Aliases for ST6GALNAC2 Gene
Aliases for ST6GALNAC2 Gene
- ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3 5
- ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 2 3
- ST6 GalNAc Alpha-2,6-Sialyltransferase 2 2 3
- GalNAc Alpha-2,6-Sialyltransferase II 3 4
- Sialyltransferase-Like 1 2 3
- Sialyltransferase 7B 3 4
- ST6GalNAc II 3 4
- ST6GalNAcII 3 4
- SIAT7-B 3 4
- SIAT7B 3 4
- SIATL1 3 4
- STHM 3 4
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) B 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) 2
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase 3
- Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- (Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide B 3
- Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2 3
- ST6GALNAC2, Alpha-2,6-Sialyltransferase 2 3
- EC 2.4.99.- 4
- ST6GalNAII 3
- SAITL1 3
- SIAT7 3
External Ids for ST6GALNAC2 Gene
- HGNC: 10867
- Entrez Gene: 10610
- Ensembl: ENSG00000070731
- OMIM: 610137
- UniProtKB: Q9UJ37
Previous HGNC Symbols for ST6GALNAC2 Gene
- SIAT7
- SIAT7B
- SIATL1
Previous GeneCards Identifiers for ST6GALNAC2 Gene
- GC17M072074
- GC17M074561
- GC17M069989
Summaries for ST6GALNAC2 Gene
-
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ST6GALNAC2 Gene
ST6GALNAC2 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST6GALNAC2 include Colorectal Cancer. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST6GALNAC1.
Additional gene information for ST6GALNAC2 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST6GALNAC2 Gene
Genomics for ST6GALNAC2 Gene
GeneHancer (GH) Regulatory Elements for ST6GALNAC2 Gene
Promoters and enhancers for ST6GALNAC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ST6GALNAC2 Gene
Genomic Locations for ST6GALNAC2 Gene
- chr17:76,565,379-76,586,956
- (GRCh38/hg38)
- Size:
- 21,578 bases
- Orientation:
- Minus strand
- chr17:74,559,792-74,583,038
- (GRCh37/hg19)
Genomic View for ST6GALNAC2 Gene
Genes around ST6GALNAC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Ensembl
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
ST6GALNAC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ST6GALNAC2 Gene
Proteins for ST6GALNAC2 Gene
-
Protein details for ST6GALNAC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJ37-SIA7B_HUMAN
- Recommended name:
- Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
- Protein Accession:
- Q9UJ37
- Q12971
Protein attributes for ST6GALNAC2 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 41939 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1 O-glycosylation, disease predisposition, and disease severity, and may contribute to the polygenic nature of IgAN.
Protein Expression for ST6GALNAC2 Gene
Post-translational modifications for ST6GALNAC2 Gene
Other Protein References for ST6GALNAC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ST6GALNAC2
- Novus Biologicals Antibodies for ST6GALNAC2
- Invitrogen Antibodies for ST6GALNAC2
- GeneTex ST6GALNAC2 antibody for ST6GALNAC2
- Sino Biological Antibodies for ST6GALNAC2
Protein Products
-
OriGene Purified Proteins for ST6GALNAC2
- Search Origene for MassSpec and Protein Over-expression Lysates for ST6GALNAC2
- Origene Custom Protein Services for ST6GALNAC2
- Sino Biological Recombinant Proteins for ST6GALNAC2
- Sino Biological Cell Lysates for ST6GALNAC2
- Search GeneTex for Proteins for ST6GALNAC2
-
ProSci Proteins for ST6GALNAC2
-
Abcam proteins for ST6GALNAC2
Assay Products
No data available for DME Specific Peptides for ST6GALNAC2 Gene
Domains & Families for ST6GALNAC2 Gene
Gene Families for ST6GALNAC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for ST6GALNAC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ST6GALNAC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UJ37- Family:
-
- Belongs to the glycosyltransferase 29 family.
Function for ST6GALNAC2 Gene
Molecular function for ST6GALNAC2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- CMP-N-acetylneuraminate + glycano-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.
Enzyme Numbers (IUBMB) for ST6GALNAC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | TAS | -- |
| GO:0008373 | sialyltransferase activity | TAS,IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
Phenotypes for ST6GALNAC2 Gene
- MGI mutant phenotypes for ST6GALNAC2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ST6GALNAC2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Increased cell death HMECs cells
Animal Models for ST6GALNAC2 Gene
- MGI Knock Outs for ST6GALNAC2:
-
- St6galnac2 tm1.1Cfg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ST6GALNAC2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ST6GALNAC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC2 gene
- Search ViGene Biosciences for ST6GALNAC2
CRISPR Products
-
OriGene CRISPR knockouts for ST6GALNAC2
- genomics-online: gRNA clones - Search results for available ST6GALNAC2 gene related products
- Applied Biological Materials CRISPR for ST6GALNAC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
- GenScript: Design CRISPR guide RNA sequences for ST6GALNAC2
miRNA Products
- Search ViGene Biosciences for ST6GALNAC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- genomics-online: shRNA clones - Search results for available ST6GALNAC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC2 gene
Clone Products
-
OriGene ORF clones in human for ST6GALNAC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ST6GALNAC2
- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ST6GALNAC2 gene related products
- orf clones - Search results for available ST6GALNAC2 gene related products
- Applied Biological Materials Clones for ST6GALNAC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ST6GALNAC2
-
ViGene Biosciences adenoviral particle packaged cDNA for ST6GALNAC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ST6GALNAC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC2 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST6GALNAC2 Gene
Localization for ST6GALNAC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene
- Golgi apparatus membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 4 |
| extracellular | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC2 Gene
Pathways & Interactions for ST6GALNAC2 Gene
Pathways by source for ST6GALNAC2 Gene
1 BioSystems pathway for ST6GALNAC2 Gene
UniProtKB/Swiss-Prot Q9UJ37-SIA7B_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for ST6GALNAC2 Gene
Selected Interacting proteins:
Q9UJ37-SIA7B_HUMAN
ENSP00000225276
for ST6GALNAC2 Gene via
IID
MINT
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0009311 | oligosaccharide metabolic process | IBA | -- |
| GO:0016266 | O-glycan processing | TAS | -- |
| GO:0018279 | protein N-linked glycosylation via asparagine | IBA | -- |
| GO:0097503 | sialylation | IBA,IEA | -- |
No data available for SIGNOR curated interactions for ST6GALNAC2 Gene
Drugs & Compounds for ST6GALNAC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cytidine monophosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Cytidine monophosphate N-acetylneuraminic acid |
|
22-12-8 |
|
Transcripts for ST6GALNAC2 Gene
mRNA/cDNA for ST6GALNAC2 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (159) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ST6GALNAC2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ST6GALNAC2
- genomics-online: gRNA clones - Search results for available ST6GALNAC2 gene related products
- Applied Biological Materials CRISPR for ST6GALNAC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
- GenScript: Design CRISPR guide RNA sequences for ST6GALNAC2
miRNA Products
- Search ViGene Biosciences for ST6GALNAC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ST6GALNAC2
- Browse OriGene Inhibitory RNA Products For ST6GALNAC2
- genomics-online: shRNA clones - Search results for available ST6GALNAC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC2 gene
Clone Products
-
OriGene ORF clones in human for ST6GALNAC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ST6GALNAC2
- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ST6GALNAC2 gene related products
- orf clones - Search results for available ST6GALNAC2 gene related products
- Applied Biological Materials Clones for ST6GALNAC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for ST6GALNAC2 Gene
- GeneLoc Exon Structure for
- ST6GALNAC2
- ECgene alternative splicing isoforms for
- ST6GALNAC2
Expression for ST6GALNAC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Adipose (Muscoskeletal System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ST6GALNAC2 Gene
This gene is overexpressed in Nerve - Tibial (x7.4), Testis (x6.1), and Whole Blood (x5.2).
This gene is overexpressed in Synovial fluid (55.7) and Placenta (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST6GALNAC2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC2 Gene:
ST6GALNAC2SOURCE GeneReport for Unigene cluster for ST6GALNAC2 Gene:
Hs.592105mRNA Expression by UniProt/SwissProt for ST6GALNAC2 Gene:
Q9UJ37-SIA7B_HUMAN
Tissue specificity:
Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes.
Evidence on tissue expression from TISSUES for ST6GALNAC2 Gene
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs for ST6GALNAC2
-
OriGene qPCR primer pairs and template standards for ST6GALNAC2
- genomics-online: primer clones - Search results for available ST6GALNAC2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC2 Gene
Orthologs for ST6GALNAC2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ST6GALNAC2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ST6GALNAC2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ST6GALNAC2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | St6galnac2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | St6galnac2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ST6GALNAC2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ST6GALNAC2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ST6GALNAC2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ST6GALNAC2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | st6galnac2 33 |
|
||
| siat7b 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15681 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | st6galnac2 33 |
|
||
| ST6GALNAC2 34 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11887 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4378 34 |
|
OneToMany |
- Species where no ortholog for ST6GALNAC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ST6GALNAC2 Gene
- ENSEMBL:
- Gene Tree for ST6GALNAC2 (if available)
- TreeFam:
- Gene Tree for ST6GALNAC2 (if available)
Paralogs for ST6GALNAC2 Gene
Paralogs for ST6GALNAC2 Gene
(2) SIMAP similar genes for ST6GALNAC2 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for ST6GALNAC2 Gene
Variants for ST6GALNAC2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031746 | -- | 76,566,938(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000093147 | -- | 76,586,256(-) | C/G | upstream_transcript_variant | |
| rs1000111407 | -- | 76,571,112(-) | T/C | intron_variant | |
| rs1000167981 | -- | 76,584,253(-) | C/T | intron_variant | |
| rs1000392070 | -- | 76,577,060(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv28008 | CNV | loss | 19812545 |
| esv3641290 | CNV | gain | 21293372 |
| esv3641291 | CNV | gain | 21293372 |
| nsv1071403 | CNV | deletion | 25765185 |
| nsv828107 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.06;
37.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ST6GALNAC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ST6GALNAC2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC2 Gene
Disorders for ST6GALNAC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
Search ST6GALNAC2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ST6GALNAC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC2 Gene
Publications for ST6GALNAC2 Gene
- Interaction between variants of two glycosyltransferase genes in IgA nephropathy. (PMID: 19357720) Zhu L … Wang H (Kidney international 2009) 3 4 44 58
- Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. (PMID: 10742600) Samyn-Petit B … Harduin-Lepers A (Biochimica et biophysica acta 2000) 3 4 22 58
- Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. (PMID: 17480010) Li GS … Wang HY (Human mutation 2007) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer. (PMID: 11984005) Sotiropoulou G … Sager R (Molecular medicine (Cambridge, Mass.) 2002) 2 22 58
Products for ST6GALNAC2 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for ST6GALNAC2
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- Browse OriGene miRNA Products For ST6GALNAC2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ST6GALNAC2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ST6GALNAC2
- GenScript Custom Assay Services for ST6GALNAC2
- GenScript Custom overexpressing Cell Line Services for ST6GALNAC2
- GenScript: Design CRISPR guide RNA sequences for ST6GALNAC2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ST6GALNAC2
- Sino Biological Human cDNA Clone for ST6GALNAC2
- Sino Biological Cell Lysates for ST6GALNAC2
- Sino Biological Recombinant Proteins for ST6GALNAC2
- Sino Biological Antibodies for ST6GALNAC2
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ST6GALNAC2
- Novus Biologicals lysates and proteins for ST6GALNAC2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Browse Lysates
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- Abcam proteins for ST6GALNAC2
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for ST6GALNAC2
- VectorBuilder custom plasmid, inducible vectors for ST6GALNAC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ST6GALNAC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 18 available ST6GALNAC2 Antibodies ranked by validation data
- Compare Top ST6GALNAC2 Antibodies
- antibodies-online: Search results for available ST6GALNAC2 related products ranked by validation data
- antibodies-online: Search results for 10 available ST6GALNAC2 Proteins ranked by validation data
- Compare Top ST6GALNAC2 Proteins
- Quality Products:
- GeneTex ST6GALNAC2 antibody for ST6GALNAC2
- Search GeneTex for Proteins for ST6GALNAC2
- ViGene Biosciences adenoviral particle packaged cDNA for ST6GALNAC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ST6GALNAC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ST6GALNAC2 gene
- Search ViGene Biosciences for ST6GALNAC2
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for ST6GALNAC2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ST6GALNAC2
- Search for ST6GALNAC2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ST6GALNAC2
- Horizon Cell Lines for ST6GALNAC2
- genomics-online: cdna clones - Search results for available ST6GALNAC2 gene related products
- orf clones - Search results for available ST6GALNAC2 gene related products
- genomics-online: gRNA clones - Search results for available ST6GALNAC2 gene related products
- genomics-online: primer clones - Search results for available ST6GALNAC2 gene related products
- genomics-online: shRNA clones - Search results for available ST6GALNAC2 gene related products
Sources for ST6GALNAC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
