ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008] See more...
Aliases for ST6GALNAC2 Gene
Aliases for ST6GALNAC2 Gene
- ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
- ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
- Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3 4
- ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
- GalNAc Alpha-2,6-Sialyltransferase II 3 4
- Sialyltransferase-Like 1 2 3
- Sialyltransferase 7B 3 4
- ST6GalNAc II 3 4
- ST6GalNAcII 3 4
- SIAT7-B 3 4
- SIAT7B 3 4
- SIATL1 3 4
- STHM 3 4
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
- EC 2.4.99.3 4
- ST6GalNAII 3
- SAITL1 3
- SIAT7 3
- SThM 4
External Ids for ST6GALNAC2 Gene
- HGNC: 10867
- Entrez Gene: 10610
- Ensembl: ENSG00000070731
- OMIM: 610137
- UniProtKB: Q9UJ37
Previous HGNC Symbols for ST6GALNAC2 Gene
- SIAT7
- SIAT7B
- SIATL1
Previous GeneCards Identifiers for ST6GALNAC2 Gene
- GC17M072074
- GC17M074561
- GC17M069989
- GC17M076563
Summaries for ST6GALNAC2 Gene
-
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST6GALNAC2 Gene
ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.
UniProtKB/Swiss-Prot Summary for ST6GALNAC2 Gene
-
Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
Additional gene information for ST6GALNAC2 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GALNAC2 Gene
Genomics for ST6GALNAC2 Gene
GeneHancer (GH) Regulatory Elements for ST6GALNAC2 Gene
Promoters and enhancers for ST6GALNAC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ST6GALNAC2 gene promoter:
-
- Egr-2
- Egr-3
- Evi-1
- FOXO4
- GATA-3
- LyF-1
- p53
- Pax-4a
- Pax-5
Genomic Locations for ST6GALNAC2 Gene
Genomic Locations for ST6GALNAC2 Gene
- chr17:76,565,379-76,586,956
- (GRCh38/hg38)
- Size:
- 21,578 bases
- Orientation:
- Minus strand
- chr17:74,559,792-74,583,038
- (GRCh37/hg19)
- Size:
- 23,247 bases
- Orientation:
- Minus strand
Genomic View for ST6GALNAC2 Gene
Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
ST6GALNAC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ST6GALNAC2 Gene
Proteins for ST6GALNAC2 Gene
-
Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJ37-SIA7B_HUMAN
- Recommended name:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
- Protein Accession:
- Q9UJ37
- Q12971
Protein attributes for ST6GALNAC2 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 41939 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.
Protein Expression for ST6GALNAC2 Gene
Post-translational modifications for ST6GALNAC2 Gene
Other Protein References for ST6GALNAC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-ST6GALNAC2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ST6GALNAC2
- Novus Biologicals Antibodies for ST6GALNAC2
- Invitrogen Antibodies for ST6GALNAC2 (AFLGC-ST6GALNAC2)
- Sino Biological Antibodies for ST6GALNAC2
Protein Products
- G Biosciences Human ST6 Sialyltransferase 2/ST6GALNAC2, Liquid
- Atlas Antibodies PrEST Antigen ST6GALNAC2
-
OriGene Purified Proteins for ST6GALNAC2
- Search Origene for MassSpec and Protein Over-expression Lysates for ST6GALNAC2
- Origene Custom Protein Services for ST6GALNAC2
- Sino Biological Cell Lysates for ST6GALNAC2
- Sino Biological Recombinant Proteins for ST6GALNAC2
-
ProSci Proteins for ST6GALNAC2
-
Abcam proteins for ST6GALNAC2
No data available for DME Specific Peptides for ST6GALNAC2 Gene
Domains & Families for ST6GALNAC2 Gene
Gene Families for ST6GALNAC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for ST6GALNAC2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Sialyltransferase 7B (SIA7B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UJ37- Family:
-
- Belongs to the glycosyltransferase 29 family.
Function for ST6GALNAC2 Gene
Molecular function for ST6GALNAC2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.99.3; Evidence={ECO:0000269 PubMed:10742600, ECO:0000269 PubMed:29251719};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=130 uM for CMP-N-acetylneuraminate {ECO:0000269 PubMed:10742600}; KM=104 uM for CMP-N-acetylneuraminate {ECO:0000269 PubMed:29251719};
Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene
Phenotypes From GWAS Catalog for ST6GALNAC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | IEA,IDA | 10742600 |
| GO:0008373 | sialyltransferase activity | IEA,TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for ST6GALNAC2 Gene
- MGI mutant phenotypes for ST6GALNAC2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ST6GALNAC2:
-
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Increased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Increased viability
- Decreased shRNA abundance
Animal Models for ST6GALNAC2 Gene
- MGI Knock Outs for ST6GALNAC2:
-
- St6galnac2 St6galnac2<tm1.1Cfg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ST6GALNAC2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ST6GALNAC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ST6GALNAC2
- genomics-online: gRNA clones - Search results for available ST6GALNAC2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2
- genomics-online: shRNA clones - Search results for available ST6GALNAC2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ST6GALNAC2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ST6GALNAC2
- Addgene plasmids for ST6GALNAC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ST6GALNAC2
- genomics-online: cdna clones - Search results for available ST6GALNAC2 gene related products
- orf clones - Search results for available ST6GALNAC2 gene related products
Cell Line Products
-
Horizon Cell Lines for ST6GALNAC2
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene
Localization for ST6GALNAC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene
Pathways & Interactions for ST6GALNAC2 Gene
Pathways by source for ST6GALNAC2 Gene
1 BioSystems pathway for ST6GALNAC2 Gene
UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for ST6GALNAC2 Gene
Selected Interacting proteins:
Q9UJ37-SIA7B_HUMAN
ENSP00000225276
for ST6GALNAC2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for ST6GALNAC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IDA,IEA | 29251719 |
| GO:0006493 | protein O-linked glycosylation | IDA | 10742600 |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0097503 | sialylation | IEA | -- |
| GO:1990743 | protein sialylation | IDA | 10742600 |
No data available for SIGNOR curated interactions for ST6GALNAC2 Gene
Drugs & Compounds for ST6GALNAC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cytidine monophosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Cytidine monophosphate N-acetylneuraminic acid |
|
22-12-8 |
|
Drug Products
- G Biosciences Human ST6 Sialyltransferase 2/ST6GALNAC2, Liquid
- Atlas Antibodies PrEST Antigen ST6GALNAC2
Transcripts for ST6GALNAC2 Gene
mRNA/cDNA for ST6GALNAC2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (159) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225276 2170 bps (ENST00000225276.9)
- ENST00000585390 536 bps (ENST00000585390.1)
- ENST00000585736 687 bps (ENST00000585736.1)
- ENST00000586520 744 bps (ENST00000586520.5)
- ENST00000588005 582 bps (ENST00000588005.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ST6GALNAC2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ST6GALNAC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ST6GALNAC2
- genomics-online: gRNA clones - Search results for available ST6GALNAC2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2
- genomics-online: shRNA clones - Search results for available ST6GALNAC2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ST6GALNAC2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ST6GALNAC2
- Addgene plasmids for ST6GALNAC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ST6GALNAC2
- genomics-online: cdna clones - Search results for available ST6GALNAC2 gene related products
- orf clones - Search results for available ST6GALNAC2 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ST6GALNAC2 Gene
- GeneLoc Exon Structure for
- ST6GALNAC2
- ECgene alternative splicing isoforms for
- ST6GALNAC2
Expression for ST6GALNAC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Adipose (Muscoskeletal System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene
This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).
This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST6GALNAC2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC2 Gene:
ST6GALNAC2SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:
Hs.592105mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:
Q9UJ37-SIA7B_HUMAN
Tissue specificity:
Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs for ST6GALNAC2
-
OriGene qPCR primer pairs and template standards for ST6GALNAC2
- genomics-online: primer clones - Search results for available ST6GALNAC2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene
Orthologs for ST6GALNAC2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ST6GALNAC2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ST6GALNAC2 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | St6galnac2 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | St6galnac2 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC2 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ST6GALNAC2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | st6galnac2 32 |
|
||
| siat7b 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15681 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | st6galnac2 32 |
|
||
| ST6GALNAC2 33 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11887 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4378 33 |
|
OneToMany |
- Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ST6GALNAC2 Gene
- ENSEMBL:
- Gene Tree for ST6GALNAC2 (if available)
- TreeFam:
- Gene Tree for ST6GALNAC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ST6GALNAC2: view image
Paralogs for ST6GALNAC2 Gene
Paralogs for ST6GALNAC2 Gene
(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:
- SIA7B_HUMAN
- K7EIW2_HUMAN
- K7EKT8_HUMAN
- K7EMI2_HUMAN
- K7EMM1_HUMAN
Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene
Variants for ST6GALNAC2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031746 | -- | 76,566,938(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000093147 | -- | 76,586,256(-) | C/G | upstream_transcript_variant | |
| rs1000111407 | -- | 76,571,112(-) | T/C | intron_variant | |
| rs1000167981 | -- | 76,584,253(-) | C/G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000392070 | -- | 76,577,060(-) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv28008 | CNV | loss | 19812545 |
| esv3641290 | CNV | gain | 21293372 |
| esv3641291 | CNV | gain | 21293372 |
| nsv1071403 | CNV | deletion | 25765185 |
| nsv828107 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.06;
37.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ST6GALNAC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ST6GALNAC2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene
Disorders for ST6GALNAC2 Gene
Additional Disease Information for ST6GALNAC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ST6GALNAC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene
Publications for ST6GALNAC2 Gene
- Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 43 56
- Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 23 56
- Expression system for structural and functional studies of human glycosylation enzymes. (PMID: 29251719) Moremen KW … Jarvis DL (Nature chemical biology 2018) 3 4 56
- Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 43 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
Products for ST6GALNAC2 Gene
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Sources for ST6GALNAC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
- (23) Novoseek
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- (25) DrugBank
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- (27) AceView
- (28) ASD
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- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
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- (40) dbSNP
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- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
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- (112) Disease Ontology
- (113) Genetics Home Reference
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- (115) MedlinePlus
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- (118) NCBI Bookshelf
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- (144) genomics-online
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- (152) RNACentral
- (153) LncRNADisease
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- (155) miR2Disease
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- (159) Biocompare
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