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This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for tr... See more...
Aliases for STAM Gene
Aliases for STAM Gene
External Ids for STAM Gene
- HGNC: 11357
- NCBI Entrez Gene: 8027
- Ensembl: ENSG00000136738
- OMIM®: 601899
- UniProtKB/Swiss-Prot: Q92783
Previous GeneCards Identifiers for STAM Gene
- GC10P017668
- GC10P017836
- GC10P017690
- GC10P017726
- GC10P017686
- GC10P017598
- GC10P017645
Summaries for STAM Gene
-
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for STAM Gene
STAM (Signal Transducing Adaptor Molecule) is a Protein Coding gene. Diseases associated with STAM include Charcot-Marie-Tooth Disease, Demyelinating, Type 1C and Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease. Among its related pathways are Clathrin-mediated endocytosis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is STAM2.
UniProtKB/Swiss-Prot Summary for STAM Gene
-
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Additional gene information for STAM Gene
- HGNC (11357)
- NCBI Entrez Gene (8027)
- Ensembl (ENSG00000136738)
- OMIM® (601899)
- UniProtKB/Swiss-Prot (Q92783)
- Open Targets Platform(ENSG00000136738)
- Alliance of Genome Resources
- Search for STAM at DataMed
- Search for STAM at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for STAM Gene
Genomics for STAM Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for STAM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around STAM on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for STAM
- Top Transcription factor binding sites by QIAGEN in the STAM gene promoter:
-
- aMEF-2
- CREB
- deltaCREB
- GR
- GR-alpha
- Ik-2
- Lmo2
- MEF-2A
- Pax-3
- RP58
Genomic Locations for STAM Gene
Latest Assembly
- chr10:17,644,150-17,716,824
- (GRCh38/hg38)
- Size:
- 72,675 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:17,686,150-17,758,823
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 72,674 bases
- Orientation:
- Plus strand
Genomic View for STAM Gene
Genes around STAM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.33 by HGNC
- 10p12.33 by Entrez Gene
- 10p12.33 by Ensembl
STAM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for STAM Gene
Proteins for STAM Gene
-
Protein details for STAM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92783-STAM1_HUMAN
- Recommended name:
- Signal transducing adapter molecule 1
- Protein Accession:
- Q92783
- B0YJ99
- D3DRU5
- Q8N6D9
Protein attributes for STAM Gene
- Size:
- 540 amino acids
- Molecular mass:
- 59180 Da
- Quaternary structure:
-
- Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:9407053, PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352).
Protein Expression for STAM Gene
Post-translational modifications for STAM Gene
- Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
- Ubiquitinated by ITCH.
-
Ubiquitination at Lys99, Lys133, Lys154, Lys185, and Lys373
- NX_Q92783 (NX_Q92783-1)
- Modification sites at PhosphoSitePlus
Other Protein References for STAM Gene
Antibodies for research
- LifeSpan BioSciences STAM1 / STAM Antibody
-
Custom Antibody ServicesOriGene Antibodies for STAM
- Novus Biologicals Antibodies for STAM
- Invitrogen Antibodies for STAM (AFLGC-STAM)
-
Santa Cruz Biotechnology (SCBT) Antibodies for STAM
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for STAM
- Origene Custom Protein Services for STAM
Assay products for research
- antibodies-online: Search results for available STAM related products ranked by validation data
No data available for DME Specific Peptides for STAM Gene
Domains & Families for STAM Gene
Gene Families for STAM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for STAM Gene
- InterPro:
- Blocks:
-
- SH3 domain signature
- VHS
- Phosphorylated immunoreceptor signaling ITAM
Suggested Antigen Peptide Sequences for STAM Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57683, highly similar to Signal transducing adapter molecule 1 (B4DZT2_HUMAN)
- Signal transducing adapter molecule 1 (STAM1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92783UniProtKB/Swiss-Prot:
STAM1_HUMAN :- The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
- Belongs to the STAM family.
- Domain:
-
- The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
- Family:
-
- Belongs to the STAM family.
Function for STAM Gene
Molecular function for STAM Gene
- UniProtKB/Swiss-Prot Function:
- Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
- GENATLAS Biochemistry:
- signal-transducin adaptor molecule involved in cytokine-mediated signal transduction
Phenotypes From GWAS Catalog for STAM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 10383417 |
| GO:0044389 | ubiquitin-like protein ligase binding | IPI | 24790097 |
Phenotypes for STAM Gene
- MGI mutant phenotypes for STAM:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for STAM:
Animal Models for STAM Gene
- MGI Knock Outs for STAM:
-
- Stam Stam<tm1Sug>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STAM - Starting at $85 >
- * STAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAM
miRNA for STAM Gene
- miRTarBase miRNAs that target STAM
-
- mmu-miR-301b-3p (MIRT007891)
- mmu-miR-19b-3p (MIRT012394)
- mmu-miR-136-5p (MIRT014961)
- hsa-miR-215-5p (MIRT024512)
- hsa-miR-192-5p (MIRT026819)
- hsa-let-7e-5p (MIRT051525)
- hsa-miR-142-3p (MIRT177133)
- hsa-miR-3668 (MIRT177138)
- hsa-miR-573 (MIRT328233)
- hsa-miR-3616-5p (MIRT328235)
- hsa-miR-4635 (MIRT328236)
- hsa-miR-4670-3p (MIRT328237)
- hsa-miR-578 (MIRT544027)
- hsa-miR-526b-5p (MIRT544028)
- hsa-miR-4724-3p (MIRT544029)
- mmu-miR-665-3p (MIRT588784)
- mmu-miR-706 (MIRT588785)
- mmu-miR-10a-5p (MIRT588786)
- mmu-miR-10b-5p (MIRT588787)
- mmu-miR-339-5p (MIRT588788)
- hsa-miR-1277-5p (MIRT707216)
- hsa-miR-1277-3p (MIRT707217)
- hsa-miR-4753-3p (MIRT707218)
- hsa-miR-190a-3p (MIRT707219)
- hsa-miR-4789-5p (MIRT707220)
- hsa-miR-3941 (MIRT707221)
- hsa-miR-376a-2-5p (MIRT707222)
- hsa-miR-3935 (MIRT707223)
- hsa-miR-130b-5p (MIRT707224)
- hsa-miR-3675-3p (MIRT707225)
- hsa-miR-5011-5p (MIRT707226)
- hsa-miR-4789-3p (MIRT707227)
- hsa-miR-603 (MIRT707228)
- hsa-miR-362-3p (MIRT707229)
- hsa-miR-329-3p (MIRT707230)
- hsa-miR-8485 (MIRT707231)
- hsa-miR-641 (MIRT707232)
- hsa-miR-3617-5p (MIRT707233)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Clone products for research
- Applied Biological Materials (abm): Clones for STAM - Starting at $45 >
- * STAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STAM
- Addgene plasmids for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
Cell Lines for research
-
Horizon Cell Lines for STAM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STAM Gene
Localization for STAM Gene
Subcellular locations from UniProtKB/Swiss-Prot for STAM Gene
- Cytoplasm. Early endosome membrane. Peripheral membrane protein. Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031901 | early endosome membrane | IEA | -- |
Pathways & Interactions for STAM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Listeria monocytogenes entry into host cells | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | Vesicle-mediated transport | ||
| 5 | Metabolism of proteins | ||
Pathways by source for STAM Gene
2 BioSystems pathways for STAM Gene
18 Reactome pathways for STAM Gene
2 KEGG pathways for STAM Gene
1 Qiagen pathway for STAM Gene
- JAK-STAT Pathway
1 Cell Signaling Technology pathway for STAM Gene
Interacting Proteins for STAM Gene
Selected Interacting proteins:
Q92783-STAM1_HUMAN
ENSP00000366746
for STAM Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for STAM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8780729 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016197 | endosomal transport | TAS | -- |
| GO:0016236 | macroautophagy | TAS | 20588296 |
Transcripts for STAM Gene
mRNA/cDNA for STAM Gene
- 9 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377500 729 nts (view in UCSC)
- ENST00000377524 3856 nts (view in UCSC)
- ENST00000445846 740 nts (view in UCSC)
- ENST00000486183 274 nts (view in UCSC)
- ENST00000494250 462 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for STAM - Starting at $85 >
- * STAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for STAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for STAM
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Clone products for research
- Applied Biological Materials (abm): Clones for STAM - Starting at $45 >
- * STAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for STAM
- Addgene plasmids for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
Relevant External Links for STAM Gene
- GeneLoc Exon Structure for
- STAM
Expression for STAM Gene
This gene is overexpressed in Pancreas (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STAM Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for STAM
SOURCE GeneReport for Unigene cluster for STAM Gene:
Hs.335391mRNA Expression by UniProt/SwissProt for STAM Gene:
Q92783-STAM1_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for STAM Gene
- Nervous system(4.8)
- Blood(4.4)
- Liver(4.3)
- Kidney(2.1)
- Heart(2.1)
- Muscle(2.1)
Primer products for research
-
OriGene qPCR primer pairs for STAM
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAM Gene
Orthologs for STAM Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | STAM 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | STAM 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | STAM 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | STAM 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Stam 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Stam 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | STAM 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | STAM 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | STAM 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | stam 29 |
|
||
| MGC76231 29 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | stam 29 30 |
|
OneToOne | |
| wufv75b10 29 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008494 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Stam 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | stam-1 29 30 |
|
ManyToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSE1 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1021 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2766 29 |
|
- Species where no ortholog for STAM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for STAM Gene
- ENSEMBL:
- Gene Tree for STAM (if available)
- TreeFam:
- Gene Tree for STAM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for STAM: view image
- Alliance of Genome Resources:
- Additional Orthologs for STAM
Paralogs for STAM Gene
Paralogs for STAM Gene
(7) SIMAP similar genes for STAM Gene using alignment to 4 proteins:
- STAM1_HUMAN
- A6NMU3_HUMAN
- B4DZT2_HUMAN
- C9J1E5_HUMAN
Variants for STAM Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for STAM Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs155482731 | A colorectal cancer sample |
p.Gly212Asp |
|||
| rs41289333 | Benign: not provided | 17,660,546(+) |
T/C NM_003473.4(STAM):c.123T>C (p.Thr41=) |
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
| rs72782571 | Benign: not provided | 17,695,245(+) |
A/G NM_003473.4(STAM):c.728+4A>G |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2618457 | CNV | insertion | 19546169 |
| esv3303988 | CNV | mobile element insertion | 20981092 |
| esv3305237 | CNV | mobile element insertion | 20981092 |
| esv3406363 | CNV | insertion | 20981092 |
| esv3408186 | CNV | insertion | 20981092 |
| esv3447679 | CNV | insertion | 20981092 |
| esv3622497 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for STAM Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAM Gene
Disorders for STAM Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease, demyelinating, type 1c |
|
|
| polycystic kidney disease 2 with or without polycystic liver disease |
|
|
| charcot-marie-tooth disease |
|
|
Search STAM in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for STAM
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for STAM Gene
Publications for STAM Gene
- Hybrid structural model of the complete human ESCRT-0 complex. (PMID: 19278655) Ren X … Hurley JH (Structure (London, England : 1993) 2009) 3 4 22
- STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 22
- Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. (PMID: 10383417) Tanaka N … Sugamura K (The Journal of biological chemistry 1999) 3 4 22
- Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. (PMID: 9407053) Asao H … Sugamura K (The Journal of biological chemistry 1997) 3 4 22
- Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. (PMID: 8780729) Takeshita T … Sugamura K (Biochemical and biophysical research communications 1996) 2 3 4
ExternalLinks
Products for STAM Gene
- Custom Antibody ServicesOriGene Antibodies for STAM
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for STAM
- Origene Custom Protein Services for STAM
- Origene shrna, sirna, and RNAi products in human, mouse, rat for STAM
- Browse OriGene Inhibitory RNA Products For STAM
- OriGene qPCR primer pairs for STAM
- OriGene CRISPR knockouts for STAM
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For STAM
- Sino Biological Human cDNA Clone for STAM
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for STAM
- Novus Biologicals proteins and lysates for STAM
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for STAM (AFLGC-STAM)
- VectorBuilder Custom and pre-made DNA vectors for STAM (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for STAM (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for STAM (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for STAM CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for STAM
- Addgene plasmids for STAM
- antibodies-online: Show 67 available STAM Antibodies ranked by validation data
- Compare Top STAM Antibodies
- antibodies-online: Search results for available STAM related products ranked by validation data
- antibodies-online: Show 8 available STAM Proteins ranked by validation data
- Compare Top STAM Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for STAM
- Search Santa Cruz Biotechnology (SCBT) for STAM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for STAM
- Horizon Cell Lines for STAM
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for STAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for STAM
- Search GeneCopoeia for miRNA 3'UTR Target clone products for STAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for STAM
Sources for STAM Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources