10 Gene
chr11:72,754,729-72,794,168
(GRCh38/hg38)
Size:
39,440 bases
Orientation:
Minus strand
chr11:72,465,774-72,504,750
(GRCh37/hg19)

Genomic View for STARD10 Gene

Genes around STARD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STARD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STARD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STARD10 Gene

Proteins for STARD10 Gene

  • Protein details for STARD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y365-STA10_HUMAN
    Recommended name:
    START domain-containing protein 10
    Protein Accession:
    Q9Y365
    Secondary Accessions:
    • O60532

    Protein attributes for STARD10 Gene

    Size:
    291 amino acids
    Molecular mass:
    33049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC18045.1; Type=Miscellaneous discrepancy; Note=Various sequencing problems as well as a translation in a wrong frame.; Evidence={ECO:0000305}; Sequence=AAD34047.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for STARD10 Gene

Post-translational modifications for STARD10 Gene

  • Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STARD10 Gene

Domains & Families for STARD10 Gene

Gene Families for STARD10 Gene

Protein Domains for STARD10 Gene

Suggested Antigen Peptide Sequences for STARD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STARD10: view

No data available for UniProtKB/Swiss-Prot for STARD10 Gene

Function for STARD10 Gene

Molecular function for STARD10 Gene

UniProtKB/Swiss-Prot Function:
May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.

Phenotypes From GWAS Catalog for STARD10 Gene

Gene Ontology (GO) - Molecular Function for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with STARD10: view
genes like me logo Genes that share phenotypes with STARD10: view

Animal Models for STARD10 Gene

MGI Knock Outs for STARD10:

Animal Model Products

miRNA for STARD10 Gene

miRTarBase miRNAs that target STARD10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STARD10 Gene

Localization for STARD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STARD10 Gene

Cell projection, cilium, flagellum. Cytoplasm. Membrane. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STARD10 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IEA --
GO:0005902 microvillus IBA,IEA --
GO:0016020 membrane IBA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with STARD10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for STARD10 Gene

Pathways & Interactions for STARD10 Gene

genes like me logo Genes that share pathways with STARD10: view

Pathways by source for STARD10 Gene

Interacting Proteins for STARD10 Gene

SIGNOR curated interactions for STARD10 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for STARD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0032782 bile acid secretion IEA --
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with STARD10: view

Drugs & Compounds for STARD10 Gene

No Compound Related Data Available

Transcripts for STARD10 Gene

Unigene Clusters for STARD10 Gene

StAR-related lipid transfer (START) domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STARD10 Gene

No ASD Table

Relevant External Links for STARD10 Gene

GeneLoc Exon Structure for
STARD10
ECgene alternative splicing isoforms for
STARD10

Expression for STARD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STARD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STARD10 Gene

This gene is overexpressed in Liver (x9.6).

Protein differential expression in normal tissues from HIPED for STARD10 Gene

This gene is overexpressed in Breast (14.2) and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STARD10 Gene



Protein tissue co-expression partners for STARD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of STARD10 Gene:

STARD10

SOURCE GeneReport for Unigene cluster for STARD10 Gene:

Hs.188606

Evidence on tissue expression from TISSUES for STARD10 Gene

  • Liver(4.4)
  • Nervous system(3.9)
  • Intestine(3.4)
  • Gall bladder(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with STARD10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STARD10 Gene

Orthologs for STARD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STARD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STARD10 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia STARD10 33 34
  • 92.9 (n)
cow
(Bos Taurus)
Mammalia STARD10 33 34
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Stard10 33 16 34
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Stard10 33
  • 90.46 (n)
oppossum
(Monodelphis domestica)
Mammalia STARD10 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves STARD10 33 34
  • 71.41 (n)
lizard
(Anolis carolinensis)
Reptilia STARD10 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stard10 33
  • 73.28 (n)
Str.11784 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8320 33
zebrafish
(Danio rerio)
Actinopterygii zgc:77147 33
  • 72.28 (n)
STARD10 34
  • 43 (a)
OneToOne
zgc56270 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5576 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008308 33
  • 50.73 (n)
worm
(Caenorhabditis elegans)
Secernentea T28D6.7 33 34
  • 47.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9553 34
  • 40 (a)
OneToOne
Species where no ortholog for STARD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STARD10 Gene

ENSEMBL:
Gene Tree for STARD10 (if available)
TreeFam:
Gene Tree for STARD10 (if available)

Paralogs for STARD10 Gene

No data available for Paralogs for STARD10 Gene

Variants for STARD10 Gene

Sequence variations from dbSNP and Humsavar for STARD10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000024933 -- 72,755,537(-) C/T intron_variant
rs1000045807 -- 72,762,753(-) G/T intron_variant
rs1000186800 -- 72,755,757(-) T/A intron_variant
rs1000269491 -- 72,761,395(-) A/G intron_variant
rs1000345065 -- 72,775,320(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STARD10 Gene

Variant ID Type Subtype PubMed ID
esv2744771 CNV deletion 23290073
nsv1070051 CNV deletion 25765185
nsv1118220 CNV deletion 24896259
nsv825992 CNV gain 20364138
nsv832207 CNV loss 17160897

Variation tolerance for STARD10 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STARD10 Gene

Human Gene Mutation Database (HGMD)
STARD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STARD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STARD10 Gene

Disorders for STARD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STARD10 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
hereditary myopathy with early respiratory failure
  • hmerf
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for STARD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STARD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STARD10 Gene

Publications for STARD10 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan MJ … Old LJ (International journal of cancer 1998) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. (PMID: 17561512) Olayioye MA … Pomorski T (The Journal of biological chemistry 2007) 3 4 58
  4. StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein. (PMID: 15911624) Olayioye MA … Pomorski T (The Journal of biological chemistry 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for STARD10 Gene

Sources for STARD10 Gene

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