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ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
ST8SIA3 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity | IDA | 9826427 |
GO:0008373 | sialyltransferase activity | IEA,IDA | 26192331 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0033691 | sialic acid binding | IC | 9826427 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001574 | ganglioside biosynthetic process | IDA | 10766765 |
GO:0006486 | protein glycosylation | IEA | -- |
GO:0006491 | N-glycan processing | IDA | 10766765 |
GO:0006688 | glycosphingolipid biosynthetic process | TAS | 9073076 |
GO:0009100 | glycoprotein metabolic process | IDA | 9826427 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ST8SIA3 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ST8SIA3 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | ST8SIA3 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | ST8SIA3 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | St8sia3 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | St8sia3 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | ST8SIA3 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SIAT8C 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | ST8SIA3 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | st8sia3 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | st8sia3 33 32 |
|
OneToOne |
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000017593 | -- | 57,356,728(+) | A/G | intron_variant | |
rs1000180448 | -- | 57,360,228(+) | G/A | coding_sequence_variant, missense_variant | |
rs1000232862 | -- | 57,359,811(+) | G/A | intron_variant | |
rs1000242604 | -- | 57,359,583(+) | T/A | intron_variant | |
rs1000553346 | -- | 57,352,508(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2677142 | CNV | deletion | 23128226 |
esv3349412 | CNV | duplication | 20981092 |
nsv953551 | CNV | deletion | 24416366 |
No disorders were found for ST8SIA3 Gene.