This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encodi... See more...

Aliases for ST3GAL4 Gene

Aliases for ST3GAL4 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 2 3 5
  • STZ 2 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 4 3 4
  • Sialyltransferase 4C (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • N-Acetyllactosaminide Alpha-2,3-Sialyltransferase 3 4
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Gal-Beta-1,4-GlcNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 4 3 4
  • Alpha 2,3-Sialyltransferase IV 3 4
  • Alpha 2,3-ST 4 3 4
  • ST3Gal IV 2 4
  • ST3GalA.2 3 4
  • Gal-NAc6S 3 4
  • ST3GalIV 3 4
  • NANTA3 3 4
  • SIAT4C 3 4
  • CGS23 3 4
  • SAT3 2 3
  • ST-4 3 4
  • Sialyltransferase 4C (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Gal-Beta-1,4-GalNAc-Alpha-2,3-Sialyltransferase 3
  • Alpha-3-N-Acetylneuraminyltransferase 3
  • Sialyltransferase 4C 4
  • EC 2.4.99.9 50
  • EC 2.4.99.2 4
  • EC 2.4.99.4 4
  • EC 2.4.99.6 4
  • EC 2.4.99 50
  • FLJ11867 2
  • ST3GAL4 5
  • SIAT4-C 4
  • SIAT4 3
  • SAT-3 4

External Ids for ST3GAL4 Gene

Previous HGNC Symbols for ST3GAL4 Gene

  • CGS23
  • SIAT4
  • NANTA3
  • SIAT4C

Previous GeneCards Identifiers for ST3GAL4 Gene

  • GC11P125732
  • GC11P126225
  • GC11P122170

Summaries for ST3GAL4 Gene

Entrez Gene Summary for ST3GAL4 Gene

  • This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ST3GAL4 Gene

ST3GAL4 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4) is a Protein Coding gene. Diseases associated with ST3GAL4 include Developmental And Epileptic Encephalopathy 15 and Hyperglycemia. Among its related pathways are Pre-NOTCH Expression and Processing and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and monosialoganglioside sialyltransferase activity. An important paralog of this gene is ST3GAL6.

UniProtKB/Swiss-Prot Summary for ST3GAL4 Gene

  • A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500).

Gene Wiki entry for ST3GAL4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST3GAL4 Gene

Genomics for ST3GAL4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ST3GAL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J126350 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 261.5 +0.4 440 11.5 IKZF1 ZNF600 NCOR1 MYC ZNF592 POLR2A NFIC ZIC2 CTCF REST ST3GAL4 GSEC HSALNG0088026 HSALNG0088028 ENSG00000255062 TIRAP STT3A FOXRED1 DCPS FAM118B
GH11J126399 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 258.7 +47.9 47909 8.2 CEBPB DEK MAX ELF1 CTBP1 YY1 TCF7L2 BHLHE40 SMARCE1 MAZ ST3GAL4 FOXRED1 FAM118B HSALNG0088029 ENSG00000278215 KIRREL3
GH11J126398 Promoter/Enhancer 0.7 EPDnew Ensembl dbSUPER 250.3 +42.9 42861 0.2 ST3GAL4 FOXRED1 HSALNG0088029 ENSG00000278215 KIRREL3
GH11J126418 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.9 +67.5 67470 10.1 BCLAF1 MYC NCOR1 IKZF1 ATF2 NFIC YY1 NONO SIN3A HES1 HSALNG0088030 ENSG00000255062 ST3GAL4 DCPS ENSG00000254694 FAM118B RPUSD4 ENSG00000255317 FEZ1 lnc-SRPRA-7
GH11J126390 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 19.9 +36.5 36480 2.9 CTCF REST BHLHE40 ZNF146 SPI1 MYC MAX POLR2A RAD51 RAD21 ST3GAL4 FOXRED1 HSALNG0088029 ENSG00000278215 KIRREL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST3GAL4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST3GAL4

Top Transcription factor binding sites by QIAGEN in the ST3GAL4 gene promoter:
  • AP-1
  • ATF-2
  • NF-kappaB
  • NF-kappaB1
  • p53
  • Sp1
  • STAT5A
  • TBP

Genomic Locations for ST3GAL4 Gene

Latest Assembly
chr11:126,355,640-126,440,344
(GRCh38/hg38)
Size:
84,705 bases
Orientation:
Plus strand

Previous Assembly
chr11:126,225,581-126,284,533
(GRCh37/hg19 by Entrez Gene)
Size:
58,953 bases
Orientation:
Plus strand

chr11:126,225,535-126,310,239
(GRCh37/hg19 by Ensembl)
Size:
84,705 bases
Orientation:
Plus strand

Genomic View for ST3GAL4 Gene

Genes around ST3GAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL4 Gene

Proteins for ST3GAL4 Gene

  • Protein details for ST3GAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11206-SIA4C_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Protein Accession:
    Q11206
    Secondary Accessions:
    • A8K6B2
    • O60497
    • Q8N6A6
    • Q8NFG7
    • Q96QQ9

    Protein attributes for ST3GAL4 Gene

    Size:
    333 amino acids
    Molecular mass:
    38045 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ST3GAL4 Gene

neXtProt entry for ST3GAL4 Gene

Selected DME Specific Peptides for ST3GAL4 Gene

Q11206:
  • RLFYPES
  • DVVIRLN
  • NKKQTIHYYEQITLKSMAGSGHNVSQEA
  • CVVVGNG

Post-translational modifications for ST3GAL4 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn61, Asn131, Asn310, and Asn329
  • Modification sites at PhosphoSitePlus

Domains & Families for ST3GAL4 Gene

Gene Families for ST3GAL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ST3GAL4 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 29

Suggested Antigen Peptide Sequences for ST3GAL4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95600, Homo sapiens sialyltransferase 4C (beta-galactosidealpha-2,3-sialyltransferase) (SIAT4C), mRNA (Q6IBE6_HUMAN)
  • Sialyltransferase 4C (SIA4C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q11206

UniProtKB/Swiss-Prot:

SIA4C_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL4: view

Function for ST3GAL4 Gene

Molecular function for ST3GAL4 Gene

UniProtKB/Swiss-Prot Function:
A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:52380, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136588, ChEBI:CHEBI:136589; EC=2.4.99.2; Evidence={ECO:0000269|PubMed:8288606};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.99.4; Evidence={ECO:0000269|PubMed:8288606};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:52316, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133507, ChEBI:CHEBI:136545; EC=2.4.99.6; Evidence={ECO:0000269|PubMed:8288606, ECO:0000269|PubMed:8611500};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.99.2; Evidence={ECO:0000269|PubMed:8288606};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence={ECO:0000269|PubMed:8288606};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+); Xref=Rhea:RHEA:47588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:87789, ChEBI:CHEBI:87791; Evidence={ECO:0000250|UniProtKB:P61131};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+); Xref=Rhea:RHEA:65432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:90376, ChEBI:CHEBI:90390; Evidence={ECO:0000269|PubMed:8611500};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+); Xref=Rhea:RHEA:18913, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:57812, ChEBI:CHEBI:58665, ChEBI:CHEBI:60377; EC=2.4.99.6; Evidence={ECO:0000305|PubMed:8611500};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for Gal-beta-1,3-GalNAc {ECO:0000269|PubMed:8288606}; KM=0.3 mM for Gal-beta-1,4-GlcNAc {ECO:0000269|PubMed:8288606};

Enzyme Numbers (IUBMB) for ST3GAL4 Gene

Phenotypes From GWAS Catalog for ST3GAL4 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA,TAS --
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity IDA 8611500
GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity IMP 25498912
GO:0008373 sialyltransferase activity IEA,IBA 21873635
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view
genes like me logo Genes that share phenotypes with ST3GAL4: view

Animal Models for ST3GAL4 Gene

MGI Knock Outs for ST3GAL4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL4

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ST3GAL4 Gene

Localization for ST3GAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST3GAL4 Gene

Pathways & Interactions for ST3GAL4 Gene

genes like me logo Genes that share pathways with ST3GAL4: view

UniProtKB/Swiss-Prot Q11206-SIA4C_HUMAN

  • Pathway: Protein modification; protein glycosylation.
  • Pathway: Glycolipid biosynthesis.

SIGNOR curated interactions for ST3GAL4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ST3GAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA,IDA 8288606
GO:0006629 lipid metabolic process IEA --
GO:0009101 glycoprotein biosynthetic process IDA 8288606
GO:0009247 glycolipid biosynthetic process IBA,IDA 8288606
GO:0009312 oligosaccharide biosynthetic process IDA 8288606
genes like me logo Genes that share ontologies with ST3GAL4: view

Drugs & Compounds for ST3GAL4 Gene

(26) Drugs for ST3GAL4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(33) Additional Compounds for ST3GAL4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine 5'-monophosphate-N-acetylneuraminic acid
  • CMP Acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Nana
  • CMP-Neu5ac
3063-71-6
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/16:0)
  • (2S,4S,5R)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,6R)-4,5-dihydroxy-6-{[(2S,3R,4E)-3-hydroxy-2-[(1-hydroxyhexadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1S,2S)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
genes like me logo Genes that share compounds with ST3GAL4: view

Transcripts for ST3GAL4 Gene

mRNA/cDNA for ST3GAL4 Gene

9 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL4

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - - - - - - - -
SP16: - - - - - - - -
SP17:
SP18: - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20:

ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: - - - - - -
SP12: -
SP13:
SP14: - -
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ST3GAL4 Gene

GeneLoc Exon Structure for
ST3GAL4

Expression for ST3GAL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST3GAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL4 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for ST3GAL4 Gene

This gene is overexpressed in Nasal epithelium (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ST3GAL4 Gene



Protein tissue co-expression partners for ST3GAL4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST3GAL4

SOURCE GeneReport for Unigene cluster for ST3GAL4 Gene:

Hs.591947

mRNA Expression by UniProt/SwissProt for ST3GAL4 Gene:

Q11206-SIA4C_HUMAN
Tissue specificity: Highly expressed in adult placenta, heart and kidney.

Evidence on tissue expression from TISSUES for ST3GAL4 Gene

  • Blood(4.4)
  • Nervous system(2.8)
  • Stomach(2.6)
  • Heart(2.5)
  • Kidney(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
  • Spleen(2.2)
  • Skin(2.1)
  • Liver(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ST3GAL4: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL4 Gene

Orthologs for ST3GAL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ST3GAL4 29 30
  • 99.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ST3GAL4 29 30
  • 91.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ST3GAL4 29
  • 89.79 (n)
ST3GAL-IV 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia St3gal4 29 16 30
  • 85.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia St3gal4 29
  • 85.89 (n)
Oppossum
(Monodelphis domestica)
Mammalia ST3GAL4 30
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 65 (a)
OneToMany
-- 30
  • 58 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ST3GAL4 29 30
  • 76.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ST3GAL4 30
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia st3gal4 29
  • 62.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15272 29
Zebrafish
(Danio rerio)
Actinopterygii st3gal4 29 30
  • 58.42 (n)
OneToOne
Species where no ortholog for ST3GAL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ST3GAL4 Gene

ENSEMBL:
Gene Tree for ST3GAL4 (if available)
TreeFam:
Gene Tree for ST3GAL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST3GAL4: view image
Alliance of Genome Resources:
Additional Orthologs for ST3GAL4

Paralogs for ST3GAL4 Gene

(6) SIMAP similar genes for ST3GAL4 Gene using alignment to 7 proteins:

  • SIA4C_HUMAN
  • E9PKJ2_HUMAN
  • E9PMC7_HUMAN
  • E9PN64_HUMAN
  • E9PNJ9_HUMAN
  • E9PPJ6_HUMAN
  • E9PQZ2_HUMAN
genes like me logo Genes that share paralogs with ST3GAL4: view

Variants for ST3GAL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST3GAL4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2230278 Benign: not specified 126,407,321(+) C/T
NM_001254757.2(ST3GAL4):c.252C>T (p.Tyr84=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs2230279 Benign: not specified 126,408,180(+) C/T
NM_001254757.2(ST3GAL4):c.423C>T (p.Tyr141=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs2298475 Benign: not specified 126,408,308(+) T/C
NM_001254757.2(ST3GAL4):c.439T>C (p.Leu147=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ST3GAL4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL4 Gene

Variant ID Type Subtype PubMed ID
dgv235e214 CNV gain 21293372
esv24669 CNV gain 19812545
esv2672750 CNV deletion 23128226
esv2745215 CNV deletion 23290073
esv2762951 CNV gain 21179565
esv3579953 CNV loss 25503493
esv3628004 CNV loss 21293372
esv3628007 CNV loss 21293372
esv3892106 CNV loss 25118596
nsv527257 CNV gain 19592680
nsv556530 CNV loss 21841781
nsv556531 CNV loss 21841781
nsv826123 CNV gain 20364138
nsv952757 CNV deletion 24416366
nsv975994 CNV duplication 23825009
nsv975995 CNV duplication 23825009

Variation tolerance for ST3GAL4 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL4
Leiden Open Variation Database (LOVD)
ST3GAL4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL4 Gene

Disorders for ST3GAL4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ST3GAL4 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ST3GAL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL4 Gene

Publications for ST3GAL4 Gene

  1. Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues. (PMID: 12441665) Grahn A … Larson G (Glycoconjugate journal 2001) 3 4 22
  2. Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase. (PMID: 8557707) Kitagawa H … Paulson JC (The Journal of biological chemistry 1996) 2 3 4
  3. Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. (PMID: 8611500) Basu SS … Basu S (Biochemistry 1996) 3 4 22
  4. Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. (PMID: 8288606) Kitagawa H … Paulson JC (The Journal of biological chemistry 1994) 2 3 4
  5. ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes. (PMID: 25498912) Mondal N … Neelamegham S (Blood 2015) 3 4

Products for ST3GAL4 Gene

Sources for ST3GAL4 Gene