The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, ... See more...

Aliases for ST3GAL1 Gene

Aliases for ST3GAL1 Gene

  • ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1 2 3 5
  • ST3GalA.1 2 3 4
  • SIATFL 2 3 4
  • ST3O 2 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 1 3 4
  • Sialyltransferase 4A (Beta-Galactosidase Alpha-2,3-Sialytransferase) 2 3
  • Gal-Beta-1,3-GalNAc-Alpha-2,3-Sialyltransferase 3 4
  • Beta-Galactoside Alpha-2,3-Sialyltransferase 1 3 4
  • Alpha 2,3-ST 1 3 4
  • EC 2.4.99.4 4 51
  • Gal-NAc6S 3 4
  • ST3Gal I 2 4
  • SIAT4-A 3 4
  • ST3GalI 3 4
  • SIAT4A 3 4
  • CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,3-Sialyltransferase 2
  • Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialyltransferase) 3
  • Sialyltransferase 4A (Beta-Galactoside Alpha-2,3-Sialytransferase) 3
  • Monosialoganglioside Sialyltransferase 4
  • Sialyltransferase 4A 4
  • EC 2.4.99.2 4
  • ST3GalIA,1 3
  • EC 2.4.99 51
  • ST3GalIA 3
  • ST3GalA 3
  • ST3GAL1 5
  • SIAT4 4

External Ids for ST3GAL1 Gene

Previous HGNC Symbols for ST3GAL1 Gene

  • SIAT4A

Previous GeneCards Identifiers for ST3GAL1 Gene

  • GC08M134541
  • GC08M129786
  • GC08M134468

Summaries for ST3GAL1 Gene

Entrez Gene Summary for ST3GAL1 Gene

  • The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for ST3GAL1 Gene

ST3GAL1 (ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1) is a Protein Coding gene. Diseases associated with ST3GAL1 include Puerperal Pulmonary Embolism. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. An important paralog of this gene is ST3GAL2.

UniProtKB/Swiss-Prot Summary for ST3GAL1 Gene

  • A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8027041) (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST3GAL1 Gene

Genomics for ST3GAL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ST3GAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST3GAL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST3GAL1

Top Transcription factor binding sites by QIAGEN in the ST3GAL1 gene promoter:
  • c-Ets-1
  • FAC1
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • Spz1
  • TBP

Genomic Locations for ST3GAL1 Gene

Latest Assembly
chr8:133,454,848-133,572,534
(GRCh38/hg38)
Size:
117,687 bases
Orientation:
Minus strand

Previous Assembly
chr8:134,467,091-134,584,130
(GRCh37/hg19 by Entrez Gene)
Size:
117,040 bases
Orientation:
Minus strand

chr8:134,467,091-134,584,183
(GRCh37/hg19 by Ensembl)
Size:
117,093 bases
Orientation:
Minus strand

Genomic View for ST3GAL1 Gene

Genes around ST3GAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST3GAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST3GAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST3GAL1 Gene

Proteins for ST3GAL1 Gene

  • Protein details for ST3GAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11201-SIA4A_HUMAN
    Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Protein Accession:
    Q11201
    Secondary Accessions:
    • O60677
    • Q9UN51

    Protein attributes for ST3GAL1 Gene

    Size:
    340 amino acids
    Molecular mass:
    39075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST3GAL1 Gene

Selected DME Specific Peptides for ST3GAL1 Gene

Q11201:
  • CRRCAVVGNSGNL
  • WHHYWENN
  • GFEADVG
  • FRKTGVHDADFE
  • IDSHDFVLRMN
  • HGRYPSTG
  • LFIFLTSF
  • VYPESFREL
  • YGFGADS

Post-translational modifications for ST3GAL1 Gene

  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn79, Asn114, Asn201, and Asn323
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SIA4A_HUMAN (1118)

Domains & Families for ST3GAL1 Gene

Gene Families for ST3GAL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ST3GAL1 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 29
ProtoNet:

Suggested Antigen Peptide Sequences for ST3GAL1 Gene

GenScript: Design optimal peptide antigens:
  • Sialyltransferase 4A (SIA4A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q11201

UniProtKB/Swiss-Prot:

SIA4A_HUMAN :
  • Belongs to the glycosyltransferase 29 family.
Family:
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST3GAL1: view

Function for ST3GAL1 Gene

Molecular function for ST3GAL1 Gene

UniProtKB/Swiss-Prot Function:
A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8027041) (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+); Xref=Rhea:RHEA:21616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:133470, ChEBI:CHEBI:139596; EC=2.4.99.4; Evidence={ECO:0000269|PubMed:31784620, ECO:0000269|PubMed:8027041};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 = CMP + ganglioside GD1a + H(+); Xref=Rhea:RHEA:48260, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82637, ChEBI:CHEBI:82639; Evidence={ECO:0000269|PubMed:8027041};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (d18:1(4E)) + H(+); Xref=Rhea:RHEA:18021, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:77709, ChEBI:CHEBI:78445; EC=2.4.99.2; Evidence={ECO:0000305|PubMed:8027041};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+); Xref=Rhea:RHEA:48248, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:73110, ChEBI:CHEBI:90153; Evidence={ECO:0000250|UniProtKB:P54751};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+); Xref=Rhea:RHEA:48244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:88069, ChEBI:CHEBI:90151; Evidence={ECO:0000269|PubMed:8027041};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+); Xref=Rhea:RHEA:47560, ChEBI:CHEBI:15378, ChEBI:CHEBI:27938, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:78568; Evidence={ECO:0000250|UniProtKB:Q02745};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+); Xref=Rhea:RHEA:48240, ChEBI:CHEBI:15378, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:82939, ChEBI:CHEBI:82940; Evidence={ECO:0000250|UniProtKB:P54751};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=106 uM for CMP-N-acetyl-beta-neuraminate {ECO:0000269|PubMed:31784620}; KM=26 uM for beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative {ECO:0000269|PubMed:31784620};

Enzyme Numbers (IUBMB) for ST3GAL1 Gene

Phenotypes From GWAS Catalog for ST3GAL1 Gene

Gene Ontology (GO) - Molecular Function for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS,ISS --
GO:0008373 sialyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047288 monosialoganglioside sialyltransferase activity IEA --
genes like me logo Genes that share ontologies with ST3GAL1: view
genes like me logo Genes that share phenotypes with ST3GAL1: view

Animal Models for ST3GAL1 Gene

MGI Knock Outs for ST3GAL1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL1

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ST3GAL1 Gene

Localization for ST3GAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST3GAL1 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in medial and trans cisternae of Golgi (PubMed:9182658). Secreted into the body fluid. {ECO:0000269 PubMed:9182658}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST3GAL1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST3GAL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ST3GAL1 Gene

Pathways & Interactions for ST3GAL1 Gene

genes like me logo Genes that share pathways with ST3GAL1: view

UniProtKB/Swiss-Prot Q11201-SIA4A_HUMAN

  • Pathway: Protein modification; protein glycosylation.
  • Pathway: Glycolipid biosynthesis.

SIGNOR curated interactions for ST3GAL1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ST3GAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002319 memory B cell differentiation IEA --
GO:0006054 N-acetylneuraminate metabolic process ISS --
GO:0006464 cellular protein modification process TAS 10504389
GO:0006468 protein phosphorylation IEA --
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with ST3GAL1: view

Drugs & Compounds for ST3GAL1 Gene

(2) Drugs for ST3GAL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine monophosphate Experimental Pharma 0

(14) Additional Compounds for ST3GAL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytidine 5'-monophosphate-N-acetylneuraminic acid
  • CMP Acetylneuraminic acid
  • CMP-beta-Neu5ac
  • CMP-N-Acetylneuraminate
  • CMP-Nana
  • CMP-Neu5ac
3063-71-6
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/16:0)
  • (2S,4S,5R)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,6R)-4,5-dihydroxy-6-{[(2S,3R,4E)-3-hydroxy-2-[(1-hydroxyhexadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-[(1S,2S)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
Ganglioside GM1 (18:1/18:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-nacylsphingosine
genes like me logo Genes that share compounds with ST3GAL1: view

Transcripts for ST3GAL1 Gene

mRNA/cDNA for ST3GAL1 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST3GAL1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ST3GAL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: -
SP11: -
SP12: - -
SP13:
SP14:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ST3GAL1 Gene

GeneLoc Exon Structure for
ST3GAL1

Expression for ST3GAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST3GAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ST3GAL1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.6).

Protein differential expression in normal tissues from HIPED for ST3GAL1 Gene

This gene is overexpressed in Lung (28.1), Placenta (12.1), Peripheral blood mononuclear cells (9.4), and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST3GAL1 Gene



Protein tissue co-expression partners for ST3GAL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST3GAL1

SOURCE GeneReport for Unigene cluster for ST3GAL1 Gene:

Hs.374257

mRNA Expression by UniProt/SwissProt for ST3GAL1 Gene:

Q11201-SIA4A_HUMAN
Tissue specificity: Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.

Evidence on tissue expression from TISSUES for ST3GAL1 Gene

  • Skin(4.3)
  • Liver(2.4)
  • Kidney(2.4)
  • Intestine(2.4)
  • Thyroid gland(2.3)
  • Nervous system(2.3)
  • Heart(2.3)
  • Lymph node(2.2)
  • Spleen(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ST3GAL1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ST3GAL1 Gene

Orthologs for ST3GAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST3GAL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ST3GAL1 30 31
  • 98.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ST3GAL1 30 31
  • 87.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ST3GAL1 30 31
  • 86.65 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia St3gal1 30
  • 82.35 (n)
Mouse
(Mus musculus)
Mammalia St3gal1 30 17 31
  • 81.9 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ST3GAL1 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ST3GAL1 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ST3GAL1 30 31
  • 67.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ST3GAL1 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia st3gal1 30
  • 64.06 (n)
Zebrafish
(Danio rerio)
Actinopterygii st3gal1l 31
  • 40 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6558 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4378 31
  • 38 (a)
OneToMany
Species where no ortholog for ST3GAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ST3GAL1 Gene

ENSEMBL:
Gene Tree for ST3GAL1 (if available)
TreeFam:
Gene Tree for ST3GAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST3GAL1: view image

Paralogs for ST3GAL1 Gene

(7) SIMAP similar genes for ST3GAL1 Gene using alignment to 6 proteins:

  • SIA4A_HUMAN
  • E5RG72_HUMAN
  • E5RGI3_HUMAN
  • E5RGL4_HUMAN
  • E5RH34_HUMAN
  • E5RHV6_HUMAN

Pseudogenes.org Pseudogenes for ST3GAL1 Gene

genes like me logo Genes that share paralogs with ST3GAL1: view

Variants for ST3GAL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST3GAL1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs112787936 Benign: not provided 133,465,935(-) A/G
NM_173344.3(ST3GAL1):c.462T>C (p.Ser154=)
SYNONYMOUS
rs117461712 Benign: not provided 133,463,467(-) T/C
NM_173344.3(ST3GAL1):c.684-8A>G
INTRON
rs142100792 Benign: not provided 133,475,754(-) C/T
NM_173344.3(ST3GAL1):c.271G>A (p.Ala91Thr)
MISSENSE
rs74421799 Benign: not provided 133,475,833(-) G/A
NM_173344.3(ST3GAL1):c.192C>T (p.Cys64=)
SYNONYMOUS
rs116342938 - p.Asn111Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ST3GAL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ST3GAL1 Gene

Variant ID Type Subtype PubMed ID
esv3335344 CNV insertion 20981092
esv3544244 CNV deletion 23714750
esv3618890 CNV loss 21293372
nsv1035043 CNV loss 25217958
nsv1115139 CNV deletion 24896259
nsv1128454 CNV deletion 24896259
nsv1137402 CNV deletion 24896259
nsv528683 CNV loss 19592680
nsv6404 CNV insertion 18451855
nsv6405 CNV deletion 18451855
nsv831464 CNV loss 17160897

Variation tolerance for ST3GAL1 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST3GAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST3GAL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST3GAL1 Gene

Disorders for ST3GAL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST3GAL1 Gene - From: COP

Disorder Aliases PubMed IDs
puerperal pulmonary embolism
  • obstetric pulmonary embolism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST3GAL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ST3GAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST3GAL1 Gene

Publications for ST3GAL1 Gene

  1. Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver. (PMID: 10504389) Shang J … Jin C (European journal of biochemistry 1999) 2 3 4 23
  2. Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies. (PMID: 7655169) Chang ML … Lau JT (Glycobiology 1995) 2 3 4 23
  3. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1). (PMID: 31784620) Ortiz-Soto ME … Seibel J (Scientific reports 2019) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Family-based association study of lithium-related and other candidate genes in bipolar disorder. (PMID: 18180429) Perlis RH … Sklar P (Archives of general psychiatry 2008) 3 23

Products for ST3GAL1 Gene

Sources for ST3GAL1 Gene