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Aliases for STAC2 Gene

Aliases for STAC2 Gene

  • SH3 And Cysteine Rich Domain 2 2 3 5
  • 24b2/STAC2 3 4
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 2 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 2 4
  • SH3 And Cysteine-Rich Domain-Containing Protein 2 3
  • 24b2 3

External Ids for STAC2 Gene

Previous GeneCards Identifiers for STAC2 Gene

  • GC17M037741
  • GC17M034620
  • GC17M037368
  • GC17M033161

Summaries for STAC2 Gene

Entrez Gene Summary for STAC2 Gene

  • This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

GeneCards Summary for STAC2 Gene

STAC2 (SH3 And Cysteine Rich Domain 2) is a Protein Coding gene. Diseases associated with STAC2 include Native American Myopathy. An important paralog of this gene is STAC.

Additional gene information for STAC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC2 Gene

Genomics for STAC2 Gene

GeneHancer (GH) Regulatory Elements for STAC2 Gene

Promoters and enhancers for STAC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039225 Promoter 0.8 EPDnew 550.8 +0.1 66 0.1 ZFHX2 MAZ PATZ1 EZH2 STAC2 GC17P039212
GH17I039226 Enhancer 0.6 ENCODE 550.8 -0.2 -191 0.2 PKNOX1 MAZ SP3 NRF1 SP2 ZFHX2 ZNF366 GLIS1 PATZ1 KLF9 STAC2 GC17P039212 LOC101929578
GH17I039208 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.2 +16.2 16241 2.5 HDGF ZNF493 ZNF133 KLF17 FEZF1 ZEB1 ZNF335 GLIS2 EGR1 ZSCAN5C STAC2 THRA CACNB1 GC17P039212 RPL19
GH17I039658 Promoter/Enhancer 2.9 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -437.8 -437818 10.4 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 PNMT TCAP PGAP3 STARD3 CDK12 LOC105371762 STAC2 FBXL20 MSL1
GH17I039191 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +28.9 28874 11.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 RPL19 CACNB1 CDK12 SNORA21 SNORD124 MED1 STARD3 RPL23 LOC105371762 MSL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STAC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAC2 gene promoter:

Genomic Locations for STAC2 Gene

Genomic Locations for STAC2 Gene
15,337 bases
Minus strand

Genomic View for STAC2 Gene

Genes around STAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC2 Gene

Proteins for STAC2 Gene

  • Protein details for STAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 and cysteine-rich domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q32MA3

    Protein attributes for STAC2 Gene

    411 amino acids
    Molecular mass:
    45009 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STAC2 Gene

    Alternative splice isoforms for STAC2 Gene


neXtProt entry for STAC2 Gene

Post-translational modifications for STAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for STAC2 Gene

No data available for DME Specific Peptides for STAC2 Gene

Domains & Families for STAC2 Gene

Gene Families for STAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STAC2 Gene

Suggested Antigen Peptide Sequences for STAC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STAC2: view

No data available for UniProtKB/Swiss-Prot for STAC2 Gene

Function for STAC2 Gene

Phenotypes From GWAS Catalog for STAC2 Gene

Gene Ontology (GO) - Molecular Function for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC2: view
genes like me logo Genes that share phenotypes with STAC2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAC2 Gene

Localization for STAC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAC2 gene
Compartment Confidence
nucleus 3
cytosol 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with STAC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for STAC2 Gene

Pathways & Interactions for STAC2 Gene

SuperPathways for STAC2 Gene

No Data Available

Interacting Proteins for STAC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZMT1-STAC2_HUMAN ENSP00000327509 for STAC2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for STAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with STAC2: view

No data available for Pathways by source and SIGNOR curated interactions for STAC2 Gene

Drugs & Compounds for STAC2 Gene

(3) Additional Compounds for STAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with STAC2: view

Transcripts for STAC2 Gene

Unigene Clusters for STAC2 Gene

SH3 and cysteine rich domain 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC2 Gene

No ASD Table

Relevant External Links for STAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC2 Gene

This gene is overexpressed in Artery - Tibial (x7.9), Breast - Mammary Tissue (x5.8), Skin - Sun Exposed (Lower leg) (x4.6), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for STAC2 Gene

This gene is overexpressed in Retina (54.0) and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAC2 Gene

Protein tissue co-expression partners for STAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STAC2 Gene:


SOURCE GeneReport for Unigene cluster for STAC2 Gene:


Evidence on tissue expression from TISSUES for STAC2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with STAC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAC2 Gene

Orthologs for STAC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STAC2 33 34
  • 93.15 (n)
(Bos Taurus)
Mammalia STAC2 33 34
  • 90.93 (n)
(Canis familiaris)
Mammalia STAC2 33 34
  • 90.93 (n)
(Mus musculus)
Mammalia Stac2 33 16 34
  • 89.46 (n)
(Rattus norvegicus)
Mammalia Stac2 33
  • 88.89 (n)
(Monodelphis domestica)
Mammalia STAC2 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia STAC2 34
  • 84 (a)
(Anolis carolinensis)
Reptilia STAC2 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stac2 33
  • 63.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 34
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Species where no ortholog for STAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for STAC2 Gene

Gene Tree for STAC2 (if available)
Gene Tree for STAC2 (if available)

Paralogs for STAC2 Gene

Paralogs for STAC2 Gene

(6) SIMAP similar genes for STAC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STAC2: view

Variants for STAC2 Gene

Sequence variations from dbSNP and Humsavar for STAC2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs863223351 likely-pathogenic, Childhood-Onset Schizophrenia 39,218,007(-) C/T coding_sequence_variant, missense_variant
rs761169200 uncertain-significance, not provided 39,215,213(-) CCACCTTCCCAC/CCAC coding_sequence_variant, frameshift
rs952472797 uncertain-significance, not provided 39,218,025(-) G/C coding_sequence_variant, missense_variant
rs1000270844 -- 39,224,313(-) T/ intron_variant
rs1000354566 -- 39,220,667(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STAC2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv833441 CNV loss 17160897

Variation tolerance for STAC2 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC2 Gene

Disorders for STAC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for STAC2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
native american myopathy
  • nam
- elite association - COSMIC cancer census association via MalaCards
Search STAC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STAC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with STAC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAC2 Gene

Publications for STAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels. (PMID: 25548159) Polster A … Beam KG (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 58
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill SJ … Livingston DM (Genes & development 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for STAC2 Gene

Sources for STAC2 Gene

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