Aliases for ST20 Gene

Subcategory (RNA class) for ST20 Gene

ncRNA

Quality Score for this RNA gene is

13

Aliases for ST20 Gene

  • Suppressor Of Tumorigenicity 20 2 3 5
  • Human Cervical Cancer Suppressor Gene 1 Protein 3 4
  • Suppressor Of Tumorigenicity 20 Protein 3 4
  • HCCS-1 3 4
  • Cervical Cancer Suppressor-1 3
  • HCCS1 4

External Ids for ST20 Gene

Previous GeneCards Identifiers for ST20 Gene

  • GC15M077980
  • GC15M080191
  • GC15M056949

Summaries for ST20 Gene

GeneCards Summary for ST20 Gene

ST20 (Suppressor Of Tumorigenicity 20) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with ST20 include Cervical Cancer. Among its related pathways are One carbon pool by folate. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot Summary for ST20 Gene

  • May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Additional gene information for ST20 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST20 Gene

Genomics for ST20 Gene

GeneHancer (GH) Regulatory Elements for ST20 Gene

Promoters and enhancers for ST20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J079921 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 781.8 +0.5 453 3.8 SP1 ZBTB40 ZBTB6 RBPJ POLR2A TCF7L2 ATF1 CREB1 HCFC1 MYC ST20 ENSG00000278600 ST20-AS1 ST20-MTHFS MTHFS BCL2A1
GH15J079919 Promoter 0.4 EPDnew 750.6 +3.9 3939 0.1 SP1 ST20 MTHFS BCL2A1 ENSG00000278600 ST20-MTHFS
GH15J079894 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 31.9 +26.5 26514 5.5 SIN3A ZBTB40 CTCF LCORL RBPJ POLR2A MIXL1 MYC ELF1 HLF MTHFS ENSG00000286813 ST20 BCL2A1 ZFAND6 RNU6-667P MINAR1 ST20-MTHFS
GH15J079942 Enhancer 0.9 Ensembl ENCODE 29.9 -19.7 -19747 3.8 ZNF24 L3MBTL2 NKRF CREM IKZF1 CREB1 TRIM22 ATF1 IKZF2 ATF7 ENSG00000259770 FDPSP9 lnc-ZFAND6-2 ST20 BCL2A1 MTHFS piR-58297-182
GH15J079909 Enhancer 0.8 Ensembl ENCODE 30.6 +13.7 13653 3 SP1 CC2D1A NFYC MAFK ZBTB33 LARP7 IKZF2 ZNF316 PKNOX1 IRF3 MTHFS ST20 BCL2A1 RNU6-667P ENSG00000278600 ST20-MTHFS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST20 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • NF-1

Genomic Locations for ST20 Gene

Genomic Locations for ST20 Gene
chr15:79,898,840-79,923,754
(GRCh38/hg38)
Size:
24,915 bases
Orientation:
Minus strand
chr15:80,191,182-80,216,096
(GRCh37/hg19)
Size:
24,915 bases
Orientation:
Minus strand

Genomic View for ST20 Gene

Genes around ST20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST20 Gene

Proteins for ST20 Gene

  • Protein details for ST20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBF5-ST20_HUMAN
    Recommended name:
    Suppressor of tumorigenicity 20 protein
    Protein Accession:
    Q9HBF5

    Protein attributes for ST20 Gene

    Size:
    79 amino acids
    Molecular mass:
    9024 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST20 Gene

Post-translational modifications for ST20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST20 Gene

No data available for DME Specific Peptides for ST20 Gene

Domains & Families for ST20 Gene

Gene Families for ST20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ST20 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ST20 Gene

GenScript: Design optimal peptide antigens:
  • Human cervical cancer suppressor gene 1 protein (ST20_HUMAN)
genes like me logo Genes that share domains with ST20: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ST20 Gene

Function for ST20 Gene

Molecular function for ST20 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor. Promotes apoptosis of cancer cells.

Phenotypes From GWAS Catalog for ST20 Gene

Gene Ontology (GO) - Molecular Function for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 11857354
genes like me logo Genes that share ontologies with ST20: view
genes like me logo Genes that share phenotypes with ST20: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST20 Gene

Localization for ST20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST20 gene
Compartment Confidence
extracellular 2
mitochondrion 0
nucleus 0
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ST20 Gene

Pathways & Interactions for ST20 Gene

PathCards logo

SuperPathways for ST20 Gene

SuperPathway Contained pathways
1 One carbon pool by folate
genes like me logo Genes that share pathways with ST20: view

Pathways by source for ST20 Gene

1 BioSystems pathway for ST20 Gene

Interacting Proteins for ST20 Gene

Gene Ontology (GO) - Biological Process for ST20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 11857354
GO:0030308 negative regulation of cell growth IDA 11857354
GO:0071494 cellular response to UV-C IMP 11857354
GO:0097190 apoptotic signaling pathway IDA 11857354
GO:1902512 positive regulation of apoptotic DNA fragmentation IDA 11857354
genes like me logo Genes that share ontologies with ST20: view

No data available for SIGNOR curated interactions for ST20 Gene

Drugs & Compounds for ST20 Gene

No Compound Related Data Available

Transcripts for ST20 Gene

mRNA/cDNA for ST20 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST20 Gene

No ASD Table

Relevant External Links for ST20 Gene

GeneLoc Exon Structure for
ST20
ECgene alternative splicing isoforms for
ST20

Expression for ST20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST20 Gene

mRNA differential expression in normal tissues according to GTEx for ST20 Gene

This gene is overexpressed in Whole Blood (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of ST20 Gene:

ST20

SOURCE GeneReport for Unigene cluster for ST20 Gene:

Hs.729127

mRNA Expression by UniProt/SwissProt for ST20 Gene:

Q9HBF5-ST20_HUMAN
Tissue specificity: Expressed in leukocytes, lung, spleen, liver, heart, kidney, muscle and uterine cervix. Down-regulated in cervical cancer.
genes like me logo Genes that share expression patterns with ST20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST20 Gene

Orthologs for ST20 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ST20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST20 33 32
  • 99.58 (n)
OneToOne
Species where no ortholog for ST20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ST20 Gene

ENSEMBL:
Gene Tree for ST20 (if available)
TreeFam:
Gene Tree for ST20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST20: view image

Paralogs for ST20 Gene

No data available for Paralogs for ST20 Gene

Variants for ST20 Gene

Sequence variations from dbSNP and Humsavar for ST20 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000064758 -- 79,918,337(-) C/T intron_variant
rs1000094335 -- 79,925,469(-) C/T upstream_transcript_variant
rs1000100403 -- 79,918,144(-) T/G intron_variant
rs1000218561 -- 79,911,716(-) G/A/C/T intron_variant
rs1000298401 -- 79,906,624(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST20 Gene

Variant ID Type Subtype PubMed ID
dgv155n21 CNV loss 19592680
esv2660680 CNV deletion 23128226
esv2672391 CNV deletion 23128226
esv3581779 CNV loss 25503493
esv3637009 CNV loss 21293372
esv3637011 CNV loss 21293372
nsv510406 OTHER sequence alteration 20534489
nsv833065 CNV loss 17160897
nsv833066 CNV loss 17160897

Variation tolerance for ST20 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST20 Gene

Disorders for ST20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST20 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cervical cancer
  • cervical cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search ST20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ST20

genes like me logo Genes that share disorders with ST20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST20 Gene

Publications for ST20 Gene

  1. Candidate tumor suppressor, HCCS-1, is downregulated in human cancers and induces apoptosis in cervical cancer. (PMID: 11857354) Kim TE … Kim JW (International journal of cancer 2002) 2 3 4 56
  2. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 56
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 56
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 56

Products for ST20 Gene

Sources for ST20 Gene