This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully char... See more...

Aliases for ST7L Gene

Aliases for ST7L Gene

  • Suppression Of Tumorigenicity 7 Like 2 3 5
  • Suppressor Of Tumorigenicity 7 Protein-Like 3 4
  • ST7-Related Protein 3 4
  • ST7R 3 4
  • Tumor Suppressor ST7 Like 3
  • FAM4B 3
  • STLR 3

External Ids for ST7L Gene

Previous GeneCards Identifiers for ST7L Gene

  • GC01M113483
  • GC01M111938
  • GC01M112168
  • GC01M112364
  • GC01M112778
  • GC01M113066
  • GC01M110925

Summaries for ST7L Gene

Entrez Gene Summary for ST7L Gene

  • This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]

GeneCards Summary for ST7L Gene

ST7L (Suppression Of Tumorigenicity 7 Like) is a Protein Coding gene. An important paralog of this gene is ST7-OT3.

Additional gene information for ST7L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST7L Gene

Genomics for ST7L Gene

GeneHancer (GH) Regulatory Elements for ST7L Gene

Promoters and enhancers for ST7L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST7L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST7L gene promoter:
  • AML1a
  • c-Myb
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta
  • Pax-5
  • POU6F1 (c2)
  • STAT5A

Genomic Locations for ST7L Gene

Genomic Locations for ST7L Gene
chr1:112,517,804-112,620,838
(GRCh38/hg38)
Size:
103,035 bases
Orientation:
Minus strand
chr1:113,066,140-113,163,447
(GRCh37/hg19)
Size:
97,308 bases
Orientation:
Minus strand

Genomic View for ST7L Gene

Genes around ST7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST7L Gene

Proteins for ST7L Gene

  • Protein details for ST7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDW4-ST7L_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 7 protein-like
    Protein Accession:
    Q8TDW4
    Secondary Accessions:
    • A8K4S7
    • Q49AH6
    • Q5TEI4
    • Q5U5K6
    • Q6N067
    • Q7Z2Z0
    • Q7Z3C2
    • Q8N7P8
    • Q8TDW1
    • Q8TDW2
    • Q8TDW3
    • Q9NXF3

    Protein attributes for ST7L Gene

    Size:
    575 amino acids
    Molecular mass:
    64779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91060.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAE45803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ST7L Gene

neXtProt entry for ST7L Gene

Post-translational modifications for ST7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST7L Gene

Domains & Families for ST7L Gene

Gene Families for ST7L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST7L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST7L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55859, highly similar to Homo sapiens suppression of tumorigenicity 7 like (ST7L), transcript variant 4, mRNA (B7Z7D4_HUMAN)
  • cDNA FLJ59279, highly similar to Homo sapiens suppression of tumorigenicity 7 like (ST7L), transcript variant 2, mRNA (B7Z8V6_HUMAN)
  • Suppression of tumorigenicity 7 like (Q5TEI0_HUMAN)
  • ST7-related protein (ST7L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDW4

UniProtKB/Swiss-Prot:

ST7L_HUMAN :
  • Belongs to the ST7 family.
Family:
  • Belongs to the ST7 family.
genes like me logo Genes that share domains with ST7L: view

Function for ST7L Gene

Phenotypes From GWAS Catalog for ST7L Gene

genes like me logo Genes that share phenotypes with ST7L: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST7L Gene

Localization for ST7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST7L Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST7L gene
Compartment Confidence
peroxisome 1
nucleus 1
cytosol 1
plasma membrane 0
extracellular 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST7L: view

Pathways & Interactions for ST7L Gene

PathCards logo

SuperPathways for ST7L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ST7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth ISS --
genes like me logo Genes that share ontologies with ST7L: view

No data available for Pathways by source and SIGNOR curated interactions for ST7L Gene

Drugs & Compounds for ST7L Gene

No Compound Related Data Available

Transcripts for ST7L Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST7L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - - - - -
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c
SP1: - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for ST7L Gene

GeneLoc Exon Structure for
ST7L
ECgene alternative splicing isoforms for
ST7L

Expression for ST7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST7L Gene

Protein differential expression in normal tissues from HIPED for ST7L Gene

This gene is overexpressed in Heart (48.1) and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST7L Gene



Protein tissue co-expression partners for ST7L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ST7L Gene:

ST7L

SOURCE GeneReport for Unigene cluster for ST7L Gene:

Hs.201921

Evidence on tissue expression from TISSUES for ST7L Gene

  • Nervous system(4.5)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ST7L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST7L Gene

Orthologs for ST7L Gene

This gene was present in the common ancestor of animals.

Orthologs for ST7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST7L 33 32
  • 99.71 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 95 (a)
OneToMany
-- 33
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ST7L 33 32
  • 94.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST7L 33 32
  • 93.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia St7l 32
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia St7l 17 33 32
  • 89.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ST7L 33
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST7L 33 32
  • 76.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST7L 33
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii st7l 33
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3634 33 34
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A10.5 33 34
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 64 (a)
OneToMany
Species where no ortholog for ST7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST7L Gene

ENSEMBL:
Gene Tree for ST7L (if available)
TreeFam:
Gene Tree for ST7L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST7L: view image

Paralogs for ST7L Gene

Paralogs for ST7L Gene

(1) SIMAP similar genes for ST7L Gene using alignment to 6 proteins:

  • ST7L_HUMAN
  • B7Z7D4_HUMAN
  • B7Z8V6_HUMAN
  • F5H2P3_HUMAN
  • H0Y7M0_HUMAN
  • Q5TEH7_HUMAN
genes like me logo Genes that share paralogs with ST7L: view

Variants for ST7L Gene

Sequence variations from dbSNP and Humsavar for ST7L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008870 -- 112,534,251(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000039184 -- 112,589,829(-) A/T intron_variant
rs1000049579 -- 112,545,784(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000054693 -- 112,592,612(-) A/G intron_variant
rs1000086745 -- 112,586,566(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST7L Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV gain+loss 19812545
esv3339804 CNV insertion 20981092
esv3578114 CNV loss 25503493
nsv831081 CNV loss 17160897

Variation tolerance for ST7L Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST7L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST7L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST7L Gene

Disorders for ST7L Gene

Additional Disease Information for ST7L

No disorders were found for ST7L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST7L Gene

Publications for ST7L Gene

  1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. (PMID: 12012006) Katoh M (International journal of oncology 2002) 2 3 4 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. (PMID: 30176933) Yan S … Tang H (Journal of experimental & clinical cancer research : CR 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma. (PMID: 28518144) Zhuang L … Wu L (Cell death & disease 2017) 3 56

Products for ST7L Gene

Sources for ST7L Gene