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Aliases for ST6GALNAC4 Gene

Aliases for ST6GALNAC4 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 2 3 5
  • Sialyltransferase 7D ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 2 3
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 4 2 3
  • Sialyltransferase 3C 3 4
  • ST6GalNAc IV 3 4
  • EC 4 56
  • SIAT3-C 3 4
  • SIAT7-D 3 4
  • SIAT7D 3 4
  • SIAT3C 3 4
  • Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3-N-Acetyl-Galactosaminide Alpha-2,6-Sialyltransferase 3
  • ST6 Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminidealpha-2,6-Sialyltransferase 4 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2, 6-Sialyltransferase Alpha2,6-Sialyltransferase 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase IV 3
  • NeuAc-Alpha-2,3-Gal-Beta-1,3-GalNAc-Alpha-2,6-Sialyltransferase 4
  • Sialyltransferase 7D 4
  • ST6GalNAc 3
  • EC 2.4.99 56
  • IV 3

External Ids for ST6GALNAC4 Gene

Previous HGNC Symbols for ST6GALNAC4 Gene

  • SIAT7D

Previous GeneCards Identifiers for ST6GALNAC4 Gene

  • GC09M127751
  • GC09M129709
  • GC09M130671
  • GC09M100287

Summaries for ST6GALNAC4 Gene

Entrez Gene Summary for ST6GALNAC4 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST6GALNAC4 Gene

ST6GALNAC4 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity. An important paralog of this gene is ST6GALNAC3.

UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

  • Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Gene Wiki entry for ST6GALNAC4 Gene

Additional gene information for ST6GALNAC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC4 Gene

Genomics for ST6GALNAC4 Gene

GeneHancer (GH) Regulatory Elements for ST6GALNAC4 Gene

Promoters and enhancers for ST6GALNAC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I127914 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.4 -1449 7.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A ZNF2 YY1 ST6GALNAC4 SNORA65 ZNF79 PIP5KL1 NAIF1 GLE1 ODF2 FPGS LOC102723566 RPL12
GH09I127761 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +150.2 150217 11.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZBTB7B YY1 TCF12 ZNF121 SH2D3C FPGS ENG LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09I127826 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +88.8 88844 3.7 HDGF ATF1 ARID4B SIN3A ZNF48 YY1 SLC30A9 TCF12 ZNF121 POLR2B FPGS ENG FAM129B AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 CDK9 ENSG00000227218 TOR2A
GH09I127962 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.8 -56.3 -56297 22.2 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D FAM102A PIP5KL1 NAIF1 DPM2 ENSG00000272593 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1
GH09I127824 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +91.6 91624 1.5 HDAC1 ELF3 PKNOX1 ATF1 RB1 ZFP64 ARID4B DMAP1 ZNF48 RAD21 ENG FPGS AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 ENSG00000222421 LOC102723566
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST6GALNAC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST6GALNAC4 gene promoter:

Genomic Locations for ST6GALNAC4 Gene

Genomic Locations for ST6GALNAC4 Gene
9,166 bases
Minus strand

Genomic View for ST6GALNAC4 Gene

Genes around ST6GALNAC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC4 Gene

Proteins for ST6GALNAC4 Gene

  • Protein details for ST6GALNAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q5T9D0
    • Q9NWU6
    • Q9UKU1
    • Q9ULB9
    • Q9Y3G3
    • Q9Y3G4

    Protein attributes for ST6GALNAC4 Gene

    302 amino acids
    Molecular mass:
    34201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC4 Gene

Selected DME Specific Peptides for ST6GALNAC4 Gene


Post-translational modifications for ST6GALNAC4 Gene

Other Protein References for ST6GALNAC4 Gene

Domains & Families for ST6GALNAC4 Gene

Gene Families for ST6GALNAC4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST6GALNAC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC4: view

Function for ST6GALNAC4 Gene

Molecular function for ST6GALNAC4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity).

Enzyme Numbers (IUBMB) for ST6GALNAC4 Gene

Phenotypes From GWAS Catalog for ST6GALNAC4 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity IEA,TAS 10207017
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity TAS --
genes like me logo Genes that share ontologies with ST6GALNAC4: view
genes like me logo Genes that share phenotypes with ST6GALNAC4: view

Animal Model Products

CRISPR Products

miRNA for ST6GALNAC4 Gene

miRTarBase miRNAs that target ST6GALNAC4

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC4 Gene

Localization for ST6GALNAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC4 gene
Compartment Confidence
golgi apparatus 4
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

Pathways & Interactions for ST6GALNAC4 Gene

genes like me logo Genes that share pathways with ST6GALNAC4: view

UniProtKB/Swiss-Prot Q9H4F1-SIA7D_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC4 Gene

Gene Ontology (GO) - Biological Process for ST6GALNAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006664 glycolipid metabolic process TAS 10207017
GO:0009311 oligosaccharide metabolic process IBA --
GO:0016266 O-glycan processing TAS --
GO:0018279 protein N-linked glycosylation via asparagine IBA --
genes like me logo Genes that share ontologies with ST6GALNAC4: view

No data available for SIGNOR curated interactions for ST6GALNAC4 Gene

Drugs & Compounds for ST6GALNAC4 Gene

(1) Drugs for ST6GALNAC4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST6GALNAC4: view

Transcripts for ST6GALNAC4 Gene

Unigene Clusters for ST6GALNAC4 Gene

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - - -
SP3: - -
SP6: - -

Relevant External Links for ST6GALNAC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST6GALNAC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST6GALNAC4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GALNAC4 Gene

Protein tissue co-expression partners for ST6GALNAC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC4 Gene:


SOURCE GeneReport for Unigene cluster for ST6GALNAC4 Gene:


mRNA Expression by UniProt/SwissProt for ST6GALNAC4 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ST6GALNAC4 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ST6GALNAC4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC4 Gene

Orthologs for ST6GALNAC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST6GALNAC4 33 34
  • 99.01 (n)
(Canis familiaris)
Mammalia ST6GALNAC4 33 34
  • 90.84 (n)
(Bos Taurus)
Mammalia ST6GALNAC4 33
  • 88.19 (n)
  • 74 (a)
(Mus musculus)
Mammalia St6galnac4 33 16 34
  • 85.98 (n)
(Rattus norvegicus)
Mammalia St6galnac4 33
  • 85.87 (n)
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC4 34
  • 73 (a)
(Gallus gallus)
Aves ST6GALNAC4 33 34
  • 73.38 (n)
(Anolis carolinensis)
Reptilia ST6GALNAC4 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac4 33
  • 64.61 (n)
(Danio rerio)
Actinopterygii st6galnac4 33 34
  • 61.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 34
  • 13 (a)
Species where no ortholog for ST6GALNAC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC4 Gene

Gene Tree for ST6GALNAC4 (if available)
Gene Tree for ST6GALNAC4 (if available)

Paralogs for ST6GALNAC4 Gene

Paralogs for ST6GALNAC4 Gene

(3) SIMAP similar genes for ST6GALNAC4 Gene using alignment to 3 proteins: Pseudogenes for ST6GALNAC4 Gene

genes like me logo Genes that share paralogs with ST6GALNAC4: view

Variants for ST6GALNAC4 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC4 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000414681 -- 127,917,451(-) C/T upstream_transcript_variant
rs1001199065 -- 127,916,566(-) G/A intron_variant
rs1001221442 -- 127,915,893(-) G/A intron_variant
rs1001230099 -- 127,916,925(-) T/C 5_prime_UTR_variant, non_coding_transcript_variant
rs1001420770 -- 127,916,985(-) G/A 5_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC4 Gene

Variant ID Type Subtype PubMed ID
nsv6722 CNV insertion 18451855
nsv615381 CNV loss 21841781
nsv466577 CNV loss 19166990
esv3621797 CNV gain 21293372
esv2739055 CNV deletion 23290073

Variation tolerance for ST6GALNAC4 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GALNAC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC4 Gene

Disorders for ST6GALNAC4 Gene

Additional Disease Information for ST6GALNAC4

No disorders were found for ST6GALNAC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC4 Gene

Publications for ST6GALNAC4 Gene

  1. Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV. (PMID: 11062056) Harduin-Lepers A … Delannoy P (The Biochemical journal 2000) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J … Fried M (Human molecular genetics 1999) 3 4 58
  5. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. (PMID: 10207017) Lee YC … Tsuji S (The Journal of biological chemistry 1999) 2 3 58

Products for ST6GALNAC4 Gene

Sources for ST6GALNAC4 Gene

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