ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008] See more...

Aliases for ST6GALNAC3 Gene

Aliases for ST6GALNAC3 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2 3 5
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) C 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 2 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 3 4
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 3 2 3
  • GalNAc Alpha-2,6-Sialyltransferase III 3 4
  • Sialyltransferase 7C 3 4
  • EC 2.4.99.7 4 50
  • SIAT7C 3 4
  • STY 3 4
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltran 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase III 3
  • ST6GALNAC III 2
  • ST6GalNAc III 4
  • ST6GALNACIII 3
  • ST6GalNAcIII 4
  • ST6GALNAC3 5
  • PRO7177 3
  • SIAT7-C 4

External Ids for ST6GALNAC3 Gene

Previous HGNC Symbols for ST6GALNAC3 Gene

  • SIAT7C

Previous GeneCards Identifiers for ST6GALNAC3 Gene

  • GC01P076253
  • GC01P076540
  • GC01P074670

Summaries for ST6GALNAC3 Gene

Entrez Gene Summary for ST6GALNAC3 Gene

  • ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC3 Gene

ST6GALNAC3 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3) is a Protein Coding gene. Diseases associated with ST6GALNAC3 include Glioblastoma Proneural Subtype. Among its related pathways are Globo Sphingolipid Metabolism and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC4.

UniProtKB/Swiss-Prot Summary for ST6GALNAC3 Gene

  • Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GALNAC3 Gene

Genomics for ST6GALNAC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ST6GALNAC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J076074 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 257.8 +0.6 586 3.4 ZNF600 JUND ZNF10 ZIC2 POLR2A BHLHE40 ZNF610 SP2 RXRA ZBTB48 ST6GALNAC3 lnc-ASB17-3 ENSG00000225605 piR-56759-028 ST6GALNAC5
GH01J076075 Enhancer 0.2 Ensembl 250.7 -1.6 -1633 0.2 lnc-ASB17-3 ST6GALNAC3 piR-31937-004 ASB17
GH01J076040 Enhancer 0.8 Ensembl ENCODE 24.9 -33.7 -33701 1.9 ZIC2 ZNF341 ZNF610 NRF1 ZNF362 ZFP69B ZNF384 PKNOX1 ZNF692 OSR2 ENSG00000230027 ST6GALNAC3 ENSG00000225605 ACADM MSH4 piR-31937-004 ASB17
GH01J076037 Enhancer 0.8 Ensembl ENCODE 23.9 -36.5 -36485 2.4 ZNF580 FEZF1 ZNF843 PRDM6 SCRT1 JUND SP7 PRDM4 POLR2A ZXDB ST6GALNAC3 ENSG00000225605 ENSG00000230027 LOC105378806 ASB17
GH01J076105 Enhancer 0.7 Ensembl 17.7 +30.9 30867 1.2 ZNF580 FEZF1 ZNF341 ZNF610 ZNF843 KLF16 PRDM6 SPI1 POLR2A ZNF664 ST6GALNAC3 ENSG00000225605 piR-56759-028 ST6GALNAC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST6GALNAC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST6GALNAC3

Top Transcription factor binding sites by QIAGEN in the ST6GALNAC3 gene promoter:
  • AP-4
  • E47
  • FOXF2
  • FOXO4
  • Gfi-1
  • Lmo2
  • Pax-3
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ST6GALNAC3 Gene

Latest Assembly
chr1:76,074,734-76,637,339
(GRCh38/hg38)
Size:
562,606 bases
Orientation:
Plus strand

Previous Assembly
chr1:76,540,431-77,103,024
(GRCh37/hg19 by Entrez Gene)
Size:
562,594 bases
Orientation:
Plus strand

chr1:76,540,404-77,100,286
(GRCh37/hg19 by Ensembl)
Size:
559,883 bases
Orientation:
Plus strand

Genomic View for ST6GALNAC3 Gene

Genes around ST6GALNAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC3 Gene

Proteins for ST6GALNAC3 Gene

  • Protein details for ST6GALNAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV1-SIA7C_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
    Protein Accession:
    Q8NDV1
    Secondary Accessions:
    • Q6PCE0
    • Q6UX29
    • Q8N259

    Protein attributes for ST6GALNAC3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST6GALNAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GALNAC3 Gene

Selected DME Specific Peptides for ST6GALNAC3 Gene

Q8NDV1:
  • HRFITEK
  • LSTGWFT
  • SHTSVPLLL

Post-translational modifications for ST6GALNAC3 Gene

  • Glycosylation at Asn148, Asn239, and Asn301
  • Modification sites at PhosphoSitePlus

Domains & Families for ST6GALNAC3 Gene

Gene Families for ST6GALNAC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST6GALNAC3 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 29

Suggested Antigen Peptide Sequences for ST6GALNAC3 Gene

GenScript: Design optimal peptide antigens:
  • Sialyltransferase 7C (SIA7C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NDV1

UniProtKB/Swiss-Prot:

SIA7C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC3: view

Function for ST6GALNAC3 Gene

Molecular function for ST6GALNAC3 Gene

UniProtKB/Swiss-Prot Function:
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+); Xref=Rhea:RHEA:53896, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:146021, ChEBI:CHEBI:149714; EC=2.4.99.7; Evidence={ECO:0000269|PubMed:16169874, ECO:0000269|PubMed:17123352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:41968, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568, ChEBI:CHEBI:78569; Evidence={ECO:0000269|PubMed:16169874, ECO:0000269|PubMed:17123352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+); Xref=Rhea:RHEA:56088, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140623, ChEBI:CHEBI:140624; Evidence={ECO:0000269|PubMed:17123352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Ser-[protein] + CMP + H(+); Xref=Rhea:RHEA:65280, Rhea:RHEA-COMP:16760, Rhea:RHEA-COMP:16761, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:156395, ChEBI:CHEBI:156397; Evidence={ECO:0000269|PubMed:16169874, ECO:0000269|PubMed:17123352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-[alpha-NeuNAc-(2->6)]-alpha-D-GalNAc-(1<->1')-L-Thr-[protein] + CMP + H(+); Xref=Rhea:RHEA:65284, Rhea:RHEA-COMP:16762, Rhea:RHEA-COMP:16763, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:156396, ChEBI:CHEBI:156398; Evidence={ECO:0000269|PubMed:16169874, ECO:0000269|PubMed:17123352};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.02 mM for ganglioside GM1b {ECO:0000269|PubMed:16169874};

Enzyme Numbers (IUBMB) for ST6GALNAC3 Gene

Phenotypes From GWAS Catalog for ST6GALNAC3 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0008373 sialyltransferase activity IEA,IDA 17123352
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC3: view
genes like me logo Genes that share phenotypes with ST6GALNAC3: view

Animal Models for research

  • Taconic Biosciences Mouse Models for ST6GALNAC3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC3 Gene

Localization for ST6GALNAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC3 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC3 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
extracellular 3
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC3: view

Pathways & Interactions for ST6GALNAC3 Gene

genes like me logo Genes that share pathways with ST6GALNAC3: view

UniProtKB/Swiss-Prot Q8NDV1-SIA7C_HUMAN

  • Pathway: Protein modification; protein glycosylation.
  • Pathway: Glycolipid biosynthesis.

Gene Ontology (GO) - Biological Process for ST6GALNAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process IBA 21873635
GO:0006486 protein glycosylation IEA --
GO:0006677 glycosylceramide metabolic process IDA 17123352
GO:0006687 glycosphingolipid metabolic process IDA 17123352
GO:0009100 glycoprotein metabolic process IDA 17123352
genes like me logo Genes that share ontologies with ST6GALNAC3: view

No data available for SIGNOR curated interactions for ST6GALNAC3 Gene

Drugs & Compounds for ST6GALNAC3 Gene

(1) Drugs for ST6GALNAC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine 5'-monophosphate-N-acetylneuraminic acid
  • CMP Acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Nana
  • CMP-Neu5ac
3063-71-6
genes like me logo Genes that share compounds with ST6GALNAC3: view

Transcripts for ST6GALNAC3 Gene

mRNA/cDNA for ST6GALNAC3 Gene

9 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC3

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC3 Gene

No ASD Table

Relevant External Links for ST6GALNAC3 Gene

GeneLoc Exon Structure for
ST6GALNAC3

Expression for ST6GALNAC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST6GALNAC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for ST6GALNAC3 Gene

This gene is overexpressed in Plasma (44.9) and Adipocyte (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST6GALNAC3 Gene



Protein tissue co-expression partners for ST6GALNAC3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST6GALNAC3

SOURCE GeneReport for Unigene cluster for ST6GALNAC3 Gene:

Hs.337040

mRNA Expression by UniProt/SwissProt for ST6GALNAC3 Gene:

Q8NDV1-SIA7C_HUMAN
Tissue specificity: Expressed in brain and kidney (PubMed:16169874, PubMed:17123352). Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules (PubMed:17123352).

Evidence on tissue expression from TISSUES for ST6GALNAC3 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ST6GALNAC3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC3 Gene

Orthologs for ST6GALNAC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GALNAC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC3 29 30
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ST6GALNAC3 29
  • 93.44 (n)
Dog
(Canis familiaris)
Mammalia ST6GALNAC3 29 30
  • 93.2 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 91 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia St6galnac3 29 16 30
  • 83.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia St6galnac3 29
  • 82.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC3 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ST6GALNAC3 29 30
  • 80.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ST6GALNAC3 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia st6galnac3 29
  • 72.02 (n)
Zebrafish
(Danio rerio)
Actinopterygii st6galnac3 29 30
  • 63.06 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta ST6Gal 30
  • 11 (a)
OneToMany
Species where no ortholog for ST6GALNAC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ST6GALNAC3 Gene

ENSEMBL:
Gene Tree for ST6GALNAC3 (if available)
TreeFam:
Gene Tree for ST6GALNAC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST6GALNAC3: view image
Alliance of Genome Resources:
Additional Orthologs for ST6GALNAC3

Paralogs for ST6GALNAC3 Gene

(3) SIMAP similar genes for ST6GALNAC3 Gene using alignment to 1 proteins:

  • SIA7C_HUMAN
genes like me logo Genes that share paralogs with ST6GALNAC3: view

Variants for ST6GALNAC3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ST6GALNAC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC3 Gene

Variant ID Type Subtype PubMed ID
dgv197n100 CNV loss 25217958
dgv198n100 CNV gain 25217958
dgv20n27 CNV loss 19166990
dgv327n54 CNV loss 21841781
dgv52n67 CNV loss 20364138
dgv57e212 CNV loss 25503493
esv2108639 CNV deletion 18987734
esv2659404 CNV deletion 23128226
esv2667591 CNV deletion 23128226
esv274979 CNV loss 21479260
esv2750007 CNV deletion 23290073
esv2750018 CNV deletion 23290073
esv2750030 CNV deletion 23290073
esv2750041 CNV deletion 23290073
esv2750052 CNV deletion 23290073
esv28849 CNV loss 19812545
esv2995021 CNV deletion 24192839
esv3364194 CNV insertion 20981092
esv3564359 CNV deletion 23714750
esv3564381 CNV deletion 23714750
esv3577970 CNV loss 25503493
esv3577973 CNV loss 25503493
esv3581693 CNV gain 25503493
esv3586494 CNV loss 21293372
esv3586495 CNV loss 21293372
esv3586497 CNV loss 21293372
esv3586499 CNV gain 21293372
esv3586500 CNV loss 21293372
nsv1122366 CNV deletion 24896259
nsv1133867 CNV deletion 24896259
nsv1151562 CNV deletion 26484159
nsv1488 CNV deletion 18451855
nsv1499 CNV deletion 18451855
nsv462006 CNV loss 19166990
nsv462017 CNV loss 19166990
nsv462028 CNV loss 19166990
nsv470718 CNV loss 18288195
nsv508315 CNV deletion 20534489
nsv518927 CNV loss 19592680
nsv522056 CNV loss 19592680
nsv523526 CNV loss 19592680
nsv526433 CNV loss 19592680
nsv546584 CNV loss 21841781
nsv546585 CNV loss 21841781
nsv546586 CNV loss 21841781
nsv546587 CNV loss 21841781
nsv947432 CNV duplication 23825009
nsv997827 CNV loss 25217958

Variation tolerance for ST6GALNAC3 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.66; 93.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GALNAC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC3
Leiden Open Variation Database (LOVD)
ST6GALNAC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST6GALNAC3 Gene

Disorders for ST6GALNAC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST6GALNAC3 Gene - From: COP

Disorder Aliases PubMed IDs
glioblastoma proneural subtype
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST6GALNAC3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ST6GALNAC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC3 Gene

Publications for ST6GALNAC3 Gene

  1. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. (PMID: 17123352) Senda M … Furukawa K (The Biochemical journal 2007) 3 4 22
  2. Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. (PMID: 16169874) Tsuchida A … Furukawa K (Journal of biochemistry 2005) 3 4 22
  3. Genome-wide association identifies candidate genes that influence the human electroencephalogram. (PMID: 20421487) Hodgkinson CA … Goldman D (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 40
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Treviño LR … Relling MV (Nature genetics 2009) 3 40

Products for ST6GALNAC3 Gene

Sources for ST6GALNAC3 Gene