ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008] See more...

Aliases for ST6GALNAC2 Gene

Aliases for ST6GALNAC2 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3 4
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
  • GalNAc Alpha-2,6-Sialyltransferase II 3 4
  • Sialyltransferase-Like 1 2 3
  • Sialyltransferase 7B 3 4
  • ST6GalNAc II 3 4
  • ST6GalNAcII 3 4
  • SIAT7-B 3 4
  • SIAT7B 3 4
  • SIATL1 3 4
  • STHM 3 4
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
  • ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
  • EC 2.4.99.3 4
  • ST6GalNAII 3
  • SAITL1 3
  • SIAT7 3
  • SThM 4

External Ids for ST6GALNAC2 Gene

Previous HGNC Symbols for ST6GALNAC2 Gene

  • SIAT7
  • SIAT7B
  • SIATL1

Previous GeneCards Identifiers for ST6GALNAC2 Gene

  • GC17M072074
  • GC17M074561
  • GC17M069989
  • GC17M076563

Summaries for ST6GALNAC2 Gene

Entrez Gene Summary for ST6GALNAC2 Gene

  • ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC2 Gene

ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.

UniProtKB/Swiss-Prot Summary for ST6GALNAC2 Gene

  • Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.

Gene Wiki entry for ST6GALNAC2 Gene

Additional gene information for ST6GALNAC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GALNAC2 Gene

Genomics for ST6GALNAC2 Gene

GeneHancer (GH) Regulatory Elements for ST6GALNAC2 Gene

Promoters and enhancers for ST6GALNAC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST6GALNAC2 gene promoter:
  • Egr-2
  • Egr-3
  • Evi-1
  • FOXO4
  • GATA-3
  • LyF-1
  • p53
  • Pax-4a
  • Pax-5

Genomic Locations for ST6GALNAC2 Gene

Genomic Locations for ST6GALNAC2 Gene
chr17:76,565,379-76,586,956
(GRCh38/hg38)
Size:
21,578 bases
Orientation:
Minus strand
chr17:74,559,792-74,583,038
(GRCh37/hg19)
Size:
23,247 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC2 Gene

Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC2 Gene

Proteins for ST6GALNAC2 Gene

  • Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ37-SIA7B_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q9UJ37
    Secondary Accessions:
    • Q12971

    Protein attributes for ST6GALNAC2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41939 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.

    Three dimensional structures from OCA and Proteopedia for ST6GALNAC2 Gene

neXtProt entry for ST6GALNAC2 Gene

Post-translational modifications for ST6GALNAC2 Gene

  • Glycosylation at Asn85, Asn130, and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for ST6GALNAC2 Gene

No data available for DME Specific Peptides for ST6GALNAC2 Gene

Domains & Families for ST6GALNAC2 Gene

Gene Families for ST6GALNAC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ST6GALNAC2 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene

GenScript: Design optimal peptide antigens:
  • Sialyltransferase 7B (SIA7B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJ37

UniProtKB/Swiss-Prot:

SIA7B_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC2: view

Function for ST6GALNAC2 Gene

Molecular function for ST6GALNAC2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.99.3; Evidence={ECO:0000269 PubMed:10742600, ECO:0000269 PubMed:29251719};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=130 uM for CMP-N-acetylneuraminate {ECO:0000269 PubMed:10742600}; KM=104 uM for CMP-N-acetylneuraminate {ECO:0000269 PubMed:29251719};

Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene

Phenotypes From GWAS Catalog for ST6GALNAC2 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA,IDA 10742600
GO:0008373 sialyltransferase activity IEA,TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view
genes like me logo Genes that share phenotypes with ST6GALNAC2: view

Animal Models for ST6GALNAC2 Gene

MGI Knock Outs for ST6GALNAC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene

Localization for ST6GALNAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene

Pathways & Interactions for ST6GALNAC2 Gene

genes like me logo Genes that share pathways with ST6GALNAC2: view

UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST6GALNAC2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 16)
STRING Interaction Network
Selected Interacting proteins: Q9UJ37-SIA7B_HUMAN ENSP00000225276 for ST6GALNAC2 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for ST6GALNAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IDA,IEA 29251719
GO:0006493 protein O-linked glycosylation IDA 10742600
GO:0016266 O-glycan processing TAS --
GO:0097503 sialylation IEA --
GO:1990743 protein sialylation IDA 10742600
genes like me logo Genes that share ontologies with ST6GALNAC2: view

No data available for SIGNOR curated interactions for ST6GALNAC2 Gene

Drugs & Compounds for ST6GALNAC2 Gene

(1) Drugs for ST6GALNAC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST6GALNAC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Sialic acid
  • CYTIDINE-5'-monophosphATE-5-N-acetylneuraminIC ACID
  • CMP-b-Neu5ac
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC2: view

Transcripts for ST6GALNAC2 Gene

mRNA/cDNA for ST6GALNAC2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for ST6GALNAC2 Gene

GeneLoc Exon Structure for
ST6GALNAC2
ECgene alternative splicing isoforms for
ST6GALNAC2

Expression for ST6GALNAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene

This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for ST6GALNAC2 Gene

This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST6GALNAC2 Gene



Protein tissue co-expression partners for ST6GALNAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC2 Gene:

ST6GALNAC2

SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:

Hs.592105

mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:

Q9UJ37-SIA7B_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.

Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with ST6GALNAC2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene

Orthologs for ST6GALNAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC2 33 32
  • 97.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GALNAC2 33 32
  • 85.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST6GALNAC2 33 32
  • 83.82 (n)
OneToOne
mouse
(Mus musculus)
Mammalia St6galnac2 17 33 32
  • 79.36 (n)
rat
(Rattus norvegicus)
Mammalia St6galnac2 32
  • 79.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC2 33
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GALNAC2 33
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC2 33 32
  • 63.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC2 33
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac2 32
  • 62.66 (n)
siat7b 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.15681 32
zebrafish
(Danio rerio)
Actinopterygii st6galnac2 32
  • 59.31 (n)
ST6GALNAC2 33
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11887 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 33
  • 22 (a)
OneToMany
Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC2 Gene

ENSEMBL:
Gene Tree for ST6GALNAC2 (if available)
TreeFam:
Gene Tree for ST6GALNAC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST6GALNAC2: view image

Paralogs for ST6GALNAC2 Gene

(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:

  • SIA7B_HUMAN
  • K7EIW2_HUMAN
  • K7EKT8_HUMAN
  • K7EMI2_HUMAN
  • K7EMM1_HUMAN

Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene

genes like me logo Genes that share paralogs with ST6GALNAC2: view

Variants for ST6GALNAC2 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000031746 -- 76,566,938(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000093147 -- 76,586,256(-) C/G upstream_transcript_variant
rs1000111407 -- 76,571,112(-) T/C intron_variant
rs1000167981 -- 76,584,253(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000392070 -- 76,577,060(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC2 Gene

Variant ID Type Subtype PubMed ID
esv28008 CNV loss 19812545
esv3641290 CNV gain 21293372
esv3641291 CNV gain 21293372
nsv1071403 CNV deletion 25765185
nsv828107 CNV loss 20364138

Variation tolerance for ST6GALNAC2 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GALNAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene

Disorders for ST6GALNAC2 Gene

Additional Disease Information for ST6GALNAC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ST6GALNAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene

Publications for ST6GALNAC2 Gene

  1. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 43 56
  2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 23 56
  3. Expression system for structural and functional studies of human glycosylation enzymes. (PMID: 29251719) Moremen KW … Jarvis DL (Nature chemical biology 2018) 3 4 56
  4. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 43 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for ST6GALNAC2 Gene

Sources for ST6GALNAC2 Gene