Aliases for ST5 Gene
External Ids for ST5 Gene
Previous GeneCards Identifiers for ST5 Gene
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ST5 Gene
ST5 (Suppression Of Tumorigenicity 5) is a Protein Coding gene. Diseases associated with ST5 include Charcot-Marie-Tooth Disease, Axonal, Type 2W and Autosomal Dominant Non-Syndromic Intellectual Disability 1. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2A.
UniProtKB/Swiss-Prot Summary for ST5 Gene
Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480).
Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Isoform 3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).