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This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
STAM (Signal Transducing Adaptor Molecule) is a Protein Coding gene. Diseases associated with STAM include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease. Among its related pathways are Signaling by GPCR and Budding and maturation of HIV virion. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is STAM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 10383417 |
GO:0044389 | ubiquitin-like protein ligase binding | IPI | 24790097 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031901 | early endosome membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Listeria monocytogenes entry into host cells | ||
2 | Clathrin-mediated endocytosis | ||
3 | HIV Life Cycle |
.45
|
|
4 | Vesicle-mediated transport | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IEA | -- |
GO:0007165 | signal transduction | TAS | 8780729 |
GO:0015031 | protein transport | IEA | -- |
GO:0016197 | endosomal transport | TAS | -- |
GO:0016236 | macroautophagy | TAS | 20588296 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | STAM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | STAM 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | STAM 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | STAM 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Stam 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Stam 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | STAM 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | STAM 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | STAM 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stam 30 |
|
||
MGC76231 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | stam 30 31 |
|
OneToOne | |
wufv75b10 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008494 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Stam 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | stam-1 30 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSE1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1021 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2766 30 |
|
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1554827317 | A colorectal cancer sample |
p.Gly212Asp |
|||
rs41289333 | Benign: not provided | 17,660,546(+) |
T/C NM_003473.4(STAM):c.123T>C (p.Thr41=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
rs72782571 | Benign: not provided | 17,695,245(+) |
A/G NM_003473.4(STAM):c.728+4A>G |
INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2618457 | CNV | insertion | 19546169 |
esv3303988 | CNV | mobile element insertion | 20981092 |
esv3305237 | CNV | mobile element insertion | 20981092 |
esv3406363 | CNV | insertion | 20981092 |
esv3408186 | CNV | insertion | 20981092 |
esv3447679 | CNV | insertion | 20981092 |
esv3622497 | CNV | loss | 21293372 |
Disorder | Aliases | PubMed IDs |
---|---|---|
charcot-marie-tooth disease, demyelinating, type 1c |
|
|
polycystic kidney disease 2 with or without polycystic liver disease |
|
|
charcot-marie-tooth disease and deafness |
|
|
charcot-marie-tooth disease |
|
|