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Aliases for ST3GAL2 Gene

Aliases for ST3GAL2 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 2 3 5
  • Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 2 3 4
  • Alpha 2,3-ST 2 3 4
  • EC 4 56
  • Gal-NAc6S 3 4
  • ST3Gal II 3 4
  • ST3GalA.2 3 4
  • ST3GALII 3 4
  • SIAT4-B 3 4
  • SIAT4B 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2 3
  • Sialyltransferase 4B 4
  • EC 56

External Ids for ST3GAL2 Gene

Previous HGNC Symbols for ST3GAL2 Gene

  • SIAT4B

Previous GeneCards Identifiers for ST3GAL2 Gene

  • GC16M068972
  • GC16M056246

Summaries for ST3GAL2 Gene

Entrez Gene Summary for ST3GAL2 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL2 Gene

ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST3GAL2 include Kidney Fibrosarcoma. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL1.

UniProtKB/Swiss-Prot for ST3GAL2 Gene

  • Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Additional gene information for ST3GAL2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST3GAL2 Gene

Genomics for ST3GAL2 Gene

GeneHancer (GH) Regulatory Elements for ST3GAL2 Gene

Promoters and enhancers for ST3GAL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I070436 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1096 3.9 FEZF1 YY1 SLC30A9 ZNF213 ZNF143 SP3 MEF2D SSRP1 ZNF610 GLIS1 ST3GAL2 SMG1P7 CLEC18A HYDIN COG4 LOC400541 AARS DDX19B FUK PDXDC2P-NPIPB14P
GH16I070426 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +8.3 8286 8.7 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 E2F8 SP3 MEF2D PIR61296 SF3B3 DDX19B NONOP1 COG4 PDPR PDXDC2P-NPIPB14P NFAT5 LOC400541 ST3GAL2
GH16I070414 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +20.0 19981 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF766 SP5 ZC3H11A REST ZNF592 LOC105371329 FUK COG4 DDX19B PDXDC2P-NPIPB14P SF3B3 NONOP1 NPIPB14P NFAT5 PDPR
GH16I070403 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 +34.7 34731 1.8 HDGF PKNOX1 ATF1 IRF4 TCF12 ZNF121 GATA2 ZNF143 FOS ATF7 EXOSC6 PDXDC2P-NPIPB14P LOC100506083 LOC105371329 ENSG00000260111 ST3GAL2
GH16I070395 Enhancer 1.1 ENCODE dbSUPER 0.3 +42.9 42889 2.2 PKNOX1 ATF1 ARID4B SIN3A ZNF2 TCF12 ARID2 ZNF143 ATF7 RUNX3 ENSG00000260111 LOC105371329 ST3GAL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST3GAL2 gene promoter:

Genomic Locations for ST3GAL2 Gene

Genomic Locations for ST3GAL2 Gene
63,260 bases
Minus strand

Genomic View for ST3GAL2 Gene

Genes around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL2 Gene

Proteins for ST3GAL2 Gene

  • Protein details for ST3GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Protein Accession:
    Secondary Accessions:
    • O00654

    Protein attributes for ST3GAL2 Gene

    350 amino acids
    Molecular mass:
    40173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL2 Gene

Selected DME Specific Peptides for ST3GAL2 Gene


Post-translational modifications for ST3GAL2 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at isoforms=92 and posLast=211211
  • Modification sites at PhosphoSitePlus

Other Protein References for ST3GAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ST3GAL2 ("ST3 beta-Gal alpha-2,3-Sialyltransferase 2/ST3GAL2")
  • Abcam antibodies for ST3GAL2

Domains & Families for ST3GAL2 Gene

Gene Families for ST3GAL2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ST3GAL2 Gene

Suggested Antigen Peptide Sequences for ST3GAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL2: view

Function for ST3GAL2 Gene

Molecular function for ST3GAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R.
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Enzyme Numbers (IUBMB) for ST3GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA,TAS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047288 monosialoganglioside sialyltransferase activity IDA 9266697
genes like me logo Genes that share ontologies with ST3GAL2: view
genes like me logo Genes that share phenotypes with ST3GAL2: view

Animal Models for ST3GAL2 Gene

MGI Knock Outs for ST3GAL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ST3GAL2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL2 Gene

Localization for ST3GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL2: view

Pathways & Interactions for ST3GAL2 Gene

genes like me logo Genes that share pathways with ST3GAL2: view

UniProtKB/Swiss-Prot Q16842-SIA4B_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IDA 9266697
GO:0009101 glycoprotein biosynthetic process IDA 9266697
GO:0009247 glycolipid biosynthetic process IDA 9266697
GO:0009311 oligosaccharide metabolic process IBA --
GO:0009312 oligosaccharide biosynthetic process IDA 9266697
genes like me logo Genes that share ontologies with ST3GAL2: view

No data available for SIGNOR curated interactions for ST3GAL2 Gene

Drugs & Compounds for ST3GAL2 Gene

(1) Drugs for ST3GAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST3GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine monophosphate N-acetylneuraminic acid
  • CMP-N-Acetylneuraminate
  • CMP-N-Acylneuraminate
  • CMP-NeuNAc
  • Cytidine 5'-monophosphate N-acetylneuraminic acid
  • Cytidine Monophosphate N-Acetylneuraminate
genes like me logo Genes that share compounds with ST3GAL2: view

Transcripts for ST3GAL2 Gene

Unigene Clusters for ST3GAL2 Gene

ST3 beta-galactoside alpha-2,3-sialyltransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP3: - -
SP4: - -

Relevant External Links for ST3GAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST3GAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST3GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST3GAL2 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for ST3GAL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ST3GAL2 Gene

Protein tissue co-expression partners for ST3GAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ST3GAL2 Gene:


SOURCE GeneReport for Unigene cluster for ST3GAL2 Gene:


mRNA Expression by UniProt/SwissProt for ST3GAL2 Gene:

Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.

Evidence on tissue expression from TISSUES for ST3GAL2 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ST3GAL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL2 Gene

Orthologs for ST3GAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST3GAL2 34 33
  • 98.95 (n)
(Bos Taurus)
Mammalia SIAT4B 34
  • 96 (a)
ST3GAL2 33
  • 92.48 (n)
(Monodelphis domestica)
Mammalia ST3GAL2 34
  • 95 (a)
(Canis familiaris)
Mammalia ST3GAL2 34 33
  • 91.9 (n)
(Mus musculus)
Mammalia St3gal2 16 34 33
  • 89.24 (n)
(Rattus norvegicus)
Mammalia St3gal2 33
  • 88.1 (n)
(Ornithorhynchus anatinus)
Mammalia ST3GAL2 34
  • 88 (a)
(Gallus gallus)
Aves ST3GAL2 33 34
  • 82.71 (n)
(Anolis carolinensis)
Reptilia ST3GAL2 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st3gal2 33
  • 69.53 (n)
st3Gal-II 33
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-II 33
(Danio rerio)
Actinopterygii st3gal2 33 34
  • 71.06 (n)
wufd05f03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7280 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4378 34
  • 38 (a)
Species where no ortholog for ST3GAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST3GAL2 Gene

Gene Tree for ST3GAL2 (if available)
Gene Tree for ST3GAL2 (if available)

Paralogs for ST3GAL2 Gene

(1) SIMAP similar genes for ST3GAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ST3GAL2: view

Variants for ST3GAL2 Gene

Sequence variations from dbSNP and Humsavar for ST3GAL2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs386352366 uncertain-significance, not provided 70,395,174(-) A/G coding_sequence_variant, missense_variant
rs1000039248 -- 70,408,034(-) C/T intron_variant
rs1000105845 -- 70,429,097(-) C/G intron_variant
rs1000149589 -- 70,393,667(-) C/G intron_variant
rs1000175288 -- 70,434,447(-) /C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL2 Gene

Variant ID Type Subtype PubMed ID
esv3638954 CNV loss 21293372
esv3638955 CNV loss 21293372
esv3892881 CNV gain 25118596
nsv1116156 CNV deletion 24896259
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897

Variation tolerance for ST3GAL2 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Disorders for ST3GAL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kidney fibrosarcoma
  • fibrosarcoma of the kidney
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL2

genes like me logo Genes that share disorders with ST3GAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL2 Gene

Publications for ST3GAL2 Gene

  1. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PMID: 9266697) Giordanengo V … Lefebvre JC (European journal of biochemistry 1997) 2 3 4 58
  2. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). (PMID: 8920913) Kim YJ … Lee YC (Biochemical and biophysical research communications 1996) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PMID: 12716912) Saito S … Miyagi T (The Journal of biological chemistry 2003) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ST3GAL2 Gene

Sources for ST3GAL2 Gene

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