The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does... See more...

Aliases for ST3GAL2 Gene

Aliases for ST3GAL2 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2 2 3 5
  • ST3GalA.2 2 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2 3 4
  • Sialyltransferase 4B (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 2 3 4
  • Monosialoganglioside Sialyltransferase 3 4
  • Alpha 2,3-ST 2 3 4
  • EC 2.4.99.4 4 50
  • Gal-NAc6S 3 4
  • ST3Gal II 3 4
  • ST3GALII 2 3
  • SIAT4-B 3 4
  • SIAT4B 3 4
  • Sialyltransferase 4B 4
  • EC 2.4.99.7 50
  • EC 2.4.99.2 4
  • ST3GalII 4
  • ST3GAL2 5

External Ids for ST3GAL2 Gene

Previous HGNC Symbols for ST3GAL2 Gene

  • SIAT4B

Previous GeneCards Identifiers for ST3GAL2 Gene

  • GC16M068972
  • GC16M070413
  • GC16M056246

Summaries for ST3GAL2 Gene

Entrez Gene Summary for ST3GAL2 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL2 Gene

ST3GAL2 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2) is a Protein Coding gene. Diseases associated with ST3GAL2 include Kidney Fibrosarcoma and Developmental And Epileptic Encephalopathy 15. Among its related pathways are Globo Sphingolipid Metabolism and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL1.

UniProtKB/Swiss-Prot Summary for ST3GAL2 Gene

  • A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST3GAL2 Gene

Genomics for ST3GAL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ST3GAL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST3GAL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST3GAL2

Top Transcription factor binding sites by QIAGEN in the ST3GAL2 gene promoter:
  • C/EBPalpha
  • CUTL1
  • FOXF2
  • HOXA5
  • IRF-1
  • MAZR
  • Olf-1
  • p53
  • Pax-4a
  • PPAR-alpha

Genomic Locations for ST3GAL2 Gene

Latest Assembly
chr16:70,375,977-70,439,237
(GRCh38/hg38)
Size:
63,261 bases
Orientation:
Minus strand

Previous Assembly
chr16:70,409,880-70,473,003
(GRCh37/hg19 by Entrez Gene)
Size:
63,124 bases
Orientation:
Minus strand

chr16:70,413,338-70,473,140
(GRCh37/hg19 by Ensembl)
Size:
59,803 bases
Orientation:
Minus strand

Genomic View for ST3GAL2 Gene

Genes around ST3GAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL2 Gene

Proteins for ST3GAL2 Gene

  • Protein details for ST3GAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16842-SIA4B_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Protein Accession:
    Q16842
    Secondary Accessions:
    • O00654

    Protein attributes for ST3GAL2 Gene

    Size:
    350 amino acids
    Molecular mass:
    40173 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Homodimer formation occurs in the endoplasmic reticulum.

neXtProt entry for ST3GAL2 Gene

Selected DME Specific Peptides for ST3GAL2 Gene

Q16842:
  • CRRCAVVGNSGNL
  • WHHYWENN
  • FRKTGVHDADFE
  • RMNQAPTVGFE
  • HGRYPSTG
  • DVGSRTTHH
  • YGFGADS

Post-translational modifications for ST3GAL2 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • N-glycosylated; necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus.
  • Glycosylation at Asn211
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SIA4B_HUMAN (1119)

Other Protein References for ST3GAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ST3GAL2 Gene

Gene Families for ST3GAL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ST3GAL2 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 29

Suggested Antigen Peptide Sequences for ST3GAL2 Gene

GenScript: Design optimal peptide antigens:
  • Sialyltransferase 4B (SIA4B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16842

UniProtKB/Swiss-Prot:

SIA4B_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL2: view

Function for ST3GAL2 Gene

Molecular function for ST3GAL2 Gene

UniProtKB/Swiss-Prot Function:
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.99.4; Evidence={ECO:0000269|PubMed:25916169, ECO:0000269|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+); Xref=Rhea:RHEA:48260, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence={ECO:0000269|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.99.2; Evidence={ECO:0000305|PubMed:8920913, ECO:0000305|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:48248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:73110, ChEBI:CHEBI:90153; Evidence={ECO:0000269|PubMed:8920913};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+); Xref=Rhea:RHEA:48244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:88069, ChEBI:CHEBI:90151; Evidence={ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence={ECO:0000305|PubMed:8920913, ECO:0000305|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+); Xref=Rhea:RHEA:48240, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82939, ChEBI:CHEBI:82940; Evidence={ECO:0000269|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+); Xref=Rhea:RHEA:47572, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78452, ChEBI:CHEBI:87785; Evidence={ECO:0000305|PubMed:9266697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + globoside GalGb4Cer = CMP + globoside MSGG + H(+); Xref=Rhea:RHEA:65372, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:140623, ChEBI:CHEBI:140691; Evidence={ECO:0000269|PubMed:12716912};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.46 mM for ganglioside GA1 {ECO:0000269|PubMed:9266697}; KM=0.87 mM for ganglioside GM1 {ECO:0000269|PubMed:9266697}; KM=0.049 mM for asialofetuin {ECO:0000269|PubMed:9266697};

Enzyme Numbers (IUBMB) for ST3GAL2 Gene

Phenotypes From GWAS Catalog for ST3GAL2 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA 8920913
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 25916169
genes like me logo Genes that share ontologies with ST3GAL2: view
genes like me logo Genes that share phenotypes with ST3GAL2: view

Animal Models for ST3GAL2 Gene

MGI Knock Outs for ST3GAL2:

Animal Models for research

  • Taconic Biosciences Mouse Models for ST3GAL2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL2 Gene

Localization for ST3GAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169). Secreted into the body fluid. {ECO:0000250, ECO:0000269 PubMed:25916169}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL2: view

Pathways & Interactions for ST3GAL2 Gene

genes like me logo Genes that share pathways with ST3GAL2: view

UniProtKB/Swiss-Prot Q16842-SIA4B_HUMAN

  • Pathway: Protein modification; protein glycosylation.
  • Pathway: Glycolipid biosynthesis.

Gene Ontology (GO) - Biological Process for ST3GAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IDA 9266697
GO:0006629 lipid metabolic process IEA --
GO:0009101 glycoprotein biosynthetic process IDA 9266697
GO:0009247 glycolipid biosynthetic process IDA 9266697
GO:0009312 oligosaccharide biosynthetic process IDA 9266697
genes like me logo Genes that share ontologies with ST3GAL2: view

No data available for SIGNOR curated interactions for ST3GAL2 Gene

Drugs & Compounds for ST3GAL2 Gene

(1) Drugs for ST3GAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(1) Additional Compounds for ST3GAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine 5'-monophosphate-N-acetylneuraminic acid
  • CMP Acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Nana
  • CMP-Neu5ac
3063-71-6
genes like me logo Genes that share compounds with ST3GAL2: view

Transcripts for ST3GAL2 Gene

mRNA/cDNA for ST3GAL2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL2

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:

Relevant External Links for ST3GAL2 Gene

GeneLoc Exon Structure for
ST3GAL2

Expression for ST3GAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST3GAL2 Gene

mRNA differential expression in normal tissues according to GTEx for ST3GAL2 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for ST3GAL2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST3GAL2 Gene



Protein tissue co-expression partners for ST3GAL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST3GAL2

SOURCE GeneReport for Unigene cluster for ST3GAL2 Gene:

Hs.368611

mRNA Expression by UniProt/SwissProt for ST3GAL2 Gene:

Q16842-SIA4B_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.

Evidence on tissue expression from TISSUES for ST3GAL2 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ST3GAL2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL2 Gene

Orthologs for ST3GAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ST3GAL2 29 30
  • 98.95 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIAT4B 30
  • 96 (a)
OneToOne
ST3GAL2 29
  • 92.48 (n)
Oppossum
(Monodelphis domestica)
Mammalia ST3GAL2 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ST3GAL2 29 30
  • 91.9 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia St3gal2 29 16 30
  • 89.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia St3gal2 29
  • 88.1 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ST3GAL2 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ST3GAL2 29 30
  • 82.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ST3GAL2 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia st3gal2 29
  • 69.53 (n)
st3Gal-II 29
African clawed frog
(Xenopus laevis)
Amphibia st3Gal-II 29
Zebrafish
(Danio rerio)
Actinopterygii st3gal2 29 30
  • 71.06 (n)
OneToOne
wufd05f03 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7280 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4378 30
  • 38 (a)
OneToMany
Species where no ortholog for ST3GAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ST3GAL2 Gene

ENSEMBL:
Gene Tree for ST3GAL2 (if available)
TreeFam:
Gene Tree for ST3GAL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST3GAL2: view image
Alliance of Genome Resources:
Additional Orthologs for ST3GAL2

Paralogs for ST3GAL2 Gene

(1) SIMAP similar genes for ST3GAL2 Gene using alignment to 1 proteins:

  • SIA4B_HUMAN
genes like me logo Genes that share paralogs with ST3GAL2: view

Variants for ST3GAL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST3GAL2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs386352366 Uncertain Significance: not provided 70,395,174(-) A/G
NM_006927.4(ST3GAL2):c.341T>C (p.Met114Thr)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ST3GAL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL2 Gene

Variant ID Type Subtype PubMed ID
esv3638954 CNV loss 21293372
esv3638955 CNV loss 21293372
esv3892881 CNV gain 25118596
nsv1116156 CNV deletion 24896259
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897

Variation tolerance for ST3GAL2 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL2
Leiden Open Variation Database (LOVD)
ST3GAL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL2 Gene

Disorders for ST3GAL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ST3GAL2 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL2

genes like me logo Genes that share disorders with ST3GAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL2 Gene

Publications for ST3GAL2 Gene

  1. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. (PMID: 12716912) Saito S … Miyagi T (The Journal of biological chemistry 2003) 3 4 22
  2. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. (PMID: 9266697) Giordanengo V … Lefebvre JC (European journal of biochemistry 1997) 2 3 4
  3. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). (PMID: 8920913) Kim YJ … Lee YC (Biochemical and biophysical research communications 1996) 2 3 4
  4. Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II. (PMID: 25916169) Ruggiero FM … Daniotti JL (The Biochemical journal 2015) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ST3GAL2 Gene

Sources for ST3GAL2 Gene