Aliases for ST14 Gene
External Ids for ST14 Gene
Previous HGNC Symbols for ST14 Gene
Previous GeneCards Identifiers for ST14 Gene
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
GeneCards Summary for ST14 Gene
ST14 (Suppression Of Tumorigenicity 14) is a Protein Coding gene. Diseases associated with ST14 include Ichthyosis, Congenital, Autosomal Recessive 11 and Ichthyosis, Follicular. Among its related pathways are MicroRNAs in cancer and Keratinization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS6.
UniProtKB/Swiss-Prot for ST14 Gene
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.