This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for tr... See more...

Aliases for STAM Gene

Aliases for STAM Gene

  • Signal Transducing Adaptor Molecule 2 3 5
  • Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif) 1 2 3
  • Signal Transducing Adapter Molecule 1 3 4
  • STAM-1 3 4
  • STAM1 3 4
  • HSE1 Homolog (S. Cerevisiae) 2
  • HSE1 Homolog 3

External Ids for STAM Gene

Previous GeneCards Identifiers for STAM Gene

  • GC10P017668
  • GC10P017836
  • GC10P017690
  • GC10P017726
  • GC10P017686
  • GC10P017598

Summaries for STAM Gene

Entrez Gene Summary for STAM Gene

  • This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for STAM Gene

STAM (Signal Transducing Adaptor Molecule) is a Protein Coding gene. Diseases associated with STAM include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease. Among its related pathways are Metabolism of proteins and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is STAM2.

UniProtKB/Swiss-Prot Summary for STAM Gene

  • Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gene Wiki entry for STAM Gene

Additional gene information for STAM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAM Gene

Genomics for STAM Gene

GeneHancer (GH) Regulatory Elements for STAM Gene

Promoters and enhancers for STAM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J017642 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 513.5 +3.0 3030 9.6 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 GTF2E2 PHF8 TEAD4 ZNF639 STAM HACD1 ENSG00000240291 NONHSAG005333.2 STAM-AS1 lnc-STAM-1 ENSG00000229190
GH10J017661 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.4 +25.5 25501 15.9 EP300 FOXK2 ZNF217 TCF12 USF1 NCOR1 BCLAF1 JUND PHB2 FOS STAM VIM HACD1 ST8SIA6 NONHSAG005333.2 ENSG00000229190
GH10J017654 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +13.2 13175 6.6 NRF1 GTF2E2 JUND AFF1 REST RELA EP300 CTBP1 JUN TRIM25 STAM HACD1 ST8SIA6 NONHSAG005333.2 ENSG00000229190
GH10J017684 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 21.9 +41.0 40951 1.2 ZBTB40 RELA RCOR1 RBM25 TCF12 NBN BATF IKZF1 TBP ATF2 STAM VIM ENSG00000229190 NONHSAG005333.2
GH10J017712 Enhancer 0.6 FANTOM5 ENCODE 23.5 +69.1 69079 0.4 ZBTB17 ZMIZ1 SMARCA4 SRF MLLT1 STAM HACD1 VIM SLC39A12 piR-59769-041 ENSG00000229190
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STAM on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAM

Top Transcription factor binding sites by QIAGEN in the STAM gene promoter:
  • aMEF-2
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • Ik-2
  • Lmo2
  • MEF-2A
  • Pax-3
  • RP58

Genomic Locations for STAM Gene

Genomic Locations for STAM Gene
chr10:17,644,125-17,716,824
(GRCh38/hg38)
Size:
72,700 bases
Orientation:
Plus strand
chr10:17,686,124-17,758,823
(GRCh37/hg19)
Size:
72,700 bases
Orientation:
Plus strand

Genomic View for STAM Gene

Genes around STAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAM Gene

Proteins for STAM Gene

  • Protein details for STAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92783-STAM1_HUMAN
    Recommended name:
    Signal transducing adapter molecule 1
    Protein Accession:
    Q92783
    Secondary Accessions:
    • B0YJ99
    • D3DRU5
    • Q8N6D9

    Protein attributes for STAM Gene

    Size:
    540 amino acids
    Molecular mass:
    59180 Da
    Quaternary structure:
    • Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:9407053, PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352).

    Three dimensional structures from OCA and Proteopedia for STAM Gene

    Alternative splice isoforms for STAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAM Gene

Post-translational modifications for STAM Gene

  • Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
  • Ubiquitinated by ITCH.
  • Ubiquitination at Lys99, Lys133, Lys154, Lys185, and Lys373
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STAM Gene

Domains & Families for STAM Gene

Gene Families for STAM Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STAM Gene

Blocks:
  • SH3 domain signature
  • Phosphorylated immunoreceptor signaling ITAM
  • VHS
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for STAM Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57683, highly similar to Signal transducing adapter molecule 1 (B4DZT2_HUMAN)
  • Signal transducing adapter molecule 1 (STAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92783

UniProtKB/Swiss-Prot:

STAM1_HUMAN :
  • The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
  • Belongs to the STAM family.
Domain:
  • The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
Family:
  • Belongs to the STAM family.
genes like me logo Genes that share domains with STAM: view

Function for STAM Gene

Molecular function for STAM Gene

UniProtKB/Swiss-Prot Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
GENATLAS Biochemistry:
signal-transducin adaptor molecule involved in cytokine-mediated signal transduction

Phenotypes From GWAS Catalog for STAM Gene

Gene Ontology (GO) - Molecular Function for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8780729
GO:0005515 protein binding IPI,IEA 10383417
GO:0044389 ubiquitin-like protein ligase binding IPI 24790097
genes like me logo Genes that share ontologies with STAM: view
genes like me logo Genes that share phenotypes with STAM: view

Animal Models for STAM Gene

MGI Knock Outs for STAM:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for STAM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAM Gene

Localization for STAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAM Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAM gene
Compartment Confidence
endosome 5
cytosol 5
plasma membrane 2
nucleus 2
lysosome 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with STAM: view

Pathways & Interactions for STAM Gene

genes like me logo Genes that share pathways with STAM: view

Pathways by source for STAM Gene

1 Qiagen pathway for STAM Gene
  • JAK-STAT Pathway
1 Cell Signaling Technology pathway for STAM Gene

SIGNOR curated interactions for STAM Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 8780729
GO:0009967 positive regulation of signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
genes like me logo Genes that share ontologies with STAM: view

Drugs & Compounds for STAM Gene

(1) Drugs for STAM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for STAM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STAM: view

Transcripts for STAM Gene

mRNA/cDNA for STAM Gene

9 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for STAM

Alternative Splicing Database (ASD) splice patterns (SP) for STAM Gene

No ASD Table

Relevant External Links for STAM Gene

GeneLoc Exon Structure for
STAM

Expression for STAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAM Gene

Protein differential expression in normal tissues from HIPED for STAM Gene

This gene is overexpressed in Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAM Gene



Protein tissue co-expression partners for STAM Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAM

SOURCE GeneReport for Unigene cluster for STAM Gene:

Hs.335391

mRNA Expression by UniProt/SwissProt for STAM Gene:

Q92783-STAM1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for STAM Gene

  • Nervous system(4.8)
  • Blood(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with STAM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAM Gene

Orthologs for STAM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAM 31 30
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STAM 31 30
  • 92.38 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STAM 31
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia STAM 31 30
  • 89.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Stam 17 31 30
  • 88.48 (n)
rat
(Rattus norvegicus)
Mammalia Stam 30
  • 87.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STAM 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAM 31 30
  • 81.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAM 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stam 30
  • 73.14 (n)
MGC76231 30
zebrafish
(Danio rerio)
Actinopterygii stam 31 30
  • 72.36 (n)
OneToOne
wufv75b10 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008494 30
  • 53.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta Stam 31 32
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea stam-1 31 30
  • 47.82 (n)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 31
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1021 31
  • 40 (a)
OneToMany
Cin.2766 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2766 30
Species where no ortholog for STAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAM Gene

ENSEMBL:
Gene Tree for STAM (if available)
TreeFam:
Gene Tree for STAM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STAM: view image

Paralogs for STAM Gene

(7) SIMAP similar genes for STAM Gene using alignment to 4 proteins:

  • STAM1_HUMAN
  • A6NMU3_HUMAN
  • B4DZT2_HUMAN
  • C9J1E5_HUMAN
genes like me logo Genes that share paralogs with STAM: view

Variants for STAM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAM Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
778035 Benign: not provided 17,660,546(+) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
782149 Benign: not provided 17,695,245(+) A/G INTRON_VARIANT
VAR_036348 A colorectal cancer sample p.Gly212Asp

Additional dbSNP identifiers (rs#s) for STAM Gene

Structural Variations from Database of Genomic Variants (DGV) for STAM Gene

Variant ID Type Subtype PubMed ID
esv2618457 CNV insertion 19546169
esv3303988 CNV mobile element insertion 20981092
esv3305237 CNV mobile element insertion 20981092
esv3406363 CNV insertion 20981092
esv3408186 CNV insertion 20981092
esv3447679 CNV insertion 20981092
esv3622497 CNV loss 21293372

Variation tolerance for STAM Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAM Gene

Human Gene Mutation Database (HGMD)
STAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM Gene

Disorders for STAM Gene

MalaCards: The human disease database

(3) MalaCards diseases for STAM Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search STAM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STAM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAM Gene

Publications for STAM Gene

  1. Hybrid structural model of the complete human ESCRT-0 complex. (PMID: 19278655) Ren X … Hurley JH (Structure (London, England : 1993) 2009) 3 4 23 54
  2. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 23 54
  3. Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. (PMID: 10383417) Tanaka N … Sugamura K (The Journal of biological chemistry 1999) 3 4 23 54
  4. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PMID: 9407053) Asao H … Sugamura K (The Journal of biological chemistry 1997) 3 4 23 54
  5. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PMID: 8780729) Takeshita T … Sugamura K (Biochemical and biophysical research communications 1996) 2 3 4 54

Products for STAM Gene

Sources for STAM Gene