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Aliases for STAC Gene

Aliases for STAC Gene

  • SH3 And Cysteine Rich Domain 2 3 5
  • SRC Homology 3 And Cysteine-Rich Domain-Containing Protein 3
  • Src Homology 3 And Cysteine-Rich Domain-Containing Protein 4
  • Src Homology Three (SH3) And Cysteine Rich Domain 2
  • SH3 And Cysteine-Rich Domain-Containing Protein 3
  • STAC1 3

External Ids for STAC Gene

Previous GeneCards Identifiers for STAC Gene

  • GC03P035724
  • GC03P036235
  • GC03P036382
  • GC03P036397

Summaries for STAC Gene

GeneCards Summary for STAC Gene

STAC (SH3 And Cysteine Rich Domain) is a Protein Coding gene. Diseases associated with STAC include Native American Myopathy. An important paralog of this gene is STAC2.

UniProtKB/Swiss-Prot for STAC Gene

  • Probably involved in a neuron-specific signal transduction.

Additional gene information for STAC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAC Gene

Genomics for STAC Gene

GeneHancer (GH) Regulatory Elements for STAC Gene

Promoters and enhancers for STAC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I036380 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 556.9 +0.5 505 1.7 ZSCAN5A KLF1 ZNF449 ZNF133 MAX KLF17 ZNF76 HIC1 E2F1 ZNF335 STAC NBPF21P
GH03I036494 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10.4 +114.6 114589 1.4 CEBPB EP300 CHD2 STAC EPM2AIP1 MLH1 NBPF21P
GH03I036496 Enhancer 0.6 Ensembl ENCODE 10.4 +116.6 116634 1.7 CEBPB EP300 STAC NBPF21P
GH03I036319 Enhancer 0.4 ENCODE 10.4 -60.5 -60457 1.2 POLR2A HNF4A EZH2 STAC RFC3P1
GH03I036296 Enhancer 0.2 ENCODE 10.6 -83.1 -83093 1.2 STAC RFC3P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STAC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STAC gene promoter:

Genomic Locations for STAC Gene

Genomic Locations for STAC Gene
167,668 bases
Plus strand

Genomic View for STAC Gene

Genes around STAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAC Gene

Proteins for STAC Gene

  • Protein details for STAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SH3 and cysteine-rich domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • B2R8S8

    Protein attributes for STAC Gene

    402 amino acids
    Molecular mass:
    44554 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for STAC Gene

neXtProt entry for STAC Gene

Post-translational modifications for STAC Gene

No Post-translational modifications

No data available for DME Specific Peptides for STAC Gene

Domains & Families for STAC Gene

Gene Families for STAC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for STAC Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with STAC: view

No data available for UniProtKB/Swiss-Prot for STAC Gene

Function for STAC Gene

Molecular function for STAC Gene

GENATLAS Biochemistry:
neuron-specific protein,expressed predominantly in hippocampus,cerebellum and inferior olive
UniProtKB/Swiss-Prot Function:
Probably involved in a neuron-specific signal transduction.

Phenotypes From GWAS Catalog for STAC Gene

Gene Ontology (GO) - Molecular Function for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16260042
GO:0044325 ion channel binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with STAC: view

Phenotypes for STAC Gene

genes like me logo Genes that share phenotypes with STAC: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STAC Gene

Localization for STAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAC Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STAC gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol NAS 8954993
GO:0030315 T-tubule IEA --
genes like me logo Genes that share ontologies with STAC: view

Pathways & Interactions for STAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for STAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IEA --
GO:0007165 signal transduction NAS 8954993
GO:0034605 cellular response to heat IEA --
GO:0035556 intracellular signal transduction IEA --
GO:1901385 regulation of voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with STAC: view

No data available for Pathways by source and SIGNOR curated interactions for STAC Gene

Drugs & Compounds for STAC Gene

(3) Additional Compounds for STAC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with STAC: view

Transcripts for STAC Gene

Unigene Clusters for STAC Gene

SH3 and cysteine rich domain:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - - -
SP4: - - - -
SP5: -

Relevant External Links for STAC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STAC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STAC Gene

This gene is overexpressed in Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for STAC Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STAC Gene

Protein tissue co-expression partners for STAC Gene

NURSA nuclear receptor signaling pathways regulating expression of STAC Gene:


SOURCE GeneReport for Unigene cluster for STAC Gene:


Evidence on tissue expression from TISSUES for STAC Gene

  • Blood(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with STAC: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STAC Gene

Orthologs for STAC Gene

This gene was present in the common ancestor of animals.

Orthologs for STAC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STAC 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia STAC 33 34
  • 92.1 (n)
(Bos Taurus)
Mammalia STAC 33 34
  • 91.69 (n)
(Mus musculus)
Mammalia Stac 33 16 34
  • 85.7 (n)
(Rattus norvegicus)
Mammalia Stac 33
  • 84.7 (n)
(Monodelphis domestica)
Mammalia STAC 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia STAC 34
  • 82 (a)
(Gallus gallus)
Aves STAC 33 34
  • 77.89 (n)
(Anolis carolinensis)
Reptilia STAC 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stac 33
  • 69.42 (n)
(Danio rerio)
Actinopterygii LOC100005402 33
  • 64.74 (n)
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43729 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for STAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STAC Gene

Gene Tree for STAC (if available)
Gene Tree for STAC (if available)

Paralogs for STAC Gene

Paralogs for STAC Gene

(6) SIMAP similar genes for STAC Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with STAC: view

Variants for STAC Gene

Sequence variations from dbSNP and Humsavar for STAC Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000003058 -- 36,480,186(+) A/G intron_variant
rs1000018457 -- 36,500,830(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000019737 -- 36,383,634(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000073444 -- 36,383,420(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000081813 -- 36,461,007(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STAC Gene

Variant ID Type Subtype PubMed ID
nsv3761 CNV insertion 18451855
nsv1150056 CNV deletion 26484159
nsv1123639 CNV deletion 24896259
nsv1123638 CNV deletion 24896259
nsv1112380 CNV deletion 24896259
nsv1072249 CNV deletion 25765185
nsv1007217 CNV gain 25217958
nsv1006443 CNV gain 25217958
esv3595866 CNV gain 21293372
esv3595865 CNV loss 21293372
esv3595864 CNV loss 21293372
esv3595863 CNV loss 21293372
esv3595861 CNV gain 21293372
esv3595854 CNV gain 21293372
esv3561751 CNV deletion 23714750
esv2763782 CNV loss 21179565
esv2760763 CNV loss 21179565
esv2725154 CNV deletion 23290073
esv2678470 CNV deletion 23128226
esv2668360 CNV deletion 23128226
esv2659382 CNV deletion 23128226
esv2658392 CNV deletion 23128226
dgv281n21 CNV loss 19592680

Variation tolerance for STAC Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STAC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAC Gene

Disorders for STAC Gene

MalaCards: The human disease database

(1) MalaCards diseases for STAC Gene - From: DISEASES

Disorder Aliases PubMed IDs
native american myopathy
  • nam
- elite association - COSMIC cancer census association via MalaCards
Search STAC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for STAC

genes like me logo Genes that share disorders with STAC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for STAC Gene

Publications for STAC Gene

  1. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains. (PMID: 8954993) Suzuki H … Watanabe S (Biochemical and biophysical research communications 1996) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611. (PMID: 10393425) Petek E … Wagner K (Cytogenetics and cell genetics 1999) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane. (PMID: 27149520) Rzhepetskyy Y … Weiss N (Channels (Austin, Tex.) 2016) 3 58

Products for STAC Gene

Sources for STAC Gene

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