Aliases for ST3GAL6 Gene
External Ids for ST3GAL6 Gene
Previous HGNC Symbols for ST3GAL6 Gene
Previous GeneCards Identifiers for ST3GAL6 Gene
The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
GeneCards Summary for ST3GAL6 Gene
ST3GAL6 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST3GAL6 include Sialuria. Among its related pathways are Pre-NOTCH Expression and Processing and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL4.
UniProtKB/Swiss-Prot Summary for ST3GAL6 Gene
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.