Aliases for STAG1 Gene
External Ids for STAG1 Gene
Previous GeneCards Identifiers for STAG1 Gene
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
GeneCards Summary for STAG1 Gene
STAG1 (Stromal Antigen 1) is a Protein Coding gene. Diseases associated with STAG1 include Mental Retardation, Autosomal Dominant 47 and Cornelia De Lange Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include chromatin binding and binding. An important paralog of this gene is STAG2.
UniProtKB/Swiss-Prot Summary for STAG1 Gene
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.