This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ... See more...

Aliases for ST5 Gene

Aliases for ST5 Gene

  • Suppression Of Tumorigenicity 5 2 3 5
  • Suppression Of Tumorigenicity 5 Protein 3 4
  • DENN/MADD Domain Containing 2B 2 3
  • HeLa Tumor Suppression 1 3 4
  • DENND2B 3 4
  • HTS1 3 4
  • DENN Domain-Containing Protein 2B 4
  • HeLa Tumor Suppression 2
  • P126 3

External Ids for ST5 Gene

Previous GeneCards Identifiers for ST5 Gene

  • GC11M009485
  • GC11M009161
  • GC11M008754
  • GC11M008679
  • GC11M008671
  • GC11M008382
  • GC11M008714

Summaries for ST5 Gene

Entrez Gene Summary for ST5 Gene

  • This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST5 Gene

ST5 (Suppression Of Tumorigenicity 5) is a Protein Coding gene. Diseases associated with ST5 include Charcot-Marie-Tooth Disease, Axonal, Type 2W and Autosomal Dominant Non-Syndromic Intellectual Disability 1. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND2A.

UniProtKB/Swiss-Prot Summary for ST5 Gene

  • Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480).
  • Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
  • Isoform 3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).

Gene Wiki entry for ST5 Gene

Additional gene information for ST5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST5 Gene

Genomics for ST5 Gene

GeneHancer (GH) Regulatory Elements for ST5 Gene

Promoters and enhancers for ST5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST5 gene promoter:
  • ATF-2
  • c-Jun
  • HNF-4alpha1

Genomic Locations for ST5 Gene

Genomic Locations for ST5 Gene
chr11:8,693,351-8,910,951
(GRCh38/hg38)
Size:
217,601 bases
Orientation:
Minus strand
chr11:8,714,898-8,932,498
(GRCh37/hg19)
Size:
217,601 bases
Orientation:
Minus strand

Genomic View for ST5 Gene

Genes around ST5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST5 Gene

Proteins for ST5 Gene

  • Protein details for ST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78524-ST5_HUMAN
    Recommended name:
    Suppression of tumorigenicity 5 protein
    Protein Accession:
    P78524
    Secondary Accessions:
    • B2R6X7
    • B3KXQ6
    • P78523
    • Q16492
    • Q7KYY2
    • Q7KZ12
    • Q8NE12
    • Q9BQQ6

    Protein attributes for ST5 Gene

    Size:
    1137 amino acids
    Molecular mass:
    126485 Da
    Quaternary structure:
    • Interacts with ITSN1 and GRB2 (PubMed:29030480). Isoform 1 interacts with the SH3 domain of ABL1.
    SequenceCaution:
    • Sequence=AAC50925.1; Type=Frameshift; Positions=159, 169; Evidence={ECO:0000305};

    Alternative splice isoforms for ST5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ST5 Gene

Post-translational modifications for ST5 Gene

  • Phosphorylated. Phosphorylation decreases ITSN1 binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ST5 Gene

Domains & Families for ST5 Gene

Gene Families for ST5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ST5 Gene

Suggested Antigen Peptide Sequences for ST5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55510, highly similar to Suppression of tumorigenicity 5 (B4DDL8_HUMAN)
  • cDNA FLJ55800, highly similar to Suppression of tumorigenicity 5 (B4DZA9_HUMAN)
  • HeLa tumor suppression 1 (ST5_HUMAN)
genes like me logo Genes that share domains with ST5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ST5 Gene

Function for ST5 Gene

Molecular function for ST5 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480).
UniProtKB/Swiss-Prot Function:
Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
UniProtKB/Swiss-Prot Function:
Isoform 3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).

Phenotypes From GWAS Catalog for ST5 Gene

Gene Ontology (GO) - Molecular Function for ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 20937701
genes like me logo Genes that share ontologies with ST5: view
genes like me logo Genes that share phenotypes with ST5: view

Animal Model Products

CRISPR Products

miRNA for ST5 Gene

miRTarBase miRNAs that target ST5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST5 Gene

Localization for ST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST5 Gene

Isoform 1: Cytoplasm, cell cortex. Cell membrane. Recycling endosome. Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. {ECO:0000269 PubMed:29030480}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST5 gene
Compartment Confidence
nucleus 4
plasma membrane 3
endosome 3
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ST5: view

Pathways & Interactions for ST5 Gene

genes like me logo Genes that share pathways with ST5: view

Pathways by source for ST5 Gene

Interacting Proteins for ST5 Gene

Gene Ontology (GO) - Biological Process for ST5 Gene

None

No data available for SIGNOR curated interactions for ST5 Gene

Drugs & Compounds for ST5 Gene

No Compound Related Data Available

Transcripts for ST5 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - -
SP24: - - - - - - - - - - - - - - -
SP25: - - - -
SP26: - -
SP27: -
SP28:
SP29:
SP30: - - - - - - -

ExUns: 14h · 14i · 14j ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17:
SP18: - - - - - - - - -
SP19:
SP20: - - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

ExUns: 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:

Relevant External Links for ST5 Gene

GeneLoc Exon Structure for
ST5
ECgene alternative splicing isoforms for
ST5

Expression for ST5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST5 Gene

Protein differential expression in normal tissues from HIPED for ST5 Gene

This gene is overexpressed in Placenta (14.0), Urinary Bladder (9.7), Testis (8.8), Heart (7.4), Uterus (7.1), and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST5 Gene



Protein tissue co-expression partners for ST5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST5 Gene:

ST5

SOURCE GeneReport for Unigene cluster for ST5 Gene:

Hs.117715

mRNA Expression by UniProt/SwissProt for ST5 Gene:

P78524-ST5_HUMAN
Tissue specificity: Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).

Evidence on tissue expression from TISSUES for ST5 Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ST5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST5 Gene

Orthologs for ST5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST5 33 32
  • 99.6 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ST5 33
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ST5 33 32
  • 92.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST5 33 32
  • 92.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia St5 17 33 32
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia St5 32
  • 89.03 (n)
oppossum
(Monodelphis domestica)
Mammalia ST5 33
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ST5 33 32
  • 74.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST5 33
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st5 32
  • 72.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1916 32
zebrafish
(Danio rerio)
Actinopterygii st5 33 32
  • 67.53 (n)
OneToOne
Dr.16306 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8836 32
Species where no ortholog for ST5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST5 Gene

ENSEMBL:
Gene Tree for ST5 (if available)
TreeFam:
Gene Tree for ST5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST5: view image

Paralogs for ST5 Gene

Paralogs for ST5 Gene

(6) SIMAP similar genes for ST5 Gene using alignment to 38 proteins:

  • ST5_HUMAN
  • B4DDL8_HUMAN
  • E9PI58_HUMAN
  • E9PI67_HUMAN
  • E9PI72_HUMAN
  • E9PII1_HUMAN
  • E9PJC3_HUMAN
  • E9PJP0_HUMAN
  • E9PJY5_HUMAN
  • E9PK36_HUMAN
  • E9PKE0_HUMAN
  • E9PKM1_HUMAN
  • E9PKN3_HUMAN
  • E9PKV3_HUMAN
  • E9PLB6_HUMAN
  • E9PLD7_HUMAN
  • E9PLH5_HUMAN
  • E9PLH6_HUMAN
  • E9PLR2_HUMAN
  • E9PM32_HUMAN
  • E9PM84_HUMAN
  • E9PME1_HUMAN
  • E9PMJ9_HUMAN
  • E9PMP1_HUMAN
  • E9PN93_HUMAN
  • E9PNM8_HUMAN
  • E9PNX7_HUMAN
  • E9PPL2_HUMAN
  • E9PPS6_HUMAN
  • E9PQA9_HUMAN
  • E9PQM5_HUMAN
  • E9PQU6_HUMAN
  • E9PRS6_HUMAN
  • H0YD60_HUMAN
  • H0YDL0_HUMAN
  • H0YE59_HUMAN
  • H0YEK3_HUMAN
  • H0YEL1_HUMAN
genes like me logo Genes that share paralogs with ST5: view

Variants for ST5 Gene

Sequence variations from dbSNP and Humsavar for ST5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs200023000 uncertain-significance, not specified 8,730,355(-) C/A/G/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000007239 -- 8,892,678(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000008231 -- 8,718,642(-) A/C intron_variant
rs1000014194 -- 8,750,123(-) A/T intron_variant
rs1000017649 -- 8,756,156(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST5 Gene

Variant ID Type Subtype PubMed ID
esv1699885 CNV deletion 17803354
esv2669920 CNV deletion 23128226
esv2744087 CNV deletion 23290073
esv2744088 CNV deletion 23290073
esv2744089 CNV deletion 23290073
esv2759803 CNV gain 17122850
esv3547293 CNV deletion 23714750
nsv1069559 CNV deletion 25765185
nsv1120084 OTHER inversion 24896259
nsv1134089 CNV deletion 24896259
nsv435923 CNV deletion 17901297
nsv478661 CNV novel sequence insertion 20440878
nsv499766 OTHER inversion 21111241
nsv509388 CNV insertion 20534489
nsv513308 CNV insertion 21212237
nsv527073 CNV loss 19592680
nsv527920 CNV loss 19592680
nsv553447 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7664 CNV insertion 18451855
nsv7665 CNV insertion 18451855
nsv7666 CNV insertion 18451855
nsv832062 CNV loss 17160897
nsv951306 CNV deletion 24416366

Variation tolerance for ST5 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.01; 95.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST5 Gene

Human Gene Mutation Database (HGMD)
ST5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST5 Gene

Disorders for ST5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ST5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2w
  • cmt2w
autosomal dominant non-syndromic intellectual disability 1
  • mrd1
campylobacteriosis
  • campylobacter infections
tinea capitis
  • dermatophytosis of scalp
opportunistic mycosis
  • opportunistic mycoses
- elite association - COSMIC cancer census association via MalaCards
Search ST5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ST5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST5 Gene

Publications for ST5 Gene

  1. Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. (PMID: 9632734) Majidi M … Lichy JH (The Journal of biological chemistry 1998) 2 3 4 23 56
  2. Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression. (PMID: 8972856) Lichy JH … Tsai MM (Nucleic acids research 1996) 3 4 23 56
  3. Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells. (PMID: 1390339) Lichy JH … Howley PM (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992) 2 3 4 56
  4. Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor. (PMID: 29030480) Ioannou MS … McPherson PS (EMBO reports 2017) 3 4 56
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56

Products for ST5 Gene

  • Boster Bio Antibodies for ST5
  • Boster Bio ELISA Kits for ST5

Sources for ST5 Gene