This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encodi... See more...

Aliases for ST3GAL4 Gene

Aliases for ST3GAL4 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 2 3 5
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 4 3 4
  • Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 4 3 4
  • Alpha 2,3-Sialyltransferase IV 3 4
  • Alpha 2,3-ST 4 3 4
  • Gal-NAc6S 3 4
  • ST3Gal IV 2 4
  • ST3GalA.2 3 4
  • ST3GalIV 3 4
  • NANTA3 3 4
  • SIAT4C 3 4
  • CGS23 3 4
  • ST-4 3 4
  • STZ 3 4
  • Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Alpha-3-N-Acetylneuraminyltransferase 3
  • Sialyltransferase 4C 4
  • EC 2.4.99.9 52
  • EC 2.4.99.2 4
  • EC 2.4.99.4 4
  • EC 2.4.99 52
  • SIAT4-C 4
  • SIAT4 3
  • SAT-3 4
  • SAT3 3

External Ids for ST3GAL4 Gene

Previous HGNC Symbols for ST3GAL4 Gene

  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C

Previous GeneCards Identifiers for ST3GAL4 Gene

  • GC11P125732
  • GC11P126225
  • GC11P122170

Summaries for ST3GAL4 Gene

Entrez Gene Summary for ST3GAL4 Gene

  • This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ST3GAL4 Gene

ST3GAL4 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4) is a Protein Coding gene. Diseases associated with ST3GAL4 include Hyperglycemia and Inflammatory Breast Carcinoma. Among its related pathways are Metabolism of proteins and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and monosialoganglioside sialyltransferase activity. An important paralog of this gene is ST3GAL6.

UniProtKB/Swiss-Prot Summary for ST3GAL4 Gene

  • Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.

Gene Wiki entry for ST3GAL4 Gene

Additional gene information for ST3GAL4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST3GAL4 Gene

Genomics for ST3GAL4 Gene

GeneHancer (GH) Regulatory Elements for ST3GAL4 Gene

Promoters and enhancers for ST3GAL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J126350 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.5 +0.4 440 11.5 HNRNPK EP300 CTCF NRF1 POLR2G BCLAF1 PHB2 ZNF639 ZBTB5 ZIC2 ST3GAL4 GSEC ENSG00000255062 STT3A FOXRED1 TIRAP DCPS FAM118B ENSG00000278215
GH11J126399 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 508.7 +47.9 47909 8.2 TEAD4 ZFX POLR2A CLOCK EP300 CTBP1 DEK FOS YY1 CEBPB ST3GAL4 FOXRED1 FAM118B ENSG00000278215 lnc-SRPRA-7
GH11J126398 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.3 +42.9 42929 0.1 ST3GAL4 FOXRED1 ENSG00000278215 lnc-SRPRA-7
GH11J126418 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.9 +67.4 67446 10.2 EP300 SIN3A PHB2 ZBTB11 AFF1 TARDBP ZNF510 HES1 TOE1 MYC ST3GAL4 ENSG00000255062 DCPS ENSG00000254694 FAM118B RPUSD4 ENSG00000255317 FEZ1 lnc-SRPRA-7 ENSG00000278215
GH11J126390 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 19.9 +36.5 36480 2.9 CTCF USF1 REST TOE1 SMC3 SPI1 NR2F2 ZNF146 BHLHE40 RAD21 ST3GAL4 FOXRED1 ENSG00000278215 lnc-SRPRA-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST3GAL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST3GAL4

Top Transcription factor binding sites by QIAGEN in the ST3GAL4 gene promoter:
  • AP-1
  • ATF-2
  • NF-kappaB
  • NF-kappaB1
  • p53
  • Sp1
  • STAT5A
  • TBP

Genomic Locations for ST3GAL4 Gene

Genomic Locations for ST3GAL4 Gene
chr11:126,355,640-126,652,917
(GRCh38/hg38)
Size:
297,278 bases
Orientation:
Plus strand
chr11:126,225,535-126,310,239
(GRCh37/hg19)
Size:
84,705 bases
Orientation:
Plus strand

Genomic View for ST3GAL4 Gene

Genes around ST3GAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL4 Gene

Proteins for ST3GAL4 Gene

  • Protein details for ST3GAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11206-SIA4C_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Protein Accession:
    Q11206
    Secondary Accessions:
    • A8K6B2
    • O60497
    • Q8N6A6
    • Q8NFG7
    • Q96QQ9

    Protein attributes for ST3GAL4 Gene

    Size:
    333 amino acids
    Molecular mass:
    38045 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL4 Gene

neXtProt entry for ST3GAL4 Gene

Selected DME Specific Peptides for ST3GAL4 Gene

Q11206:
  • RLFYPES
  • DVVIRLN
  • NKKQTIHYYEQITLKSMAGSGHNVSQEA
  • CVVVGNG

Post-translational modifications for ST3GAL4 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn61, Asn131, Asn310, and Asn329
  • Modification sites at PhosphoSitePlus

Domains & Families for ST3GAL4 Gene

Gene Families for ST3GAL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST3GAL4 Gene

Blocks:
  • Glycosyl transferase, family 29
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST3GAL4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95600, Homo sapiens sialyltransferase 4C (beta-galactosidealpha-2,3-sialyltransferase) (SIAT4C), mRNA (Q6IBE6_HUMAN)
  • Sialyltransferase 4C (SIA4C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q11206

UniProtKB/Swiss-Prot:

SIA4C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL4: view

Function for ST3GAL4 Gene

Molecular function for ST3GAL4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:52380, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136588, ChEBI:CHEBI:136589; EC=2.4.99.2; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.99.4; Evidence=. ;.

Enzyme Numbers (IUBMB) for ST3GAL4 Gene

Phenotypes From GWAS Catalog for ST3GAL4 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS,IDA --
GO:0008373 sialyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047288 monosialoganglioside sialyltransferase activity IDA 8288606
genes like me logo Genes that share ontologies with ST3GAL4: view
genes like me logo Genes that share phenotypes with ST3GAL4: view

Animal Models for ST3GAL4 Gene

MGI Knock Outs for ST3GAL4:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST3GAL4 Gene

Localization for ST3GAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST3GAL4 Gene

Pathways & Interactions for ST3GAL4 Gene

genes like me logo Genes that share pathways with ST3GAL4: view

UniProtKB/Swiss-Prot Q11206-SIA4C_HUMAN

  • Pathway: Protein modification; protein glycosylation.

SIGNOR curated interactions for ST3GAL4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IDA 8288606
GO:0009101 glycoprotein biosynthetic process IDA 8288606
GO:0009247 glycolipid biosynthetic process IBA,IDA 8288606
GO:0009312 oligosaccharide biosynthetic process IDA 8288606
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with ST3GAL4: view

Drugs & Compounds for ST3GAL4 Gene

(25) Drugs for ST3GAL4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(34) Additional Compounds for ST3GAL4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Sialic acid
  • CYTIDINE-5'-monophosphATE-5-N-acetylneuraminIC ACID
  • CMP-b-Neu5ac
22-12-8
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
genes like me logo Genes that share compounds with ST3GAL4: view

Transcripts for ST3GAL4 Gene

mRNA/cDNA for ST3GAL4 Gene

9 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20:

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: - - - - - -
SP12: -
SP13:
SP14: - -
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ST3GAL4 Gene

GeneLoc Exon Structure for
ST3GAL4

Expression for ST3GAL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST3GAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL4 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for ST3GAL4 Gene

This gene is overexpressed in Nasal epithelium (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST3GAL4 Gene



Protein tissue co-expression partners for ST3GAL4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST3GAL4

SOURCE GeneReport for Unigene cluster for ST3GAL4 Gene:

Hs.591947

mRNA Expression by UniProt/SwissProt for ST3GAL4 Gene:

Q11206-SIA4C_HUMAN
Tissue specificity: Highly expressed in adult placenta, ovary and testes.

Evidence on tissue expression from TISSUES for ST3GAL4 Gene

  • Blood(4.3)
  • Nervous system(2.5)
  • Muscle(2.2)
  • Stomach(2.2)
  • Heart(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ST3GAL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL4 Gene

Orthologs for ST3GAL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL4 31 30
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ST3GAL4 31 30
  • 91.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ST3GAL4 30
  • 89.79 (n)
ST3GAL-IV 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal4 17 31 30
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia St3gal4 30
  • 85.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL4 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST3GAL4 31 30
  • 76.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST3GAL4 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal4 30
  • 62.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15272 30
zebrafish
(Danio rerio)
Actinopterygii st3gal4 31 30
  • 58.42 (n)
OneToOne
Species where no ortholog for ST3GAL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL4 Gene

ENSEMBL:
Gene Tree for ST3GAL4 (if available)
TreeFam:
Gene Tree for ST3GAL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST3GAL4: view image

Paralogs for ST3GAL4 Gene

(6) SIMAP similar genes for ST3GAL4 Gene using alignment to 7 proteins:

  • SIA4C_HUMAN
  • E9PKJ2_HUMAN
  • E9PMC7_HUMAN
  • E9PN64_HUMAN
  • E9PNJ9_HUMAN
  • E9PPJ6_HUMAN
  • E9PQZ2_HUMAN
genes like me logo Genes that share paralogs with ST3GAL4: view

Variants for ST3GAL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST3GAL4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2230278 Benign: not specified 126,407,321(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs2230279 Benign: not specified 126,408,180(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs2298475 Benign: not specified 126,408,308(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ST3GAL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL4 Gene

Variant ID Type Subtype PubMed ID
dgv235e214 CNV gain 21293372
esv24669 CNV gain 19812545
esv2672750 CNV deletion 23128226
esv2745215 CNV deletion 23290073
esv2762951 CNV gain 21179565
esv3579953 CNV loss 25503493
esv3628004 CNV loss 21293372
esv3628007 CNV loss 21293372
esv3892106 CNV loss 25118596
nsv527257 CNV gain 19592680
nsv556530 CNV loss 21841781
nsv556531 CNV loss 21841781
nsv826123 CNV gain 20364138
nsv952757 CNV deletion 24416366
nsv975994 CNV duplication 23825009
nsv975995 CNV duplication 23825009

Variation tolerance for ST3GAL4 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Disorders for ST3GAL4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ST3GAL4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST3GAL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL4 Gene

Publications for ST3GAL4 Gene

  1. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PMID: 8557707) Kitagawa H … Paulson JC (The Journal of biological chemistry 1996) 2 3 4 54
  2. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PMID: 8611500) Basu SS … Basu S (Biochemistry 1996) 3 4 23 54
  3. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PMID: 8288606) Kitagawa H … Paulson JC (The Journal of biological chemistry 1994) 2 3 4 54
  4. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 41 54
  5. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 41 54

Products for ST3GAL4 Gene

Sources for ST3GAL4 Gene