Aliases for STAG2 Gene
External Ids for STAG2 Gene
Previous GeneCards Identifiers for STAG2 Gene
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for STAG2 Gene
STAG2 (Stromal Antigen 2) is a Protein Coding gene. Diseases associated with STAG2 include Mullegama-Klein-Martinez Syndrome and Holoprosencephaly 13, X-Linked. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include chromatin binding and binding. An important paralog of this gene is STAG1.
UniProtKB/Swiss-Prot Summary for STAG2 Gene
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.