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ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
ST8SIA3 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | IDA | 9826427 |
GO:0008373 | sialyltransferase activity | IEA,IDA | 26192331 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0033691 | sialic acid binding | IC | 9826427 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001574 | ganglioside biosynthetic process | IDA | 10766765 |
GO:0006486 | protein glycosylation | IEA | -- |
GO:0006491 | N-glycan processing | IDA | 10766765 |
GO:0006688 | glycosphingolipid biosynthetic process | TAS | 9073076 |
GO:0009100 | glycoprotein metabolic process | IDA | 9826427 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ST8SIA3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ST8SIA3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ST8SIA3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ST8SIA3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | St8sia3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | St8sia3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ST8SIA3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SIAT8C 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | ST8SIA3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | st8sia3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | st8sia3 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3745060 | - | p.Lys91Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2677142 | CNV | deletion | 23128226 |
esv3349412 | CNV | duplication | 20981092 |
nsv953551 | CNV | deletion | 24416366 |
No disorders were found for ST8SIA3 Gene.