Aliases for ST8SIA3 Gene
External Ids for ST8SIA3 Gene
Previous HGNC Symbols for ST8SIA3 Gene
Previous GeneCards Identifiers for ST8SIA3 Gene
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST8SIA3 Gene
ST8SIA3 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA2.
UniProtKB/Swiss-Prot Summary for ST8SIA3 Gene
Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.