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ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | IEA,IDA | 10742600 |
GO:0008373 | sialyltransferase activity | IEA,TAS | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | IEA,IDA | 29251719 |
GO:0006493 | protein O-linked glycosylation | IDA | 10742600 |
GO:0016266 | O-glycan processing | TAS | -- |
GO:0097503 | sialylation | IEA | -- |
GO:1990743 | protein sialylation | IDA | 10742600 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cytidine monophosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Cytidine 5'-monophosphate-N-acetylneuraminic acid |
|
3063-71-6 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ST6GALNAC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | St6galnac2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | St6galnac2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ST6GALNAC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | st6galnac2 30 |
|
||
siat7b 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15681 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | st6galnac2 30 |
|
||
ST6GALNAC2 31 |
|
OneToOne | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11887 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4378 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv28008 | CNV | loss | 19812545 |
esv3641290 | CNV | gain | 21293372 |
esv3641291 | CNV | gain | 21293372 |
nsv1071403 | CNV | deletion | 25765185 |
nsv828107 | CNV | loss | 20364138 |
No disorders were found for ST6GALNAC2 Gene.