The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM... See more...

Aliases for STAM2 Gene

Aliases for STAM2 Gene

  • Signal Transducing Adaptor Molecule 2 2 3 5
  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 2 2 3
  • Signal Transducing Adapter Molecule 2 3 4
  • Hrs-Binding Protein 3 4
  • STAM-2 3 4
  • Hbp 2 3
  • STAM-Like Protein Containing SH3 And ITAM Domains 2 3
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3
  • STAM2A 3
  • STAM2B 3
  • STAM2 5
  • HBP 4

External Ids for STAM2 Gene

Previous GeneCards Identifiers for STAM2 Gene

  • GC02M150726
  • GC02M151504
  • GC02M152939
  • GC02M153177
  • GC02M152800
  • GC02M152683
  • GC02M144859

Summaries for STAM2 Gene

Entrez Gene Summary for STAM2 Gene

  • The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for STAM2 Gene

STAM2 (Signal Transducing Adaptor Molecule 2) is a Protein Coding gene. Among its related pathways are Clathrin-mediated endocytosis and Signaling by GPCR. An important paralog of this gene is STAM.

UniProtKB/Swiss-Prot Summary for STAM2 Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Gene Wiki entry for STAM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAM2 Gene

Genomics for STAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for STAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J152173 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 264 +0.8 776 4 BCLAF1 SP1 ZNF207 ZNF654 MYC ZNF600 NCOR1 IKZF1 SSRP1 ZNF580 STAM2 ENSG00000286234 LOC105373689 RIF1 PRPF40A piR-48820-055 CACNB4
GH02J152715 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 33.2 -542.6 -542624 6 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SIX5 SSRP1 JUND PRPF40A ARL6IP6 HSALNG0019679 HSALNG0019680 lnc-PRPF40A-5 STAM2 RPL30P2 RPRM
GH02J151408 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 33.2 +765.5 765501 3.8 BCLAF1 SP1 NCOR1 MYC IKZF1 SIX5 ZNF580 KLF9 POLR2A ZNF10 RIF1 STAM2 RPL30P2 TNFAIP6 RBM43 piR-49150 NEB
GH02J151288 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 25.1 +886.2 886233 3.9 BCLAF1 ZNF207 MYC IKZF1 ZNF592 POLR2A ATF3 NFIC ZIC2 YY1 NMI RBM43 HSALNG0019606 lnc-RBM43-3 TNFAIP6 RIF1 STAM2 RPL30P2
GH02J152503 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 32.5 -330.2 -330151 4.2 BCLAF1 BCL11A REST CEBPB BHLHE40 EP300 RXRA TAL1 ZNF316 NFE2 STAM2 PRPF40A RPL30P2 FMNL2 piR-60146-082 ENSG00000287085 ARL6IP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAM2

Top Transcription factor binding sites by QIAGEN in the STAM2 gene promoter:
  • c-Ets-1
  • CUTL1
  • E47
  • Evi-1
  • FOXI1
  • Hand1
  • HFH-3
  • LCR-F1
  • POU2F1
  • POU2F1a

Genomic Locations for STAM2 Gene

Latest Assembly
chr2:152,116,801-152,175,777
(GRCh38/hg38)
Size:
58,977 bases
Orientation:
Minus strand

Previous Assembly
chr2:152,973,315-153,032,277
(GRCh37/hg19 by Entrez Gene)
Size:
58,963 bases
Orientation:
Minus strand

chr2:152,973,315-153,032,506
(GRCh37/hg19 by Ensembl)
Size:
59,192 bases
Orientation:
Minus strand

Genomic View for STAM2 Gene

Genes around STAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM2 Gene

Proteins for STAM2 Gene

  • Protein details for STAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75886-STAM2_HUMAN
    Recommended name:
    Signal transducing adapter molecule 2
    Protein Accession:
    O75886
    Secondary Accessions:
    • A8K8A0
    • D3DPA1
    • Q7LDQ0
    • Q9UF58

    Protein attributes for STAM2 Gene

    Size:
    525 amino acids
    Molecular mass:
    58164 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity).

    Three dimensional structures from OCA and Proteopedia for STAM2 Gene

    Alternative splice isoforms for STAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM2 Gene

Post-translational modifications for STAM2 Gene

  • Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
  • Ubiquitination at Lys134, Lys189, Lys202, and Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for STAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STAM2 Gene

Domains & Families for STAM2 Gene

Gene Families for STAM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STAM2 Gene

InterPro:
Blocks:
  • SH3 domain signature
  • VHS

Suggested Antigen Peptide Sequences for STAM2 Gene

GenScript: Design optimal peptide antigens:
  • Hrs-binding protein (STAM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75886

UniProtKB/Swiss-Prot:

STAM2_HUMAN :
  • The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
  • Belongs to the STAM family.
Domain:
  • The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
  • The SH3 domain mediates the interaction with USP8.
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Family:
  • Belongs to the STAM family.
genes like me logo Genes that share domains with STAM2: view

Function for STAM2 Gene

Molecular function for STAM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Phenotypes From GWAS Catalog for STAM2 Gene

Gene Ontology (GO) - Molecular Function for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15231748
genes like me logo Genes that share ontologies with STAM2: view
genes like me logo Genes that share phenotypes with STAM2: view

Animal Models for STAM2 Gene

MGI Knock Outs for STAM2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAM2 Gene

Localization for STAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM2 Gene

Cytoplasm. Early endosome membrane. Peripheral membrane protein. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAM2 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 4
lysosome 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STAM2: view

Pathways & Interactions for STAM2 Gene

genes like me logo Genes that share pathways with STAM2: view

Pathways by source for STAM2 Gene

2 GeneGo (Thomson Reuters) pathways for STAM2 Gene
  • Delta508-CFTR traffic / Sorting endosome formation in CF
  • wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
2 Cell Signaling Technology pathways for STAM2 Gene

SIGNOR curated interactions for STAM2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for STAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0016236 macroautophagy TAS 20588296
genes like me logo Genes that share ontologies with STAM2: view

Drugs & Compounds for STAM2 Gene

No Compound Related Data Available

Transcripts for STAM2 Gene

mRNA/cDNA for STAM2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM2

Alternative Splicing Database (ASD) splice patterns (SP) for STAM2 Gene

No ASD Table

Relevant External Links for STAM2 Gene

GeneLoc Exon Structure for
STAM2

Expression for STAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAM2 Gene

Protein differential expression in normal tissues from HIPED for STAM2 Gene

This gene is overexpressed in Bone marrow stromal cell (9.3) and Fetal Brain (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAM2 Gene



Protein tissue co-expression partners for STAM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAM2

SOURCE GeneReport for Unigene cluster for STAM2 Gene:

Hs.17200

mRNA Expression by UniProt/SwissProt for STAM2 Gene:

O75886-STAM2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for STAM2 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Kidney(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with STAM2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAM2 Gene

Orthologs for STAM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STAM2 29 30
  • 99.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STAM2 29 30
  • 93.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia STAM2 29 30
  • 92.9 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia STAM2 30
  • 88 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Stam2 29 16 30
  • 86.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Stam2 29
  • 84.45 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 82 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
Chicken
(Gallus gallus)
Aves STAM2 29 30
  • 79.66 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STAM2 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia stam2 29
  • 70.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia stam2-prov 29
Zebrafish
(Danio rerio)
Actinopterygii stam2 30
  • 62 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Stam 29 30 31
  • 53.65 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea stam-1 30
  • 32 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 30 32
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1021 30
  • 38 (a)
OneToMany
Species where no ortholog for STAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for STAM2 Gene

ENSEMBL:
Gene Tree for STAM2 (if available)
TreeFam:
Gene Tree for STAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAM2: view image
Alliance of Genome Resources:
Additional Orthologs for STAM2

Paralogs for STAM2 Gene

(2) SIMAP similar genes for STAM2 Gene using alignment to 1 proteins:

  • STAM2_HUMAN
genes like me logo Genes that share paralogs with STAM2: view

Variants for STAM2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for STAM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for STAM2 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV loss 17911159
esv3592922 CNV loss 21293372
esv3592929 CNV loss 21293372
esv3592930 CNV gain 21293372
nsv1116802 CNV deletion 24896259
nsv459740 CNV loss 19166990
nsv583316 CNV loss 21841781
nsv7331 OTHER inversion 18451855
nsv821757 CNV gain 20364138

Variation tolerance for STAM2 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 45.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAM2
Leiden Open Variation Database (LOVD)
STAM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAM2 Gene

Disorders for STAM2 Gene

Additional Disease Information for STAM2

No disorders were found for STAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STAM2 Gene

Publications for STAM2 Gene

  1. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 22
  2. STAM2, a new member of the STAM family, binding to the Janus kinases. (PMID: 10899310) Endo K … Sugamura K (FEBS letters 2000) 2 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  4. The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. (PMID: 15882967) Lechner MS … Rauscher FJ (Biochemical and biophysical research communications 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for STAM2 Gene

Sources for STAM2 Gene