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Aliases for ST20-MTHFS Gene

Aliases for ST20-MTHFS Gene

  • ST20-MTHFS Readthrough 2 3 5

External Ids for ST20-MTHFS Gene

Previous GeneCards Identifiers for ST20-MTHFS Gene

  • GC15U901328
  • GC15M080140

Summaries for ST20-MTHFS Gene

Entrez Gene Summary for ST20-MTHFS Gene

  • This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

GeneCards Summary for ST20-MTHFS Gene

ST20-MTHFS (ST20-MTHFS Readthrough) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Metabolism. An important paralog of this gene is MTHFS.

Additional gene information for ST20-MTHFS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST20-MTHFS Gene

Genomics for ST20-MTHFS Gene

GeneHancer (GH) Regulatory Elements for ST20-MTHFS Gene

Promoters and enhancers for ST20-MTHFS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I079921 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 410 2.9 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ST20 ENSG00000278600 ST20-AS1 ST20-MTHFS MTHFS BCL2A1
GH15I079964 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.9 -44.6 -44569 7.5 HDGF PKNOX1 FOXA2 SMAD1 SIN3A IRF4 ZNF207 ZNF143 ATF7 FOS BCL2A1 MTHFS ST20-MTHFS ST20 RNU6-667P LOC101929560 ZFAND6 GC15P079945
GH15I079973 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -50.1 -50050 0.8 ZNF687 BCL11A IKZF1 ETV6 DPF2 IKZF2 RUNX3 ZNF592 BCL2A1 ST20-MTHFS MTHFS ST20 ZFAND6 LOC100420205
GH15I079961 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.7 -38.5 -38484 1.3 ZNF687 L3MBTL2 ZBED1 MAX ELF1 ZNF592 ZNF217 POLR2A NFATC1 IKZF1 BCL2A1 RNU6-667P ZFAND6 ST20-MTHFS MTHFS ST20 GC15P079945
GH15I079900 Enhancer 0.8 FANTOM5 ENCODE 6.2 +23.5 23476 0.3 ZNF687 ETV6 MLLT1 RUNX3 BCL2A1 RNU6-667P ST20-MTHFS ZFAND6 MTHFS ST20 GC15M079918
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ST20-MTHFS on UCSC Golden Path with GeneCards custom track

Genomic Locations for ST20-MTHFS Gene

Genomic Locations for ST20-MTHFS Gene
80,208 bases
Minus strand

Genomic View for ST20-MTHFS Gene

Genes around ST20-MTHFS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST20-MTHFS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST20-MTHFS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20-MTHFS Gene

Proteins for ST20-MTHFS Gene

  • Protein details for ST20-MTHFS Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    5-formyltetrahydrofolate cyclo-ligase
    Protein Accession:

    Protein attributes for ST20-MTHFS Gene

    179 amino acids
    Molecular mass:
    20519 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
  • Protein details for ST20-MTHFS Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    ST20-MTHFS readthrough
    Protein Accession:

    Protein attributes for ST20-MTHFS Gene

    122 amino acids
    Molecular mass:
    14011 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20-MTHFS Gene

Post-translational modifications for ST20-MTHFS Gene

No Post-translational modifications

Other Protein References for ST20-MTHFS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ST20-MTHFS Gene

Domains & Families for ST20-MTHFS Gene

Gene Families for ST20-MTHFS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ST20-MTHFS Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ST20-MTHFS: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ST20-MTHFS Gene

Function for ST20-MTHFS Gene

Phenotypes From GWAS Catalog for ST20-MTHFS Gene

Gene Ontology (GO) - Molecular Function for ST20-MTHFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ST20-MTHFS: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST20-MTHFS Gene

Localization for ST20-MTHFS Gene

Gene Ontology (GO) - Cellular Components for ST20-MTHFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with ST20-MTHFS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ST20-MTHFS Gene

Pathways & Interactions for ST20-MTHFS Gene

genes like me logo Genes that share pathways with ST20-MTHFS: view

Pathways by source for ST20-MTHFS Gene

2 KEGG pathways for ST20-MTHFS Gene

Interacting Proteins for ST20-MTHFS Gene

Gene Ontology (GO) - Biological Process for ST20-MTHFS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009396 folic acid-containing compound biosynthetic process IBA --
GO:0035999 tetrahydrofolate interconversion IBA --
genes like me logo Genes that share ontologies with ST20-MTHFS: view

No data available for SIGNOR curated interactions for ST20-MTHFS Gene

Drugs & Compounds for ST20-MTHFS Gene

No Compound Related Data Available

Transcripts for ST20-MTHFS Gene

mRNA/cDNA for ST20-MTHFS Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ST20-MTHFS Gene

No ASD Table

Relevant External Links for ST20-MTHFS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST20-MTHFS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST20-MTHFS Gene

Protein differential expression in normal tissues from HIPED for ST20-MTHFS Gene

This gene is overexpressed in Liver (19.7), Peripheral blood mononuclear cells (12.1), and Gallbladder (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for ST20-MTHFS Gene

Protein tissue co-expression partners for ST20-MTHFS Gene

genes like me logo Genes that share expression patterns with ST20-MTHFS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST20-MTHFS Gene

Orthologs for ST20-MTHFS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ST20-MTHFS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTHFS 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
(Canis familiaris)
Mammalia -- 34
  • 70 (a)
(Mus musculus)
Mammalia Gm2382 34
  • 70 (a)
Mthfs 34
  • 70 (a)
(Bos Taurus)
Mammalia MTHFS 34
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
-- 34
  • 68 (a)
(Gallus gallus)
Aves MTHFS 34
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
(Danio rerio)
Actinopterygii MTHFS 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34424 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y106G6E.4 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAU1 34
  • 24 (a)
Species where no ortholog for ST20-MTHFS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ST20-MTHFS Gene

Gene Tree for ST20-MTHFS (if available)
Gene Tree for ST20-MTHFS (if available)

Paralogs for ST20-MTHFS Gene

Paralogs for ST20-MTHFS Gene

genes like me logo Genes that share paralogs with ST20-MTHFS: view

Variants for ST20-MTHFS Gene

Sequence variations from dbSNP and Humsavar for ST20-MTHFS Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000009187 -- 79,848,487(-) T/G intron_variant
rs1000012239 -- 79,874,104(-) C/T intron_variant
rs1000064758 -- 79,918,337(-) C/T intron_variant
rs1000076340 -- 79,890,269(-) G/A intron_variant
rs1000084032 -- 79,848,817(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST20-MTHFS Gene

Variant ID Type Subtype PubMed ID
dgv155n21 CNV loss 19592680
esv2660680 CNV deletion 23128226
esv2672391 CNV deletion 23128226
esv2678719 CNV deletion 23128226
esv28440 CNV loss 19812545
esv3581779 CNV loss 25503493
esv3637008 CNV loss 21293372
esv3637009 CNV loss 21293372
esv3637011 CNV loss 21293372
nsv510406 OTHER sequence alteration 20534489
nsv833065 CNV loss 17160897
nsv833066 CNV loss 17160897

Variation tolerance for ST20-MTHFS Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST20-MTHFS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST20-MTHFS Gene

Disorders for ST20-MTHFS Gene

Additional Disease Information for ST20-MTHFS

No disorders were found for ST20-MTHFS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ST20-MTHFS Gene

Publications for ST20-MTHFS Gene

  1. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 58

Products for ST20-MTHFS Gene

Sources for ST20-MTHFS Gene

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