The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue s... See more...

Aliases for ST13 Gene

Aliases for ST13 Gene

  • ST13 Hsp70 Interacting Protein 2 3 5
  • Progesterone Receptor-Associated P48 Protein 2 3 4
  • Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) 2 3
  • Suppression Of Tumorigenicity 13 Protein 3 4
  • Renal Carcinoma Antigen NY-REN-33 3 4
  • Putative Tumor Suppressor ST13 3 4
  • Aging-Associated Protein 2 3 4
  • Hsc70-Interacting Protein 3 4
  • FAM10A1 3 4
  • AAG2 3 4
  • SNC6 3 4
  • HIP 3 4
  • Testis Secretory Sperm-Binding Protein Li 233m 3
  • Heat Shock 70kD Protein Binding Protein 3
  • ST13, Hsp70 Interacting Protein 2
  • Hsp70-Interacting Protein 3
  • Protein FAM10A1 4
  • FAM10A4 3
  • HSPABP1 3
  • PRO0786 3
  • HSPABP 3
  • HOP 3
  • P48 3
  • Hip 4

External Ids for ST13 Gene

Previous GeneCards Identifiers for ST13 Gene

  • GC22M037835
  • GC22M039463
  • GC22M039545
  • GC22M041220
  • GC22M040825
  • GC22M042785
  • GC22M042899
  • GC22M042956
  • GC22M040957
  • GC22M040960
  • GC22M041090
  • GC22M041488
  • GC22M041896
  • GC22M042326
  • GC22M042675

Summaries for ST13 Gene

Entrez Gene Summary for ST13 Gene

  • The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for ST13 Gene

ST13 (ST13 Hsp70 Interacting Protein) is a Protein Coding gene. Diseases associated with ST13 include Spinocerebellar Ataxia, Autosomal Recessive 16 and West Nile Fever. Among its related pathways are Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is TTC4.

UniProtKB/Swiss-Prot Summary for ST13 Gene

  • One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Gene Wiki entry for ST13 Gene

Additional gene information for ST13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ST13 Gene

Genomics for ST13 Gene

GeneHancer (GH) Regulatory Elements for ST13 Gene

Promoters and enhancers for ST13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ST13

Top Transcription factor binding sites by QIAGEN in the ST13 gene promoter:
  • AREB6
  • C/EBPalpha
  • Elk-1
  • Evi-1
  • HNF-1
  • HNF-1A
  • Pax-3
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ST13 Gene

Genomic Locations for ST13 Gene
chr22:40,824,535-40,857,008
(GRCh38/hg38)
Size:
32,474 bases
Orientation:
Minus strand
chr22:41,220,539-41,253,026
(GRCh37/hg19)
Size:
32,488 bases
Orientation:
Minus strand

Genomic View for ST13 Gene

Genes around ST13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST13 Gene

Proteins for ST13 Gene

  • Protein details for ST13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50502-F10A1_HUMAN
    Recommended name:
    Hsc70-interacting protein
    Protein Accession:
    P50502
    Secondary Accessions:
    • O14999
    • Q2TU77

    Protein attributes for ST13 Gene

    Size:
    369 amino acids
    Molecular mass:
    41332 Da
    Quaternary structure:
    • Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5.

    Three dimensional structures from OCA and Proteopedia for ST13 Gene

neXtProt entry for ST13 Gene

Post-translational modifications for ST13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ST13 Gene

No data available for DME Specific Peptides for ST13 Gene

Domains & Families for ST13 Gene

Gene Families for ST13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ST13 Gene

Blocks:
  • Heat shock chaperonin-binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ST13 Gene

GenScript: Design optimal peptide antigens:
  • Suppression of tumorigenicity 13 (Colon carcinoma) (Hsp70 interacting protein) (B1AHN5_HUMAN)
  • Suppression of tumorigenicity 13 protein (F10A1_HUMAN)
  • ST13 protein (Q0IJ56_HUMAN)
  • Suppression of tumorigenicity 13 (Colon carcinoma) (Hsp70 interacting protein), isoform CRA_a (Q2TU77_HUMAN)
  • ST13 protein (Q9P1I4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50502

UniProtKB/Swiss-Prot:

F10A1_HUMAN :
  • Belongs to the FAM10 family.
Family:
  • Belongs to the FAM10 family.
genes like me logo Genes that share domains with ST13: view

Function for ST13 Gene

Molecular function for ST13 Gene

UniProtKB/Swiss-Prot Function:
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
GENATLAS Biochemistry:
suppression of tumorigenicity 13,colon carcinoma,see TSG22C

Phenotypes From GWAS Catalog for ST13 Gene

Gene Ontology (GO) - Molecular Function for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0019904 protein domain specific binding IEA --
GO:0030544 Hsp70 protein binding IEA --
GO:0030674 protein binding, bridging TAS 8721986
GO:0032564 dATP binding IEA --
genes like me logo Genes that share ontologies with ST13: view
genes like me logo Genes that share phenotypes with ST13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ST13 Gene

Localization for ST13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST13 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST13 gene
Compartment Confidence
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8721986
GO:0005829 cytosol IDA --
GO:0032991 protein-containing complex IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ST13: view

Pathways & Interactions for ST13 Gene

genes like me logo Genes that share pathways with ST13: view

Gene Ontology (GO) - Biological Process for ST13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 8721986
GO:0009617 response to bacterium IEA --
GO:0051085 chaperone cofactor-dependent protein refolding IBA 21873635
GO:0051260 protein homooligomerization IEA --
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with ST13: view

No data available for SIGNOR curated interactions for ST13 Gene

Drugs & Compounds for ST13 Gene

(3) Drugs for ST13 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0

(3) Additional Compounds for ST13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ST13: view

Transcripts for ST13 Gene

mRNA/cDNA for ST13 Gene

2 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ST13

Alternative Splicing Database (ASD) splice patterns (SP) for ST13 Gene

No ASD Table

Relevant External Links for ST13 Gene

GeneLoc Exon Structure for
ST13

Expression for ST13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ST13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ST13 Gene

This gene is overexpressed in Bone (30.1) and Nasal epithelium (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ST13 Gene



Protein tissue co-expression partners for ST13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ST13

SOURCE GeneReport for Unigene cluster for ST13 Gene:

Hs.712713

Evidence on tissue expression from TISSUES for ST13 Gene

  • Nervous system(4.8)
  • Skin(4.6)
  • Liver(4.5)
  • Intestine(4.4)
  • Muscle(2.6)
  • Kidney(2.4)
  • Heart(2.3)
  • Stomach(2.2)
  • Eye(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with ST13: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST13 Gene

Orthologs for ST13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ST13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ST13 30
  • 100 (n)
cow
(Bos Taurus)
Mammalia ST13 31 30
  • 93.59 (n)
OneToMany
-- 31
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia St13 30
  • 89.67 (n)
mouse
(Mus musculus)
Mammalia St13 17 31 30
  • 89.22 (n)
dog
(Canis familiaris)
Mammalia ST13 31
  • 89 (a)
OneToMany
-- 31
  • 81 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ST13 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves ST13 31 30
  • 79.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ST13 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia st13 30
  • 69.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4814 30
zebrafish
(Danio rerio)
Actinopterygii st13 31 30 30
  • 66.01 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009119 30
  • 52.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta HIP-R 31 30
  • 49.79 (n)
OneToMany
HIP 31
  • 38 (a)
OneToMany
CG2947 32
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea hip-1 31 30
  • 51.69 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons HIP1 30
  • 58.42 (n)
rice
(Oryza sativa)
Liliopsida Os02g0100300 30
  • 55.2 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9783 30
corn
(Zea mays)
Liliopsida Zm.4878 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10176 31
  • 36 (a)
OneToOne
Species where no ortholog for ST13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ST13 Gene

ENSEMBL:
Gene Tree for ST13 (if available)
TreeFam:
Gene Tree for ST13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ST13: view image

Paralogs for ST13 Gene

(2) SIMAP similar genes for ST13 Gene using alignment to 7 proteins:

  • F10A1_HUMAN
  • F6VDH7_HUMAN
  • F8WAQ7_HUMAN
  • H7C3I1_HUMAN
  • Q0IJ56_HUMAN
  • Q3KNR6_HUMAN
  • Q9P1I4_HUMAN
genes like me logo Genes that share paralogs with ST13: view

Variants for ST13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ST13 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
714908 Benign: not provided 40,827,202(-) T/C MISSENSE_VARIANT
rs710193 - p.Met297Ile

Additional dbSNP identifiers (rs#s) for ST13 Gene

Structural Variations from Database of Genomic Variants (DGV) for ST13 Gene

Variant ID Type Subtype PubMed ID
nsv834206 CNV gain 17160897
nsv964634 CNV duplication 23825009
nsv979679 CNV duplication 23825009
nsv979680 CNV duplication 23825009

Variation tolerance for ST13 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ST13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST13 Gene

Disorders for ST13 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ST13 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ST13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ST13

genes like me logo Genes that share disorders with ST13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST13 Gene

Publications for ST13 Gene

  1. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. (PMID: 8721986) Prapapanich V … Smith DF (Molecular endocrinology (Baltimore, Md.) 1996) 2 3 4 23 54
  2. Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24-->q25 by in situ hybridization. (PMID: 9925927) Zhang Y … Zheng S (Cytogenetics and cell genetics 1998) 2 3 23 54
  3. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. (PMID: 21728385) Barker BL … Benovic JL (Biochemistry 2011) 3 4 54
  4. Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip). (PMID: 17535810) Bédard J … Jarvis P (The Journal of biological chemistry 2007) 3 23 54
  5. Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. (PMID: 17013759) Caruso JA … Reiners JJ (Apoptosis : an international journal on programmed cell death 2006) 3 23 54

Products for ST13 Gene

Sources for ST13 Gene