This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] See more...

Aliases for ST8SIA6 Gene

Aliases for ST8SIA6 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6 2 3 5
  • SIAT8F 2 3 4
  • Alpha-2,8-Sialyltransferase 8F 3 4
  • Sialyltransferase St8Sia VI 3 4
  • ST8SiaVI 3 4
  • SIAT8-F 3 4
  • ST8 Alpha-N-Acetylneuraminate Alpha-2,8-Sialyltransferase 6 3
  • Sialyltransferase 8F (Alpha-2, 8-Sialyltransferase) 3
  • Sialyltransferase 8F 4
  • EC 2.4.99.- 4
  • ST8SIA-VI 3
  • ST8Sia VI 2
  • SIA8F 3

External Ids for ST8SIA6 Gene

Previous HGNC Symbols for ST8SIA6 Gene

  • SIAT8F

Previous GeneCards Identifiers for ST8SIA6 Gene

  • GC10M017403
  • GC10M017276

Summaries for ST8SIA6 Gene

Entrez Gene Summary for ST8SIA6 Gene

  • This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for ST8SIA6 Gene

ST8SIA6 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST8SIA6 include Acute Hemorrhagic Conjunctivitis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot Summary for ST8SIA6 Gene

  • Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

Additional gene information for ST8SIA6 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST8SIA6 Gene

Genomics for ST8SIA6 Gene

GeneHancer (GH) Regulatory Elements for ST8SIA6 Gene

Promoters and enhancers for ST8SIA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J017451 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.5 +2.0 1995 4.7 NRF1 PHB2 ZFX ZIC2 ZBTB10 CLOCK AFF1 ZBTB26 TARDBP DNMT1 ST8SIA6 lnc-STAM-5 HACD1 LOC105376436 ST8SIA6-AS1
GH10J017456 Enhancer 0.9 Ensembl dbSUPER 500.7 -1.8 -1762 0.9 PHB2 ZBTB11 NCOR1 NFIC ARNT TRIM24 IRF1 ZNF592 EHMT2 TAL1 ST8SIA6 HACD1 LOC105376437
GH10J017423 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 17.1 +28.8 28802 6.2 BCLAF1 PHB2 ZBTB5 ZIC2 ZBTB11 AFF1 TARDBP REST DNMT1 HES1 lnc-VIM-2 ST8SIA6 TMEM236 ST8SIA6-AS1 STAM TRDMT1 ENSG00000251803
GH10J017504 Enhancer 1.1 FANTOM5 Ensembl ENCODE 18.3 -50.7 -50728 4.1 JUND RELA ZNF316 MAFF IRF1 MAFK ZNF592 NFE2 KDM4B IRF2 ST8SIA6 HACD1 STAM piR-32214-039 lnc-ST8SIA6-2
GH10J017479 Enhancer 0.6 Ensembl 19.4 -24.5 -24491 0.4 KDM4B PBX2 IKZF1 NFATC3 TBX21 MEIS2 PBX3 SPI1 ATF7 BHLHE40 ST8SIA6 RF00100-015 LOC105376437
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST8SIA6

Top Transcription factor binding sites by QIAGEN in the ST8SIA6 gene promoter:
  • CBF(2)
  • CUTL1
  • FOXO1
  • FOXO1a
  • NF-Y
  • Pax-5
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ST8SIA6 Gene

Genomic Locations for ST8SIA6 Gene
chr10:17,315,414-17,455,510
(GRCh38/hg38)
Size:
140,097 bases
Orientation:
Minus strand
chr10:17,360,382-17,496,329
(GRCh37/hg19)
Size:
135,948 bases
Orientation:
Minus strand

Genomic View for ST8SIA6 Gene

Genes around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST8SIA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST8SIA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA6 Gene

Proteins for ST8SIA6 Gene

  • Protein details for ST8SIA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61647-SIA8F_HUMAN
    Recommended name:
    Alpha-2,8-sialyltransferase 8F
    Protein Accession:
    P61647
    Secondary Accessions:
    • B0YJ97
    • B9EH72
    • Q5VZH4

    Protein attributes for ST8SIA6 Gene

    Size:
    398 amino acids
    Molecular mass:
    44836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST8SIA6 Gene

Post-translational modifications for ST8SIA6 Gene

  • Glycosylation at Asn66, Asn93, Asn151, and Asn196
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST8SIA6 Gene

Domains & Families for ST8SIA6 Gene

Gene Families for ST8SIA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ST8SIA6 Gene

Blocks:
  • Glycosyl transferase, family 29
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST8SIA6 Gene

GenScript: Design optimal peptide antigens:
  • Sialytransferase St8Sia VI (SIA8F_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61647

UniProtKB/Swiss-Prot:

SIA8F_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA6: view

Function for ST8SIA6 Gene

Molecular function for ST8SIA6 Gene

UniProtKB/Swiss-Prot Function:
Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

Enzyme Numbers (IUBMB) for ST8SIA6 Gene

Phenotypes From GWAS Catalog for ST8SIA6 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008373 sialyltransferase activity ISS 11980897
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST8SIA6: view
genes like me logo Genes that share phenotypes with ST8SIA6: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST8SIA6 Gene

Localization for ST8SIA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST8SIA6 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
plasma membrane 2
endoplasmic reticulum 2
lysosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA6: view

Pathways & Interactions for ST8SIA6 Gene

genes like me logo Genes that share pathways with ST8SIA6: view

UniProtKB/Swiss-Prot P61647-SIA8F_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST8SIA6 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000366827 P61647-SIA8F_HUMAN for ST8SIA6 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IEA,ISS 11980897
GO:0001835 blastocyst hatching IEA --
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation ISS 11980897
GO:0009100 glycoprotein metabolic process IEA,ISS 11980897
genes like me logo Genes that share ontologies with ST8SIA6: view

No data available for SIGNOR curated interactions for ST8SIA6 Gene

Drugs & Compounds for ST8SIA6 Gene

No Compound Related Data Available

Transcripts for ST8SIA6 Gene

mRNA/cDNA for ST8SIA6 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA6 Gene

No ASD Table

Relevant External Links for ST8SIA6 Gene

GeneLoc Exon Structure for
ST8SIA6

Expression for ST8SIA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST8SIA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST8SIA6

SOURCE GeneReport for Unigene cluster for ST8SIA6 Gene:

Hs.677766
genes like me logo Genes that share expression patterns with ST8SIA6: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST8SIA6 Gene

Orthologs for ST8SIA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST8SIA6 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ST8SIA6 31 30
  • 85.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia St8sia6 17 31 30
  • 82.33 (n)
rat
(Rattus norvegicus)
Mammalia St8sia6 30
  • 81.32 (n)
cow
(Bos Taurus)
Mammalia ST8SIA6 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST8SIA6 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST8SIA6 31 30
  • 68.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST8SIA6 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia6 30
  • 64.13 (n)
zebrafish
(Danio rerio)
Actinopterygii st8sia6 31 30
  • 53.99 (n)
OneToOne
Species where no ortholog for ST8SIA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA6 Gene

ENSEMBL:
Gene Tree for ST8SIA6 (if available)
TreeFam:
Gene Tree for ST8SIA6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST8SIA6: view image

Paralogs for ST8SIA6 Gene

Paralogs for ST8SIA6 Gene

(7) SIMAP similar genes for ST8SIA6 Gene using alignment to 2 proteins:

  • SIA8F_HUMAN
  • H0Y405_HUMAN
genes like me logo Genes that share paralogs with ST8SIA6: view

Variants for ST8SIA6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST8SIA6 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs193920832 Uncertain Significance: Malignant tumor of prostate 17,359,547(-) C/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ST8SIA6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA6 Gene

Variant ID Type Subtype PubMed ID
esv2027380 CNV deletion 18987734
esv2658114 CNV deletion 23128226
esv2733639 CNV deletion 23290073
esv2733650 CNV deletion 23290073
esv3407759 CNV insertion 20981092
esv3576094 CNV gain 25503493
esv3578664 CNV loss 25503493
esv3622484 CNV gain 21293372
esv3622485 CNV loss 21293372
esv3891766 CNV loss 25118596
nsv1039697 CNV loss 25217958
nsv1046522 CNV loss 25217958
nsv1068286 CNV deletion 25765185
nsv1069028 CNV deletion 25765185
nsv1116633 CNV tandem duplication 24896259
nsv1127090 CNV deletion 24896259
nsv24310 CNV deletion 16902084
nsv474853 CNV novel sequence insertion 20440878
nsv5954 CNV deletion 18451855
nsv5966 CNV insertion 18451855

Variation tolerance for ST8SIA6 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST8SIA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST8SIA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Disorders for ST8SIA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST8SIA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute hemorrhagic conjunctivitis
  • apollo disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST8SIA6

genes like me logo Genes that share disorders with ST8SIA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST8SIA6 Gene

Publications for ST8SIA6 Gene

  1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PMID: 19176441) Yang JJ … Relling MV (JAMA 2009) 3 41 54
  2. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PMID: 16857734) Avril T … Crocker PR (Journal of leukocyte biology 2006) 3 23 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. (PMID: 11980897) Takashima S … Tsujimoto M (The Journal of biological chemistry 2002) 2 3 54
  5. Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. (PMID: 27490539) Yoon HK … Lee YC (International journal of molecular sciences 2016) 3 54

Products for ST8SIA6 Gene

Sources for ST8SIA6 Gene