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This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for tr... See more...
Aliases for STAM Gene
Aliases for STAM Gene
External Ids for STAM Gene
- HGNC: 11357
- NCBI Entrez Gene: 8027
- Ensembl: ENSG00000136738
- OMIM®: 601899
- UniProtKB/Swiss-Prot: Q92783
Previous GeneCards Identifiers for STAM Gene
- GC10P017668
- GC10P017836
- GC10P017690
- GC10P017726
- GC10P017686
- GC10P017598
Summaries for STAM Gene
-
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for STAM Gene
STAM (Signal Transducing Adaptor Molecule) is a Protein Coding gene. Diseases associated with STAM include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease. Among its related pathways are Signaling by GPCR and Budding and maturation of HIV virion. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is STAM2.
UniProtKB/Swiss-Prot Summary for STAM Gene
-
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Additional gene information for STAM Gene
- HGNC (11357)
- NCBI Entrez Gene (8027)
- Ensembl (ENSG00000136738)
- OMIM® (601899)
- UniProtKB/Swiss-Prot (Q92783)
- Open Targets Platform(ENSG00000136738)
- Search for STAM at DataMed
- Search for STAM at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAM Gene
Genomics for STAM Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STAM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STAM on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAM
- Top Transcription factor binding sites by QIAGEN in the STAM gene promoter:
-
- aMEF-2
- CREB
- deltaCREB
- GR
- GR-alpha
- Ik-2
- Lmo2
- MEF-2A
- Pax-3
- RP58
Genomic Locations for STAM Gene
Latest Assembly
- chr10:17,644,150-17,716,824
- (GRCh38/hg38)
- Size:
- 72,675 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:17,686,150-17,758,823
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 72,674 bases
- Orientation:
- Plus strand
- chr10:17,686,124-17,757,913
- (GRCh37/hg19 by Ensembl)
- Size:
- 71,790 bases
- Orientation:
- Plus strand
Genomic View for STAM Gene
Genes around STAM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.33 by HGNC
- 10p12.33 by Entrez Gene
- 10p12.33 by Ensembl
STAM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAM Gene
Proteins for STAM Gene
-
Protein details for STAM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92783-STAM1_HUMAN
- Recommended name:
- Signal transducing adapter molecule 1
- Protein Accession:
- Q92783
- B0YJ99
- D3DRU5
- Q8N6D9
Protein attributes for STAM Gene
- Size:
- 540 amino acids
- Molecular mass:
- 59180 Da
- Quaternary structure:
-
- Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:9407053, PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352).
Protein Expression for STAM Gene
Post-translational modifications for STAM Gene
- Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
- Ubiquitinated by ITCH.
-
Ubiquitination at Lys99, Lys133, Lys154, Lys185, and Lys373
- NX_Q92783 (NX_Q92783-1)
- Modification sites at PhosphoSitePlus
Other Protein References for STAM Gene
Antibodies for research
- LifeSpan BioSciences STAM1 / STAM Antibody
-
Custom Antibody ServicesOriGene Antibodies for STAM
- Novus Biologicals Antibodies for STAM
- Invitrogen Antibodies for STAM (AFLGC-STAM)
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAM
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for STAM
- Origene Custom Protein Services for STAM
Assay products for research
- antibodies-online: Search results for available STAM related products ranked by validation data
No data available for DME Specific Peptides for STAM Gene
Domains & Families for STAM Gene
Gene Families for STAM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for STAM Gene
- InterPro:
- Blocks:
-
- SH3 domain signature
- VHS
- Phosphorylated immunoreceptor signaling ITAM
- ProtoNet:
Suggested Antigen Peptide Sequences for STAM Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57683, highly similar to Signal transducing adapter molecule 1 (B4DZT2_HUMAN)
- Signal transducing adapter molecule 1 (STAM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92783UniProtKB/Swiss-Prot:
STAM1_HUMAN :- The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
- Belongs to the STAM family.
- Domain:
-
- The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
- Family:
-
- Belongs to the STAM family.
Function for STAM Gene
Molecular function for STAM Gene
- UniProtKB/Swiss-Prot Function:
- Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
- GENATLAS Biochemistry:
- signal-transducin adaptor molecule involved in cytokine-mediated signal transduction
Phenotypes From GWAS Catalog for STAM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 10383417 |
| GO:0044389 | ubiquitin-like protein ligase binding | IPI | 24790097 |
Phenotypes for STAM Gene
- MGI mutant phenotypes for STAM:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for STAM:
Animal Models for STAM Gene
- MGI Knock Outs for STAM:
-
- Stam Stam<tm1Sug>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STAM - Starting at $85 >
- * STAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAM
miRNA for STAM Gene
- miRTarBase miRNAs that target STAM
-
- mmu-miR-301b-3p (MIRT007891)
- mmu-miR-19b-3p (MIRT012394)
- mmu-miR-136-5p (MIRT014961)
- hsa-miR-215-5p (MIRT024512)
- hsa-miR-192-5p (MIRT026819)
- hsa-let-7e-5p (MIRT051525)
- hsa-miR-142-3p (MIRT177133)
- hsa-miR-3668 (MIRT177138)
- hsa-miR-573 (MIRT328233)
- hsa-miR-3616-5p (MIRT328235)
- hsa-miR-4635 (MIRT328236)
- hsa-miR-4670-3p (MIRT328237)
- hsa-miR-578 (MIRT544027)
- hsa-miR-526b-5p (MIRT544028)
- hsa-miR-4724-3p (MIRT544029)
- mmu-miR-665-3p (MIRT588784)
- mmu-miR-706 (MIRT588785)
- mmu-miR-10a-5p (MIRT588786)
- mmu-miR-10b-5p (MIRT588787)
- mmu-miR-339-5p (MIRT588788)
- hsa-miR-1277-5p (MIRT707216)
- hsa-miR-1277-3p (MIRT707217)
- hsa-miR-4753-3p (MIRT707218)
- hsa-miR-190a-3p (MIRT707219)
- hsa-miR-4789-5p (MIRT707220)
- hsa-miR-3941 (MIRT707221)
- hsa-miR-376a-2-5p (MIRT707222)
- hsa-miR-3935 (MIRT707223)
- hsa-miR-130b-5p (MIRT707224)
- hsa-miR-3675-3p (MIRT707225)
- hsa-miR-5011-5p (MIRT707226)
- hsa-miR-4789-3p (MIRT707227)
- hsa-miR-603 (MIRT707228)
- hsa-miR-362-3p (MIRT707229)
- hsa-miR-329-3p (MIRT707230)
- hsa-miR-8485 (MIRT707231)
- hsa-miR-641 (MIRT707232)
- hsa-miR-3617-5p (MIRT707233)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Clone products for research
- Applied Biological Materials (abm): Clones for STAM - Starting at $45 >
- * STAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STAM
- Addgene plasmids for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
Cell Lines for research
-
Horizon Cell Lines for STAM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAM Gene
Localization for STAM Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAM Gene
- Cytoplasm. Early endosome membrane. Peripheral membrane protein. Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031901 | early endosome membrane | IEA | -- |
Pathways & Interactions for STAM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Listeria monocytogenes entry into host cells | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | Vesicle-mediated transport | ||
| 5 | Metabolism of proteins | ||
Pathways by source for STAM Gene
2 BioSystems pathways for STAM Gene
18 Reactome pathways for STAM Gene
2 KEGG pathways for STAM Gene
1 Qiagen pathway for STAM Gene
- JAK-STAT Pathway
1 Cell Signaling Technology pathway for STAM Gene
Interacting Proteins for STAM Gene
Selected Interacting proteins:
Q92783-STAM1_HUMAN
ENSP00000366746
for STAM Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STAM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8780729 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016197 | endosomal transport | TAS | -- |
| GO:0016236 | macroautophagy | TAS | 20588296 |
Transcripts for STAM Gene
mRNA/cDNA for STAM Gene
- 9 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377500 729 nts (view in UCSC)
- ENST00000377524 3856 nts (view in UCSC)
- ENST00000445846 740 nts (view in UCSC)
- ENST00000486183 274 nts (view in UCSC)
- ENST00000494250 462 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STAM - Starting at $85 >
- * STAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAM
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Clone products for research
- Applied Biological Materials (abm): Clones for STAM - Starting at $45 >
- * STAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STAM
- Addgene plasmids for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
Relevant External Links for STAM Gene
- GeneLoc Exon Structure for
- STAM
Expression for STAM Gene
This gene is overexpressed in Pancreas (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAM Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAM
SOURCE GeneReport for Unigene cluster for STAM Gene:
Hs.335391mRNA Expression by UniProt/SwissProt for STAM Gene:
Q92783-STAM1_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for STAM Gene
- Nervous system(4.8)
- Blood(4.4)
- Liver(4.3)
- Kidney(2.1)
- Heart(2.1)
- Muscle(2.1)
Primer products for research
-
OriGene qPCR primer pairs for STAM
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAM Gene
Orthologs for STAM Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STAM 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STAM 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | STAM 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STAM 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Stam 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stam 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STAM 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STAM 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STAM 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stam 30 |
|
||
| MGC76231 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | stam 30 31 |
|
OneToOne | |
| wufv75b10 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008494 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Stam 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | stam-1 30 31 |
|
ManyToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSE1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1021 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2766 30 |
|
- Species where no ortholog for STAM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STAM Gene
- ENSEMBL:
- Gene Tree for STAM (if available)
- TreeFam:
- Gene Tree for STAM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAM: view image
Paralogs for STAM Gene
Paralogs for STAM Gene
(7) SIMAP similar genes for STAM Gene using alignment to 4 proteins:
- STAM1_HUMAN
- A6NMU3_HUMAN
- B4DZT2_HUMAN
- C9J1E5_HUMAN
Variants for STAM Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAM Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1554827317 | A colorectal cancer sample |
p.Gly212Asp |
|||
| rs41289333 | Benign: not provided | 17,660,546(+) |
T/C NM_003473.4(STAM):c.123T>C (p.Thr41=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
| rs72782571 | Benign: not provided | 17,695,245(+) |
A/G NM_003473.4(STAM):c.728+4A>G |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2618457 | CNV | insertion | 19546169 |
| esv3303988 | CNV | mobile element insertion | 20981092 |
| esv3305237 | CNV | mobile element insertion | 20981092 |
| esv3406363 | CNV | insertion | 20981092 |
| esv3408186 | CNV | insertion | 20981092 |
| esv3447679 | CNV | insertion | 20981092 |
| esv3622497 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAM Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM Gene
Disorders for STAM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease, demyelinating, type 1c |
|
|
| polycystic kidney disease 2 with or without polycystic liver disease |
|
|
| charcot-marie-tooth disease and deafness |
|
|
| charcot-marie-tooth disease |
|
|
Search STAM in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STAM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STAM Gene
Publications for STAM Gene
- Hybrid structural model of the complete human ESCRT-0 complex. (PMID: 19278655) Ren X … Hurley JH (Structure (London, England : 1993) 2009) 3 4 23
- STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 23
- Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. (PMID: 10383417) Tanaka N … Sugamura K (The Journal of biological chemistry 1999) 3 4 23
- Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PMID: 9407053) Asao H … Sugamura K (The Journal of biological chemistry 1997) 3 4 23
- Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PMID: 8780729) Takeshita T … Sugamura K (Biochemical and biophysical research communications 1996) 2 3 4
ExternalLinks
Products for STAM Gene
- Custom Antibody ServicesOriGene Antibodies for STAM
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STAM
- Origene Custom Protein Services for STAM
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- OriGene qPCR primer pairs for STAM
- OriGene CRISPR knockouts for STAM
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STAM
- Sino Biological Human cDNA Clone for STAM
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STAM
- Novus Biologicals proteins and lysates for STAM
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for STAM (AFLGC-STAM)
- VectorBuilder Custom and pre-made DNA vectors for STAM (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for STAM (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for STAM (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for STAM CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STAM
- Addgene plasmids for STAM
- antibodies-online: Show 67 available STAM Antibodies ranked by validation data
- Compare Top STAM Antibodies
- antibodies-online: Search results for available STAM related products ranked by validation data
- antibodies-online: Show 8 available STAM Proteins ranked by validation data
- Compare Top STAM Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for STAM
- Search Santa Cruz Biotechnology (SCBT) for STAM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STAM
- Horizon Cell Lines for STAM
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Sources for STAM Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB