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ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008] See more...
Aliases for ST6GALNAC2 Gene
Aliases for ST6GALNAC2 Gene
- ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
- STHM 2 3 4
- ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
- Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3 4
- ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
- GalNAc Alpha-2,6-Sialyltransferase II 3 4
- Sialyltransferase-Like 1 2 3
- Sialyltransferase 7B 3 4
- ST6GalNAc II 3 4
- ST6GalNAcII 3 4
- ST6GalNAII 2 3
- SIAT7-B 3 4
- SIAT7B 3 4
- SIATL1 3 4
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
- EC 2.4.99.3 4
- ST6GALNAC2 5
- SAITL1 3
- SIAT7 3
- SThM 4
External Ids for ST6GALNAC2 Gene
- HGNC: 10867
- Entrez Gene: 10610
- Ensembl: ENSG00000070731
- OMIM: 610137
- UniProtKB: Q9UJ37
Previous HGNC Symbols for ST6GALNAC2 Gene
- SIAT7
- SIAT7B
- SIATL1
Previous GeneCards Identifiers for ST6GALNAC2 Gene
- GC17M072074
- GC17M074561
- GC17M069989
- GC17M076563
Summaries for ST6GALNAC2 Gene
-
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST6GALNAC2 Gene
ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.
UniProtKB/Swiss-Prot Summary for ST6GALNAC2 Gene
-
Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
Additional gene information for ST6GALNAC2 Gene
- HGNC(10867)
- Entrez Gene(10610)
- Ensembl(ENSG00000070731)
- OMIM(610137)
- UniProtKB(Q9UJ37)
- Open Targets Platform(ENSG00000070731)
- Search for ST6GALNAC2 at DataMed
- Search for ST6GALNAC2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GALNAC2 Gene
Genomics for ST6GALNAC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ST6GALNAC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ST6GALNAC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST6GALNAC2
- Top Transcription factor binding sites by QIAGEN in the ST6GALNAC2 gene promoter:
-
- Egr-2
- Egr-3
- Evi-1
- FOXO4
- GATA-3
- LyF-1
- p53
- Pax-4a
- Pax-5
Genomic Locations for ST6GALNAC2 Gene
Genomic Locations for ST6GALNAC2 Gene
- chr17:76,565,377-76,586,956
- (GRCh38/hg38)
- Size:
- 21,580 bases
- Orientation:
- Minus strand
- chr17:74,559,792-74,583,038
- (GRCh37/hg19)
- Size:
- 23,247 bases
- Orientation:
- Minus strand
Genomic View for ST6GALNAC2 Gene
Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
ST6GALNAC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ST6GALNAC2 Gene
Proteins for ST6GALNAC2 Gene
-
Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJ37-SIA7B_HUMAN
- Recommended name:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
- Protein Accession:
- Q9UJ37
- Q12971
Protein attributes for ST6GALNAC2 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 41939 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.
Protein Expression for ST6GALNAC2 Gene
Post-translational modifications for ST6GALNAC2 Gene
Other Protein References for ST6GALNAC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ST6GALNAC2
- Novus Biologicals Antibodies for ST6GALNAC2
- Invitrogen Antibodies for ST6GALNAC2 (AFLGC-ST6GALNAC2)
- Sino Biological Antibodies for ST6GALNAC2
Protein Products
- G Biosciences Human ST6 Sialyltransferase 2/ST6GALNAC2, Liquid
-
OriGene Purified Proteins for ST6GALNAC2
- Search Origene for MassSpec and Protein Over-expression Lysates for ST6GALNAC2
- Origene Custom Protein Services for ST6GALNAC2
- Sino Biological Recombinant Proteins for ST6GALNAC2
- Sino Biological Cell Lysates for ST6GALNAC2
-
Signalway Proteins for ST6GALNAC2
-
ProSci Proteins for ST6GALNAC2
-
Abcam proteins for ST6GALNAC2
No data available for DME Specific Peptides for ST6GALNAC2 Gene
Domains & Families for ST6GALNAC2 Gene
Gene Families for ST6GALNAC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ST6GALNAC2 Gene
- InterPro:
- Blocks:
-
- Glycosyl transferase, family 29
- ProtoNet:
Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Sialyltransferase 7B (SIA7B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UJ37- Family:
-
- Belongs to the glycosyltransferase 29 family.
Function for ST6GALNAC2 Gene
Molecular function for ST6GALNAC2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.99.3; Evidence={ECO:0000269|PubMed:10742600, ECO:0000269|PubMed:29251719};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=130 uM for CMP-N-acetylneuraminate {ECO:0000269|PubMed:10742600}; KM=104 uM for CMP-N-acetylneuraminate {ECO:0000269|PubMed:29251719};
Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene
Phenotypes From GWAS Catalog for ST6GALNAC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | IEA,IDA | 10742600 |
| GO:0008373 | sialyltransferase activity | IEA,TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for ST6GALNAC2 Gene
- MGI mutant phenotypes for ST6GALNAC2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ST6GALNAC2:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Increased nuclear migration distance
Animal Models for ST6GALNAC2 Gene
- MGI Knock Outs for ST6GALNAC2:
-
- St6galnac2 St6galnac2<tm1.1Cfg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ST6GALNAC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ST6GALNAC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2
Clone Products
- Applied Biological Materials (abm): Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ST6GALNAC2
- Addgene plasmids for ST6GALNAC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ST6GALNAC2
Cell Line Products
-
Horizon Cell Lines for ST6GALNAC2
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene
Localization for ST6GALNAC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene
Pathways & Interactions for ST6GALNAC2 Gene
Pathways by source for ST6GALNAC2 Gene
1 BioSystems pathway for ST6GALNAC2 Gene
UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for ST6GALNAC2 Gene
Selected Interacting proteins:
Q9UJ37-SIA7B_HUMAN
ENSP00000225276
for ST6GALNAC2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for ST6GALNAC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA,IDA | 29251719 |
| GO:0006493 | protein O-linked glycosylation | IDA | 10742600 |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0097503 | sialylation | IEA | -- |
| GO:1990743 | protein sialylation | IDA | 10742600 |
No data available for SIGNOR curated interactions for ST6GALNAC2 Gene
Drugs & Compounds for ST6GALNAC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cytidine monophosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Cytidine monophosphate N-acetylneuraminic acid |
|
22-12-8 |
|
Drug Products
- G Biosciences Human ST6 Sialyltransferase 2/ST6GALNAC2, Liquid
Transcripts for ST6GALNAC2 Gene
mRNA/cDNA for ST6GALNAC2 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000225276 1904 nts (view in UCSC)
- ENST00000585390 536 nts (view in UCSC)
- ENST00000585736 687 nts (view in UCSC)
- ENST00000586520 744 nts (view in UCSC)
- ENST00000588005 582 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ST6GALNAC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ST6GALNAC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2
Clone Products
- Applied Biological Materials (abm): Clones for ST6GALNAC2 - Select products 50% OFF >
- * ST6GALNAC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ST6GALNAC2
- Addgene plasmids for ST6GALNAC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ST6GALNAC2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ST6GALNAC2 Gene
- GeneLoc Exon Structure for
- ST6GALNAC2
Expression for ST6GALNAC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Adipose (Muscoskeletal System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene
This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).
This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST6GALNAC2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST6GALNAC2
SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:
Hs.592105mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:
Q9UJ37-SIA7B_HUMAN
Tissue specificity:
Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene
- Skin(4.5)
- Blood(2.5)
- Lung(2.3)
- Kidney(2.2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for ST6GALNAC2
-
OriGene qPCR primer pairs and template standards for ST6GALNAC2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene
Orthologs for ST6GALNAC2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | St6galnac2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | St6galnac2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ST6GALNAC2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | st6galnac2 30 |
|
||
| siat7b 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15681 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | st6galnac2 30 |
|
||
| ST6GALNAC2 31 |
|
OneToOne | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11887 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4378 31 |
|
OneToMany |
- Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ST6GALNAC2 Gene
- ENSEMBL:
- Gene Tree for ST6GALNAC2 (if available)
- TreeFam:
- Gene Tree for ST6GALNAC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ST6GALNAC2: view image
Paralogs for ST6GALNAC2 Gene
Paralogs for ST6GALNAC2 Gene
(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:
- SIA7B_HUMAN
- K7EIW2_HUMAN
- K7EKT8_HUMAN
- K7EMI2_HUMAN
- K7EMM1_HUMAN
Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene
Variants for ST6GALNAC2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv28008 | CNV | loss | 19812545 |
| esv3641290 | CNV | gain | 21293372 |
| esv3641291 | CNV | gain | 21293372 |
| nsv1071403 | CNV | deletion | 25765185 |
| nsv828107 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.06;
37.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ST6GALNAC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ST6GALNAC2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST6GALNAC2 Gene
Disorders for ST6GALNAC2 Gene
Additional Disease Information for ST6GALNAC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for ST6GALNAC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene
Publications for ST6GALNAC2 Gene
- Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 41
- Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 23
- Expression system for structural and functional studies of human glycosylation enzymes. (PMID: 29251719) Moremen KW … Jarvis DL (Nature chemical biology 2018) 3 4
- Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
Products for ST6GALNAC2 Gene
- Custom Antibody ServicesOriGene Antibodies for ST6GALNAC2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ST6GALNAC2
- Search Origene for MassSpec and Protein Over-expression Lysates for ST6GALNAC2
- Origene Custom Protein Services for ST6GALNAC2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- OriGene qPCR primer pairs for ST6GALNAC2
- OriGene qPCR primer pairs and template standards for ST6GALNAC2
- OriGene CRISPR knockouts for ST6GALNAC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ST6GALNAC2
- Sino Biological Human cDNA Clone for ST6GALNAC2
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- Novus Biologicals proteins and lysates for ST6GALNAC2
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- Invitrogen Antibodies for ST6GALNAC2 (AFLGC-ST6GALNAC2)
- VectorBuilder Custom and pre-made DNA vectors for ST6GALNAC2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ST6GALNAC2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ST6GALNAC2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ST6GALNAC2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ST6GALNAC2
- Addgene plasmids for ST6GALNAC2
- antibodies-online: Show 14 available ST6GALNAC2 Antibodies ranked by validation data
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- antibodies-online: Search results for available ST6GALNAC2 related products ranked by validation data
- antibodies-online: Show 11 available ST6GALNAC2 Proteins ranked by validation data
- Compare Top ST6GALNAC2 Proteins
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for ST6GALNAC2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
- Search for ST6GALNAC2 Antibodies at ProSci
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- Horizon Cell Lines for ST6GALNAC2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ST6GALNAC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ST6GALNAC2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ST6GALNAC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GALNAC2
- Signalway Proteins for ST6GALNAC2
Sources for ST6GALNAC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB