This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] See more...

Aliases for ST6GAL2 Gene

Aliases for ST6GAL2 Gene

  • ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2 2 3 5
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 2 3 4
  • Sialyltransferase 2 (Monosialoganglioside Sialyltransferase) 2 3
  • ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 2 2 3
  • Beta-Galactoside Alpha-2,6-Sialyltransferase 2 3 4
  • Alpha 2,6-ST 2 3 4
  • EC 2.4.99.1 4 52
  • ST6GalII 3 4
  • SIAT2 3 4
  • Beta-Galactoside Alpha-2,6-Sialyltransferase II 3
  • Sialyltransferase 2 4
  • HST6Gal II 4
  • ST6Gal II 4
  • EC 2.4.99 52
  • KIAA1877 4

External Ids for ST6GAL2 Gene

Previous HGNC Symbols for ST6GAL2 Gene

  • SIAT2

Previous GeneCards Identifiers for ST6GAL2 Gene

  • GC02M106877
  • GC02M107418
  • GC02M101093

Summaries for ST6GAL2 Gene

Entrez Gene Summary for ST6GAL2 Gene

  • This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

GeneCards Summary for ST6GAL2 Gene

ST6GAL2 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Globo Sphingolipid Metabolism. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST6GAL1.

UniProtKB/Swiss-Prot Summary for ST6GAL2 Gene

  • Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

Additional gene information for ST6GAL2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST6GAL2 Gene

Genomics for ST6GAL2 Gene

GeneHancer (GH) Regulatory Elements for ST6GAL2 Gene

Promoters and enhancers for ST6GAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J106885 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 518.2 +1.3 1292 4.1 MYC TCF12 TEAD4 GABPA ZBTB26 HDAC2 MXI1 POLR2A SMC3 SP2 ST6GAL2 lnc-CD8B2-17 lnc-ST6GAL2-6 ENSG00000227294
GH02J106839 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.4 +47.3 47264 0.8 CTCF SMC3 GATA3 RAD21 SMARCA4 CREM EP300 SP1 ZNF143 ZNF148 ST6GAL2 ENSG00000227294 lnc-CD8B2-17 lnc-ST6GAL2-6
GH02J106859 Enhancer 0.4 dbSUPER 16.7 +27.1 27091 1.4 RBM25 CTCF RAD21 MAFK ST6GAL2 ENSG00000227294 lnc-CD8B2-17 lnc-ST6GAL2-6
GH02J106849 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +34.9 34864 4 NFIC RAD21 CTCF EP300 ZNF384 ST6GAL2 ENSG00000227294 lnc-CD8B2-17 lnc-ST6GAL2-6
GH02J106960 Enhancer 0.6 Ensembl ENCODE 7.5 -73.9 -73911 2 EP300 FOXA1 POLR2A ESR1 ST6GAL2 ENSG00000226905 HSALNG0017666 lnc-CD8B2-7 ENSG00000286218
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST6GAL2

Top Transcription factor binding sites by QIAGEN in the ST6GAL2 gene promoter:
  • CUTL1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Nkx2-5

Genomic Locations for ST6GAL2 Gene

Genomic Locations for ST6GAL2 Gene
chr2:106,794,128-106,887,265
(GRCh38/hg38)
Size:
93,138 bases
Orientation:
Minus strand
chr2:107,418,056-107,503,564
(GRCh37/hg19)
Size:
85,509 bases
Orientation:
Minus strand

Genomic View for ST6GAL2 Gene

Genes around ST6GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST6GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST6GAL2 Gene

Proteins for ST6GAL2 Gene

  • Protein details for ST6GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JF0-SIAT2_HUMAN
    Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
    Protein Accession:
    Q96JF0
    Secondary Accessions:
    • D3DVK3
    • Q53QP4
    • Q86Y44
    • Q8IUG7
    • Q96HE4

    Protein attributes for ST6GAL2 Gene

    Size:
    529 amino acids
    Molecular mass:
    60158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08680.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB47506.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ST6GAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST6GAL2 Gene

Selected DME Specific Peptides for ST6GAL2 Gene

Q96JF0:
  • YYDAACTLGAYHPL
  • HDAVLRFN
  • EVHVYEYIPSVRQT
  • SMSRAFLYRLWKG
  • GYEKDVG
  • RIINSQIL
  • SAGAILNSSLG
  • WYKKPDYNLFTPY
  • QPFYILHPKFIWQLWDIIQENT
  • IQPNPPSSG

Post-translational modifications for ST6GAL2 Gene

Domains & Families for ST6GAL2 Gene

Gene Families for ST6GAL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST6GAL2 Gene

Blocks:
  • Glycosyl transferase, family 29
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST6GAL2 Gene

GenScript: Design optimal peptide antigens:
  • ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (C4N9P8_HUMAN)
  • Sialyltransferase 2 (SIAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96JF0

UniProtKB/Swiss-Prot:

SIAT2_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST6GAL2: view

Function for ST6GAL2 Gene

Molecular function for ST6GAL2 Gene

UniProtKB/Swiss-Prot Function:
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:52104, ChEBI:CHEBI:15378, ChEBI:CHEBI:28034, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136398; EC=2.4.99.1; Evidence={ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328, ECO:0000269 PubMed:16439063};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.71 mM for Gal-beta-1,4-GlcNAc {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328}; KM=0.48 mM for lacto-N-neotetraose {ECO:0000269 PubMed:12235148, ECO:0000269 PubMed:12603328};
UniProtKB/Swiss-Prot Induction:
By IL6/interleukin-6 and IL8//interleukin-8.

Enzyme Numbers (IUBMB) for ST6GAL2 Gene

Phenotypes From GWAS Catalog for ST6GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity IBA,IDA 12235148
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view
genes like me logo Genes that share phenotypes with ST6GAL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GAL2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST6GAL2 Gene

Localization for ST6GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST6GAL2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2
extracellular 2
endoplasmic reticulum 2
lysosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view

Pathways & Interactions for ST6GAL2 Gene

genes like me logo Genes that share pathways with ST6GAL2: view

Interacting Proteins for ST6GAL2 Gene

;

Gene Ontology (GO) - Biological Process for ST6GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006486 protein glycosylation IEA --
GO:0009311 oligosaccharide metabolic process IDA 12235148
GO:0097503 sialylation IEA --
genes like me logo Genes that share ontologies with ST6GAL2: view

No data available for SIGNOR curated interactions for ST6GAL2 Gene

Drugs & Compounds for ST6GAL2 Gene

(1) Drugs for ST6GAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(2) Additional Compounds for ST6GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(N-acetylneuraminosyl(a2-6)lactosamine)
  • 6-Sialyllactosamine
  • alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • alpha-NeuNAc-(2->6)-beta-D-gal-(1->4)-beta-D-glcnac
  • alpha-NeupNAc-(2->6)-beta-D-galp-(1->4)-beta-D-glcpnac
  • N-Acetylneuraminosyl(alpha2-6)lactosamine
64364-50-7
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Sialic acid
  • CYTIDINE-5'-monophosphATE-5-N-acetylneuraminIC ACID
  • CMP-b-Neu5ac
22-12-8
genes like me logo Genes that share compounds with ST6GAL2: view

Transcripts for ST6GAL2 Gene

mRNA/cDNA for ST6GAL2 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST6GAL2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST6GAL2 Gene

No ASD Table

Relevant External Links for ST6GAL2 Gene

GeneLoc Exon Structure for
ST6GAL2

Expression for ST6GAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST6GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST6GAL2 Gene

This gene is overexpressed in Artery - Aorta (x11.5), Artery - Coronary (x8.0), and Thyroid (x4.9).

Protein differential expression in normal tissues from HIPED for ST6GAL2 Gene

This gene is overexpressed in Cerebrospinal fluid (59.2) and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST6GAL2 Gene



Protein tissue co-expression partners for ST6GAL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST6GAL2

SOURCE GeneReport for Unigene cluster for ST6GAL2 Gene:

Hs.98265

mRNA Expression by UniProt/SwissProt for ST6GAL2 Gene:

Q96JF0-SIAT2_HUMAN
Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain.

Evidence on tissue expression from TISSUES for ST6GAL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ST6GAL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST6GAL2 Gene

Orthologs for ST6GAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ST6GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST6GAL2 31 30
  • 99.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ST6GAL2 31 30
  • 83.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia St6gal2 30
  • 80.48 (n)
cow
(Bos Taurus)
Mammalia ST6GAL2 31 30
  • 78.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia St6gal2 17 31 30
  • 77.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ST6GAL2 31
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ST6GAL2 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST6GAL2 31 30
  • 70.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST6GAL2 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st6gal2 30
  • 59.82 (n)
Str.17205 30
zebrafish
(Danio rerio)
Actinopterygii st6gal2a 31 30
  • 58.89 (n)
OneToMany
st6gal2b 31
  • 52 (a)
OneToMany
Dr.17176 30
fruit fly
(Drosophila melanogaster)
Insecta ST6Gal 31
  • 28 (a)
OneToMany
Species where no ortholog for ST6GAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST6GAL2 Gene

ENSEMBL:
Gene Tree for ST6GAL2 (if available)
TreeFam:
Gene Tree for ST6GAL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST6GAL2: view image

Paralogs for ST6GAL2 Gene

(1) SIMAP similar genes for ST6GAL2 Gene using alignment to 4 proteins:

  • SIAT2_HUMAN
  • C4N9P8_HUMAN
  • C9JIK2_HUMAN
  • H7BY52_HUMAN
genes like me logo Genes that share paralogs with ST6GAL2: view

Variants for ST6GAL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST6GAL2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs12615112 - p.Ile341Val
rs3796110 - p.Gly154Arg

Additional dbSNP identifiers (rs#s) for ST6GAL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ST6GAL2 Gene

Variant ID Type Subtype PubMed ID
dgv4034n100 CNV gain 25217958
dgv6988n54 CNV loss 21841781
esv2670283 CNV deletion 23128226
esv2720482 CNV deletion 23290073
esv2720492 CNV deletion 23290073
esv3591883 CNV loss 21293372
nsv1014939 CNV loss 25217958
nsv471617 CNV gain 15918152

Variation tolerance for ST6GAL2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.31; 85.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST6GAL2 Gene

Human Gene Mutation Database (HGMD)
ST6GAL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST6GAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST6GAL2 Gene

Disorders for ST6GAL2 Gene

Additional Disease Information for ST6GAL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ST6GAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST6GAL2 Gene

Publications for ST6GAL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 41 54
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  5. Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II. (PMID: 12603328) Krzewinski-Recchi MA … Delannoy P (European journal of biochemistry 2003) 3 4 54

Products for ST6GAL2 Gene

Sources for ST6GAL2 Gene