Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ike... See more...

Aliases for ST6GALNAC1 Gene

Aliases for ST6GALNAC1 Gene

  • ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3 5
  • Sialyltransferase 7 ((Alpha-N-Acetylneuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetyl Galactosaminide Alpha-2,6-Sialyltransferase) A 2 3
  • ST6 (Alpha-N-Acetyl-Neuraminyl-2,3-Beta-Galactosyl-1,3)-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 2 3
  • Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 3 4
  • ST6 GalNAc Alpha-2,6-Sialyltransferase 1 2 3
  • GalNAc Alpha-2,6-Sialyltransferase I 3 4
  • Sialyltransferase 7A 3 4
  • ST6GalNAc I 3 4
  • ST6GalNAcI 3 4
  • SIAT7-A 3 4
  • SIAT7A 3 4
  • GalNAc Alpha-2, 6-Sialyltransferase I, Long Form 3
  • ST6GALNAC1, Alpha-2,6-Sialyltransferase 1 3
  • EC 2.4.99.3 4
  • HSY11339 3
  • STYI 3

External Ids for ST6GALNAC1 Gene

Previous HGNC Symbols for ST6GALNAC1 Gene

  • SIAT7A

Previous GeneCards Identifiers for ST6GALNAC1 Gene

  • GC17M072133
  • GC17M074620
  • GC17M070050

Summaries for ST6GALNAC1 Gene

Entrez Gene Summary for ST6GALNAC1 Gene

  • Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ST6GALNAC1 Gene

ST6GALNAC1 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GALNAC2.

Gene Wiki entry for ST6GALNAC1 Gene

Additional gene information for ST6GALNAC1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GALNAC1 Gene

Genomics for ST6GALNAC1 Gene

GeneHancer (GH) Regulatory Elements for ST6GALNAC1 Gene

Promoters and enhancers for ST6GALNAC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST6GALNAC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST6GALNAC1 gene promoter:
  • GR-alpha
  • GR-beta
  • Ik-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RORalpha2
  • Zic1

Genomic Locations for ST6GALNAC1 Gene

Genomic Locations for ST6GALNAC1 Gene
chr17:76,617,774-76,643,838
(GRCh38/hg38)
Size:
26,065 bases
Orientation:
Minus strand
chr17:74,620,843-74,639,920
(GRCh37/hg19)
Size:
19,078 bases
Orientation:
Minus strand

Genomic View for ST6GALNAC1 Gene

Genes around ST6GALNAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GALNAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GALNAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GALNAC1 Gene

Proteins for ST6GALNAC1 Gene

  • Protein details for ST6GALNAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSC7-SIA7A_HUMAN
    Recommended name:
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    Protein Accession:
    Q9NSC7
    Secondary Accessions:
    • Q6UW90
    • Q9NSC6

    Protein attributes for ST6GALNAC1 Gene

    Size:
    600 amino acids
    Molecular mass:
    68564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST6GALNAC1 Gene

Post-translational modifications for ST6GALNAC1 Gene

  • Glycosylation at Asn300, Asn311, Asn331, Asn375, Asn460, and Thr595
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ST6GALNAC1 Gene

Domains & Families for ST6GALNAC1 Gene

Gene Families for ST6GALNAC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST6GALNAC1 Gene

Suggested Antigen Peptide Sequences for ST6GALNAC1 Gene

GenScript: Design optimal peptide antigens:
  • ST6GALNAC1 protein (Q8TBJ6_HUMAN)
  • Sialyltransferase 7A (SIA7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NSC7

UniProtKB/Swiss-Prot:

SIA7A_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GALNAC1: view

Function for ST6GALNAC1 Gene

Molecular function for ST6GALNAC1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:11136, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:140764; EC=2.4.99.3;.

Enzyme Numbers (IUBMB) for ST6GALNAC1 Gene

Phenotypes From GWAS Catalog for ST6GALNAC1 Gene

Gene Ontology (GO) - Molecular Function for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA,IBA 21873635
GO:0008373 sialyltransferase activity IEA,NAS 10536037
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GALNAC1: view
genes like me logo Genes that share phenotypes with ST6GALNAC1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GALNAC1 Gene

Localization for ST6GALNAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GALNAC1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GALNAC1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST6GALNAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST6GALNAC1 Gene

Pathways & Interactions for ST6GALNAC1 Gene

genes like me logo Genes that share pathways with ST6GALNAC1: view

UniProtKB/Swiss-Prot Q9NSC7-SIA7A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST6GALNAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA,NAS 10536037
GO:0009312 oligosaccharide biosynthetic process IEA --
GO:0097503 sialylation IEA --
genes like me logo Genes that share ontologies with ST6GALNAC1: view

No data available for SIGNOR curated interactions for ST6GALNAC1 Gene

Drugs & Compounds for ST6GALNAC1 Gene

(1) Drugs for ST6GALNAC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(2) Additional Compounds for ST6GALNAC1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Sialic acid
  • CYTIDINE-5'-monophosphATE-5-N-acetylneuraminIC ACID
  • CMP-b-Neu5ac
22-12-8
genes like me logo Genes that share compounds with ST6GALNAC1: view

Transcripts for ST6GALNAC1 Gene

mRNA/cDNA for ST6GALNAC1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GALNAC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -

Relevant External Links for ST6GALNAC1 Gene

GeneLoc Exon Structure for
ST6GALNAC1
ECgene alternative splicing isoforms for
ST6GALNAC1

Expression for ST6GALNAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST6GALNAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST6GALNAC1 Gene

This gene is overexpressed in Colon - Transverse (x18.9), Stomach (x6.4), and Small Intestine - Terminal Ileum (x5.4).

Protein differential expression in normal tissues from HIPED for ST6GALNAC1 Gene

This gene is overexpressed in Serum (33.8), Cervix (7.2), and Oral epithelium (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST6GALNAC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ST6GALNAC1 Gene:

ST6GALNAC1

SOURCE GeneReport for Unigene cluster for ST6GALNAC1 Gene:

Hs.105352

Evidence on tissue expression from TISSUES for ST6GALNAC1 Gene

  • Intestine(3.1)
genes like me logo Genes that share expression patterns with ST6GALNAC1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GALNAC1 Gene

Orthologs for ST6GALNAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST6GALNAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GALNAC1 33 32
  • 98.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST6GALNAC1 33 32
  • 78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6galnac1 32
  • 76.97 (n)
mouse
(Mus musculus)
Mammalia St6galnac1 17 33 32
  • 75.87 (n)
dog
(Canis familiaris)
Mammalia ST6GALNAC1 33 32
  • 75.2 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GALNAC1 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GALNAC1 33 32
  • 67.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GALNAC1 33
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6galnac1 32
  • 55.68 (n)
zebrafish
(Danio rerio)
Actinopterygii st6galnac1.1 33 32
  • 52.78 (n)
OneToMany
st6galnac1.2 33
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 33
  • 21 (a)
OneToMany
Species where no ortholog for ST6GALNAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GALNAC1 Gene

ENSEMBL:
Gene Tree for ST6GALNAC1 (if available)
TreeFam:
Gene Tree for ST6GALNAC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST6GALNAC1: view image

Paralogs for ST6GALNAC1 Gene

(2) SIMAP similar genes for ST6GALNAC1 Gene using alignment to 7 proteins:

  • SIA7A_HUMAN
  • G3XAD9_HUMAN
  • K7EJA8_HUMAN
  • K7EJC9_HUMAN
  • K7ELU9_HUMAN
  • K7EMB6_HUMAN
  • Q8TBJ6_HUMAN
genes like me logo Genes that share paralogs with ST6GALNAC1: view

Variants for ST6GALNAC1 Gene

Sequence variations from dbSNP and Humsavar for ST6GALNAC1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030302 -- 76,638,808(-) T/C intron_variant
rs1000278937 -- 76,622,450(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000319731 -- 76,638,708(-) A/G intron_variant
rs1000519010 -- 76,618,156(-) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000541746 -- 76,621,533(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST6GALNAC1 Gene

Variant ID Type Subtype PubMed ID
dgv588e214 CNV loss 21293372
esv2671702 CNV deletion 23128226
esv2716257 CNV deletion 23290073
esv3305624 CNV mobile element insertion 20981092
esv3331560 CNV insertion 20981092
esv3641295 CNV gain 21293372
nsv1058486 CNV gain 25217958
nsv1060182 CNV gain 25217958
nsv518385 CNV gain 19592680
nsv820158 CNV gain 19587683

Variation tolerance for ST6GALNAC1 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GALNAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GALNAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GALNAC1 Gene

Disorders for ST6GALNAC1 Gene

Additional Disease Information for ST6GALNAC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ST6GALNAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GALNAC1 Gene

Publications for ST6GALNAC1 Gene

  1. Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA. (PMID: 12820722) Julien S … Delannoy P (Glycoconjugate journal 2001) 3 4 23 56
  2. Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens. (PMID: 10536037) Ikehara Y … Narimatsu H (Glycobiology 1999) 3 4 23 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. (PMID: 16319059) Sewell R … Taylor-Papadimitriou J (The Journal of biological chemistry 2006) 3 23 56
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56

Products for ST6GALNAC1 Gene

Sources for ST6GALNAC1 Gene