Free for academic non-profit institutions. Other users need a Commercial license
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | IEA,IDA | 10742600 |
GO:0008373 | sialyltransferase activity | IEA,TAS | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | IEA,IDA | 29251719 |
GO:0006493 | protein O-linked glycosylation | IDA | 10742600 |
GO:0016266 | O-glycan processing | TAS | -- |
GO:0097503 | sialylation | IEA | -- |
GO:1990743 | protein sialylation | IDA | 10742600 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cytidine monophosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Cytidine monophosphate N-acetylneuraminic acid |
|
22-12-8 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | St6galnac2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | St6galnac2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ST6GALNAC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | st6galnac2 30 |
|
||
siat7b 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15681 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | st6galnac2 30 |
|
||
ST6GALNAC2 31 |
|
OneToOne | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11887 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4378 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv28008 | CNV | loss | 19812545 |
esv3641290 | CNV | gain | 21293372 |
esv3641291 | CNV | gain | 21293372 |
nsv1071403 | CNV | deletion | 25765185 |
nsv828107 | CNV | loss | 20364138 |
No disorders were found for ST6GALNAC2 Gene.