Aliases for ST8SIA2 Gene
External Ids for ST8SIA2 Gene
Previous HGNC Symbols for ST8SIA2 Gene
Previous GeneCards Identifiers for ST8SIA2 Gene
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
GeneCards Summary for ST8SIA2 Gene
ST8SIA2 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST8SIA2 include Epileptic Encephalopathy, Early Infantile, 26 and Amelogenesis Imperfecta, Type Iiia. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. An important paralog of this gene is ST8SIA4.
UniProtKB/Swiss-Prot Summary for ST8SIA2 Gene
May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.