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Aliases for ST3GAL4 Gene

Aliases for ST3GAL4 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 2 3 5
  • Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 4 3 4
  • Alpha 2,3-Sialyltransferase IV 3 4
  • Alpha 2,3-ST 4 3 4
  • Gal-NAc6S 3 4
  • ST3GalA.2 3 4
  • ST3Gal IV 2 4
  • ST3GalIV 3 4
  • NANTA3 3 4
  • SIAT4C 3 4
  • CGS23 3 4
  • ST-4 3 4
  • STZ 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 4 3
  • Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Alpha-3-N-Acetylneuraminyltransferase 3
  • Sialyltransferase 4C 4
  • EC 2.4.99.9 56
  • EC 2.4.99.2 4
  • EC 2.4.99.4 4
  • EC 2.4.99 56
  • SIAT4-C 4
  • SIAT4 3
  • SAT-3 4
  • SAT3 3

External Ids for ST3GAL4 Gene

Previous HGNC Symbols for ST3GAL4 Gene

  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C

Previous GeneCards Identifiers for ST3GAL4 Gene

  • GC11P125732
  • GC11P126225
  • GC11P122170

Summaries for ST3GAL4 Gene

Entrez Gene Summary for ST3GAL4 Gene

  • This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ST3GAL4 Gene

ST3GAL4 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4) is a Protein Coding gene. Diseases associated with ST3GAL4 include Hyperglycemia and Diabetes Mellitus, Insulin-Dependent. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and monosialoganglioside sialyltransferase activity. An important paralog of this gene is ST3GAL3.

UniProtKB/Swiss-Prot for ST3GAL4 Gene

  • Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.

Gene Wiki entry for ST3GAL4 Gene

Additional gene information for ST3GAL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL4 Gene

Genomics for ST3GAL4 Gene

GeneHancer (GH) Regulatory Elements for ST3GAL4 Gene

Promoters and enhancers for ST3GAL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I126350 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 561.6 +0.4 440 11.5 HDGF PKNOX1 ARNT SIN3A YBX1 DMAP1 POLR2B ZNF766 E2F8 FOS ST3GAL4 GSEC HP11014 TIRAP STT3A FOXRED1 DCPS FAM118B ENSG00000278215
GH11I126399 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 558.7 +47.9 47909 8.2 ELK4 SMARCE1 NCOA3 ZNF687 MAX CEBPB E2F4 ELF1 CTBP1 POLR2A ST3GAL4 TIRAP HP11014 FOXRED1 FAM118B ENSG00000278215 KIRREL3-AS1
GH11I126398 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.3 +42.9 42929 0.1 ST3GAL4 FOXRED1 ENSG00000278215 KIRREL3-AS1
GH11I126418 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +67.5 67470 10.1 SMAD1 ATF1 ARNT YY1 NCOA2 TCF12 ZNF766 GATA2 ATF7 RUNX3 HP11014 ST3GAL4 DCPS FAM118B RPUSD4 ENSG00000254694 LOC105369558 FEZ1 ENSG00000278215 KIRREL3-AS1
GH11I126413 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +60.0 59951 4.4 KLF1 MAZ L3MBTL2 MAX RAD21 NR2F2 POLR2A ZBTB33 ZFX ZBTB26 ST3GAL4 HP11014 DCPS ENSG00000278215 KIRREL3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST3GAL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST3GAL4 gene promoter:

Genomic Locations for ST3GAL4 Gene

Genomic Locations for ST3GAL4 Gene
chr11:126,355,640-126,652,917
(GRCh38/hg38)
Size:
297,278 bases
Orientation:
Plus strand
chr11:126,225,535-126,310,239
(GRCh37/hg19)

Genomic View for ST3GAL4 Gene

Genes around ST3GAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL4 Gene

Proteins for ST3GAL4 Gene

  • Protein details for ST3GAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11206-SIA4C_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Protein Accession:
    Q11206
    Secondary Accessions:
    • A8K6B2
    • O60497
    • Q8N6A6
    • Q8NFG7
    • Q96QQ9

    Protein attributes for ST3GAL4 Gene

    Size:
    333 amino acids
    Molecular mass:
    38045 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL4 Gene

neXtProt entry for ST3GAL4 Gene

Selected DME Specific Peptides for ST3GAL4 Gene

Q11206:
  • RLFYPES
  • DVVIRLN
  • NKKQTIHYYEQITLKSMAGSGHNVSQEA
  • CVVVGNG

Post-translational modifications for ST3GAL4 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at posLast=6161, isoforms=2, 3, 4, 5, 6, 7131, posLast=310310, and posLast=329329

Domains & Families for ST3GAL4 Gene

Gene Families for ST3GAL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for ST3GAL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q11206

UniProtKB/Swiss-Prot:

SIA4C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL4: view

Function for ST3GAL4 Gene

Molecular function for ST3GAL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R = CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R.
UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant.

Enzyme Numbers (IUBMB) for ST3GAL4 Gene

Phenotypes From GWAS Catalog for ST3GAL4 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS,IDA --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047288 monosialoganglioside sialyltransferase activity IDA 8288606
genes like me logo Genes that share ontologies with ST3GAL4: view
genes like me logo Genes that share phenotypes with ST3GAL4: view

Animal Models for ST3GAL4 Gene

MGI Knock Outs for ST3GAL4:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST3GAL4 Gene

Localization for ST3GAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST3GAL4 Gene

Pathways & Interactions for ST3GAL4 Gene

genes like me logo Genes that share pathways with ST3GAL4: view

UniProtKB/Swiss-Prot Q11206-SIA4C_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IDA 8288606
GO:0009101 glycoprotein biosynthetic process IDA 8288606
GO:0009247 glycolipid biosynthetic process IDA 8288606
GO:0009311 oligosaccharide metabolic process IBA --
GO:0009312 oligosaccharide biosynthetic process IDA 8288606
genes like me logo Genes that share ontologies with ST3GAL4: view

No data available for SIGNOR curated interactions for ST3GAL4 Gene

Drugs & Compounds for ST3GAL4 Gene

(26) Drugs for ST3GAL4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(28) Additional Compounds for ST3GAL4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
22-12-8
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (d18:1/24:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
genes like me logo Genes that share compounds with ST3GAL4: view

Transcripts for ST3GAL4 Gene

Unigene Clusters for ST3GAL4 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20:

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: - - - - - -
SP12: -
SP13:
SP14: - -
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ST3GAL4 Gene

GeneLoc Exon Structure for
ST3GAL4
ECgene alternative splicing isoforms for
ST3GAL4

Expression for ST3GAL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST3GAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL4 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for ST3GAL4 Gene

This gene is overexpressed in Nasal epithelium (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ST3GAL4 Gene



Protein tissue co-expression partners for ST3GAL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL4 Gene:

ST3GAL4

SOURCE GeneReport for Unigene cluster for ST3GAL4 Gene:

Hs.591947

mRNA Expression by UniProt/SwissProt for ST3GAL4 Gene:

Q11206-SIA4C_HUMAN
Tissue specificity: Highly expressed in adult placenta, ovary and testes.

Evidence on tissue expression from TISSUES for ST3GAL4 Gene

  • Blood(4.3)
  • Nervous system(2.5)
  • Muscle(2.2)
  • Stomach(2.2)
  • Heart(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ST3GAL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL4 Gene

Orthologs for ST3GAL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST3GAL4 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia ST3GAL4 33 34
  • 91.59 (n)
cow
(Bos Taurus)
Mammalia ST3GAL4 33
  • 89.79 (n)
ST3GAL-IV 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia St3gal4 33 16 34
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia St3gal4 33
  • 85.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ST3GAL4 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST3GAL4 33 34
  • 76.02 (n)
lizard
(Anolis carolinensis)
Reptilia ST3GAL4 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal4 33
  • 62.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15272 33
zebrafish
(Danio rerio)
Actinopterygii st3gal4 33 34
  • 58.42 (n)
Species where no ortholog for ST3GAL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL4 Gene

ENSEMBL:
Gene Tree for ST3GAL4 (if available)
TreeFam:
Gene Tree for ST3GAL4 (if available)

Paralogs for ST3GAL4 Gene

(6) SIMAP similar genes for ST3GAL4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ST3GAL4: view

Variants for ST3GAL4 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1057519593 likely-pathogenic, Mental retardation, autosomal dominant 4 126,424,898(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs114378922 pathogenic, Mental retardation, autosomal dominant 4 126,446,877(+) C/T genic_downstream_transcript_variant, intron_variant
rs119462980 pathogenic, uncertain-significance, Mental retardation, autosomal dominant 4, not specified 126,424,726(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1064795581 likely-pathogenic, not provided 126,449,008(+) C/T genic_downstream_transcript_variant, intron_variant
rs186782738 likely-benign, not specified 126,436,863(+) C/G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL4 Gene

Variant ID Type Subtype PubMed ID
nsv975995 CNV duplication 23825009
nsv975994 CNV duplication 23825009
nsv952757 CNV deletion 24416366
nsv826123 CNV gain 20364138
nsv556531 CNV loss 21841781
nsv556530 CNV loss 21841781
nsv527257 CNV gain 19592680
esv3892106 CNV loss 25118596
esv3628007 CNV loss 21293372
esv3628004 CNV loss 21293372
esv3579953 CNV loss 25503493
esv2762951 CNV gain 21179565
esv2745215 CNV deletion 23290073
esv2672750 CNV deletion 23128226
esv24669 CNV gain 19812545
dgv235e214 CNV gain 21293372

Variation tolerance for ST3GAL4 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Disorders for ST3GAL4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ST3GAL4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ST3GAL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL4 Gene

Publications for ST3GAL4 Gene

  1. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PMID: 8611500) Basu SS … Basu S (Biochemistry 1996) 3 4 22 58
  2. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PMID: 8557707) Kitagawa H … Paulson JC (The Journal of biological chemistry 1996) 2 3 4 58
  3. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PMID: 8288606) Kitagawa H … Paulson JC (The Journal of biological chemistry 1994) 2 3 4 58
  4. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 44 58
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 44 58

Products for ST3GAL4 Gene

Sources for ST3GAL4 Gene

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